Amino acid dipepetide frequency for Idiomarinaceae phage 1N2-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.71AlaAla: 8.71 ± 2.104
0.269AlaCys: 0.269 ± 0.133
6.286AlaAsp: 6.286 ± 0.686
7.364AlaGlu: 7.364 ± 0.848
3.053AlaPhe: 3.053 ± 0.474
9.878AlaGly: 9.878 ± 1.019
1.616AlaHis: 1.616 ± 0.319
6.555AlaIle: 6.555 ± 0.746
4.58AlaLys: 4.58 ± 0.728
6.555AlaLeu: 6.555 ± 0.838
2.784AlaMet: 2.784 ± 0.508
4.041AlaAsn: 4.041 ± 0.812
4.041AlaPro: 4.041 ± 0.62
3.951AlaGln: 3.951 ± 0.581
5.298AlaArg: 5.298 ± 0.678
5.119AlaSer: 5.119 ± 0.78
4.221AlaThr: 4.221 ± 0.433
6.106AlaVal: 6.106 ± 0.72
1.437AlaTrp: 1.437 ± 0.311
2.514AlaTyr: 2.514 ± 0.515
0.0AlaXaa: 0.0 ± 0.0
Cys
1.167CysAla: 1.167 ± 0.351
0.269CysCys: 0.269 ± 0.188
0.898CysAsp: 0.898 ± 0.313
0.629CysGlu: 0.629 ± 0.197
0.359CysPhe: 0.359 ± 0.139
0.898CysGly: 0.898 ± 0.312
0.269CysHis: 0.269 ± 0.148
0.18CysIle: 0.18 ± 0.122
0.808CysLys: 0.808 ± 0.274
1.078CysLeu: 1.078 ± 0.302
0.0CysMet: 0.0 ± 0.0
0.269CysAsn: 0.269 ± 0.142
0.629CysPro: 0.629 ± 0.272
0.449CysGln: 0.449 ± 0.189
0.898CysArg: 0.898 ± 0.365
0.269CysSer: 0.269 ± 0.138
0.718CysThr: 0.718 ± 0.29
0.539CysVal: 0.539 ± 0.219
0.449CysTrp: 0.449 ± 0.197
0.18CysTyr: 0.18 ± 0.146
0.0CysXaa: 0.0 ± 0.0
Asp
7.453AspAla: 7.453 ± 1.058
0.629AspCys: 0.629 ± 0.253
4.759AspAsp: 4.759 ± 0.701
5.388AspGlu: 5.388 ± 0.666
1.976AspPhe: 1.976 ± 0.544
6.196AspGly: 6.196 ± 0.776
1.347AspHis: 1.347 ± 0.353
3.951AspIle: 3.951 ± 0.67
3.053AspLys: 3.053 ± 0.574
6.825AspLeu: 6.825 ± 0.947
2.604AspMet: 2.604 ± 0.363
2.874AspAsn: 2.874 ± 0.64
2.784AspPro: 2.784 ± 0.585
1.078AspGln: 1.078 ± 0.275
2.245AspArg: 2.245 ± 0.349
2.963AspSer: 2.963 ± 0.645
3.682AspThr: 3.682 ± 0.551
3.502AspVal: 3.502 ± 0.704
0.718AspTrp: 0.718 ± 0.263
1.796AspTyr: 1.796 ± 0.347
0.0AspXaa: 0.0 ± 0.0
Glu
5.747GluAla: 5.747 ± 0.722
1.078GluCys: 1.078 ± 0.434
2.155GluAsp: 2.155 ± 0.453
2.335GluGlu: 2.335 ± 0.503
1.257GluPhe: 1.257 ± 0.434
4.67GluGly: 4.67 ± 0.6
1.527GluHis: 1.527 ± 0.334
4.49GluIle: 4.49 ± 0.777
2.514GluLys: 2.514 ± 0.558
6.915GluLeu: 6.915 ± 0.946
2.335GluMet: 2.335 ± 0.502
2.155GluAsn: 2.155 ± 0.31
2.514GluPro: 2.514 ± 0.393
4.759GluGln: 4.759 ± 0.686
4.4GluArg: 4.4 ± 0.691
3.502GluSer: 3.502 ± 0.492
2.065GluThr: 2.065 ± 0.446
4.4GluVal: 4.4 ± 0.621
1.796GluTrp: 1.796 ± 0.37
3.233GluTyr: 3.233 ± 0.58
0.0GluXaa: 0.0 ± 0.0
Phe
2.065PheAla: 2.065 ± 0.377
0.449PheCys: 0.449 ± 0.175
3.053PheAsp: 3.053 ± 0.648
2.065PheGlu: 2.065 ± 0.43
1.167PhePhe: 1.167 ± 0.333
2.694PheGly: 2.694 ± 0.437
0.449PheHis: 0.449 ± 0.17
1.796PheIle: 1.796 ± 0.442
1.616PheLys: 1.616 ± 0.37
1.527PheLeu: 1.527 ± 0.393
0.718PheMet: 0.718 ± 0.297
2.065PheAsn: 2.065 ± 0.449
0.629PhePro: 0.629 ± 0.25
0.449PheGln: 0.449 ± 0.165
2.245PheArg: 2.245 ± 0.53
2.425PheSer: 2.425 ± 0.576
2.694PheThr: 2.694 ± 0.483
1.886PheVal: 1.886 ± 0.347
0.449PheTrp: 0.449 ± 0.196
0.898PheTyr: 0.898 ± 0.264
0.0PheXaa: 0.0 ± 0.0
Gly
6.825GlyAla: 6.825 ± 0.904
0.718GlyCys: 0.718 ± 0.281
5.837GlyAsp: 5.837 ± 0.696
5.478GlyGlu: 5.478 ± 0.708
3.412GlyPhe: 3.412 ± 0.437
10.686GlyGly: 10.686 ± 1.825
2.065GlyHis: 2.065 ± 0.589
4.939GlyIle: 4.939 ± 0.575
4.49GlyLys: 4.49 ± 0.838
5.568GlyLeu: 5.568 ± 0.86
2.155GlyMet: 2.155 ± 0.619
3.592GlyAsn: 3.592 ± 0.608
0.898GlyPro: 0.898 ± 0.323
3.682GlyGln: 3.682 ± 0.418
5.208GlyArg: 5.208 ± 0.548
4.67GlySer: 4.67 ± 0.746
3.053GlyThr: 3.053 ± 0.568
6.376GlyVal: 6.376 ± 0.673
0.988GlyTrp: 0.988 ± 0.297
2.425GlyTyr: 2.425 ± 0.578
0.0GlyXaa: 0.0 ± 0.0
His
2.245HisAla: 2.245 ± 0.407
0.808HisCys: 0.808 ± 0.323
1.257HisAsp: 1.257 ± 0.326
1.527HisGlu: 1.527 ± 0.314
0.449HisPhe: 0.449 ± 0.184
1.706HisGly: 1.706 ± 0.476
0.808HisHis: 0.808 ± 0.342
1.078HisIle: 1.078 ± 0.294
1.527HisLys: 1.527 ± 0.352
1.347HisLeu: 1.347 ± 0.379
0.449HisMet: 0.449 ± 0.223
1.706HisAsn: 1.706 ± 0.388
1.078HisPro: 1.078 ± 0.285
0.808HisGln: 0.808 ± 0.257
1.706HisArg: 1.706 ± 0.447
0.898HisSer: 0.898 ± 0.302
1.616HisThr: 1.616 ± 0.409
0.898HisVal: 0.898 ± 0.35
0.449HisTrp: 0.449 ± 0.194
0.718HisTyr: 0.718 ± 0.227
0.0HisXaa: 0.0 ± 0.0
Ile
4.67IleAla: 4.67 ± 0.654
0.539IleCys: 0.539 ± 0.194
4.759IleAsp: 4.759 ± 0.535
4.131IleGlu: 4.131 ± 0.692
1.527IlePhe: 1.527 ± 0.334
3.772IleGly: 3.772 ± 0.53
1.796IleHis: 1.796 ± 0.512
3.861IleIle: 3.861 ± 0.582
3.143IleLys: 3.143 ± 0.551
2.514IleLeu: 2.514 ± 0.524
1.167IleMet: 1.167 ± 0.233
3.861IleAsn: 3.861 ± 0.588
2.245IlePro: 2.245 ± 0.469
2.963IleGln: 2.963 ± 0.707
4.31IleArg: 4.31 ± 0.62
3.772IleSer: 3.772 ± 0.728
4.49IleThr: 4.49 ± 0.647
3.951IleVal: 3.951 ± 0.731
0.359IleTrp: 0.359 ± 0.146
1.796IleTyr: 1.796 ± 0.373
0.0IleXaa: 0.0 ± 0.0
Lys
6.555LysAla: 6.555 ± 0.807
0.449LysCys: 0.449 ± 0.194
3.682LysAsp: 3.682 ± 0.629
2.694LysGlu: 2.694 ± 0.488
1.437LysPhe: 1.437 ± 0.324
3.861LysGly: 3.861 ± 0.648
1.527LysHis: 1.527 ± 0.385
2.784LysIle: 2.784 ± 0.591
3.143LysLys: 3.143 ± 0.591
3.951LysLeu: 3.951 ± 0.688
1.347LysMet: 1.347 ± 0.344
2.694LysAsn: 2.694 ± 0.482
1.976LysPro: 1.976 ± 0.517
2.245LysGln: 2.245 ± 0.518
3.053LysArg: 3.053 ± 0.577
4.041LysSer: 4.041 ± 0.69
2.784LysThr: 2.784 ± 0.523
2.604LysVal: 2.604 ± 0.507
0.539LysTrp: 0.539 ± 0.177
1.167LysTyr: 1.167 ± 0.34
0.0LysXaa: 0.0 ± 0.0
Leu
6.555LeuAla: 6.555 ± 0.565
0.629LeuCys: 0.629 ± 0.212
5.388LeuAsp: 5.388 ± 0.658
4.67LeuGlu: 4.67 ± 0.549
1.616LeuPhe: 1.616 ± 0.328
4.58LeuGly: 4.58 ± 0.593
1.347LeuHis: 1.347 ± 0.404
5.478LeuIle: 5.478 ± 0.615
4.4LeuLys: 4.4 ± 0.603
5.029LeuLeu: 5.029 ± 0.587
2.155LeuMet: 2.155 ± 0.381
3.143LeuAsn: 3.143 ± 0.61
3.323LeuPro: 3.323 ± 0.539
2.604LeuGln: 2.604 ± 0.5
5.657LeuArg: 5.657 ± 0.574
6.106LeuSer: 6.106 ± 0.805
4.939LeuThr: 4.939 ± 0.79
3.772LeuVal: 3.772 ± 0.739
1.347LeuTrp: 1.347 ± 0.317
2.335LeuTyr: 2.335 ± 0.506
0.0LeuXaa: 0.0 ± 0.0
Met
2.604MetAla: 2.604 ± 0.436
0.359MetCys: 0.359 ± 0.181
1.167MetAsp: 1.167 ± 0.318
1.437MetGlu: 1.437 ± 0.374
1.078MetPhe: 1.078 ± 0.336
1.886MetGly: 1.886 ± 0.433
0.718MetHis: 0.718 ± 0.276
1.167MetIle: 1.167 ± 0.294
1.706MetLys: 1.706 ± 0.467
2.155MetLeu: 2.155 ± 0.532
0.808MetMet: 0.808 ± 0.238
1.527MetAsn: 1.527 ± 0.341
0.808MetPro: 0.808 ± 0.322
1.886MetGln: 1.886 ± 0.502
1.886MetArg: 1.886 ± 0.319
2.784MetSer: 2.784 ± 0.541
1.706MetThr: 1.706 ± 0.418
1.078MetVal: 1.078 ± 0.269
0.269MetTrp: 0.269 ± 0.197
0.359MetTyr: 0.359 ± 0.176
0.0MetXaa: 0.0 ± 0.0
Asn
5.208AsnAla: 5.208 ± 0.925
0.898AsnCys: 0.898 ± 0.329
2.425AsnAsp: 2.425 ± 0.532
2.065AsnGlu: 2.065 ± 0.468
1.527AsnPhe: 1.527 ± 0.269
3.951AsnGly: 3.951 ± 0.553
1.616AsnHis: 1.616 ± 0.44
2.784AsnIle: 2.784 ± 0.545
1.706AsnLys: 1.706 ± 0.359
4.221AsnLeu: 4.221 ± 0.589
0.988AsnMet: 0.988 ± 0.306
1.437AsnAsn: 1.437 ± 0.397
2.604AsnPro: 2.604 ± 0.36
1.706AsnGln: 1.706 ± 0.372
2.604AsnArg: 2.604 ± 0.502
3.233AsnSer: 3.233 ± 0.584
3.143AsnThr: 3.143 ± 0.476
2.694AsnVal: 2.694 ± 0.404
0.629AsnTrp: 0.629 ± 0.248
0.539AsnTyr: 0.539 ± 0.204
0.0AsnXaa: 0.0 ± 0.0
Pro
3.412ProAla: 3.412 ± 0.526
0.449ProCys: 0.449 ± 0.224
2.604ProAsp: 2.604 ± 0.413
2.694ProGlu: 2.694 ± 0.466
1.527ProPhe: 1.527 ± 0.383
1.796ProGly: 1.796 ± 0.332
0.808ProHis: 0.808 ± 0.314
2.604ProIle: 2.604 ± 0.423
1.976ProLys: 1.976 ± 0.445
1.976ProLeu: 1.976 ± 0.358
1.257ProMet: 1.257 ± 0.309
2.245ProAsn: 2.245 ± 0.566
1.257ProPro: 1.257 ± 0.254
1.257ProGln: 1.257 ± 0.336
1.437ProArg: 1.437 ± 0.358
3.502ProSer: 3.502 ± 0.616
2.335ProThr: 2.335 ± 0.604
2.963ProVal: 2.963 ± 0.516
0.808ProTrp: 0.808 ± 0.251
0.808ProTyr: 0.808 ± 0.289
0.0ProXaa: 0.0 ± 0.0
Gln
5.029GlnAla: 5.029 ± 0.619
0.359GlnCys: 0.359 ± 0.152
1.616GlnAsp: 1.616 ± 0.343
2.425GlnGlu: 2.425 ± 0.658
1.437GlnPhe: 1.437 ± 0.305
2.963GlnGly: 2.963 ± 0.356
1.257GlnHis: 1.257 ± 0.332
1.976GlnIle: 1.976 ± 0.524
1.976GlnLys: 1.976 ± 0.447
4.4GlnLeu: 4.4 ± 0.671
1.347GlnMet: 1.347 ± 0.349
1.796GlnAsn: 1.796 ± 0.376
1.706GlnPro: 1.706 ± 0.357
2.065GlnGln: 2.065 ± 0.465
2.874GlnArg: 2.874 ± 0.672
2.335GlnSer: 2.335 ± 0.512
2.425GlnThr: 2.425 ± 0.485
1.976GlnVal: 1.976 ± 0.457
0.808GlnTrp: 0.808 ± 0.263
1.078GlnTyr: 1.078 ± 0.304
0.0GlnXaa: 0.0 ± 0.0
Arg
5.388ArgAla: 5.388 ± 0.591
0.718ArgCys: 0.718 ± 0.192
4.131ArgAsp: 4.131 ± 0.632
4.041ArgGlu: 4.041 ± 0.649
2.065ArgPhe: 2.065 ± 0.396
4.49ArgGly: 4.49 ± 0.771
0.988ArgHis: 0.988 ± 0.258
3.592ArgIle: 3.592 ± 0.58
3.772ArgLys: 3.772 ± 0.516
4.759ArgLeu: 4.759 ± 0.567
2.155ArgMet: 2.155 ± 0.507
2.425ArgAsn: 2.425 ± 0.544
2.065ArgPro: 2.065 ± 0.567
3.053ArgGln: 3.053 ± 0.541
3.233ArgArg: 3.233 ± 0.553
2.694ArgSer: 2.694 ± 0.565
2.155ArgThr: 2.155 ± 0.35
5.388ArgVal: 5.388 ± 0.574
1.347ArgTrp: 1.347 ± 0.366
1.796ArgTyr: 1.796 ± 0.357
0.0ArgXaa: 0.0 ± 0.0
Ser
5.747SerAla: 5.747 ± 0.944
0.539SerCys: 0.539 ± 0.2
5.029SerAsp: 5.029 ± 0.791
4.131SerGlu: 4.131 ± 0.607
2.425SerPhe: 2.425 ± 0.418
6.466SerGly: 6.466 ± 0.853
0.988SerHis: 0.988 ± 0.421
4.4SerIle: 4.4 ± 0.555
2.963SerLys: 2.963 ± 0.521
4.58SerLeu: 4.58 ± 0.764
1.437SerMet: 1.437 ± 0.432
2.514SerAsn: 2.514 ± 0.461
2.514SerPro: 2.514 ± 0.568
2.425SerGln: 2.425 ± 0.606
2.963SerArg: 2.963 ± 0.499
3.682SerSer: 3.682 ± 0.758
3.143SerThr: 3.143 ± 0.569
4.849SerVal: 4.849 ± 0.765
0.808SerTrp: 0.808 ± 0.264
1.257SerTyr: 1.257 ± 0.292
0.0SerXaa: 0.0 ± 0.0
Thr
5.568ThrAla: 5.568 ± 0.82
0.269ThrCys: 0.269 ± 0.142
4.221ThrAsp: 4.221 ± 0.553
3.502ThrGlu: 3.502 ± 0.602
2.245ThrPhe: 2.245 ± 0.481
5.927ThrGly: 5.927 ± 0.67
1.886ThrHis: 1.886 ± 0.474
2.694ThrIle: 2.694 ± 0.386
2.335ThrLys: 2.335 ± 0.504
3.233ThrLeu: 3.233 ± 0.677
1.527ThrMet: 1.527 ± 0.364
2.335ThrAsn: 2.335 ± 0.415
2.335ThrPro: 2.335 ± 0.445
1.527ThrGln: 1.527 ± 0.424
2.874ThrArg: 2.874 ± 0.465
3.861ThrSer: 3.861 ± 0.577
2.694ThrThr: 2.694 ± 0.583
4.31ThrVal: 4.31 ± 0.666
0.449ThrTrp: 0.449 ± 0.182
1.976ThrTyr: 1.976 ± 0.371
0.0ThrXaa: 0.0 ± 0.0
Val
5.208ValAla: 5.208 ± 0.858
0.898ValCys: 0.898 ± 0.285
3.592ValAsp: 3.592 ± 0.36
4.759ValGlu: 4.759 ± 0.66
1.976ValPhe: 1.976 ± 0.415
4.131ValGly: 4.131 ± 0.744
0.808ValHis: 0.808 ± 0.316
2.784ValIle: 2.784 ± 0.476
4.4ValLys: 4.4 ± 0.579
4.759ValLeu: 4.759 ± 0.655
1.347ValMet: 1.347 ± 0.251
3.323ValAsn: 3.323 ± 0.675
2.604ValPro: 2.604 ± 0.428
2.425ValGln: 2.425 ± 0.551
4.31ValArg: 4.31 ± 0.49
4.759ValSer: 4.759 ± 0.718
5.478ValThr: 5.478 ± 0.763
5.029ValVal: 5.029 ± 0.562
0.808ValTrp: 0.808 ± 0.25
1.886ValTyr: 1.886 ± 0.487
0.0ValXaa: 0.0 ± 0.0
Trp
1.527TrpAla: 1.527 ± 0.315
0.269TrpCys: 0.269 ± 0.184
0.988TrpAsp: 0.988 ± 0.319
0.988TrpGlu: 0.988 ± 0.275
0.269TrpPhe: 0.269 ± 0.145
0.898TrpGly: 0.898 ± 0.239
0.269TrpHis: 0.269 ± 0.141
0.449TrpIle: 0.449 ± 0.184
0.988TrpLys: 0.988 ± 0.264
1.616TrpLeu: 1.616 ± 0.373
0.269TrpMet: 0.269 ± 0.171
0.09TrpAsn: 0.09 ± 0.082
0.629TrpPro: 0.629 ± 0.243
0.898TrpGln: 0.898 ± 0.303
1.347TrpArg: 1.347 ± 0.252
0.718TrpSer: 0.718 ± 0.208
0.718TrpThr: 0.718 ± 0.225
1.167TrpVal: 1.167 ± 0.423
0.09TrpTrp: 0.09 ± 0.087
0.718TrpTyr: 0.718 ± 0.229
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.694TyrAla: 2.694 ± 0.452
0.359TyrCys: 0.359 ± 0.192
1.976TyrAsp: 1.976 ± 0.314
1.527TyrGlu: 1.527 ± 0.427
0.629TyrPhe: 0.629 ± 0.224
1.616TyrGly: 1.616 ± 0.309
0.988TyrHis: 0.988 ± 0.324
2.065TyrIle: 2.065 ± 0.492
1.437TyrLys: 1.437 ± 0.437
2.065TyrLeu: 2.065 ± 0.43
0.449TyrMet: 0.449 ± 0.178
1.886TyrAsn: 1.886 ± 0.416
1.078TyrPro: 1.078 ± 0.283
1.616TyrGln: 1.616 ± 0.353
1.706TyrArg: 1.706 ± 0.432
1.527TyrSer: 1.527 ± 0.409
1.706TyrThr: 1.706 ± 0.445
1.796TyrVal: 1.796 ± 0.464
0.359TyrTrp: 0.359 ± 0.162
0.808TyrTyr: 0.808 ± 0.282
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 56 proteins (11137 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski