Amino acid dipepetide frequency for Thermoplasmatales archaeon SCGC AB-539-C06

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.66AlaAla: 3.66 ± 0.2
0.783AlaCys: 0.783 ± 0.068
3.411AlaAsp: 3.411 ± 0.147
3.866AlaGlu: 3.866 ± 0.189
2.252AlaPhe: 2.252 ± 0.126
4.54AlaGly: 4.54 ± 0.227
1.032AlaHis: 1.032 ± 0.074
5.244AlaIle: 5.244 ± 0.187
4.565AlaLys: 4.565 ± 0.214
5.008AlaLeu: 5.008 ± 0.198
1.335AlaMet: 1.335 ± 0.085
2.021AlaAsn: 2.021 ± 0.12
1.669AlaPro: 1.669 ± 0.094
1.323AlaGln: 1.323 ± 0.086
2.3AlaArg: 2.3 ± 0.115
3.654AlaSer: 3.654 ± 0.157
3.126AlaThr: 3.126 ± 0.179
4.328AlaVal: 4.328 ± 0.173
0.595AlaTrp: 0.595 ± 0.072
1.87AlaTyr: 1.87 ± 0.087
0.0AlaXaa: 0.0 ± 0.0
Cys
0.716CysAla: 0.716 ± 0.076
0.2CysCys: 0.2 ± 0.038
0.619CysAsp: 0.619 ± 0.055
0.734CysGlu: 0.734 ± 0.064
0.571CysPhe: 0.571 ± 0.068
1.317CysGly: 1.317 ± 0.092
0.34CysHis: 0.34 ± 0.045
1.171CysIle: 1.171 ± 0.091
0.995CysLys: 0.995 ± 0.073
0.929CysLeu: 0.929 ± 0.083
0.285CysMet: 0.285 ± 0.041
0.571CysAsn: 0.571 ± 0.062
0.692CysPro: 0.692 ± 0.069
0.297CysGln: 0.297 ± 0.037
0.643CysArg: 0.643 ± 0.06
1.093CysSer: 1.093 ± 0.091
0.722CysThr: 0.722 ± 0.07
0.85CysVal: 0.85 ± 0.072
0.176CysTrp: 0.176 ± 0.035
0.467CysTyr: 0.467 ± 0.051
0.0CysXaa: 0.0 ± 0.0
Asp
3.502AspAla: 3.502 ± 0.168
0.674AspCys: 0.674 ± 0.071
3.557AspAsp: 3.557 ± 0.212
4.273AspGlu: 4.273 ± 0.19
2.835AspPhe: 2.835 ± 0.145
4.376AspGly: 4.376 ± 0.235
1.032AspHis: 1.032 ± 0.088
5.87AspIle: 5.87 ± 0.194
4.431AspLys: 4.431 ± 0.184
4.838AspLeu: 4.838 ± 0.192
1.402AspMet: 1.402 ± 0.089
3.126AspAsn: 3.126 ± 0.183
1.997AspPro: 1.997 ± 0.115
1.056AspGln: 1.056 ± 0.082
1.87AspArg: 1.87 ± 0.124
3.369AspSer: 3.369 ± 0.143
2.61AspThr: 2.61 ± 0.126
4.376AspVal: 4.376 ± 0.173
1.032AspTrp: 1.032 ± 0.095
2.222AspTyr: 2.222 ± 0.118
0.0AspXaa: 0.0 ± 0.0
Glu
3.411GluAla: 3.411 ± 0.198
0.771GluCys: 0.771 ± 0.082
3.393GluAsp: 3.393 ± 0.17
5.73GluGlu: 5.73 ± 0.242
2.938GluPhe: 2.938 ± 0.126
3.788GluGly: 3.788 ± 0.152
1.171GluHis: 1.171 ± 0.078
7.065GluIle: 7.065 ± 0.231
7.715GluLys: 7.715 ± 0.325
5.627GluLeu: 5.627 ± 0.199
1.742GluMet: 1.742 ± 0.112
3.812GluAsn: 3.812 ± 0.17
1.906GluPro: 1.906 ± 0.118
1.675GluGln: 1.675 ± 0.099
2.683GluArg: 2.683 ± 0.137
3.296GluSer: 3.296 ± 0.141
3.599GluThr: 3.599 ± 0.142
3.939GluVal: 3.939 ± 0.149
0.971GluTrp: 0.971 ± 0.078
2.543GluTyr: 2.543 ± 0.134
0.0GluXaa: 0.0 ± 0.0
Phe
2.659PheAla: 2.659 ± 0.149
0.668PheCys: 0.668 ± 0.076
2.962PheAsp: 2.962 ± 0.147
2.895PheGlu: 2.895 ± 0.142
2.483PhePhe: 2.483 ± 0.153
3.047PheGly: 3.047 ± 0.142
0.716PheHis: 0.716 ± 0.07
3.83PheIle: 3.83 ± 0.175
2.871PheLys: 2.871 ± 0.128
4.279PheLeu: 4.279 ± 0.217
1.117PheMet: 1.117 ± 0.098
2.039PheAsn: 2.039 ± 0.108
1.633PhePro: 1.633 ± 0.107
1.117PheGln: 1.117 ± 0.081
1.548PheArg: 1.548 ± 0.097
3.557PheSer: 3.557 ± 0.148
2.41PheThr: 2.41 ± 0.121
3.15PheVal: 3.15 ± 0.143
0.625PheTrp: 0.625 ± 0.061
1.609PheTyr: 1.609 ± 0.099
0.0PheXaa: 0.0 ± 0.0
Gly
4.267GlyAla: 4.267 ± 0.188
1.153GlyCys: 1.153 ± 0.094
3.976GlyAsp: 3.976 ± 0.23
4.54GlyGlu: 4.54 ± 0.173
3.533GlyPhe: 3.533 ± 0.167
5.341GlyGly: 5.341 ± 0.25
1.214GlyHis: 1.214 ± 0.094
6.586GlyIle: 6.586 ± 0.267
5.524GlyLys: 5.524 ± 0.228
5.548GlyLeu: 5.548 ± 0.183
1.9GlyMet: 1.9 ± 0.113
3.521GlyAsn: 3.521 ± 0.242
1.809GlyPro: 1.809 ± 0.096
1.517GlyGln: 1.517 ± 0.103
2.616GlyArg: 2.616 ± 0.138
4.237GlySer: 4.237 ± 0.183
3.994GlyThr: 3.994 ± 0.216
4.874GlyVal: 4.874 ± 0.193
0.819GlyTrp: 0.819 ± 0.075
2.901GlyTyr: 2.901 ± 0.165
0.0GlyXaa: 0.0 ± 0.0
His
1.147HisAla: 1.147 ± 0.082
0.34HisCys: 0.34 ± 0.052
1.062HisAsp: 1.062 ± 0.096
0.91HisGlu: 0.91 ± 0.075
0.819HisPhe: 0.819 ± 0.071
1.439HisGly: 1.439 ± 0.086
0.449HisHis: 0.449 ± 0.059
1.524HisIle: 1.524 ± 0.092
1.165HisLys: 1.165 ± 0.09
1.627HisLeu: 1.627 ± 0.111
0.546HisMet: 0.546 ± 0.061
0.862HisAsn: 0.862 ± 0.072
0.947HisPro: 0.947 ± 0.07
0.467HisGln: 0.467 ± 0.049
0.741HisArg: 0.741 ± 0.059
1.032HisSer: 1.032 ± 0.079
0.995HisThr: 0.995 ± 0.085
1.214HisVal: 1.214 ± 0.084
0.237HisTrp: 0.237 ± 0.037
0.656HisTyr: 0.656 ± 0.075
0.0HisXaa: 0.0 ± 0.0
Ile
5.323IleAla: 5.323 ± 0.234
1.275IleCys: 1.275 ± 0.074
5.845IleAsp: 5.845 ± 0.186
5.888IleGlu: 5.888 ± 0.219
4.431IlePhe: 4.431 ± 0.197
6.738IleGly: 6.738 ± 0.253
1.505IleHis: 1.505 ± 0.09
8.212IleIle: 8.212 ± 0.278
7.32IleLys: 7.32 ± 0.218
8.018IleLeu: 8.018 ± 0.24
2.203IleMet: 2.203 ± 0.131
4.237IleAsn: 4.237 ± 0.18
4.085IlePro: 4.085 ± 0.175
2.319IleGln: 2.319 ± 0.121
3.351IleArg: 3.351 ± 0.132
6.392IleSer: 6.392 ± 0.213
4.868IleThr: 4.868 ± 0.198
6.422IleVal: 6.422 ± 0.215
0.935IleTrp: 0.935 ± 0.078
3.126IleTyr: 3.126 ± 0.131
0.0IleXaa: 0.0 ± 0.0
Lys
4.297LysAla: 4.297 ± 0.182
0.904LysCys: 0.904 ± 0.088
4.419LysAsp: 4.419 ± 0.181
7.108LysGlu: 7.108 ± 0.31
2.379LysPhe: 2.379 ± 0.14
4.546LysGly: 4.546 ± 0.2
1.754LysHis: 1.754 ± 0.105
8.492LysIle: 8.492 ± 0.26
10.112LysLys: 10.112 ± 0.402
6.361LysLeu: 6.361 ± 0.231
2.276LysMet: 2.276 ± 0.105
5.487LysAsn: 5.487 ± 0.199
2.81LysPro: 2.81 ± 0.127
2.3LysGln: 2.3 ± 0.136
3.605LysArg: 3.605 ± 0.17
4.2LysSer: 4.2 ± 0.178
5.22LysThr: 5.22 ± 0.192
4.115LysVal: 4.115 ± 0.156
0.716LysTrp: 0.716 ± 0.064
2.968LysTyr: 2.968 ± 0.151
0.0LysXaa: 0.0 ± 0.0
Leu
5.293LeuAla: 5.293 ± 0.193
1.05LeuCys: 1.05 ± 0.089
5.014LeuAsp: 5.014 ± 0.188
5.651LeuGlu: 5.651 ± 0.219
3.909LeuPhe: 3.909 ± 0.216
5.657LeuGly: 5.657 ± 0.192
1.432LeuHis: 1.432 ± 0.09
7.442LeuIle: 7.442 ± 0.257
6.974LeuLys: 6.974 ± 0.256
7.751LeuLeu: 7.751 ± 0.302
2.228LeuMet: 2.228 ± 0.126
4.103LeuAsn: 4.103 ± 0.185
3.381LeuPro: 3.381 ± 0.129
2.137LeuGln: 2.137 ± 0.12
3.138LeuArg: 3.138 ± 0.151
5.748LeuSer: 5.748 ± 0.179
4.528LeuThr: 4.528 ± 0.17
5.25LeuVal: 5.25 ± 0.208
0.862LeuTrp: 0.862 ± 0.072
3.017LeuTyr: 3.017 ± 0.125
0.0LeuXaa: 0.0 ± 0.0
Met
1.426MetAla: 1.426 ± 0.113
0.279MetCys: 0.279 ± 0.041
1.524MetAsp: 1.524 ± 0.096
1.524MetGlu: 1.524 ± 0.097
1.062MetPhe: 1.062 ± 0.076
1.76MetGly: 1.76 ± 0.121
0.449MetHis: 0.449 ± 0.05
2.27MetIle: 2.27 ± 0.121
2.489MetLys: 2.489 ± 0.113
2.222MetLeu: 2.222 ± 0.12
0.801MetMet: 0.801 ± 0.074
1.402MetAsn: 1.402 ± 0.1
1.05MetPro: 1.05 ± 0.082
0.674MetGln: 0.674 ± 0.062
1.038MetArg: 1.038 ± 0.065
1.481MetSer: 1.481 ± 0.104
1.372MetThr: 1.372 ± 0.095
1.839MetVal: 1.839 ± 0.102
0.255MetTrp: 0.255 ± 0.034
0.704MetTyr: 0.704 ± 0.068
0.0MetXaa: 0.0 ± 0.0
Asn
2.701AsnAla: 2.701 ± 0.147
0.801AsnCys: 0.801 ± 0.081
2.519AsnAsp: 2.519 ± 0.128
3.138AsnGlu: 3.138 ± 0.157
2.27AsnPhe: 2.27 ± 0.118
3.363AsnGly: 3.363 ± 0.165
0.874AsnHis: 0.874 ± 0.077
5.572AsnIle: 5.572 ± 0.234
3.964AsnLys: 3.964 ± 0.156
4.516AsnLeu: 4.516 ± 0.198
1.25AsnMet: 1.25 ± 0.096
3.272AsnAsn: 3.272 ± 0.269
2.392AsnPro: 2.392 ± 0.121
1.22AsnGln: 1.22 ± 0.09
1.712AsnArg: 1.712 ± 0.111
2.98AsnSer: 2.98 ± 0.154
2.665AsnThr: 2.665 ± 0.145
3.502AsnVal: 3.502 ± 0.16
0.765AsnTrp: 0.765 ± 0.068
2.222AsnTyr: 2.222 ± 0.13
0.0AsnXaa: 0.0 ± 0.0
Pro
1.948ProAla: 1.948 ± 0.13
0.455ProCys: 0.455 ± 0.051
2.41ProAsp: 2.41 ± 0.127
2.683ProGlu: 2.683 ± 0.13
1.712ProPhe: 1.712 ± 0.098
2.349ProGly: 2.349 ± 0.142
0.765ProHis: 0.765 ± 0.072
3.175ProIle: 3.175 ± 0.145
2.574ProLys: 2.574 ± 0.121
3.114ProLeu: 3.114 ± 0.172
0.838ProMet: 0.838 ± 0.072
1.7ProAsn: 1.7 ± 0.105
1.384ProPro: 1.384 ± 0.099
0.783ProGln: 0.783 ± 0.077
1.287ProArg: 1.287 ± 0.088
2.61ProSer: 2.61 ± 0.139
2.07ProThr: 2.07 ± 0.1
2.531ProVal: 2.531 ± 0.143
0.364ProTrp: 0.364 ± 0.044
1.602ProTyr: 1.602 ± 0.096
0.0ProXaa: 0.0 ± 0.0
Gln
1.384GlnAla: 1.384 ± 0.092
0.34GlnCys: 0.34 ± 0.053
1.165GlnAsp: 1.165 ± 0.089
1.669GlnGlu: 1.669 ± 0.105
1.038GlnPhe: 1.038 ± 0.07
1.42GlnGly: 1.42 ± 0.087
0.461GlnHis: 0.461 ± 0.053
2.319GlnIle: 2.319 ± 0.119
2.264GlnLys: 2.264 ± 0.12
1.924GlnLeu: 1.924 ± 0.111
0.71GlnMet: 0.71 ± 0.069
1.299GlnAsn: 1.299 ± 0.099
0.856GlnPro: 0.856 ± 0.065
0.904GlnGln: 0.904 ± 0.098
1.129GlnArg: 1.129 ± 0.081
1.584GlnSer: 1.584 ± 0.091
1.481GlnThr: 1.481 ± 0.094
1.378GlnVal: 1.378 ± 0.083
0.267GlnTrp: 0.267 ± 0.048
0.923GlnTyr: 0.923 ± 0.068
0.0GlnXaa: 0.0 ± 0.0
Arg
1.785ArgAla: 1.785 ± 0.1
0.564ArgCys: 0.564 ± 0.067
2.07ArgAsp: 2.07 ± 0.116
2.653ArgGlu: 2.653 ± 0.164
1.803ArgPhe: 1.803 ± 0.109
2.489ArgGly: 2.489 ± 0.144
0.734ArgHis: 0.734 ± 0.074
3.29ArgIle: 3.29 ± 0.13
3.788ArgLys: 3.788 ± 0.16
3.083ArgLeu: 3.083 ± 0.133
1.165ArgMet: 1.165 ± 0.085
2.203ArgAsn: 2.203 ± 0.123
1.135ArgPro: 1.135 ± 0.074
0.935ArgGln: 0.935 ± 0.083
2.039ArgArg: 2.039 ± 0.134
1.9ArgSer: 1.9 ± 0.109
1.712ArgThr: 1.712 ± 0.124
2.191ArgVal: 2.191 ± 0.127
0.473ArgTrp: 0.473 ± 0.061
1.736ArgTyr: 1.736 ± 0.103
0.0ArgXaa: 0.0 ± 0.0
Ser
3.15SerAla: 3.15 ± 0.139
0.917SerCys: 0.917 ± 0.076
3.521SerAsp: 3.521 ± 0.18
3.909SerGlu: 3.909 ± 0.159
3.175SerPhe: 3.175 ± 0.151
5.214SerGly: 5.214 ± 0.232
1.111SerHis: 1.111 ± 0.087
5.542SerIle: 5.542 ± 0.191
4.935SerLys: 4.935 ± 0.208
5.354SerLeu: 5.354 ± 0.19
1.724SerMet: 1.724 ± 0.118
3.351SerAsn: 3.351 ± 0.182
1.973SerPro: 1.973 ± 0.135
1.73SerGln: 1.73 ± 0.111
2.258SerArg: 2.258 ± 0.114
4.492SerSer: 4.492 ± 0.208
3.15SerThr: 3.15 ± 0.143
3.854SerVal: 3.854 ± 0.159
0.929SerTrp: 0.929 ± 0.088
2.525SerTyr: 2.525 ± 0.121
0.0SerXaa: 0.0 ± 0.0
Thr
3.235ThrAla: 3.235 ± 0.14
0.625ThrCys: 0.625 ± 0.059
3.053ThrAsp: 3.053 ± 0.172
3.09ThrGlu: 3.09 ± 0.135
2.428ThrPhe: 2.428 ± 0.12
4.006ThrGly: 4.006 ± 0.191
0.959ThrHis: 0.959 ± 0.069
5.348ThrIle: 5.348 ± 0.212
3.866ThrLys: 3.866 ± 0.17
4.486ThrLeu: 4.486 ± 0.184
1.36ThrMet: 1.36 ± 0.083
2.513ThrAsn: 2.513 ± 0.128
2.3ThrPro: 2.3 ± 0.112
1.123ThrGln: 1.123 ± 0.081
1.712ThrArg: 1.712 ± 0.092
3.587ThrSer: 3.587 ± 0.143
3.302ThrThr: 3.302 ± 0.142
4.364ThrVal: 4.364 ± 0.204
0.643ThrTrp: 0.643 ± 0.062
2.228ThrTyr: 2.228 ± 0.144
0.0ThrXaa: 0.0 ± 0.0
Val
4.006ValAla: 4.006 ± 0.17
0.825ValCys: 0.825 ± 0.072
4.431ValAsp: 4.431 ± 0.169
4.613ValGlu: 4.613 ± 0.164
3.284ValPhe: 3.284 ± 0.158
4.522ValGly: 4.522 ± 0.173
1.05ValHis: 1.05 ± 0.074
5.621ValIle: 5.621 ± 0.198
5.281ValLys: 5.281 ± 0.231
5.536ValLeu: 5.536 ± 0.209
1.596ValMet: 1.596 ± 0.09
3.338ValAsn: 3.338 ± 0.169
2.373ValPro: 2.373 ± 0.116
1.511ValGln: 1.511 ± 0.109
2.118ValArg: 2.118 ± 0.123
4.2ValSer: 4.2 ± 0.162
3.86ValThr: 3.86 ± 0.188
4.656ValVal: 4.656 ± 0.206
0.656ValTrp: 0.656 ± 0.066
2.598ValTyr: 2.598 ± 0.155
0.0ValXaa: 0.0 ± 0.0
Trp
0.558TrpAla: 0.558 ± 0.063
0.146TrpCys: 0.146 ± 0.028
0.995TrpAsp: 0.995 ± 0.098
0.643TrpGlu: 0.643 ± 0.07
0.546TrpPhe: 0.546 ± 0.056
0.917TrpGly: 0.917 ± 0.082
0.279TrpHis: 0.279 ± 0.035
1.05TrpIle: 1.05 ± 0.076
0.947TrpLys: 0.947 ± 0.088
1.002TrpLeu: 1.002 ± 0.088
0.358TrpMet: 0.358 ± 0.048
0.643TrpAsn: 0.643 ± 0.072
0.291TrpPro: 0.291 ± 0.048
0.322TrpGln: 0.322 ± 0.046
0.443TrpArg: 0.443 ± 0.05
0.892TrpSer: 0.892 ± 0.092
0.643TrpThr: 0.643 ± 0.062
0.668TrpVal: 0.668 ± 0.068
0.322TrpTrp: 0.322 ± 0.055
0.455TrpTyr: 0.455 ± 0.053
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.112TyrAla: 2.112 ± 0.117
0.619TyrCys: 0.619 ± 0.077
2.501TyrAsp: 2.501 ± 0.131
2.258TyrGlu: 2.258 ± 0.122
1.754TyrPhe: 1.754 ± 0.107
3.041TyrGly: 3.041 ± 0.149
0.85TyrHis: 0.85 ± 0.064
2.871TyrIle: 2.871 ± 0.162
2.294TyrLys: 2.294 ± 0.119
3.344TyrLeu: 3.344 ± 0.145
0.777TyrMet: 0.777 ± 0.072
2.197TyrAsn: 2.197 ± 0.148
1.669TyrPro: 1.669 ± 0.104
1.105TyrGln: 1.105 ± 0.077
1.517TyrArg: 1.517 ± 0.096
2.507TyrSer: 2.507 ± 0.134
1.9TyrThr: 1.9 ± 0.129
2.574TyrVal: 2.574 ± 0.135
0.48TyrTrp: 0.48 ± 0.055
1.87TyrTyr: 1.87 ± 0.123
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 780 proteins (164750 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski