Amino acid dipepetide frequency for Salmonella phage Segz_1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.408AlaAla: 10.408 ± 2.394
0.908AlaCys: 0.908 ± 0.239
4.959AlaAsp: 4.959 ± 0.548
7.195AlaGlu: 7.195 ± 0.91
2.305AlaPhe: 2.305 ± 0.373
6.845AlaGly: 6.845 ± 0.617
0.838AlaHis: 0.838 ± 0.239
5.518AlaIle: 5.518 ± 0.517
7.265AlaLys: 7.265 ± 0.955
6.566AlaLeu: 6.566 ± 0.746
3.143AlaMet: 3.143 ± 0.545
3.562AlaAsn: 3.562 ± 0.594
1.816AlaPro: 1.816 ± 0.34
4.261AlaGln: 4.261 ± 0.92
4.61AlaArg: 4.61 ± 0.578
4.54AlaSer: 4.54 ± 0.585
5.379AlaThr: 5.379 ± 0.963
5.448AlaVal: 5.448 ± 0.667
1.257AlaTrp: 1.257 ± 0.258
2.445AlaTyr: 2.445 ± 0.396
0.0AlaXaa: 0.0 ± 0.0
Cys
1.048CysAla: 1.048 ± 0.255
0.559CysCys: 0.559 ± 0.287
1.187CysAsp: 1.187 ± 0.278
0.838CysGlu: 0.838 ± 0.264
0.629CysPhe: 0.629 ± 0.247
1.327CysGly: 1.327 ± 0.44
0.419CysHis: 0.419 ± 0.16
0.699CysIle: 0.699 ± 0.227
1.118CysLys: 1.118 ± 0.279
1.048CysLeu: 1.048 ± 0.303
0.279CysMet: 0.279 ± 0.137
0.838CysAsn: 0.838 ± 0.272
0.419CysPro: 0.419 ± 0.19
0.21CysGln: 0.21 ± 0.104
0.768CysArg: 0.768 ± 0.209
0.768CysSer: 0.768 ± 0.271
0.838CysThr: 0.838 ± 0.202
0.14CysVal: 0.14 ± 0.105
0.559CysTrp: 0.559 ± 0.231
0.559CysTyr: 0.559 ± 0.18
0.0CysXaa: 0.0 ± 0.0
Asp
6.077AspAla: 6.077 ± 0.592
1.118AspCys: 1.118 ± 0.286
5.309AspAsp: 5.309 ± 0.742
4.82AspGlu: 4.82 ± 0.636
3.493AspPhe: 3.493 ± 0.437
6.776AspGly: 6.776 ± 0.94
1.187AspHis: 1.187 ± 0.273
4.401AspIle: 4.401 ± 0.55
2.934AspLys: 2.934 ± 0.51
3.213AspLeu: 3.213 ± 0.445
2.026AspMet: 2.026 ± 0.445
2.165AspAsn: 2.165 ± 0.425
1.676AspPro: 1.676 ± 0.36
1.537AspGln: 1.537 ± 0.411
3.283AspArg: 3.283 ± 0.523
3.632AspSer: 3.632 ± 0.491
2.724AspThr: 2.724 ± 0.422
4.261AspVal: 4.261 ± 0.544
0.419AspTrp: 0.419 ± 0.172
2.515AspTyr: 2.515 ± 0.465
0.0AspXaa: 0.0 ± 0.0
Glu
5.169GluAla: 5.169 ± 0.623
1.187GluCys: 1.187 ± 0.269
3.702GluAsp: 3.702 ± 0.563
4.331GluGlu: 4.331 ± 0.538
2.026GluPhe: 2.026 ± 0.437
2.864GluGly: 2.864 ± 0.462
0.768GluHis: 0.768 ± 0.215
5.518GluIle: 5.518 ± 0.505
3.982GluLys: 3.982 ± 0.571
5.588GluLeu: 5.588 ± 0.666
2.515GluMet: 2.515 ± 0.411
3.004GluAsn: 3.004 ± 0.396
2.165GluPro: 2.165 ± 0.373
4.61GluGln: 4.61 ± 0.585
3.632GluArg: 3.632 ± 0.501
3.772GluSer: 3.772 ± 0.534
3.423GluThr: 3.423 ± 0.504
3.772GluVal: 3.772 ± 0.5
1.257GluTrp: 1.257 ± 0.289
2.724GluTyr: 2.724 ± 0.453
0.0GluXaa: 0.0 ± 0.0
Phe
1.886PheAla: 1.886 ± 0.392
0.768PheCys: 0.768 ± 0.24
3.004PheAsp: 3.004 ± 0.431
2.026PheGlu: 2.026 ± 0.373
0.699PhePhe: 0.699 ± 0.222
3.004PheGly: 3.004 ± 0.358
0.489PheHis: 0.489 ± 0.169
2.445PheIle: 2.445 ± 0.593
2.026PheLys: 2.026 ± 0.349
2.305PheLeu: 2.305 ± 0.381
1.257PheMet: 1.257 ± 0.325
2.375PheAsn: 2.375 ± 0.439
1.397PhePro: 1.397 ± 0.303
1.118PheGln: 1.118 ± 0.234
1.886PheArg: 1.886 ± 0.409
2.375PheSer: 2.375 ± 0.432
1.746PheThr: 1.746 ± 0.375
1.607PheVal: 1.607 ± 0.274
0.699PheTrp: 0.699 ± 0.205
1.257PheTyr: 1.257 ± 0.292
0.0PheXaa: 0.0 ± 0.0
Gly
5.588GlyAla: 5.588 ± 0.669
0.908GlyCys: 0.908 ± 0.219
4.75GlyAsp: 4.75 ± 0.626
4.89GlyGlu: 4.89 ± 0.609
2.934GlyPhe: 2.934 ± 0.538
5.309GlyGly: 5.309 ± 0.754
1.187GlyHis: 1.187 ± 0.299
4.54GlyIle: 4.54 ± 0.482
5.798GlyLys: 5.798 ± 0.622
4.121GlyLeu: 4.121 ± 0.421
2.305GlyMet: 2.305 ± 0.404
3.143GlyAsn: 3.143 ± 0.416
0.838GlyPro: 0.838 ± 0.255
2.096GlyGln: 2.096 ± 0.472
3.353GlyArg: 3.353 ± 0.533
5.518GlySer: 5.518 ± 0.805
4.261GlyThr: 4.261 ± 0.486
6.845GlyVal: 6.845 ± 0.709
0.978GlyTrp: 0.978 ± 0.227
2.934GlyTyr: 2.934 ± 0.469
0.0GlyXaa: 0.0 ± 0.0
His
1.187HisAla: 1.187 ± 0.34
0.21HisCys: 0.21 ± 0.136
1.048HisAsp: 1.048 ± 0.249
1.187HisGlu: 1.187 ± 0.271
0.768HisPhe: 0.768 ± 0.236
1.816HisGly: 1.816 ± 0.347
0.699HisHis: 0.699 ± 0.494
0.978HisIle: 0.978 ± 0.33
1.607HisLys: 1.607 ± 0.317
1.537HisLeu: 1.537 ± 0.349
0.489HisMet: 0.489 ± 0.202
0.699HisAsn: 0.699 ± 0.207
0.908HisPro: 0.908 ± 0.279
0.489HisGln: 0.489 ± 0.194
1.257HisArg: 1.257 ± 0.358
0.699HisSer: 0.699 ± 0.21
0.629HisThr: 0.629 ± 0.235
1.187HisVal: 1.187 ± 0.325
0.21HisTrp: 0.21 ± 0.126
0.699HisTyr: 0.699 ± 0.23
0.0HisXaa: 0.0 ± 0.0
Ile
5.798IleAla: 5.798 ± 0.659
0.908IleCys: 0.908 ± 0.276
4.75IleAsp: 4.75 ± 0.554
4.331IleGlu: 4.331 ± 0.479
1.537IlePhe: 1.537 ± 0.33
5.309IleGly: 5.309 ± 0.577
1.397IleHis: 1.397 ± 0.29
4.68IleIle: 4.68 ± 0.586
4.191IleLys: 4.191 ± 0.554
4.051IleLeu: 4.051 ± 0.552
1.676IleMet: 1.676 ± 0.389
3.423IleAsn: 3.423 ± 0.518
2.375IlePro: 2.375 ± 0.335
2.305IleGln: 2.305 ± 0.411
4.051IleArg: 4.051 ± 0.531
3.842IleSer: 3.842 ± 0.521
3.982IleThr: 3.982 ± 0.442
4.261IleVal: 4.261 ± 0.472
0.489IleTrp: 0.489 ± 0.164
1.816IleTyr: 1.816 ± 0.343
0.0IleXaa: 0.0 ± 0.0
Lys
6.007LysAla: 6.007 ± 0.775
1.327LysCys: 1.327 ± 0.338
3.912LysAsp: 3.912 ± 0.564
3.143LysGlu: 3.143 ± 0.497
2.026LysPhe: 2.026 ± 0.435
3.772LysGly: 3.772 ± 0.539
1.676LysHis: 1.676 ± 0.444
3.562LysIle: 3.562 ± 0.567
4.051LysLys: 4.051 ± 0.525
4.75LysLeu: 4.75 ± 0.594
2.934LysMet: 2.934 ± 0.499
2.864LysAsn: 2.864 ± 0.44
2.515LysPro: 2.515 ± 0.509
2.445LysGln: 2.445 ± 0.409
3.493LysArg: 3.493 ± 0.618
4.191LysSer: 4.191 ± 0.528
3.772LysThr: 3.772 ± 0.584
4.051LysVal: 4.051 ± 0.506
1.187LysTrp: 1.187 ± 0.338
2.235LysTyr: 2.235 ± 0.393
0.0LysXaa: 0.0 ± 0.0
Leu
6.287LeuAla: 6.287 ± 0.775
1.187LeuCys: 1.187 ± 0.317
2.864LeuAsp: 2.864 ± 0.458
4.68LeuGlu: 4.68 ± 0.5
2.096LeuPhe: 2.096 ± 0.436
4.68LeuGly: 4.68 ± 0.532
1.257LeuHis: 1.257 ± 0.256
4.54LeuIle: 4.54 ± 0.624
4.68LeuLys: 4.68 ± 0.622
4.68LeuLeu: 4.68 ± 0.569
2.305LeuMet: 2.305 ± 0.429
3.283LeuAsn: 3.283 ± 0.56
2.934LeuPro: 2.934 ± 0.541
3.004LeuGln: 3.004 ± 0.525
4.75LeuArg: 4.75 ± 0.551
4.82LeuSer: 4.82 ± 0.534
4.959LeuThr: 4.959 ± 0.491
4.331LeuVal: 4.331 ± 0.543
1.257LeuTrp: 1.257 ± 0.231
2.515LeuTyr: 2.515 ± 0.456
0.0LeuXaa: 0.0 ± 0.0
Met
3.632MetAla: 3.632 ± 0.585
0.559MetCys: 0.559 ± 0.216
1.886MetAsp: 1.886 ± 0.452
1.676MetGlu: 1.676 ± 0.355
1.118MetPhe: 1.118 ± 0.317
1.257MetGly: 1.257 ± 0.33
0.838MetHis: 0.838 ± 0.315
1.746MetIle: 1.746 ± 0.377
2.585MetLys: 2.585 ± 0.447
1.676MetLeu: 1.676 ± 0.294
1.467MetMet: 1.467 ± 0.294
1.956MetAsn: 1.956 ± 0.349
1.467MetPro: 1.467 ± 0.389
1.257MetGln: 1.257 ± 0.329
1.467MetArg: 1.467 ± 0.287
2.794MetSer: 2.794 ± 0.454
1.886MetThr: 1.886 ± 0.349
1.048MetVal: 1.048 ± 0.276
0.349MetTrp: 0.349 ± 0.15
0.908MetTyr: 0.908 ± 0.277
0.0MetXaa: 0.0 ± 0.0
Asn
3.912AsnAla: 3.912 ± 0.532
0.349AsnCys: 0.349 ± 0.155
3.632AsnAsp: 3.632 ± 0.527
2.934AsnGlu: 2.934 ± 0.347
1.257AsnPhe: 1.257 ± 0.383
4.401AsnGly: 4.401 ± 0.607
1.187AsnHis: 1.187 ± 0.287
2.794AsnIle: 2.794 ± 0.387
2.724AsnLys: 2.724 ± 0.458
3.004AsnLeu: 3.004 ± 0.421
0.838AsnMet: 0.838 ± 0.236
2.375AsnAsn: 2.375 ± 0.427
1.676AsnPro: 1.676 ± 0.382
1.746AsnGln: 1.746 ± 0.314
2.934AsnArg: 2.934 ± 0.567
3.073AsnSer: 3.073 ± 0.592
2.654AsnThr: 2.654 ± 0.407
3.004AsnVal: 3.004 ± 0.668
0.699AsnTrp: 0.699 ± 0.229
1.607AsnTyr: 1.607 ± 0.377
0.0AsnXaa: 0.0 ± 0.0
Pro
3.423ProAla: 3.423 ± 0.577
0.559ProCys: 0.559 ± 0.23
2.305ProAsp: 2.305 ± 0.421
2.934ProGlu: 2.934 ± 0.512
0.838ProPhe: 0.838 ± 0.218
1.956ProGly: 1.956 ± 0.384
0.629ProHis: 0.629 ± 0.207
1.467ProIle: 1.467 ± 0.287
1.746ProLys: 1.746 ± 0.38
2.096ProLeu: 2.096 ± 0.416
0.838ProMet: 0.838 ± 0.24
1.048ProAsn: 1.048 ± 0.231
1.257ProPro: 1.257 ± 0.324
1.397ProGln: 1.397 ± 0.389
1.467ProArg: 1.467 ± 0.299
1.607ProSer: 1.607 ± 0.363
1.886ProThr: 1.886 ± 0.384
3.213ProVal: 3.213 ± 0.476
0.419ProTrp: 0.419 ± 0.204
1.607ProTyr: 1.607 ± 0.292
0.0ProXaa: 0.0 ± 0.0
Gln
3.423GlnAla: 3.423 ± 0.677
0.21GlnCys: 0.21 ± 0.129
1.537GlnAsp: 1.537 ± 0.329
2.724GlnGlu: 2.724 ± 0.356
1.956GlnPhe: 1.956 ± 0.368
1.816GlnGly: 1.816 ± 0.476
0.978GlnHis: 0.978 ± 0.286
2.654GlnIle: 2.654 ± 0.51
2.165GlnLys: 2.165 ± 0.41
4.471GlnLeu: 4.471 ± 0.705
1.467GlnMet: 1.467 ± 0.287
1.257GlnAsn: 1.257 ± 0.412
1.118GlnPro: 1.118 ± 0.246
2.724GlnGln: 2.724 ± 0.725
1.886GlnArg: 1.886 ± 0.359
3.143GlnSer: 3.143 ± 0.49
2.235GlnThr: 2.235 ± 0.522
2.515GlnVal: 2.515 ± 0.488
0.699GlnTrp: 0.699 ± 0.222
1.327GlnTyr: 1.327 ± 0.28
0.0GlnXaa: 0.0 ± 0.0
Arg
5.379ArgAla: 5.379 ± 0.532
0.978ArgCys: 0.978 ± 0.376
3.143ArgAsp: 3.143 ± 0.412
4.191ArgGlu: 4.191 ± 0.537
1.676ArgPhe: 1.676 ± 0.363
3.283ArgGly: 3.283 ± 0.467
1.048ArgHis: 1.048 ± 0.295
3.423ArgIle: 3.423 ± 0.41
3.283ArgLys: 3.283 ± 0.432
4.68ArgLeu: 4.68 ± 0.546
1.676ArgMet: 1.676 ± 0.393
3.842ArgAsn: 3.842 ± 0.553
1.327ArgPro: 1.327 ± 0.272
2.026ArgGln: 2.026 ± 0.467
3.004ArgArg: 3.004 ± 0.446
2.724ArgSer: 2.724 ± 0.447
2.026ArgThr: 2.026 ± 0.357
3.283ArgVal: 3.283 ± 0.473
0.699ArgTrp: 0.699 ± 0.245
2.515ArgTyr: 2.515 ± 0.375
0.0ArgXaa: 0.0 ± 0.0
Ser
5.798SerAla: 5.798 ± 0.684
0.768SerCys: 0.768 ± 0.263
4.191SerAsp: 4.191 ± 0.605
3.213SerGlu: 3.213 ± 0.436
2.654SerPhe: 2.654 ± 0.367
6.147SerGly: 6.147 ± 0.769
0.838SerHis: 0.838 ± 0.258
3.912SerIle: 3.912 ± 0.529
3.562SerLys: 3.562 ± 0.577
6.287SerLeu: 6.287 ± 0.775
1.816SerMet: 1.816 ± 0.336
2.026SerAsn: 2.026 ± 0.338
2.165SerPro: 2.165 ± 0.421
3.213SerGln: 3.213 ± 0.542
3.213SerArg: 3.213 ± 0.541
3.912SerSer: 3.912 ± 0.559
3.842SerThr: 3.842 ± 0.64
3.423SerVal: 3.423 ± 0.418
0.908SerTrp: 0.908 ± 0.247
2.375SerTyr: 2.375 ± 0.349
0.0SerXaa: 0.0 ± 0.0
Thr
4.75ThrAla: 4.75 ± 1.088
0.768ThrCys: 0.768 ± 0.243
3.423ThrAsp: 3.423 ± 0.535
3.632ThrGlu: 3.632 ± 0.49
2.235ThrPhe: 2.235 ± 0.423
4.75ThrGly: 4.75 ± 0.547
0.908ThrHis: 0.908 ± 0.267
3.912ThrIle: 3.912 ± 0.542
3.493ThrLys: 3.493 ± 0.621
3.143ThrLeu: 3.143 ± 0.604
1.187ThrMet: 1.187 ± 0.242
2.934ThrAsn: 2.934 ± 0.507
3.423ThrPro: 3.423 ± 0.546
1.676ThrGln: 1.676 ± 0.335
3.004ThrArg: 3.004 ± 0.383
3.982ThrSer: 3.982 ± 0.565
3.702ThrThr: 3.702 ± 0.725
3.842ThrVal: 3.842 ± 0.691
0.908ThrTrp: 0.908 ± 0.265
1.397ThrTyr: 1.397 ± 0.339
0.0ThrXaa: 0.0 ± 0.0
Val
5.658ValAla: 5.658 ± 0.695
0.279ValCys: 0.279 ± 0.151
4.261ValAsp: 4.261 ± 0.54
4.68ValGlu: 4.68 ± 0.517
2.165ValPhe: 2.165 ± 0.488
3.702ValGly: 3.702 ± 0.534
0.908ValHis: 0.908 ± 0.245
4.959ValIle: 4.959 ± 0.65
3.842ValLys: 3.842 ± 0.516
3.982ValLeu: 3.982 ± 0.467
2.515ValMet: 2.515 ± 0.428
3.912ValAsn: 3.912 ± 0.569
1.537ValPro: 1.537 ± 0.351
2.165ValGln: 2.165 ± 0.382
3.213ValArg: 3.213 ± 0.51
5.099ValSer: 5.099 ± 0.613
3.842ValThr: 3.842 ± 0.881
3.982ValVal: 3.982 ± 0.682
0.978ValTrp: 0.978 ± 0.259
2.375ValTyr: 2.375 ± 0.32
0.0ValXaa: 0.0 ± 0.0
Trp
0.838TrpAla: 0.838 ± 0.26
0.21TrpCys: 0.21 ± 0.134
0.838TrpAsp: 0.838 ± 0.267
0.699TrpGlu: 0.699 ± 0.229
0.699TrpPhe: 0.699 ± 0.204
0.629TrpGly: 0.629 ± 0.233
0.419TrpHis: 0.419 ± 0.169
1.118TrpIle: 1.118 ± 0.293
1.118TrpLys: 1.118 ± 0.275
1.467TrpLeu: 1.467 ± 0.332
0.21TrpMet: 0.21 ± 0.114
0.768TrpAsn: 0.768 ± 0.26
0.419TrpPro: 0.419 ± 0.146
0.559TrpGln: 0.559 ± 0.178
1.257TrpArg: 1.257 ± 0.328
0.629TrpSer: 0.629 ± 0.234
0.978TrpThr: 0.978 ± 0.253
1.257TrpVal: 1.257 ± 0.321
0.14TrpTrp: 0.14 ± 0.102
0.699TrpTyr: 0.699 ± 0.216
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.004TyrAla: 3.004 ± 0.419
0.489TyrCys: 0.489 ± 0.14
2.864TyrAsp: 2.864 ± 0.511
1.886TyrGlu: 1.886 ± 0.325
1.257TyrPhe: 1.257 ± 0.32
2.654TyrGly: 2.654 ± 0.483
0.629TyrHis: 0.629 ± 0.199
2.305TyrIle: 2.305 ± 0.414
1.746TyrLys: 1.746 ± 0.372
2.445TyrLeu: 2.445 ± 0.444
0.559TyrMet: 0.559 ± 0.156
1.327TyrAsn: 1.327 ± 0.31
1.257TyrPro: 1.257 ± 0.276
1.537TyrGln: 1.537 ± 0.27
1.676TyrArg: 1.676 ± 0.343
3.143TyrSer: 3.143 ± 0.464
2.305TyrThr: 2.305 ± 0.43
2.585TyrVal: 2.585 ± 0.371
0.838TyrTrp: 0.838 ± 0.227
1.327TyrTyr: 1.327 ± 0.248
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 75 proteins (14317 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski