Amino acid dipepetide frequency for Elstera cyanobacteriorum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.728AlaAla: 20.728 ± 0.221	1.08AlaCys: 1.08 ± 0.032	7.779AlaAsp: 7.779 ± 0.094	8.068AlaGlu: 8.068 ± 0.093	4.424AlaPhe: 4.424 ± 0.068	10.985AlaGly: 10.985 ± 0.108	2.14AlaHis: 2.14 ± 0.049	5.719AlaIle: 5.719 ± 0.074	4.16AlaLys: 4.16 ± 0.062	16.549AlaLeu: 16.549 ± 0.173	3.292AlaMet: 3.292 ± 0.063	2.534AlaAsn: 2.534 ± 0.051	6.727AlaPro: 6.727 ± 0.096	4.911AlaGln: 4.911 ± 0.067	9.111AlaArg: 9.111 ± 0.109	5.603AlaSer: 5.603 ± 0.075	6.579AlaThr: 6.579 ± 0.084	9.724AlaVal: 9.724 ± 0.094	1.661AlaTrp: 1.661 ± 0.042	2.754AlaTyr: 2.754 ± 0.055	0.001AlaXaa: 0.001 ± 0.001
Cys	0.939CysAla: 0.939 ± 0.031	0.098CysCys: 0.098 ± 0.009	0.484CysAsp: 0.484 ± 0.02	0.308CysGlu: 0.308 ± 0.016	0.321CysPhe: 0.321 ± 0.015	0.883CysGly: 0.883 ± 0.029	0.244CysHis: 0.244 ± 0.015	0.335CysIle: 0.335 ± 0.018	0.148CysLys: 0.148 ± 0.013	0.924CysLeu: 0.924 ± 0.031	0.11CysMet: 0.11 ± 0.011	0.135CysAsn: 0.135 ± 0.012	0.464CysPro: 0.464 ± 0.022	0.225CysGln: 0.225 ± 0.013	0.584CysArg: 0.584 ± 0.025	0.372CysSer: 0.372 ± 0.017	0.455CysThr: 0.455 ± 0.018	0.506CysVal: 0.506 ± 0.02	0.098CysTrp: 0.098 ± 0.009	0.162CysTyr: 0.162 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.222AspAla: 7.222 ± 0.08	0.441AspCys: 0.441 ± 0.02	2.633AspAsp: 2.633 ± 0.057	2.587AspGlu: 2.587 ± 0.049	2.087AspPhe: 2.087 ± 0.045	5.073AspGly: 5.073 ± 0.076	1.186AspHis: 1.186 ± 0.035	2.805AspIle: 2.805 ± 0.055	1.682AspLys: 1.682 ± 0.045	6.896AspLeu: 6.896 ± 0.077	1.069AspMet: 1.069 ± 0.032	0.968AspAsn: 0.968 ± 0.034	3.77AspPro: 3.77 ± 0.06	1.981AspGln: 1.981 ± 0.045	4.474AspArg: 4.474 ± 0.069	2.042AspSer: 2.042 ± 0.046	2.562AspThr: 2.562 ± 0.047	3.526AspVal: 3.526 ± 0.057	1.055AspTrp: 1.055 ± 0.031	1.437AspTyr: 1.437 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	8.001GluAla: 8.001 ± 0.102	0.288GluCys: 0.288 ± 0.016	2.333GluAsp: 2.333 ± 0.05	2.619GluGlu: 2.619 ± 0.056	1.598GluPhe: 1.598 ± 0.038	3.696GluGly: 3.696 ± 0.056	0.879GluHis: 0.879 ± 0.029	3.163GluIle: 3.163 ± 0.055	2.138GluLys: 2.138 ± 0.051	4.103GluLeu: 4.103 ± 0.064	1.243GluMet: 1.243 ± 0.035	1.337GluAsn: 1.337 ± 0.031	2.325GluPro: 2.325 ± 0.047	1.841GluGln: 1.841 ± 0.04	3.822GluArg: 3.822 ± 0.062	1.924GluSer: 1.924 ± 0.045	3.941GluThr: 3.941 ± 0.061	3.564GluVal: 3.564 ± 0.059	0.58GluTrp: 0.58 ± 0.022	0.814GluTyr: 0.814 ± 0.023	0.001GluXaa: 0.001 ± 0.001
Phe	4.361PheAla: 4.361 ± 0.065	0.425PheCys: 0.425 ± 0.016	2.508PheAsp: 2.508 ± 0.051	1.756PheGlu: 1.756 ± 0.039	1.433PhePhe: 1.433 ± 0.043	3.531PheGly: 3.531 ± 0.06	0.717PheHis: 0.717 ± 0.025	1.745PheIle: 1.745 ± 0.044	0.954PheLys: 0.954 ± 0.027	3.704PheLeu: 3.704 ± 0.064	0.657PheMet: 0.657 ± 0.025	0.993PheAsn: 0.993 ± 0.033	1.683PhePro: 1.683 ± 0.039	1.084PheGln: 1.084 ± 0.032	2.204PheArg: 2.204 ± 0.045	1.953PheSer: 1.953 ± 0.046	2.164PheThr: 2.164 ± 0.051	2.35PheVal: 2.35 ± 0.053	0.586PheTrp: 0.586 ± 0.028	0.952PheTyr: 0.952 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.632GlyAla: 9.632 ± 0.109	0.793GlyCys: 0.793 ± 0.026	4.321GlyAsp: 4.321 ± 0.058	4.198GlyGlu: 4.198 ± 0.067	3.657GlyPhe: 3.657 ± 0.06	7.475GlyGly: 7.475 ± 0.112	1.646GlyHis: 1.646 ± 0.04	4.526GlyIle: 4.526 ± 0.067	3.207GlyLys: 3.207 ± 0.061	10.125GlyLeu: 10.125 ± 0.117	2.101GlyMet: 2.101 ± 0.044	1.835GlyAsn: 1.835 ± 0.05	3.832GlyPro: 3.832 ± 0.061	3.349GlyGln: 3.349 ± 0.049	5.875GlyArg: 5.875 ± 0.076	4.258GlySer: 4.258 ± 0.068	4.899GlyThr: 4.899 ± 0.082	6.319GlyVal: 6.319 ± 0.085	1.395GlyTrp: 1.395 ± 0.043	2.105GlyTyr: 2.105 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.122HisAla: 2.122 ± 0.049	0.206HisCys: 0.206 ± 0.013	0.989HisAsp: 0.989 ± 0.032	0.762HisGlu: 0.762 ± 0.027	0.786HisPhe: 0.786 ± 0.029	1.689HisGly: 1.689 ± 0.041	0.546HisHis: 0.546 ± 0.026	0.876HisIle: 0.876 ± 0.024	0.455HisLys: 0.455 ± 0.021	2.272HisLeu: 2.272 ± 0.047	0.381HisMet: 0.381 ± 0.018	0.39HisAsn: 0.39 ± 0.019	1.457HisPro: 1.457 ± 0.035	0.593HisGln: 0.593 ± 0.022	1.546HisArg: 1.546 ± 0.039	0.843HisSer: 0.843 ± 0.028	0.833HisThr: 0.833 ± 0.024	1.161HisVal: 1.161 ± 0.037	0.319HisTrp: 0.319 ± 0.016	0.487HisTyr: 0.487 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.334IleAla: 7.334 ± 0.085	0.428IleCys: 0.428 ± 0.016	3.59IleAsp: 3.59 ± 0.06	2.901IleGlu: 2.901 ± 0.054	1.624IlePhe: 1.624 ± 0.04	5.131IleGly: 5.131 ± 0.074	0.849IleHis: 0.849 ± 0.028	2.273IleIle: 2.273 ± 0.05	1.227IleLys: 1.227 ± 0.035	5.064IleLeu: 5.064 ± 0.075	0.817IleMet: 0.817 ± 0.028	1.306IleAsn: 1.306 ± 0.035	2.404IlePro: 2.404 ± 0.04	1.342IleGln: 1.342 ± 0.041	2.98IleArg: 2.98 ± 0.05	2.528IleSer: 2.528 ± 0.047	2.849IleThr: 2.849 ± 0.058	3.727IleVal: 3.727 ± 0.057	0.488IleTrp: 0.488 ± 0.02	1.013IleTyr: 1.013 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.176LysAla: 4.176 ± 0.079	0.105LysCys: 0.105 ± 0.009	1.619LysAsp: 1.619 ± 0.037	1.332LysGlu: 1.332 ± 0.033	0.943LysPhe: 0.943 ± 0.03	2.448LysGly: 2.448 ± 0.05	0.52LysHis: 0.52 ± 0.025	1.812LysIle: 1.812 ± 0.043	1.123LysLys: 1.123 ± 0.038	3.486LysLeu: 3.486 ± 0.062	0.661LysMet: 0.661 ± 0.025	0.85LysAsn: 0.85 ± 0.034	2.056LysPro: 2.056 ± 0.045	1.034LysGln: 1.034 ± 0.036	2.272LysArg: 2.272 ± 0.046	1.63LysSer: 1.63 ± 0.039	1.977LysThr: 1.977 ± 0.04	2.171LysVal: 2.171 ± 0.048	0.261LysTrp: 0.261 ± 0.015	0.541LysTyr: 0.541 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	16.416LeuAla: 16.416 ± 0.167	0.923LeuCys: 0.923 ± 0.03	6.292LeuAsp: 6.292 ± 0.079	4.971LeuGlu: 4.971 ± 0.067	3.717LeuPhe: 3.717 ± 0.067	9.34LeuGly: 9.34 ± 0.112	2.056LeuHis: 2.056 ± 0.04	5.786LeuIle: 5.786 ± 0.078	3.653LeuLys: 3.653 ± 0.055	12.194LeuLeu: 12.194 ± 0.163	2.346LeuMet: 2.346 ± 0.047	2.609LeuAsn: 2.609 ± 0.046	7.363LeuPro: 7.363 ± 0.111	2.921LeuGln: 2.921 ± 0.056	7.561LeuArg: 7.561 ± 0.09	6.606LeuSer: 6.606 ± 0.085	7.649LeuThr: 7.649 ± 0.106	7.449LeuVal: 7.449 ± 0.098	1.426LeuTrp: 1.426 ± 0.041	2.31LeuTyr: 2.31 ± 0.049	0.001LeuXaa: 0.001 ± 0.001
Met	2.855MetAla: 2.855 ± 0.05	0.117MetCys: 0.117 ± 0.01	0.978MetAsp: 0.978 ± 0.027	0.867MetGlu: 0.867 ± 0.024	0.53MetPhe: 0.53 ± 0.022	1.687MetGly: 1.687 ± 0.04	0.303MetHis: 0.303 ± 0.014	1.319MetIle: 1.319 ± 0.036	0.706MetLys: 0.706 ± 0.025	2.284MetLeu: 2.284 ± 0.04	0.58MetMet: 0.58 ± 0.021	0.564MetAsn: 0.564 ± 0.021	1.286MetPro: 1.286 ± 0.032	0.745MetGln: 0.745 ± 0.027	1.522MetArg: 1.522 ± 0.037	1.384MetSer: 1.384 ± 0.03	1.733MetThr: 1.733 ± 0.037	1.644MetVal: 1.644 ± 0.043	0.136MetTrp: 0.136 ± 0.01	0.273MetTyr: 0.273 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.705AsnAla: 2.705 ± 0.051	0.209AsnCys: 0.209 ± 0.016	1.188AsnAsp: 1.188 ± 0.04	0.907AsnGlu: 0.907 ± 0.027	0.933AsnPhe: 0.933 ± 0.031	2.092AsnGly: 2.092 ± 0.044	0.436AsnHis: 0.436 ± 0.017	1.245AsnIle: 1.245 ± 0.034	0.632AsnLys: 0.632 ± 0.024	2.595AsnLeu: 2.595 ± 0.054	0.44AsnMet: 0.44 ± 0.021	0.64AsnAsn: 0.64 ± 0.027	1.75AsnPro: 1.75 ± 0.049	0.788AsnGln: 0.788 ± 0.026	1.825AsnArg: 1.825 ± 0.041	1.166AsnSer: 1.166 ± 0.037	1.024AsnThr: 1.024 ± 0.032	1.479AsnVal: 1.479 ± 0.036	0.31AsnTrp: 0.31 ± 0.016	0.571AsnTyr: 0.571 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.234ProAla: 7.234 ± 0.093	0.31ProCys: 0.31 ± 0.015	3.886ProAsp: 3.886 ± 0.067	3.575ProGlu: 3.575 ± 0.055	1.959ProPhe: 1.959 ± 0.041	4.891ProGly: 4.891 ± 0.069	1.083ProHis: 1.083 ± 0.032	2.498ProIle: 2.498 ± 0.049	1.728ProLys: 1.728 ± 0.044	6.172ProLeu: 6.172 ± 0.1	1.25ProMet: 1.25 ± 0.036	1.345ProAsn: 1.345 ± 0.037	3.61ProPro: 3.61 ± 0.103	1.97ProGln: 1.97 ± 0.045	3.11ProArg: 3.11 ± 0.056	2.835ProSer: 2.835 ± 0.05	3.149ProThr: 3.149 ± 0.048	4.689ProVal: 4.689 ± 0.063	0.772ProTrp: 0.772 ± 0.025	1.176ProTyr: 1.176 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	5.051GlnAla: 5.051 ± 0.075	0.188GlnCys: 0.188 ± 0.013	1.568GlnAsp: 1.568 ± 0.043	1.598GlnGlu: 1.598 ± 0.039	1.104GlnPhe: 1.104 ± 0.032	2.729GlnGly: 2.729 ± 0.051	0.621GlnHis: 0.621 ± 0.024	1.982GlnIle: 1.982 ± 0.045	1.199GlnLys: 1.199 ± 0.03	2.695GlnLeu: 2.695 ± 0.048	0.844GlnMet: 0.844 ± 0.025	0.888GlnAsn: 0.888 ± 0.032	1.948GlnPro: 1.948 ± 0.04	1.43GlnGln: 1.43 ± 0.047	2.79GlnArg: 2.79 ± 0.06	1.803GlnSer: 1.803 ± 0.044	2.25GlnThr: 2.25 ± 0.05	2.624GlnVal: 2.624 ± 0.052	0.366GlnTrp: 0.366 ± 0.018	0.539GlnTyr: 0.539 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.656ArgAla: 8.656 ± 0.102	0.527ArgCys: 0.527 ± 0.02	3.967ArgAsp: 3.967 ± 0.055	3.215ArgGlu: 3.215 ± 0.061	2.915ArgPhe: 2.915 ± 0.055	4.773ArgGly: 4.773 ± 0.068	1.488ArgHis: 1.488 ± 0.039	3.387ArgIle: 3.387 ± 0.056	1.919ArgLys: 1.919 ± 0.044	9.239ArgLeu: 9.239 ± 0.118	1.51ArgMet: 1.51 ± 0.041	1.536ArgAsn: 1.536 ± 0.038	3.837ArgPro: 3.837 ± 0.059	2.788ArgGln: 2.788 ± 0.055	5.62ArgArg: 5.62 ± 0.085	3.177ArgSer: 3.177 ± 0.06	3.235ArgThr: 3.235 ± 0.053	4.884ArgVal: 4.884 ± 0.065	1.087ArgTrp: 1.087 ± 0.032	1.632ArgTyr: 1.632 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.085SerAla: 6.085 ± 0.078	0.353SerCys: 0.353 ± 0.018	2.582SerAsp: 2.582 ± 0.048	2.186SerGlu: 2.186 ± 0.046	2.188SerPhe: 2.188 ± 0.048	5.015SerGly: 5.015 ± 0.071	0.941SerHis: 0.941 ± 0.024	2.282SerIle: 2.282 ± 0.049	1.329SerLys: 1.329 ± 0.04	6.078SerLeu: 6.078 ± 0.076	1.029SerMet: 1.029 ± 0.029	1.138SerAsn: 1.138 ± 0.032	2.72SerPro: 2.72 ± 0.052	1.52SerGln: 1.52 ± 0.037	2.951SerArg: 2.951 ± 0.049	2.268SerSer: 2.268 ± 0.058	2.39SerThr: 2.39 ± 0.044	3.922SerVal: 3.922 ± 0.064	0.573SerTrp: 0.573 ± 0.028	1.12SerTyr: 1.12 ± 0.032	0.001SerXaa: 0.001 ± 0.001
Thr	7.686ThrAla: 7.686 ± 0.101	0.388ThrCys: 0.388 ± 0.018	3.162ThrAsp: 3.162 ± 0.05	2.991ThrGlu: 2.991 ± 0.05	1.71ThrPhe: 1.71 ± 0.039	5.414ThrGly: 5.414 ± 0.074	1.051ThrHis: 1.051 ± 0.03	2.803ThrIle: 2.803 ± 0.059	1.448ThrLys: 1.448 ± 0.036	7.287ThrLeu: 7.287 ± 0.101	0.926ThrMet: 0.926 ± 0.025	1.291ThrAsn: 1.291 ± 0.037	3.946ThrPro: 3.946 ± 0.061	1.832ThrGln: 1.832 ± 0.044	3.402ThrArg: 3.402 ± 0.053	2.509ThrSer: 2.509 ± 0.05	2.699ThrThr: 2.699 ± 0.066	4.883ThrVal: 4.883 ± 0.066	0.642ThrTrp: 0.642 ± 0.026	1.245ThrTyr: 1.245 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	9.396ValAla: 9.396 ± 0.103	0.562ValCys: 0.562 ± 0.024	3.716ValAsp: 3.716 ± 0.059	3.863ValGlu: 3.863 ± 0.062	2.475ValPhe: 2.475 ± 0.047	5.599ValGly: 5.599 ± 0.079	1.213ValHis: 1.213 ± 0.037	3.856ValIle: 3.856 ± 0.058	2.371ValLys: 2.371 ± 0.05	7.715ValLeu: 7.715 ± 0.097	1.633ValMet: 1.633 ± 0.039	1.727ValAsn: 1.727 ± 0.047	4.194ValPro: 4.194 ± 0.065	2.453ValGln: 2.453 ± 0.046	4.759ValArg: 4.759 ± 0.068	3.999ValSer: 3.999 ± 0.062	5.091ValThr: 5.091 ± 0.085	4.742ValVal: 4.742 ± 0.072	0.876ValTrp: 0.876 ± 0.03	1.389ValTyr: 1.389 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.426TrpAla: 1.426 ± 0.036	0.119TrpCys: 0.119 ± 0.009	0.652TrpAsp: 0.652 ± 0.023	0.536TrpGlu: 0.536 ± 0.024	0.501TrpPhe: 0.501 ± 0.021	1.045TrpGly: 1.045 ± 0.033	0.298TrpHis: 0.298 ± 0.018	0.61TrpIle: 0.61 ± 0.023	0.356TrpLys: 0.356 ± 0.018	1.74TrpLeu: 1.74 ± 0.042	0.289TrpMet: 0.289 ± 0.019	0.34TrpAsn: 0.34 ± 0.017	0.75TrpPro: 0.75 ± 0.026	0.625TrpGln: 0.625 ± 0.022	1.135TrpArg: 1.135 ± 0.031	0.712TrpSer: 0.712 ± 0.024	0.664TrpThr: 0.664 ± 0.022	0.908TrpVal: 0.908 ± 0.029	0.194TrpTrp: 0.194 ± 0.014	0.278TrpTyr: 0.278 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.505TyrAla: 2.505 ± 0.049	0.236TyrCys: 0.236 ± 0.014	1.251TyrAsp: 1.251 ± 0.034	0.972TyrGlu: 0.972 ± 0.03	0.853TyrPhe: 0.853 ± 0.027	2.052TyrGly: 2.052 ± 0.047	0.496TyrHis: 0.496 ± 0.021	0.852TyrIle: 0.852 ± 0.028	0.583TyrLys: 0.583 ± 0.024	2.464TyrLeu: 2.464 ± 0.056	0.333TyrMet: 0.333 ± 0.016	0.513TyrAsn: 0.513 ± 0.023	1.119TyrPro: 1.119 ± 0.032	0.782TyrGln: 0.782 ± 0.026	1.849TyrArg: 1.849 ± 0.037	1.06TyrSer: 1.06 ± 0.029	1.169TyrThr: 1.169 ± 0.034	1.356TyrVal: 1.356 ± 0.036	0.35TyrTrp: 0.35 ± 0.017	0.587TyrTyr: 0.587 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3712 proteins (1198734 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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