Amino acid dipepetide frequency for Parvibium lacunae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.138AlaAla: 14.138 ± 0.184
1.269AlaCys: 1.269 ± 0.048
5.544AlaAsp: 5.544 ± 0.093
6.57AlaGlu: 6.57 ± 0.113
3.457AlaPhe: 3.457 ± 0.069
8.34AlaGly: 8.34 ± 0.119
2.507AlaHis: 2.507 ± 0.067
5.917AlaIle: 5.917 ± 0.091
4.28AlaLys: 4.28 ± 0.091
13.261AlaLeu: 13.261 ± 0.153
2.645AlaMet: 2.645 ± 0.06
3.664AlaAsn: 3.664 ± 0.068
4.965AlaPro: 4.965 ± 0.107
6.988AlaGln: 6.988 ± 0.132
6.411AlaArg: 6.411 ± 0.095
5.884AlaSer: 5.884 ± 0.093
5.957AlaThr: 5.957 ± 0.098
7.381AlaVal: 7.381 ± 0.115
1.668AlaTrp: 1.668 ± 0.054
2.911AlaTyr: 2.911 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
1.073CysAla: 1.073 ± 0.04
0.174CysCys: 0.174 ± 0.016
0.47CysAsp: 0.47 ± 0.023
0.473CysGlu: 0.473 ± 0.023
0.359CysPhe: 0.359 ± 0.023
0.933CysGly: 0.933 ± 0.041
0.308CysHis: 0.308 ± 0.023
0.455CysIle: 0.455 ± 0.024
0.256CysLys: 0.256 ± 0.018
1.168CysLeu: 1.168 ± 0.042
0.189CysMet: 0.189 ± 0.016
0.278CysAsn: 0.278 ± 0.017
0.495CysPro: 0.495 ± 0.025
0.5CysGln: 0.5 ± 0.026
0.571CysArg: 0.571 ± 0.031
0.474CysSer: 0.474 ± 0.025
0.476CysThr: 0.476 ± 0.026
0.703CysVal: 0.703 ± 0.032
0.164CysTrp: 0.164 ± 0.014
0.263CysTyr: 0.263 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.958AspAla: 4.958 ± 0.07
0.499AspCys: 0.499 ± 0.024
2.149AspAsp: 2.149 ± 0.07
2.768AspGlu: 2.768 ± 0.073
2.035AspPhe: 2.035 ± 0.05
3.322AspGly: 3.322 ± 0.086
1.049AspHis: 1.049 ± 0.041
2.788AspIle: 2.788 ± 0.066
2.003AspLys: 2.003 ± 0.058
5.011AspLeu: 5.011 ± 0.089
1.113AspMet: 1.113 ± 0.037
1.412AspAsn: 1.412 ± 0.045
2.492AspPro: 2.492 ± 0.062
1.885AspGln: 1.885 ± 0.053
2.45AspArg: 2.45 ± 0.06
2.55AspSer: 2.55 ± 0.064
2.47AspThr: 2.47 ± 0.074
3.204AspVal: 3.204 ± 0.067
1.01AspTrp: 1.01 ± 0.042
1.685AspTyr: 1.685 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
5.852GluAla: 5.852 ± 0.089
0.424GluCys: 0.424 ± 0.025
1.843GluAsp: 1.843 ± 0.043
2.817GluGlu: 2.817 ± 0.079
1.882GluPhe: 1.882 ± 0.053
3.148GluGly: 3.148 ± 0.07
1.24GluHis: 1.24 ± 0.042
3.524GluIle: 3.524 ± 0.078
2.909GluLys: 2.909 ± 0.071
5.662GluLeu: 5.662 ± 0.105
1.39GluMet: 1.39 ± 0.046
1.818GluAsn: 1.818 ± 0.044
2.137GluPro: 2.137 ± 0.054
3.401GluGln: 3.401 ± 0.075
3.879GluArg: 3.879 ± 0.082
2.769GluSer: 2.769 ± 0.062
2.911GluThr: 2.911 ± 0.069
3.728GluVal: 3.728 ± 0.076
0.795GluTrp: 0.795 ± 0.031
1.338GluTyr: 1.338 ± 0.044
0.0GluXaa: 0.0 ± 0.0
Phe
3.941PheAla: 3.941 ± 0.084
0.46PheCys: 0.46 ± 0.023
2.122PheAsp: 2.122 ± 0.048
1.857PheGlu: 1.857 ± 0.046
1.558PhePhe: 1.558 ± 0.043
2.942PheGly: 2.942 ± 0.068
0.728PheHis: 0.728 ± 0.033
1.969PheIle: 1.969 ± 0.063
1.384PheLys: 1.384 ± 0.046
3.247PheLeu: 3.247 ± 0.079
0.84PheMet: 0.84 ± 0.038
1.424PheAsn: 1.424 ± 0.04
1.534PhePro: 1.534 ± 0.045
1.2PheGln: 1.2 ± 0.043
1.728PheArg: 1.728 ± 0.048
2.438PheSer: 2.438 ± 0.059
2.072PheThr: 2.072 ± 0.048
2.425PheVal: 2.425 ± 0.055
0.51PheTrp: 0.51 ± 0.028
1.055PheTyr: 1.055 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
6.721GlyAla: 6.721 ± 0.113
0.863GlyCys: 0.863 ± 0.036
3.201GlyAsp: 3.201 ± 0.096
3.911GlyGlu: 3.911 ± 0.076
2.812GlyPhe: 2.812 ± 0.064
5.317GlyGly: 5.317 ± 0.123
1.657GlyHis: 1.657 ± 0.047
4.11GlyIle: 4.11 ± 0.075
3.459GlyLys: 3.459 ± 0.085
8.512GlyLeu: 8.512 ± 0.12
2.025GlyMet: 2.025 ± 0.047
2.339GlyAsn: 2.339 ± 0.111
2.328GlyPro: 2.328 ± 0.054
4.003GlyGln: 4.003 ± 0.075
3.889GlyArg: 3.889 ± 0.075
3.873GlySer: 3.873 ± 0.08
3.559GlyThr: 3.559 ± 0.073
5.428GlyVal: 5.428 ± 0.083
1.266GlyTrp: 1.266 ± 0.046
2.355GlyTyr: 2.355 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
2.659HisAla: 2.659 ± 0.058
0.318HisCys: 0.318 ± 0.02
1.2HisAsp: 1.2 ± 0.042
1.134HisGlu: 1.134 ± 0.043
0.973HisPhe: 0.973 ± 0.038
1.792HisGly: 1.792 ± 0.052
0.784HisHis: 0.784 ± 0.034
1.193HisIle: 1.193 ± 0.035
0.68HisLys: 0.68 ± 0.033
2.43HisLeu: 2.43 ± 0.064
0.444HisMet: 0.444 ± 0.027
0.636HisAsn: 0.636 ± 0.028
1.565HisPro: 1.565 ± 0.047
1.078HisGln: 1.078 ± 0.037
1.179HisArg: 1.179 ± 0.036
1.253HisSer: 1.253 ± 0.043
1.37HisThr: 1.37 ± 0.038
1.38HisVal: 1.38 ± 0.043
0.46HisTrp: 0.46 ± 0.025
0.84HisTyr: 0.84 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.275IleAla: 6.275 ± 0.095
0.526IleCys: 0.526 ± 0.022
3.126IleAsp: 3.126 ± 0.069
3.617IleGlu: 3.617 ± 0.077
1.735IlePhe: 1.735 ± 0.052
4.217IleGly: 4.217 ± 0.086
1.16IleHis: 1.16 ± 0.038
2.387IleIle: 2.387 ± 0.064
2.08IleLys: 2.08 ± 0.047
5.096IleLeu: 5.096 ± 0.082
1.006IleMet: 1.006 ± 0.04
1.964IleAsn: 1.964 ± 0.047
2.677IlePro: 2.677 ± 0.057
2.614IleGln: 2.614 ± 0.062
3.053IleArg: 3.053 ± 0.07
3.179IleSer: 3.179 ± 0.069
3.092IleThr: 3.092 ± 0.069
3.564IleVal: 3.564 ± 0.077
0.618IleTrp: 0.618 ± 0.029
1.228IleTyr: 1.228 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
3.996LysAla: 3.996 ± 0.11
0.191LysCys: 0.191 ± 0.017
1.542LysAsp: 1.542 ± 0.054
1.972LysGlu: 1.972 ± 0.063
1.196LysPhe: 1.196 ± 0.04
2.314LysGly: 2.314 ± 0.06
0.834LysHis: 0.834 ± 0.03
2.277LysIle: 2.277 ± 0.056
1.818LysLys: 1.818 ± 0.06
4.345LysLeu: 4.345 ± 0.08
1.025LysMet: 1.025 ± 0.035
1.384LysAsn: 1.384 ± 0.045
2.135LysPro: 2.135 ± 0.057
2.327LysGln: 2.327 ± 0.058
2.468LysArg: 2.468 ± 0.053
1.904LysSer: 1.904 ± 0.057
2.399LysThr: 2.399 ± 0.059
2.754LysVal: 2.754 ± 0.064
0.418LysTrp: 0.418 ± 0.024
0.884LysTyr: 0.884 ± 0.037
0.0LysXaa: 0.0 ± 0.0
Leu
14.065LeuAla: 14.065 ± 0.168
1.243LeuCys: 1.243 ± 0.039
5.52LeuAsp: 5.52 ± 0.093
5.644LeuGlu: 5.644 ± 0.091
3.954LeuPhe: 3.954 ± 0.086
8.064LeuGly: 8.064 ± 0.105
2.5LeuHis: 2.5 ± 0.065
5.624LeuIle: 5.624 ± 0.105
4.09LeuLys: 4.09 ± 0.076
12.661LeuLeu: 12.661 ± 0.189
2.13LeuMet: 2.13 ± 0.052
4.029LeuAsn: 4.029 ± 0.068
6.584LeuPro: 6.584 ± 0.114
6.111LeuGln: 6.111 ± 0.111
6.911LeuArg: 6.911 ± 0.111
7.026LeuSer: 7.026 ± 0.105
6.39LeuThr: 6.39 ± 0.084
7.005LeuVal: 7.005 ± 0.101
1.329LeuTrp: 1.329 ± 0.047
2.522LeuTyr: 2.522 ± 0.054
0.0LeuXaa: 0.0 ± 0.0
Met
2.495MetAla: 2.495 ± 0.06
0.134MetCys: 0.134 ± 0.011
0.89MetAsp: 0.89 ± 0.036
0.998MetGlu: 0.998 ± 0.036
0.59MetPhe: 0.59 ± 0.025
1.569MetGly: 1.569 ± 0.047
0.5MetHis: 0.5 ± 0.025
1.091MetIle: 1.091 ± 0.039
0.861MetLys: 0.861 ± 0.032
2.645MetLeu: 2.645 ± 0.062
0.568MetMet: 0.568 ± 0.03
0.818MetAsn: 0.818 ± 0.031
1.355MetPro: 1.355 ± 0.04
1.39MetGln: 1.39 ± 0.042
1.543MetArg: 1.543 ± 0.048
1.475MetSer: 1.475 ± 0.042
1.438MetThr: 1.438 ± 0.041
1.482MetVal: 1.482 ± 0.043
0.184MetTrp: 0.184 ± 0.016
0.376MetTyr: 0.376 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.543AsnAla: 3.543 ± 0.064
0.304AsnCys: 0.304 ± 0.021
1.57AsnAsp: 1.57 ± 0.083
1.575AsnGlu: 1.575 ± 0.047
1.091AsnPhe: 1.091 ± 0.037
2.459AsnGly: 2.459 ± 0.075
0.711AsnHis: 0.711 ± 0.031
1.687AsnIle: 1.687 ± 0.051
1.298AsnLys: 1.298 ± 0.039
3.644AsnLeu: 3.644 ± 0.067
0.72AsnMet: 0.72 ± 0.031
1.178AsnAsn: 1.178 ± 0.05
2.367AsnPro: 2.367 ± 0.053
1.862AsnGln: 1.862 ± 0.056
1.899AsnArg: 1.899 ± 0.049
1.649AsnSer: 1.649 ± 0.053
1.934AsnThr: 1.934 ± 0.055
2.037AsnVal: 2.037 ± 0.049
0.506AsnTrp: 0.506 ± 0.027
0.904AsnTyr: 0.904 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
6.304ProAla: 6.304 ± 0.102
0.396ProCys: 0.396 ± 0.023
2.777ProAsp: 2.777 ± 0.069
2.967ProGlu: 2.967 ± 0.063
1.737ProPhe: 1.737 ± 0.045
3.341ProGly: 3.341 ± 0.063
1.26ProHis: 1.26 ± 0.041
2.523ProIle: 2.523 ± 0.055
1.695ProLys: 1.695 ± 0.051
5.382ProLeu: 5.382 ± 0.1
1.068ProMet: 1.068 ± 0.036
1.943ProAsn: 1.943 ± 0.057
2.36ProPro: 2.36 ± 0.059
2.402ProGln: 2.402 ± 0.056
2.39ProArg: 2.39 ± 0.064
2.954ProSer: 2.954 ± 0.063
3.084ProThr: 3.084 ± 0.07
3.734ProVal: 3.734 ± 0.08
0.665ProTrp: 0.665 ± 0.034
1.379ProTyr: 1.379 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
7.713GlnAla: 7.713 ± 0.137
0.368GlnCys: 0.368 ± 0.024
2.034GlnAsp: 2.034 ± 0.056
2.538GlnGlu: 2.538 ± 0.065
1.762GlnPhe: 1.762 ± 0.046
3.597GlnGly: 3.597 ± 0.083
1.684GlnHis: 1.684 ± 0.05
2.926GlnIle: 2.926 ± 0.059
1.762GlnLys: 1.762 ± 0.048
5.895GlnLeu: 5.895 ± 0.101
1.044GlnMet: 1.044 ± 0.038
1.326GlnAsn: 1.326 ± 0.04
3.034GlnPro: 3.034 ± 0.069
4.121GlnGln: 4.121 ± 0.096
4.168GlnArg: 4.168 ± 0.079
2.777GlnSer: 2.777 ± 0.061
3.234GlnThr: 3.234 ± 0.076
3.644GlnVal: 3.644 ± 0.074
0.733GlnTrp: 0.733 ± 0.033
1.266GlnTyr: 1.266 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
5.987ArgAla: 5.987 ± 0.098
0.491ArgCys: 0.491 ± 0.025
2.823ArgAsp: 2.823 ± 0.058
3.572ArgGlu: 3.572 ± 0.073
2.395ArgPhe: 2.395 ± 0.057
3.674ArgGly: 3.674 ± 0.071
1.553ArgHis: 1.553 ± 0.046
3.401ArgIle: 3.401 ± 0.07
2.035ArgLys: 2.035 ± 0.053
7.169ArgLeu: 7.169 ± 0.117
1.439ArgMet: 1.439 ± 0.043
1.727ArgAsn: 1.727 ± 0.048
2.657ArgPro: 2.657 ± 0.066
3.803ArgGln: 3.803 ± 0.087
3.423ArgArg: 3.423 ± 0.078
2.818ArgSer: 2.818 ± 0.067
2.643ArgThr: 2.643 ± 0.057
4.009ArgVal: 4.009 ± 0.071
1.056ArgTrp: 1.056 ± 0.034
2.127ArgTyr: 2.127 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
6.284SerAla: 6.284 ± 0.091
0.424SerCys: 0.424 ± 0.023
2.402SerAsp: 2.402 ± 0.06
2.673SerGlu: 2.673 ± 0.059
2.078SerPhe: 2.078 ± 0.052
4.477SerGly: 4.477 ± 0.089
1.295SerHis: 1.295 ± 0.039
2.777SerIle: 2.777 ± 0.066
1.975SerLys: 1.975 ± 0.055
6.679SerLeu: 6.679 ± 0.099
1.304SerMet: 1.304 ± 0.044
1.819SerAsn: 1.819 ± 0.049
2.856SerPro: 2.856 ± 0.069
2.846SerGln: 2.846 ± 0.064
3.024SerArg: 3.024 ± 0.06
3.366SerSer: 3.366 ± 0.081
3.269SerThr: 3.269 ± 0.071
3.648SerVal: 3.648 ± 0.071
0.794SerTrp: 0.794 ± 0.035
1.519SerTyr: 1.519 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
5.912ThrAla: 5.912 ± 0.103
0.465ThrCys: 0.465 ± 0.025
2.593ThrAsp: 2.593 ± 0.06
2.748ThrGlu: 2.748 ± 0.062
1.74ThrPhe: 1.74 ± 0.05
4.21ThrGly: 4.21 ± 0.097
1.301ThrHis: 1.301 ± 0.039
2.782ThrIle: 2.782 ± 0.065
1.655ThrLys: 1.655 ± 0.048
7.309ThrLeu: 7.309 ± 0.109
0.964ThrMet: 0.964 ± 0.033
1.655ThrAsn: 1.655 ± 0.045
3.641ThrPro: 3.641 ± 0.071
3.097ThrGln: 3.097 ± 0.063
2.992ThrArg: 2.992 ± 0.071
2.783ThrSer: 2.783 ± 0.072
3.263ThrThr: 3.263 ± 0.078
3.998ThrVal: 3.998 ± 0.069
0.818ThrTrp: 0.818 ± 0.036
1.36ThrTyr: 1.36 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
7.608ValAla: 7.608 ± 0.111
0.725ValCys: 0.725 ± 0.031
3.316ValAsp: 3.316 ± 0.062
3.694ValGlu: 3.694 ± 0.076
2.378ValPhe: 2.378 ± 0.052
4.887ValGly: 4.887 ± 0.085
1.26ValHis: 1.26 ± 0.037
3.961ValIle: 3.961 ± 0.07
2.744ValLys: 2.744 ± 0.068
7.64ValLeu: 7.64 ± 0.114
1.737ValMet: 1.737 ± 0.05
2.453ValAsn: 2.453 ± 0.052
3.117ValPro: 3.117 ± 0.064
2.978ValGln: 2.978 ± 0.064
3.831ValArg: 3.831 ± 0.081
4.088ValSer: 4.088 ± 0.088
3.898ValThr: 3.898 ± 0.067
5.368ValVal: 5.368 ± 0.098
0.981ValTrp: 0.981 ± 0.039
1.713ValTyr: 1.713 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
1.28TrpAla: 1.28 ± 0.043
0.159TrpCys: 0.159 ± 0.015
0.51TrpAsp: 0.51 ± 0.024
0.629TrpGlu: 0.629 ± 0.031
0.566TrpPhe: 0.566 ± 0.029
0.854TrpGly: 0.854 ± 0.036
0.425TrpHis: 0.425 ± 0.025
0.715TrpIle: 0.715 ± 0.033
0.373TrpLys: 0.373 ± 0.02
2.484TrpLeu: 2.484 ± 0.073
0.333TrpMet: 0.333 ± 0.021
0.348TrpAsn: 0.348 ± 0.023
0.694TrpPro: 0.694 ± 0.033
1.42TrpGln: 1.42 ± 0.05
1.154TrpArg: 1.154 ± 0.044
0.671TrpSer: 0.671 ± 0.033
0.519TrpThr: 0.519 ± 0.026
1.028TrpVal: 1.028 ± 0.034
0.291TrpTrp: 0.291 ± 0.022
0.336TrpTyr: 0.336 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.952TyrAla: 2.952 ± 0.059
0.348TyrCys: 0.348 ± 0.018
1.225TyrAsp: 1.225 ± 0.047
1.313TyrGlu: 1.313 ± 0.043
1.134TyrPhe: 1.134 ± 0.038
2.173TyrGly: 2.173 ± 0.063
0.611TyrHis: 0.611 ± 0.029
1.11TyrIle: 1.11 ± 0.038
0.824TyrLys: 0.824 ± 0.037
3.162TyrLeu: 3.162 ± 0.065
0.418TyrMet: 0.418 ± 0.025
0.724TyrAsn: 0.724 ± 0.031
1.37TyrPro: 1.37 ± 0.044
1.6TyrGln: 1.6 ± 0.042
1.838TyrArg: 1.838 ± 0.055
1.575TyrSer: 1.575 ± 0.056
1.306TyrThr: 1.306 ± 0.046
1.855TyrVal: 1.855 ± 0.054
0.523TyrTrp: 0.523 ± 0.026
0.76TyrTyr: 0.76 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2432 proteins (799854 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski