Amino acid dipepetide frequency for Acetobacter sp. DmW_043

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.233AlaAla: 13.233 ± 0.182	1.408AlaCys: 1.408 ± 0.052	5.871AlaAsp: 5.871 ± 0.096	6.75AlaGlu: 6.75 ± 0.128	3.689AlaPhe: 3.689 ± 0.078	10.011AlaGly: 10.011 ± 0.133	2.409AlaHis: 2.409 ± 0.056	4.94AlaIle: 4.94 ± 0.082	3.084AlaLys: 3.084 ± 0.077	12.426AlaLeu: 12.426 ± 0.156	2.845AlaMet: 2.845 ± 0.059	2.312AlaAsn: 2.312 ± 0.063	5.23AlaPro: 5.23 ± 0.099	4.491AlaGln: 4.491 ± 0.102	7.553AlaArg: 7.553 ± 0.11	6.568AlaSer: 6.568 ± 0.104	5.628AlaThr: 5.628 ± 0.102	7.718AlaVal: 7.718 ± 0.123	1.364AlaTrp: 1.364 ± 0.051	2.276AlaTyr: 2.276 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	1.196CysAla: 1.196 ± 0.043	0.173CysCys: 0.173 ± 0.018	0.595CysAsp: 0.595 ± 0.032	0.453CysGlu: 0.453 ± 0.028	0.452CysPhe: 0.452 ± 0.026	1.073CysGly: 1.073 ± 0.042	0.31CysHis: 0.31 ± 0.019	0.624CysIle: 0.624 ± 0.032	0.263CysLys: 0.263 ± 0.02	1.188CysLeu: 1.188 ± 0.047	0.217CysMet: 0.217 ± 0.017	0.286CysAsn: 0.286 ± 0.021	0.508CysPro: 0.508 ± 0.029	0.334CysGln: 0.334 ± 0.022	0.639CysArg: 0.639 ± 0.034	0.723CysSer: 0.723 ± 0.029	0.573CysThr: 0.573 ± 0.026	0.85CysVal: 0.85 ± 0.043	0.125CysTrp: 0.125 ± 0.014	0.254CysTyr: 0.254 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	5.567AspAla: 5.567 ± 0.101	0.515AspCys: 0.515 ± 0.028	2.709AspAsp: 2.709 ± 0.075	3.031AspGlu: 3.031 ± 0.078	1.989AspPhe: 1.989 ± 0.056	4.114AspGly: 4.114 ± 0.088	1.141AspHis: 1.141 ± 0.041	3.466AspIle: 3.466 ± 0.074	1.966AspLys: 1.966 ± 0.066	5.199AspLeu: 5.199 ± 0.086	1.495AspMet: 1.495 ± 0.047	1.625AspAsn: 1.625 ± 0.044	2.747AspPro: 2.747 ± 0.072	1.797AspGln: 1.797 ± 0.056	3.004AspArg: 3.004 ± 0.069	2.604AspSer: 2.604 ± 0.064	3.003AspThr: 3.003 ± 0.065	3.983AspVal: 3.983 ± 0.088	0.828AspTrp: 0.828 ± 0.038	1.439AspTyr: 1.439 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	6.63GluAla: 6.63 ± 0.124	0.433GluCys: 0.433 ± 0.025	2.541GluAsp: 2.541 ± 0.072	3.406GluGlu: 3.406 ± 0.095	1.562GluPhe: 1.562 ± 0.056	4.004GluGly: 4.004 ± 0.086	1.435GluHis: 1.435 ± 0.049	3.056GluIle: 3.056 ± 0.073	3.093GluLys: 3.093 ± 0.088	4.774GluLeu: 4.774 ± 0.089	1.413GluMet: 1.413 ± 0.044	2.065GluAsn: 2.065 ± 0.06	2.012GluPro: 2.012 ± 0.051	2.582GluGln: 2.582 ± 0.077	3.97GluArg: 3.97 ± 0.101	2.643GluSer: 2.643 ± 0.06	3.542GluThr: 3.542 ± 0.077	3.332GluVal: 3.332 ± 0.078	0.658GluTrp: 0.658 ± 0.029	1.092GluTyr: 1.092 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.596PheAla: 3.596 ± 0.078	0.546PheCys: 0.546 ± 0.028	2.219PheAsp: 2.219 ± 0.055	1.866PheGlu: 1.866 ± 0.059	1.692PhePhe: 1.692 ± 0.06	3.088PheGly: 3.088 ± 0.069	0.896PheHis: 0.896 ± 0.037	1.997PheIle: 1.997 ± 0.064	1.067PheLys: 1.067 ± 0.041	3.86PheLeu: 3.86 ± 0.081	1.007PheMet: 1.007 ± 0.039	1.247PheAsn: 1.247 ± 0.049	1.553PhePro: 1.553 ± 0.052	1.048PheGln: 1.048 ± 0.041	2.107PheArg: 2.107 ± 0.053	3.177PheSer: 3.177 ± 0.073	2.17PheThr: 2.17 ± 0.056	2.564PheVal: 2.564 ± 0.064	0.515PheTrp: 0.515 ± 0.03	1.072PheTyr: 1.072 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	7.59GlyAla: 7.59 ± 0.113	0.974GlyCys: 0.974 ± 0.041	3.604GlyAsp: 3.604 ± 0.081	3.909GlyGlu: 3.909 ± 0.07	3.384GlyPhe: 3.384 ± 0.077	6.719GlyGly: 6.719 ± 0.147	2.126GlyHis: 2.126 ± 0.063	4.488GlyIle: 4.488 ± 0.088	3.319GlyLys: 3.319 ± 0.074	8.291GlyLeu: 8.291 ± 0.12	2.257GlyMet: 2.257 ± 0.056	2.406GlyAsn: 2.406 ± 0.078	2.997GlyPro: 2.997 ± 0.072	3.264GlyGln: 3.264 ± 0.074	5.056GlyArg: 5.056 ± 0.094	4.813GlySer: 4.813 ± 0.097	4.652GlyThr: 4.652 ± 0.101	5.941GlyVal: 5.941 ± 0.091	1.317GlyTrp: 1.317 ± 0.055	2.325GlyTyr: 2.325 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	2.408HisAla: 2.408 ± 0.06	0.275HisCys: 0.275 ± 0.021	1.37HisAsp: 1.37 ± 0.05	1.215HisGlu: 1.215 ± 0.044	0.999HisPhe: 0.999 ± 0.04	1.838HisGly: 1.838 ± 0.05	0.728HisHis: 0.728 ± 0.04	1.491HisIle: 1.491 ± 0.048	0.911HisLys: 0.911 ± 0.037	2.275HisLeu: 2.275 ± 0.061	0.629HisMet: 0.629 ± 0.029	0.89HisAsn: 0.89 ± 0.034	1.371HisPro: 1.371 ± 0.04	0.806HisGln: 0.806 ± 0.032	1.301HisArg: 1.301 ± 0.042	1.395HisSer: 1.395 ± 0.051	1.439HisThr: 1.439 ± 0.05	1.711HisVal: 1.711 ± 0.056	0.329HisTrp: 0.329 ± 0.024	0.719HisTyr: 0.719 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.113IleAla: 6.113 ± 0.106	0.689IleCys: 0.689 ± 0.032	2.969IleAsp: 2.969 ± 0.07	2.919IleGlu: 2.919 ± 0.068	1.95IlePhe: 1.95 ± 0.054	4.107IleGly: 4.107 ± 0.08	1.004IleHis: 1.004 ± 0.035	3.025IleIle: 3.025 ± 0.081	1.776IleLys: 1.776 ± 0.061	4.959IleLeu: 4.959 ± 0.102	1.336IleMet: 1.336 ± 0.049	1.729IleAsn: 1.729 ± 0.06	2.657IlePro: 2.657 ± 0.072	1.466IleGln: 1.466 ± 0.041	3.285IleArg: 3.285 ± 0.073	3.852IleSer: 3.852 ± 0.087	3.68IleThr: 3.68 ± 0.075	3.702IleVal: 3.702 ± 0.081	0.592IleTrp: 0.592 ± 0.034	1.197IleTyr: 1.197 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.286LysAla: 4.286 ± 0.078	0.218LysCys: 0.218 ± 0.018	1.89LysAsp: 1.89 ± 0.06	2.135LysGlu: 2.135 ± 0.067	0.973LysPhe: 0.973 ± 0.042	2.781LysGly: 2.781 ± 0.058	0.757LysHis: 0.757 ± 0.037	2.244LysIle: 2.244 ± 0.058	2.17LysLys: 2.17 ± 0.068	3.375LysLeu: 3.375 ± 0.07	0.896LysMet: 0.896 ± 0.034	1.677LysAsn: 1.677 ± 0.061	2.033LysPro: 2.033 ± 0.055	1.42LysGln: 1.42 ± 0.048	2.21LysArg: 2.21 ± 0.054	1.935LysSer: 1.935 ± 0.053	2.603LysThr: 2.603 ± 0.062	2.328LysVal: 2.328 ± 0.073	0.437LysTrp: 0.437 ± 0.026	0.703LysTyr: 0.703 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	11.422LeuAla: 11.422 ± 0.155	1.32LeuCys: 1.32 ± 0.043	5.101LeuAsp: 5.101 ± 0.098	4.99LeuGlu: 4.99 ± 0.115	3.822LeuPhe: 3.822 ± 0.094	6.786LeuGly: 6.786 ± 0.12	2.533LeuHis: 2.533 ± 0.065	5.214LeuIle: 5.214 ± 0.107	4.041LeuLys: 4.041 ± 0.084	10.217LeuLeu: 10.217 ± 0.169	2.476LeuMet: 2.476 ± 0.059	3.227LeuAsn: 3.227 ± 0.08	6.677LeuPro: 6.677 ± 0.102	3.412LeuGln: 3.412 ± 0.069	6.891LeuArg: 6.891 ± 0.129	8.083LeuSer: 8.083 ± 0.122	6.621LeuThr: 6.621 ± 0.114	6.516LeuVal: 6.516 ± 0.106	1.237LeuTrp: 1.237 ± 0.04	2.272LeuTyr: 2.272 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.867MetAla: 2.867 ± 0.068	0.176MetCys: 0.176 ± 0.014	1.032MetAsp: 1.032 ± 0.035	1.045MetGlu: 1.045 ± 0.042	0.697MetPhe: 0.697 ± 0.037	1.831MetGly: 1.831 ± 0.055	0.534MetHis: 0.534 ± 0.033	1.283MetIle: 1.283 ± 0.045	1.084MetLys: 1.084 ± 0.039	2.651MetLeu: 2.651 ± 0.062	0.666MetMet: 0.666 ± 0.027	0.843MetAsn: 0.843 ± 0.039	1.575MetPro: 1.575 ± 0.044	1.11MetGln: 1.11 ± 0.046	1.599MetArg: 1.599 ± 0.045	1.863MetSer: 1.863 ± 0.046	2.102MetThr: 2.102 ± 0.049	1.615MetVal: 1.615 ± 0.051	0.223MetTrp: 0.223 ± 0.019	0.329MetTyr: 0.329 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.298AsnAla: 3.298 ± 0.075	0.294AsnCys: 0.294 ± 0.02	1.513AsnAsp: 1.513 ± 0.05	1.34AsnGlu: 1.34 ± 0.046	1.169AsnPhe: 1.169 ± 0.049	2.716AsnGly: 2.716 ± 0.075	0.648AsnHis: 0.648 ± 0.029	1.999AsnIle: 1.999 ± 0.066	1.237AsnLys: 1.237 ± 0.055	2.781AsnLeu: 2.781 ± 0.067	0.734AsnMet: 0.734 ± 0.028	1.177AsnAsn: 1.177 ± 0.058	1.958AsnPro: 1.958 ± 0.052	0.98AsnGln: 0.98 ± 0.042	1.742AsnArg: 1.742 ± 0.051	1.681AsnSer: 1.681 ± 0.052	1.963AsnThr: 1.963 ± 0.061	2.034AsnVal: 2.034 ± 0.065	0.41AsnTrp: 0.41 ± 0.026	0.808AsnTyr: 0.808 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	6.286ProAla: 6.286 ± 0.113	0.425ProCys: 0.425 ± 0.026	3.863ProAsp: 3.863 ± 0.087	4.066ProGlu: 4.066 ± 0.074	2.03ProPhe: 2.03 ± 0.057	4.529ProGly: 4.529 ± 0.095	1.348ProHis: 1.348 ± 0.044	1.441ProIle: 1.441 ± 0.06	1.275ProLys: 1.275 ± 0.044	4.863ProLeu: 4.863 ± 0.092	0.992ProMet: 0.992 ± 0.04	0.954ProAsn: 0.954 ± 0.038	2.654ProPro: 2.654 ± 0.091	1.969ProGln: 1.969 ± 0.054	2.477ProArg: 2.477 ± 0.054	3.171ProSer: 3.171 ± 0.072	1.99ProThr: 1.99 ± 0.054	5.263ProVal: 5.263 ± 0.107	0.725ProTrp: 0.725 ± 0.034	1.262ProTyr: 1.262 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	4.947GlnAla: 4.947 ± 0.104	0.269GlnCys: 0.269 ± 0.02	1.86GlnAsp: 1.86 ± 0.058	1.927GlnGlu: 1.927 ± 0.053	1.208GlnPhe: 1.208 ± 0.046	2.541GlnGly: 2.541 ± 0.067	1.011GlnHis: 1.011 ± 0.038	2.297GlnIle: 2.297 ± 0.058	1.841GlnLys: 1.841 ± 0.053	3.232GlnLeu: 3.232 ± 0.084	0.939GlnMet: 0.939 ± 0.033	1.383GlnAsn: 1.383 ± 0.047	1.946GlnPro: 1.946 ± 0.058	1.68GlnGln: 1.68 ± 0.067	2.235GlnArg: 2.235 ± 0.064	2.327GlnSer: 2.327 ± 0.062	2.281GlnThr: 2.281 ± 0.056	2.452GlnVal: 2.452 ± 0.067	0.409GlnTrp: 0.409 ± 0.025	0.778GlnTyr: 0.778 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	6.118ArgAla: 6.118 ± 0.107	0.534ArgCys: 0.534 ± 0.03	3.13ArgAsp: 3.13 ± 0.075	3.466ArgGlu: 3.466 ± 0.098	2.527ArgPhe: 2.527 ± 0.065	3.918ArgGly: 3.918 ± 0.083	1.832ArgHis: 1.832 ± 0.049	3.658ArgIle: 3.658 ± 0.076	2.582ArgLys: 2.582 ± 0.062	7.297ArgLeu: 7.297 ± 0.13	1.65ArgMet: 1.65 ± 0.04	2.052ArgAsn: 2.052 ± 0.058	2.958ArgPro: 2.958 ± 0.075	2.857ArgGln: 2.857 ± 0.073	4.492ArgArg: 4.492 ± 0.109	3.556ArgSer: 3.556 ± 0.076	3.288ArgThr: 3.288 ± 0.071	4.089ArgVal: 4.089 ± 0.072	0.85ArgTrp: 0.85 ± 0.033	1.817ArgTyr: 1.817 ± 0.057	0.0ArgXaa: 0.0 ± 0.0
Ser	7.141SerAla: 7.141 ± 0.128	0.7SerCys: 0.7 ± 0.037	3.472SerAsp: 3.472 ± 0.067	3.373SerGlu: 3.373 ± 0.073	2.758SerPhe: 2.758 ± 0.067	6.132SerGly: 6.132 ± 0.131	1.436SerHis: 1.436 ± 0.043	2.672SerIle: 2.672 ± 0.082	1.733SerLys: 1.733 ± 0.047	6.826SerLeu: 6.826 ± 0.097	1.463SerMet: 1.463 ± 0.046	1.642SerAsn: 1.642 ± 0.06	3.341SerPro: 3.341 ± 0.077	2.12SerGln: 2.12 ± 0.063	3.76SerArg: 3.76 ± 0.073	4.413SerSer: 4.413 ± 0.114	3.043SerThr: 3.043 ± 0.088	5.4SerVal: 5.4 ± 0.096	1.027SerTrp: 1.027 ± 0.037	1.615SerTyr: 1.615 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	6.065ThrAla: 6.065 ± 0.109	0.555ThrCys: 0.555 ± 0.027	3.121ThrAsp: 3.121 ± 0.065	3.149ThrGlu: 3.149 ± 0.071	2.108ThrPhe: 2.108 ± 0.06	5.601ThrGly: 5.601 ± 0.101	1.377ThrHis: 1.377 ± 0.049	2.91ThrIle: 2.91 ± 0.078	1.569ThrLys: 1.569 ± 0.044	7.315ThrLeu: 7.315 ± 0.114	1.15ThrMet: 1.15 ± 0.043	1.491ThrAsn: 1.491 ± 0.051	3.762ThrPro: 3.762 ± 0.078	2.059ThrGln: 2.059 ± 0.06	3.363ThrArg: 3.363 ± 0.075	3.615ThrSer: 3.615 ± 0.083	3.313ThrThr: 3.313 ± 0.078	4.289ThrVal: 4.289 ± 0.098	0.723ThrTrp: 0.723 ± 0.031	1.36ThrTyr: 1.36 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	7.584ValAla: 7.584 ± 0.106	0.856ValCys: 0.856 ± 0.038	3.246ValAsp: 3.246 ± 0.088	3.484ValGlu: 3.484 ± 0.08	2.885ValPhe: 2.885 ± 0.072	4.514ValGly: 4.514 ± 0.079	1.51ValHis: 1.51 ± 0.048	4.287ValIle: 4.287 ± 0.095	2.681ValLys: 2.681 ± 0.068	7.46ValLeu: 7.46 ± 0.12	2.093ValMet: 2.093 ± 0.05	2.056ValAsn: 2.056 ± 0.057	3.804ValPro: 3.804 ± 0.077	2.511ValGln: 2.511 ± 0.058	4.441ValArg: 4.441 ± 0.093	5.382ValSer: 5.382 ± 0.1	4.926ValThr: 4.926 ± 0.091	5.478ValVal: 5.478 ± 0.111	0.908ValTrp: 0.908 ± 0.037	1.546ValTyr: 1.546 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.989TrpAla: 0.989 ± 0.042	0.195TrpCys: 0.195 ± 0.019	0.57TrpAsp: 0.57 ± 0.028	0.52TrpGlu: 0.52 ± 0.027	0.508TrpPhe: 0.508 ± 0.024	0.905TrpGly: 0.905 ± 0.037	0.48TrpHis: 0.48 ± 0.028	0.669TrpIle: 0.669 ± 0.032	0.523TrpLys: 0.523 ± 0.029	1.655TrpLeu: 1.655 ± 0.053	0.337TrpMet: 0.337 ± 0.025	0.467TrpAsn: 0.467 ± 0.026	0.679TrpPro: 0.679 ± 0.036	0.709TrpGln: 0.709 ± 0.033	1.004TrpArg: 1.004 ± 0.039	0.871TrpSer: 0.871 ± 0.038	0.679TrpThr: 0.679 ± 0.035	0.839TrpVal: 0.839 ± 0.033	0.199TrpTrp: 0.199 ± 0.017	0.338TrpTyr: 0.338 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.471TyrAla: 2.471 ± 0.055	0.282TyrCys: 0.282 ± 0.017	1.55TyrAsp: 1.55 ± 0.059	1.199TyrGlu: 1.199 ± 0.04	0.889TyrPhe: 0.889 ± 0.039	2.22TyrGly: 2.22 ± 0.069	0.583TyrHis: 0.583 ± 0.03	1.246TyrIle: 1.246 ± 0.048	0.856TyrLys: 0.856 ± 0.039	2.213TyrLeu: 2.213 ± 0.056	0.529TyrMet: 0.529 ± 0.031	0.954TyrAsn: 0.954 ± 0.049	1.122TyrPro: 1.122 ± 0.041	0.946TyrGln: 0.946 ± 0.042	1.546TyrArg: 1.546 ± 0.051	1.395TyrSer: 1.395 ± 0.053	1.4TyrThr: 1.4 ± 0.044	1.549TyrVal: 1.549 ± 0.053	0.254TyrTrp: 0.254 ± 0.021	0.762TyrTyr: 0.762 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2062 proteins (677384 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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