Amino acid dipepetide frequency for Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.828AlaAla: 3.828 ± 0.414
0.669AlaCys: 0.669 ± 0.12
2.698AlaAsp: 2.698 ± 0.253
2.514AlaGlu: 2.514 ± 0.26
2.052AlaPhe: 2.052 ± 0.234
2.675AlaGly: 2.675 ± 0.305
1.084AlaHis: 1.084 ± 0.189
3.113AlaIle: 3.113 ± 0.299
3.044AlaLys: 3.044 ± 0.296
4.774AlaLeu: 4.774 ± 0.415
1.038AlaMet: 1.038 ± 0.147
2.583AlaAsn: 2.583 ± 0.396
3.205AlaPro: 3.205 ± 0.381
2.79AlaGln: 2.79 ± 0.274
2.514AlaArg: 2.514 ± 0.286
3.367AlaSer: 3.367 ± 0.33
4.22AlaThr: 4.22 ± 0.467
3.205AlaVal: 3.205 ± 0.365
0.577AlaTrp: 0.577 ± 0.11
1.499AlaTyr: 1.499 ± 0.2
0.0AlaXaa: 0.0 ± 0.0
Cys
0.853CysAla: 0.853 ± 0.17
0.53CysCys: 0.53 ± 0.126
0.853CysAsp: 0.853 ± 0.17
0.876CysGlu: 0.876 ± 0.142
0.715CysPhe: 0.715 ± 0.107
1.176CysGly: 1.176 ± 0.193
0.577CysHis: 0.577 ± 0.158
1.084CysIle: 1.084 ± 0.194
1.015CysLys: 1.015 ± 0.147
1.43CysLeu: 1.43 ± 0.183
0.369CysMet: 0.369 ± 0.081
0.853CysAsn: 0.853 ± 0.176
1.153CysPro: 1.153 ± 0.181
0.553CysGln: 0.553 ± 0.097
1.13CysArg: 1.13 ± 0.15
1.499CysSer: 1.499 ± 0.193
1.268CysThr: 1.268 ± 0.218
1.107CysVal: 1.107 ± 0.185
0.231CysTrp: 0.231 ± 0.092
0.553CysTyr: 0.553 ± 0.104
0.0CysXaa: 0.0 ± 0.0
Asp
2.998AspAla: 2.998 ± 0.312
1.13AspCys: 1.13 ± 0.169
3.92AspAsp: 3.92 ± 0.349
4.105AspGlu: 4.105 ± 0.322
2.652AspPhe: 2.652 ± 0.263
3.713AspGly: 3.713 ± 0.378
1.314AspHis: 1.314 ± 0.215
2.698AspIle: 2.698 ± 0.281
2.813AspLys: 2.813 ± 0.261
6.157AspLeu: 6.157 ± 0.507
1.153AspMet: 1.153 ± 0.142
2.606AspAsn: 2.606 ± 0.243
3.39AspPro: 3.39 ± 0.326
2.56AspGln: 2.56 ± 0.246
2.444AspArg: 2.444 ± 0.301
4.036AspSer: 4.036 ± 0.392
2.721AspThr: 2.721 ± 0.308
3.736AspVal: 3.736 ± 0.318
1.015AspTrp: 1.015 ± 0.146
2.836AspTyr: 2.836 ± 0.241
0.0AspXaa: 0.0 ± 0.0
Glu
3.159GluAla: 3.159 ± 0.305
1.084GluCys: 1.084 ± 0.148
3.113GluAsp: 3.113 ± 0.324
3.897GluGlu: 3.897 ± 0.373
2.652GluPhe: 2.652 ± 0.26
2.214GluGly: 2.214 ± 0.215
0.807GluHis: 0.807 ± 0.118
3.298GluIle: 3.298 ± 0.322
4.727GluLys: 4.727 ± 0.414
4.82GluLeu: 4.82 ± 0.297
1.245GluMet: 1.245 ± 0.155
3.413GluAsn: 3.413 ± 0.319
2.467GluPro: 2.467 ± 0.258
2.744GluGln: 2.744 ± 0.245
3.021GluArg: 3.021 ± 0.352
3.782GluSer: 3.782 ± 0.338
3.943GluThr: 3.943 ± 0.336
2.467GluVal: 2.467 ± 0.286
1.199GluTrp: 1.199 ± 0.169
2.491GluTyr: 2.491 ± 0.197
0.0GluXaa: 0.0 ± 0.0
Phe
2.006PheAla: 2.006 ± 0.208
0.807PheCys: 0.807 ± 0.136
2.398PheAsp: 2.398 ± 0.213
2.56PheGlu: 2.56 ± 0.264
1.799PhePhe: 1.799 ± 0.269
2.398PheGly: 2.398 ± 0.226
1.153PheHis: 1.153 ± 0.178
3.067PheIle: 3.067 ± 0.289
3.528PheLys: 3.528 ± 0.287
3.989PheLeu: 3.989 ± 0.31
1.084PheMet: 1.084 ± 0.17
2.56PheAsn: 2.56 ± 0.242
1.753PhePro: 1.753 ± 0.208
2.122PheGln: 2.122 ± 0.189
2.145PheArg: 2.145 ± 0.245
2.79PheSer: 2.79 ± 0.268
2.86PheThr: 2.86 ± 0.221
3.136PheVal: 3.136 ± 0.291
0.369PheTrp: 0.369 ± 0.075
1.706PheTyr: 1.706 ± 0.226
0.0PheXaa: 0.0 ± 0.0
Gly
2.467GlyAla: 2.467 ± 0.334
0.83GlyCys: 0.83 ± 0.139
3.067GlyAsp: 3.067 ± 0.416
2.813GlyGlu: 2.813 ± 0.246
2.237GlyPhe: 2.237 ± 0.232
3.782GlyGly: 3.782 ± 0.596
1.13GlyHis: 1.13 ± 0.155
2.675GlyIle: 2.675 ± 0.315
3.298GlyLys: 3.298 ± 0.253
4.22GlyLeu: 4.22 ± 0.354
1.015GlyMet: 1.015 ± 0.202
1.914GlyAsn: 1.914 ± 0.178
2.052GlyPro: 2.052 ± 0.362
2.214GlyGln: 2.214 ± 0.314
1.822GlyArg: 1.822 ± 0.213
4.128GlySer: 4.128 ± 0.408
4.197GlyThr: 4.197 ± 0.686
3.482GlyVal: 3.482 ± 0.337
0.692GlyTrp: 0.692 ± 0.143
1.799GlyTyr: 1.799 ± 0.216
0.0GlyXaa: 0.0 ± 0.0
His
0.83HisAla: 0.83 ± 0.166
0.484HisCys: 0.484 ± 0.102
0.807HisAsp: 0.807 ± 0.122
1.13HisGlu: 1.13 ± 0.205
0.945HisPhe: 0.945 ± 0.142
0.876HisGly: 0.876 ± 0.153
1.084HisHis: 1.084 ± 0.156
1.268HisIle: 1.268 ± 0.16
1.199HisLys: 1.199 ± 0.16
2.444HisLeu: 2.444 ± 0.226
0.415HisMet: 0.415 ± 0.095
1.176HisAsn: 1.176 ± 0.174
1.176HisPro: 1.176 ± 0.161
1.176HisGln: 1.176 ± 0.162
1.107HisArg: 1.107 ± 0.183
1.222HisSer: 1.222 ± 0.216
1.291HisThr: 1.291 ± 0.198
1.776HisVal: 1.776 ± 0.23
0.323HisTrp: 0.323 ± 0.096
1.084HisTyr: 1.084 ± 0.177
0.0HisXaa: 0.0 ± 0.0
Ile
2.675IleAla: 2.675 ± 0.289
0.992IleCys: 0.992 ± 0.18
3.759IleAsp: 3.759 ± 0.292
3.182IleGlu: 3.182 ± 0.284
3.067IlePhe: 3.067 ± 0.292
2.767IleGly: 2.767 ± 0.275
1.153IleHis: 1.153 ± 0.171
3.228IleIle: 3.228 ± 0.323
5.073IleLys: 5.073 ± 0.415
5.073IleLeu: 5.073 ± 0.382
1.268IleMet: 1.268 ± 0.183
3.436IleAsn: 3.436 ± 0.31
3.021IlePro: 3.021 ± 0.306
2.421IleGln: 2.421 ± 0.234
3.113IleArg: 3.113 ± 0.315
4.335IleSer: 4.335 ± 0.309
3.205IleThr: 3.205 ± 0.283
4.727IleVal: 4.727 ± 0.367
0.623IleTrp: 0.623 ± 0.129
2.237IleTyr: 2.237 ± 0.183
0.0IleXaa: 0.0 ± 0.0
Lys
2.514LysAla: 2.514 ± 0.265
1.176LysCys: 1.176 ± 0.213
3.067LysAsp: 3.067 ± 0.245
3.344LysGlu: 3.344 ± 0.289
3.39LysPhe: 3.39 ± 0.259
2.467LysGly: 2.467 ± 0.315
1.268LysHis: 1.268 ± 0.188
5.811LysIle: 5.811 ± 0.372
6.226LysLys: 6.226 ± 0.511
6.088LysLeu: 6.088 ± 0.375
2.352LysMet: 2.352 ± 0.26
4.912LysAsn: 4.912 ± 0.446
3.897LysPro: 3.897 ± 0.427
2.744LysGln: 2.744 ± 0.267
3.69LysArg: 3.69 ± 0.342
4.958LysSer: 4.958 ± 0.366
4.82LysThr: 4.82 ± 0.426
4.243LysVal: 4.243 ± 0.387
0.876LysTrp: 0.876 ± 0.151
3.044LysTyr: 3.044 ± 0.344
0.0LysXaa: 0.0 ± 0.0
Leu
4.774LeuAla: 4.774 ± 0.367
1.476LeuCys: 1.476 ± 0.198
5.304LeuAsp: 5.304 ± 0.429
5.996LeuGlu: 5.996 ± 0.498
3.828LeuPhe: 3.828 ± 0.412
4.474LeuGly: 4.474 ± 0.377
1.499LeuHis: 1.499 ± 0.18
4.266LeuIle: 4.266 ± 0.417
7.771LeuLys: 7.771 ± 0.555
7.541LeuLeu: 7.541 ± 0.476
1.96LeuMet: 1.96 ± 0.203
5.281LeuAsn: 5.281 ± 0.37
4.312LeuPro: 4.312 ± 0.308
3.482LeuGln: 3.482 ± 0.344
4.405LeuArg: 4.405 ± 0.446
5.189LeuSer: 5.189 ± 0.35
5.996LeuThr: 5.996 ± 0.505
7.841LeuVal: 7.841 ± 0.478
1.084LeuTrp: 1.084 ± 0.153
3.344LeuTyr: 3.344 ± 0.311
0.0LeuXaa: 0.0 ± 0.0
Met
1.637MetAla: 1.637 ± 0.203
0.392MetCys: 0.392 ± 0.097
1.868MetAsp: 1.868 ± 0.235
1.706MetGlu: 1.706 ± 0.203
0.876MetPhe: 0.876 ± 0.157
1.66MetGly: 1.66 ± 0.18
0.415MetHis: 0.415 ± 0.105
1.107MetIle: 1.107 ± 0.182
1.061MetLys: 1.061 ± 0.149
1.314MetLeu: 1.314 ± 0.167
0.346MetMet: 0.346 ± 0.082
1.038MetAsn: 1.038 ± 0.167
0.461MetPro: 0.461 ± 0.099
0.53MetGln: 0.53 ± 0.106
0.669MetArg: 0.669 ± 0.119
1.476MetSer: 1.476 ± 0.181
1.361MetThr: 1.361 ± 0.181
2.214MetVal: 2.214 ± 0.278
0.3MetTrp: 0.3 ± 0.086
0.784MetTyr: 0.784 ± 0.145
0.0MetXaa: 0.0 ± 0.0
Asn
2.56AsnAla: 2.56 ± 0.268
0.784AsnCys: 0.784 ± 0.186
2.306AsnAsp: 2.306 ± 0.221
2.744AsnGlu: 2.744 ± 0.257
3.182AsnPhe: 3.182 ± 0.262
3.344AsnGly: 3.344 ± 0.326
1.568AsnHis: 1.568 ± 0.198
2.975AsnIle: 2.975 ± 0.284
4.013AsnLys: 4.013 ± 0.335
5.327AsnLeu: 5.327 ± 0.438
1.153AsnMet: 1.153 ± 0.158
2.56AsnAsn: 2.56 ± 0.271
3.367AsnPro: 3.367 ± 0.305
2.537AsnGln: 2.537 ± 0.251
2.444AsnArg: 2.444 ± 0.207
3.113AsnSer: 3.113 ± 0.259
2.421AsnThr: 2.421 ± 0.263
3.759AsnVal: 3.759 ± 0.264
0.692AsnTrp: 0.692 ± 0.125
2.283AsnTyr: 2.283 ± 0.272
0.0AsnXaa: 0.0 ± 0.0
Pro
2.052ProAla: 2.052 ± 0.243
0.876ProCys: 0.876 ± 0.176
3.09ProAsp: 3.09 ± 0.334
3.275ProGlu: 3.275 ± 0.309
2.191ProPhe: 2.191 ± 0.214
1.822ProGly: 1.822 ± 0.218
1.176ProHis: 1.176 ± 0.191
3.252ProIle: 3.252 ± 0.284
3.736ProLys: 3.736 ± 0.408
4.52ProLeu: 4.52 ± 0.313
1.038ProMet: 1.038 ± 0.155
2.56ProAsn: 2.56 ± 0.257
4.681ProPro: 4.681 ± 0.729
2.813ProGln: 2.813 ± 0.294
2.029ProArg: 2.029 ± 0.25
5.027ProSer: 5.027 ± 0.668
4.681ProThr: 4.681 ± 0.428
3.344ProVal: 3.344 ± 0.278
0.577ProTrp: 0.577 ± 0.134
1.73ProTyr: 1.73 ± 0.23
0.0ProXaa: 0.0 ± 0.0
Gln
2.145GlnAla: 2.145 ± 0.272
0.784GlnCys: 0.784 ± 0.157
2.145GlnAsp: 2.145 ± 0.212
2.606GlnGlu: 2.606 ± 0.273
1.799GlnPhe: 1.799 ± 0.209
1.384GlnGly: 1.384 ± 0.173
0.922GlnHis: 0.922 ± 0.147
2.744GlnIle: 2.744 ± 0.294
2.813GlnLys: 2.813 ± 0.283
5.143GlnLeu: 5.143 ± 0.451
0.945GlnMet: 0.945 ± 0.149
1.845GlnAsn: 1.845 ± 0.244
2.491GlnPro: 2.491 ± 0.244
2.606GlnGln: 2.606 ± 0.337
1.683GlnArg: 1.683 ± 0.179
3.09GlnSer: 3.09 ± 0.235
3.367GlnThr: 3.367 ± 0.308
2.629GlnVal: 2.629 ± 0.275
0.784GlnTrp: 0.784 ± 0.147
1.891GlnTyr: 1.891 ± 0.244
0.0GlnXaa: 0.0 ± 0.0
Arg
2.283ArgAla: 2.283 ± 0.275
0.807ArgCys: 0.807 ± 0.15
3.69ArgAsp: 3.69 ± 0.315
2.652ArgGlu: 2.652 ± 0.3
1.845ArgPhe: 1.845 ± 0.204
1.799ArgGly: 1.799 ± 0.219
0.899ArgHis: 0.899 ± 0.139
2.56ArgIle: 2.56 ± 0.258
3.782ArgLys: 3.782 ± 0.363
5.119ArgLeu: 5.119 ± 0.381
1.015ArgMet: 1.015 ± 0.115
2.444ArgAsn: 2.444 ± 0.259
2.421ArgPro: 2.421 ± 0.257
2.491ArgGln: 2.491 ± 0.26
2.79ArgArg: 2.79 ± 0.251
3.252ArgSer: 3.252 ± 0.438
2.375ArgThr: 2.375 ± 0.222
3.067ArgVal: 3.067 ± 0.32
0.715ArgTrp: 0.715 ± 0.131
2.214ArgTyr: 2.214 ± 0.193
0.0ArgXaa: 0.0 ± 0.0
Ser
3.667SerAla: 3.667 ± 0.321
1.43SerCys: 1.43 ± 0.197
3.943SerAsp: 3.943 ± 0.411
3.459SerGlu: 3.459 ± 0.342
3.275SerPhe: 3.275 ± 0.297
3.92SerGly: 3.92 ± 0.53
1.453SerHis: 1.453 ± 0.178
4.266SerIle: 4.266 ± 0.369
4.727SerLys: 4.727 ± 0.382
5.673SerLeu: 5.673 ± 0.319
1.268SerMet: 1.268 ± 0.129
3.759SerAsn: 3.759 ± 0.38
4.497SerPro: 4.497 ± 0.549
2.606SerGln: 2.606 ± 0.325
3.574SerArg: 3.574 ± 0.48
6.272SerSer: 6.272 ± 1.013
5.419SerThr: 5.419 ± 0.354
4.289SerVal: 4.289 ± 0.382
0.623SerTrp: 0.623 ± 0.136
2.467SerTyr: 2.467 ± 0.22
0.0SerXaa: 0.0 ± 0.0
Thr
4.543ThrAla: 4.543 ± 0.48
1.222ThrCys: 1.222 ± 0.165
2.998ThrAsp: 2.998 ± 0.369
2.929ThrGlu: 2.929 ± 0.284
2.652ThrPhe: 2.652 ± 0.257
3.367ThrGly: 3.367 ± 0.525
1.522ThrHis: 1.522 ± 0.22
5.927ThrIle: 5.927 ± 0.362
3.597ThrLys: 3.597 ± 0.369
5.996ThrLeu: 5.996 ± 0.4
1.245ThrMet: 1.245 ± 0.175
3.228ThrAsn: 3.228 ± 0.318
3.874ThrPro: 3.874 ± 0.327
2.514ThrGln: 2.514 ± 0.28
3.736ThrArg: 3.736 ± 0.336
4.197ThrSer: 4.197 ± 0.426
6.78ThrThr: 6.78 ± 0.592
4.958ThrVal: 4.958 ± 0.41
0.876ThrTrp: 0.876 ± 0.161
1.522ThrTyr: 1.522 ± 0.176
0.0ThrXaa: 0.0 ± 0.0
Val
4.105ValAla: 4.105 ± 0.355
1.384ValCys: 1.384 ± 0.183
5.096ValAsp: 5.096 ± 0.392
4.52ValGlu: 4.52 ± 0.398
2.467ValPhe: 2.467 ± 0.286
3.321ValGly: 3.321 ± 0.301
1.499ValHis: 1.499 ± 0.171
2.836ValIle: 2.836 ± 0.251
4.935ValLys: 4.935 ± 0.35
5.65ValLeu: 5.65 ± 0.341
1.038ValMet: 1.038 ± 0.132
3.621ValAsn: 3.621 ± 0.368
3.966ValPro: 3.966 ± 0.34
3.321ValGln: 3.321 ± 0.245
3.205ValArg: 3.205 ± 0.287
4.704ValSer: 4.704 ± 0.383
3.551ValThr: 3.551 ± 0.38
5.673ValVal: 5.673 ± 0.434
1.361ValTrp: 1.361 ± 0.17
2.491ValTyr: 2.491 ± 0.29
0.0ValXaa: 0.0 ± 0.0
Trp
0.784TrpAla: 0.784 ± 0.142
0.369TrpCys: 0.369 ± 0.102
0.807TrpAsp: 0.807 ± 0.177
0.577TrpGlu: 0.577 ± 0.121
0.922TrpPhe: 0.922 ± 0.129
0.53TrpGly: 0.53 ± 0.115
0.161TrpHis: 0.161 ± 0.043
0.945TrpIle: 0.945 ± 0.192
0.715TrpLys: 0.715 ± 0.142
1.084TrpLeu: 1.084 ± 0.141
0.3TrpMet: 0.3 ± 0.076
0.876TrpAsn: 0.876 ± 0.202
0.415TrpPro: 0.415 ± 0.13
0.115TrpGln: 0.115 ± 0.058
0.461TrpArg: 0.461 ± 0.139
1.614TrpSer: 1.614 ± 0.221
0.83TrpThr: 0.83 ± 0.152
0.83TrpVal: 0.83 ± 0.126
0.208TrpTrp: 0.208 ± 0.072
0.969TrpTyr: 0.969 ± 0.152
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.568TyrAla: 1.568 ± 0.202
0.6TyrCys: 0.6 ± 0.135
3.067TyrAsp: 3.067 ± 0.302
1.66TyrGlu: 1.66 ± 0.223
1.683TyrPhe: 1.683 ± 0.18
2.145TyrGly: 2.145 ± 0.262
1.13TyrHis: 1.13 ± 0.154
2.26TyrIle: 2.26 ± 0.194
2.813TyrLys: 2.813 ± 0.303
3.459TyrLeu: 3.459 ± 0.296
0.945TyrMet: 0.945 ± 0.158
2.467TyrAsn: 2.467 ± 0.275
1.868TyrPro: 1.868 ± 0.209
1.476TyrGln: 1.476 ± 0.242
2.237TyrArg: 2.237 ± 0.217
2.537TyrSer: 2.537 ± 0.292
2.375TyrThr: 2.375 ± 0.261
2.26TyrVal: 2.26 ± 0.351
0.392TyrTrp: 0.392 ± 0.098
1.914TyrTyr: 1.914 ± 0.272
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 126 proteins (43365 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski