Amino acid dipepetide frequency for Desulfovibrio vulgaris (strain DSM 19637 / Miyazaki F)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.841AlaAla: 17.841 ± 0.186	1.747AlaCys: 1.747 ± 0.05	7.167AlaAsp: 7.167 ± 0.093	7.377AlaGlu: 7.377 ± 0.095	3.682AlaPhe: 3.682 ± 0.06	11.299AlaGly: 11.299 ± 0.136	2.627AlaHis: 2.627 ± 0.054	4.3AlaIle: 4.3 ± 0.076	2.999AlaLys: 2.999 ± 0.06	13.547AlaLeu: 13.547 ± 0.149	3.568AlaMet: 3.568 ± 0.055	2.42AlaAsn: 2.42 ± 0.045	7.339AlaPro: 7.339 ± 0.114	3.739AlaGln: 3.739 ± 0.075	10.122AlaArg: 10.122 ± 0.12	6.242AlaSer: 6.242 ± 0.09	6.286AlaThr: 6.286 ± 0.087	9.455AlaVal: 9.455 ± 0.119	1.647AlaTrp: 1.647 ± 0.044	2.243AlaTyr: 2.243 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.58CysAla: 1.58 ± 0.043	0.242CysCys: 0.242 ± 0.015	0.663CysAsp: 0.663 ± 0.024	0.565CysGlu: 0.565 ± 0.026	0.36CysPhe: 0.36 ± 0.017	1.446CysGly: 1.446 ± 0.04	0.404CysHis: 0.404 ± 0.03	0.617CysIle: 0.617 ± 0.024	0.319CysLys: 0.319 ± 0.019	1.273CysLeu: 1.273 ± 0.033	0.312CysMet: 0.312 ± 0.02	0.355CysAsn: 0.355 ± 0.019	0.958CysPro: 0.958 ± 0.032	0.266CysGln: 0.266 ± 0.014	0.995CysArg: 0.995 ± 0.031	0.633CysSer: 0.633 ± 0.022	0.7CysThr: 0.7 ± 0.026	0.955CysVal: 0.955 ± 0.029	0.13CysTrp: 0.13 ± 0.01	0.264CysTyr: 0.264 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.025AspAla: 8.025 ± 0.114	0.634AspCys: 0.634 ± 0.024	3.441AspAsp: 3.441 ± 0.07	3.534AspGlu: 3.534 ± 0.066	2.001AspPhe: 2.001 ± 0.052	5.52AspGly: 5.52 ± 0.098	1.132AspHis: 1.132 ± 0.036	3.04AspIle: 3.04 ± 0.059	1.718AspLys: 1.718 ± 0.043	5.617AspLeu: 5.617 ± 0.074	1.895AspMet: 1.895 ± 0.043	1.299AspAsn: 1.299 ± 0.039	3.054AspPro: 3.054 ± 0.045	1.233AspGln: 1.233 ± 0.037	3.749AspArg: 3.749 ± 0.076	2.115AspSer: 2.115 ± 0.052	3.001AspThr: 3.001 ± 0.057	4.465AspVal: 4.465 ± 0.075	0.755AspTrp: 0.755 ± 0.028	1.388AspTyr: 1.388 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.228GluAla: 7.228 ± 0.102	0.579GluCys: 0.579 ± 0.022	2.809GluAsp: 2.809 ± 0.056	3.359GluGlu: 3.359 ± 0.062	1.756GluPhe: 1.756 ± 0.038	4.52GluGly: 4.52 ± 0.076	1.428GluHis: 1.428 ± 0.043	2.478GluIle: 2.478 ± 0.06	2.145GluLys: 2.145 ± 0.054	5.944GluLeu: 5.944 ± 0.078	1.655GluMet: 1.655 ± 0.045	1.476GluAsn: 1.476 ± 0.035	2.386GluPro: 2.386 ± 0.053	2.297GluGln: 2.297 ± 0.059	5.005GluArg: 5.005 ± 0.097	2.507GluSer: 2.507 ± 0.051	2.939GluThr: 2.939 ± 0.053	4.251GluVal: 4.251 ± 0.07	0.6GluTrp: 0.6 ± 0.024	1.206GluTyr: 1.206 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.794PheAla: 3.794 ± 0.068	0.522PheCys: 0.522 ± 0.023	2.014PheAsp: 2.014 ± 0.049	1.765PheGlu: 1.765 ± 0.042	1.339PhePhe: 1.339 ± 0.033	3.118PheGly: 3.118 ± 0.052	0.755PheHis: 0.755 ± 0.026	1.487PheIle: 1.487 ± 0.043	0.894PheLys: 0.894 ± 0.032	3.506PheLeu: 3.506 ± 0.061	0.891PheMet: 0.891 ± 0.03	0.85PheAsn: 0.85 ± 0.027	1.582PhePro: 1.582 ± 0.043	0.769PheGln: 0.769 ± 0.03	2.489PheArg: 2.489 ± 0.049	1.971PheSer: 1.971 ± 0.05	2.125PheThr: 2.125 ± 0.049	2.515PheVal: 2.515 ± 0.043	0.487PheTrp: 0.487 ± 0.021	0.787PheTyr: 0.787 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	9.897GlyAla: 9.897 ± 0.111	1.395GlyCys: 1.395 ± 0.039	4.841GlyAsp: 4.841 ± 0.076	4.734GlyGlu: 4.734 ± 0.081	3.108GlyPhe: 3.108 ± 0.058	8.309GlyGly: 8.309 ± 0.121	2.07GlyHis: 2.07 ± 0.049	4.017GlyIle: 4.017 ± 0.061	3.302GlyLys: 3.302 ± 0.064	8.944GlyLeu: 8.944 ± 0.097	3.034GlyMet: 3.034 ± 0.055	2.285GlyAsn: 2.285 ± 0.064	4.053GlyPro: 4.053 ± 0.068	3.294GlyGln: 3.294 ± 0.065	6.302GlyArg: 6.302 ± 0.092	4.269GlySer: 4.269 ± 0.084	5.162GlyThr: 5.162 ± 0.082	7.084GlyVal: 7.084 ± 0.09	1.194GlyTrp: 1.194 ± 0.033	2.235GlyTyr: 2.235 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.899HisAla: 2.899 ± 0.068	0.339HisCys: 0.339 ± 0.018	1.492HisAsp: 1.492 ± 0.035	1.287HisGlu: 1.287 ± 0.033	0.835HisPhe: 0.835 ± 0.028	2.386HisGly: 2.386 ± 0.05	0.631HisHis: 0.631 ± 0.03	0.93HisIle: 0.93 ± 0.028	0.574HisLys: 0.574 ± 0.028	2.326HisLeu: 2.326 ± 0.049	0.585HisMet: 0.585 ± 0.022	0.549HisAsn: 0.549 ± 0.025	1.601HisPro: 1.601 ± 0.042	0.554HisGln: 0.554 ± 0.022	1.513HisArg: 1.513 ± 0.043	0.995HisSer: 0.995 ± 0.031	1.032HisThr: 1.032 ± 0.029	1.637HisVal: 1.637 ± 0.038	0.287HisTrp: 0.287 ± 0.018	0.516HisTyr: 0.516 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	4.834IleAla: 4.834 ± 0.075	0.534IleCys: 0.534 ± 0.024	2.332IleAsp: 2.332 ± 0.053	2.357IleGlu: 2.357 ± 0.056	1.325IlePhe: 1.325 ± 0.034	3.344IleGly: 3.344 ± 0.062	0.815IleHis: 0.815 ± 0.028	2.03IleIle: 2.03 ± 0.048	1.236IleLys: 1.236 ± 0.036	3.811IleLeu: 3.811 ± 0.068	1.061IleMet: 1.061 ± 0.031	1.183IleAsn: 1.183 ± 0.039	2.219IlePro: 2.219 ± 0.044	0.993IleGln: 0.993 ± 0.036	2.914IleArg: 2.914 ± 0.059	2.397IleSer: 2.397 ± 0.051	2.326IleThr: 2.326 ± 0.05	3.262IleVal: 3.262 ± 0.057	0.372IleTrp: 0.372 ± 0.019	0.888IleTyr: 0.888 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.697LysAla: 3.697 ± 0.073	0.278LysCys: 0.278 ± 0.016	1.653LysAsp: 1.653 ± 0.05	1.738LysGlu: 1.738 ± 0.049	0.818LysPhe: 0.818 ± 0.024	2.813LysGly: 2.813 ± 0.052	0.548LysHis: 0.548 ± 0.025	1.19LysIle: 1.19 ± 0.043	1.367LysLys: 1.367 ± 0.046	2.818LysLeu: 2.818 ± 0.061	0.805LysMet: 0.805 ± 0.03	0.819LysAsn: 0.819 ± 0.031	1.738LysPro: 1.738 ± 0.042	0.931LysGln: 0.931 ± 0.034	1.921LysArg: 1.921 ± 0.045	1.387LysSer: 1.387 ± 0.038	1.56LysThr: 1.56 ± 0.039	2.349LysVal: 2.349 ± 0.051	0.286LysTrp: 0.286 ± 0.016	0.701LysTyr: 0.701 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	14.466LeuAla: 14.466 ± 0.15	1.48LeuCys: 1.48 ± 0.033	6.331LeuAsp: 6.331 ± 0.084	5.599LeuGlu: 5.599 ± 0.088	3.698LeuPhe: 3.698 ± 0.066	8.444LeuGly: 8.444 ± 0.1	2.634LeuHis: 2.634 ± 0.049	3.088LeuIle: 3.088 ± 0.063	2.977LeuLys: 2.977 ± 0.053	11.92LeuLeu: 11.92 ± 0.135	2.188LeuMet: 2.188 ± 0.043	2.31LeuAsn: 2.31 ± 0.048	6.859LeuPro: 6.859 ± 0.098	2.448LeuGln: 2.448 ± 0.051	8.937LeuArg: 8.937 ± 0.117	5.746LeuSer: 5.746 ± 0.079	5.306LeuThr: 5.306 ± 0.077	7.612LeuVal: 7.612 ± 0.089	1.071LeuTrp: 1.071 ± 0.035	2.149LeuTyr: 2.149 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	3.412MetAla: 3.412 ± 0.065	0.227MetCys: 0.227 ± 0.016	1.69MetAsp: 1.69 ± 0.038	1.585MetGlu: 1.585 ± 0.039	0.769MetPhe: 0.769 ± 0.028	2.199MetGly: 2.199 ± 0.051	0.642MetHis: 0.642 ± 0.027	0.862MetIle: 0.862 ± 0.029	0.876MetLys: 0.876 ± 0.034	2.859MetLeu: 2.859 ± 0.057	0.519MetMet: 0.519 ± 0.023	0.78MetAsn: 0.78 ± 0.028	1.78MetPro: 1.78 ± 0.046	0.996MetGln: 0.996 ± 0.028	1.916MetArg: 1.916 ± 0.049	1.504MetSer: 1.504 ± 0.037	1.597MetThr: 1.597 ± 0.038	2.025MetVal: 2.025 ± 0.042	0.189MetTrp: 0.189 ± 0.013	0.46MetTyr: 0.46 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.999AsnAla: 2.999 ± 0.061	0.326AsnCys: 0.326 ± 0.017	1.232AsnAsp: 1.232 ± 0.036	1.178AsnGlu: 1.178 ± 0.033	0.843AsnPhe: 0.843 ± 0.026	2.121AsnGly: 2.121 ± 0.054	0.478AsnHis: 0.478 ± 0.022	1.293AsnIle: 1.293 ± 0.042	0.667AsnLys: 0.667 ± 0.027	2.534AsnLeu: 2.534 ± 0.047	0.711AsnMet: 0.711 ± 0.028	0.592AsnAsn: 0.592 ± 0.026	1.765AsnPro: 1.765 ± 0.042	0.539AsnGln: 0.539 ± 0.022	1.649AsnArg: 1.649 ± 0.037	1.002AsnSer: 1.002 ± 0.036	1.205AsnThr: 1.205 ± 0.04	1.947AsnVal: 1.947 ± 0.048	0.304AsnTrp: 0.304 ± 0.016	0.6AsnTyr: 0.6 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.759ProAla: 7.759 ± 0.122	0.723ProCys: 0.723 ± 0.028	4.568ProAsp: 4.568 ± 0.088	4.039ProGlu: 4.039 ± 0.068	2.002ProPhe: 2.002 ± 0.049	5.94ProGly: 5.94 ± 0.093	1.45ProHis: 1.45 ± 0.041	1.431ProIle: 1.431 ± 0.037	1.304ProLys: 1.304 ± 0.037	5.435ProLeu: 5.435 ± 0.067	1.164ProMet: 1.164 ± 0.034	1.068ProAsn: 1.068 ± 0.03	3.3ProPro: 3.3 ± 0.082	1.836ProGln: 1.836 ± 0.045	3.518ProArg: 3.518 ± 0.07	2.739ProSer: 2.739 ± 0.049	2.386ProThr: 2.386 ± 0.045	4.995ProVal: 4.995 ± 0.067	0.754ProTrp: 0.754 ± 0.026	1.192ProTyr: 1.192 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.193GlnAla: 4.193 ± 0.067	0.356GlnCys: 0.356 ± 0.019	1.548GlnAsp: 1.548 ± 0.039	1.621GlnGlu: 1.621 ± 0.038	0.867GlnPhe: 0.867 ± 0.026	2.683GlnGly: 2.683 ± 0.054	0.668GlnHis: 0.668 ± 0.026	1.089GlnIle: 1.089 ± 0.035	0.98GlnLys: 0.98 ± 0.037	2.766GlnLeu: 2.766 ± 0.057	0.848GlnMet: 0.848 ± 0.028	0.727GlnAsn: 0.727 ± 0.025	1.79GlnPro: 1.79 ± 0.048	1.274GlnGln: 1.274 ± 0.034	2.39GlnArg: 2.39 ± 0.047	1.474GlnSer: 1.474 ± 0.036	1.468GlnThr: 1.468 ± 0.047	2.327GlnVal: 2.327 ± 0.046	0.406GlnTrp: 0.406 ± 0.021	0.617GlnTyr: 0.617 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	8.496ArgAla: 8.496 ± 0.116	0.949ArgCys: 0.949 ± 0.03	4.366ArgAsp: 4.366 ± 0.078	5.008ArgGlu: 5.008 ± 0.086	2.626ArgPhe: 2.626 ± 0.053	5.211ArgGly: 5.211 ± 0.08	2.022ArgHis: 2.022 ± 0.05	3.677ArgIle: 3.677 ± 0.055	2.703ArgLys: 2.703 ± 0.061	8.245ArgLeu: 8.245 ± 0.11	2.369ArgMet: 2.369 ± 0.041	2.072ArgAsn: 2.072 ± 0.045	3.795ArgPro: 3.795 ± 0.073	2.775ArgGln: 2.775 ± 0.058	6.07ArgArg: 6.07 ± 0.115	3.189ArgSer: 3.189 ± 0.051	3.869ArgThr: 3.869 ± 0.062	5.373ArgVal: 5.373 ± 0.077	0.859ArgTrp: 0.859 ± 0.03	1.678ArgTyr: 1.678 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.468SerAla: 5.468 ± 0.08	0.63SerCys: 0.63 ± 0.024	2.47SerAsp: 2.47 ± 0.056	2.296SerGlu: 2.296 ± 0.052	1.775SerPhe: 1.775 ± 0.041	5.824SerGly: 5.824 ± 0.094	0.989SerHis: 0.989 ± 0.036	2.219SerIle: 2.219 ± 0.052	1.131SerLys: 1.131 ± 0.033	5.235SerLeu: 5.235 ± 0.08	1.332SerMet: 1.332 ± 0.036	1.024SerAsn: 1.024 ± 0.036	3.15SerPro: 3.15 ± 0.056	1.398SerGln: 1.398 ± 0.035	3.376SerArg: 3.376 ± 0.053	2.624SerSer: 2.624 ± 0.062	2.559SerThr: 2.559 ± 0.056	3.806SerVal: 3.806 ± 0.065	0.523SerTrp: 0.523 ± 0.025	1.103SerTyr: 1.103 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.289ThrAla: 6.289 ± 0.094	0.609ThrCys: 0.609 ± 0.023	2.823ThrAsp: 2.823 ± 0.058	2.491ThrGlu: 2.491 ± 0.048	1.787ThrPhe: 1.787 ± 0.045	5.8ThrGly: 5.8 ± 0.088	1.123ThrHis: 1.123 ± 0.033	2.019ThrIle: 2.019 ± 0.049	1.145ThrLys: 1.145 ± 0.036	5.796ThrLeu: 5.796 ± 0.087	1.232ThrMet: 1.232 ± 0.035	1.122ThrAsn: 1.122 ± 0.034	4.023ThrPro: 4.023 ± 0.067	1.355ThrGln: 1.355 ± 0.039	3.515ThrArg: 3.515 ± 0.059	2.483ThrSer: 2.483 ± 0.054	2.71ThrThr: 2.71 ± 0.063	4.471ThrVal: 4.471 ± 0.088	0.576ThrTrp: 0.576 ± 0.024	1.086ThrTyr: 1.086 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.261ValAla: 9.261 ± 0.104	1.005ValCys: 1.005 ± 0.03	4.156ValAsp: 4.156 ± 0.072	4.348ValGlu: 4.348 ± 0.062	2.764ValPhe: 2.764 ± 0.055	5.668ValGly: 5.668 ± 0.081	1.751ValHis: 1.751 ± 0.039	3.194ValIle: 3.194 ± 0.064	2.043ValLys: 2.043 ± 0.057	8.884ValLeu: 8.884 ± 0.094	1.876ValMet: 1.876 ± 0.041	2.062ValAsn: 2.062 ± 0.048	4.354ValPro: 4.354 ± 0.056	2.303ValGln: 2.303 ± 0.045	6.236ValArg: 6.236 ± 0.089	4.026ValSer: 4.026 ± 0.067	4.461ValThr: 4.461 ± 0.081	6.417ValVal: 6.417 ± 0.09	0.85ValTrp: 0.85 ± 0.028	1.659ValTyr: 1.659 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.15TrpAla: 1.15 ± 0.035	0.152TrpCys: 0.152 ± 0.011	0.672TrpAsp: 0.672 ± 0.027	0.584TrpGlu: 0.584 ± 0.025	0.454TrpPhe: 0.454 ± 0.021	0.86TrpGly: 0.86 ± 0.03	0.305TrpHis: 0.305 ± 0.017	0.426TrpIle: 0.426 ± 0.021	0.402TrpLys: 0.402 ± 0.023	1.509TrpLeu: 1.509 ± 0.039	0.353TrpMet: 0.353 ± 0.02	0.402TrpAsn: 0.402 ± 0.02	0.681TrpPro: 0.681 ± 0.028	0.482TrpGln: 0.482 ± 0.021	1.028TrpArg: 1.028 ± 0.031	0.567TrpSer: 0.567 ± 0.025	0.605TrpThr: 0.605 ± 0.024	0.73TrpVal: 0.73 ± 0.028	0.193TrpTrp: 0.193 ± 0.013	0.241TrpTyr: 0.241 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.358TyrAla: 2.358 ± 0.044	0.31TyrCys: 0.31 ± 0.016	1.347TyrAsp: 1.347 ± 0.036	1.101TyrGlu: 1.101 ± 0.034	0.853TyrPhe: 0.853 ± 0.03	2.024TyrGly: 2.024 ± 0.049	0.495TyrHis: 0.495 ± 0.021	0.848TyrIle: 0.848 ± 0.031	0.635TyrLys: 0.635 ± 0.023	2.293TyrLeu: 2.293 ± 0.047	0.485TyrMet: 0.485 ± 0.021	0.591TyrAsn: 0.591 ± 0.026	1.177TyrPro: 1.177 ± 0.034	0.611TyrGln: 0.611 ± 0.024	1.709TyrArg: 1.709 ± 0.039	1.061TyrSer: 1.061 ± 0.033	1.161TyrThr: 1.161 ± 0.036	1.644TyrVal: 1.644 ± 0.04	0.311TyrTrp: 0.311 ± 0.017	0.639TyrTyr: 0.639 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3178 proteins (1107925 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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