Amino acid dipepetide frequency for Paucibacter toxinivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.44AlaAla: 18.44 ± 0.17
1.293AlaCys: 1.293 ± 0.025
6.418AlaAsp: 6.418 ± 0.059
7.348AlaGlu: 7.348 ± 0.077
3.88AlaPhe: 3.88 ± 0.048
10.939AlaGly: 10.939 ± 0.128
2.605AlaHis: 2.605 ± 0.036
4.758AlaIle: 4.758 ± 0.049
4.085AlaLys: 4.085 ± 0.066
16.744AlaLeu: 16.744 ± 0.141
3.649AlaMet: 3.649 ± 0.052
2.956AlaAsn: 2.956 ± 0.044
6.228AlaPro: 6.228 ± 0.07
6.488AlaGln: 6.488 ± 0.078
8.977AlaArg: 8.977 ± 0.09
7.073AlaSer: 7.073 ± 0.082
5.917AlaThr: 5.917 ± 0.065
8.774AlaVal: 8.774 ± 0.062
2.058AlaTrp: 2.058 ± 0.04
2.455AlaTyr: 2.455 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
1.113CysAla: 1.113 ± 0.024
0.119CysCys: 0.119 ± 0.007
0.52CysAsp: 0.52 ± 0.016
0.491CysGlu: 0.491 ± 0.017
0.29CysPhe: 0.29 ± 0.011
0.931CysGly: 0.931 ± 0.028
0.26CysHis: 0.26 ± 0.012
0.384CysIle: 0.384 ± 0.013
0.241CysLys: 0.241 ± 0.013
0.947CysLeu: 0.947 ± 0.022
0.199CysMet: 0.199 ± 0.01
0.226CysAsn: 0.226 ± 0.013
0.469CysPro: 0.469 ± 0.016
0.3CysGln: 0.3 ± 0.013
0.553CysArg: 0.553 ± 0.019
0.507CysSer: 0.507 ± 0.018
0.449CysThr: 0.449 ± 0.014
0.646CysVal: 0.646 ± 0.018
0.137CysTrp: 0.137 ± 0.009
0.192CysTyr: 0.192 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
6.914AspAla: 6.914 ± 0.079
0.45AspCys: 0.45 ± 0.016
2.574AspAsp: 2.574 ± 0.051
3.233AspGlu: 3.233 ± 0.042
1.936AspPhe: 1.936 ± 0.037
4.697AspGly: 4.697 ± 0.06
1.009AspHis: 1.009 ± 0.024
2.179AspIle: 2.179 ± 0.031
1.669AspLys: 1.669 ± 0.032
5.577AspLeu: 5.577 ± 0.057
1.164AspMet: 1.164 ± 0.028
1.119AspAsn: 1.119 ± 0.025
2.752AspPro: 2.752 ± 0.038
1.816AspGln: 1.816 ± 0.034
3.053AspArg: 3.053 ± 0.044
2.437AspSer: 2.437 ± 0.04
2.372AspThr: 2.372 ± 0.038
3.594AspVal: 3.594 ± 0.051
0.987AspTrp: 0.987 ± 0.026
1.318AspTyr: 1.318 ± 0.028
0.0AspXaa: 0.0 ± 0.0
Glu
7.438GluAla: 7.438 ± 0.079
0.357GluCys: 0.357 ± 0.014
2.055GluAsp: 2.055 ± 0.033
2.111GluGlu: 2.111 ± 0.042
1.765GluPhe: 1.765 ± 0.034
3.72GluGly: 3.72 ± 0.048
1.358GluHis: 1.358 ± 0.03
2.363GluIle: 2.363 ± 0.035
1.444GluLys: 1.444 ± 0.03
6.842GluLeu: 6.842 ± 0.065
1.178GluMet: 1.178 ± 0.025
1.035GluAsn: 1.035 ± 0.025
2.659GluPro: 2.659 ± 0.049
3.019GluGln: 3.019 ± 0.044
4.792GluArg: 4.792 ± 0.065
2.416GluSer: 2.416 ± 0.036
2.332GluThr: 2.332 ± 0.032
4.044GluVal: 4.044 ± 0.051
0.704GluTrp: 0.704 ± 0.022
0.93GluTyr: 0.93 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
4.11PheAla: 4.11 ± 0.056
0.367PheCys: 0.367 ± 0.014
2.486PheAsp: 2.486 ± 0.039
2.202PheGlu: 2.202 ± 0.037
1.255PhePhe: 1.255 ± 0.029
3.313PheGly: 3.313 ± 0.038
0.685PheHis: 0.685 ± 0.021
1.401PheIle: 1.401 ± 0.03
1.289PheLys: 1.289 ± 0.026
2.72PheLeu: 2.72 ± 0.044
0.776PheMet: 0.776 ± 0.019
1.105PheAsn: 1.105 ± 0.025
1.356PhePro: 1.356 ± 0.03
1.051PheGln: 1.051 ± 0.021
1.74PheArg: 1.74 ± 0.032
2.125PheSer: 2.125 ± 0.04
1.789PheThr: 1.789 ± 0.031
2.703PheVal: 2.703 ± 0.046
0.492PheTrp: 0.492 ± 0.017
0.817PheTyr: 0.817 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
9.47GlyAla: 9.47 ± 0.101
0.851GlyCys: 0.851 ± 0.022
3.985GlyAsp: 3.985 ± 0.061
4.375GlyGlu: 4.375 ± 0.051
3.255GlyPhe: 3.255 ± 0.042
7.138GlyGly: 7.138 ± 0.124
1.923GlyHis: 1.923 ± 0.036
3.501GlyIle: 3.501 ± 0.044
2.988GlyLys: 2.988 ± 0.047
10.394GlyLeu: 10.394 ± 0.085
2.183GlyMet: 2.183 ± 0.035
2.127GlyAsn: 2.127 ± 0.046
3.295GlyPro: 3.295 ± 0.048
3.763GlyGln: 3.763 ± 0.051
5.787GlyArg: 5.787 ± 0.058
4.961GlySer: 4.961 ± 0.078
4.286GlyThr: 4.286 ± 0.056
6.182GlyVal: 6.182 ± 0.064
1.483GlyTrp: 1.483 ± 0.03
2.211GlyTyr: 2.211 ± 0.035
0.0GlyXaa: 0.0 ± 0.0
His
2.717HisAla: 2.717 ± 0.042
0.289HisCys: 0.289 ± 0.012
1.097HisAsp: 1.097 ± 0.024
1.227HisGlu: 1.227 ± 0.026
0.823HisPhe: 0.823 ± 0.021
2.048HisGly: 2.048 ± 0.037
0.602HisHis: 0.602 ± 0.019
0.851HisIle: 0.851 ± 0.021
0.547HisLys: 0.547 ± 0.019
2.382HisLeu: 2.382 ± 0.04
0.436HisMet: 0.436 ± 0.015
0.436HisAsn: 0.436 ± 0.016
1.392HisPro: 1.392 ± 0.031
0.88HisGln: 0.88 ± 0.021
1.477HisArg: 1.477 ± 0.028
1.067HisSer: 1.067 ± 0.024
0.949HisThr: 0.949 ± 0.024
1.469HisVal: 1.469 ± 0.027
0.392HisTrp: 0.392 ± 0.015
0.611HisTyr: 0.611 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
5.926IleAla: 5.926 ± 0.065
0.395IleCys: 0.395 ± 0.014
2.783IleAsp: 2.783 ± 0.039
2.906IleGlu: 2.906 ± 0.037
1.14IlePhe: 1.14 ± 0.03
3.818IleGly: 3.818 ± 0.053
0.744IleHis: 0.744 ± 0.02
1.388IleIle: 1.388 ± 0.03
1.516IleLys: 1.516 ± 0.033
2.836IleLeu: 2.836 ± 0.05
0.67IleMet: 0.67 ± 0.02
1.398IleAsn: 1.398 ± 0.028
1.762IlePro: 1.762 ± 0.033
1.239IleGln: 1.239 ± 0.026
2.164IleArg: 2.164 ± 0.033
2.505IleSer: 2.505 ± 0.035
2.407IleThr: 2.407 ± 0.037
3.113IleVal: 3.113 ± 0.042
0.454IleTrp: 0.454 ± 0.016
0.913IleTyr: 0.913 ± 0.02
0.0IleXaa: 0.0 ± 0.0
Lys
4.072LysAla: 4.072 ± 0.062
0.146LysCys: 0.146 ± 0.009
1.507LysAsp: 1.507 ± 0.031
1.302LysGlu: 1.302 ± 0.027
0.877LysPhe: 0.877 ± 0.024
2.326LysGly: 2.326 ± 0.042
0.677LysHis: 0.677 ± 0.02
1.314LysIle: 1.314 ± 0.03
1.216LysLys: 1.216 ± 0.033
3.693LysLeu: 3.693 ± 0.057
0.675LysMet: 0.675 ± 0.024
0.85LysAsn: 0.85 ± 0.025
2.18LysPro: 2.18 ± 0.041
1.275LysGln: 1.275 ± 0.027
2.289LysArg: 2.289 ± 0.037
1.728LysSer: 1.728 ± 0.037
1.857LysThr: 1.857 ± 0.034
2.308LysVal: 2.308 ± 0.043
0.302LysTrp: 0.302 ± 0.013
0.596LysTyr: 0.596 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
16.267LeuAla: 16.267 ± 0.106
1.075LeuCys: 1.075 ± 0.024
6.245LeuAsp: 6.245 ± 0.063
5.266LeuGlu: 5.266 ± 0.056
3.503LeuPhe: 3.503 ± 0.046
9.595LeuGly: 9.595 ± 0.086
2.425LeuHis: 2.425 ± 0.036
4.462LeuIle: 4.462 ± 0.053
3.878LeuLys: 3.878 ± 0.06
13.26LeuLeu: 13.26 ± 0.137
2.861LeuMet: 2.861 ± 0.043
3.041LeuAsn: 3.041 ± 0.035
6.515LeuPro: 6.515 ± 0.069
5.126LeuGln: 5.126 ± 0.063
8.614LeuArg: 8.614 ± 0.082
7.346LeuSer: 7.346 ± 0.075
5.61LeuThr: 5.61 ± 0.068
7.839LeuVal: 7.839 ± 0.06
1.444LeuTrp: 1.444 ± 0.034
2.033LeuTyr: 2.033 ± 0.034
0.0LeuXaa: 0.0 ± 0.0
Met
3.061MetAla: 3.061 ± 0.046
0.157MetCys: 0.157 ± 0.01
1.14MetAsp: 1.14 ± 0.022
0.985MetGlu: 0.985 ± 0.024
0.683MetPhe: 0.683 ± 0.02
1.893MetGly: 1.893 ± 0.036
0.496MetHis: 0.496 ± 0.017
0.864MetIle: 0.864 ± 0.023
0.936MetLys: 0.936 ± 0.025
2.839MetLeu: 2.839 ± 0.042
0.618MetMet: 0.618 ± 0.02
0.818MetAsn: 0.818 ± 0.018
1.415MetPro: 1.415 ± 0.031
1.146MetGln: 1.146 ± 0.029
1.769MetArg: 1.769 ± 0.03
1.781MetSer: 1.781 ± 0.033
1.404MetThr: 1.404 ± 0.028
1.71MetVal: 1.71 ± 0.032
0.201MetTrp: 0.201 ± 0.01
0.343MetTyr: 0.343 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.214AsnAla: 3.214 ± 0.045
0.242AsnCys: 0.242 ± 0.011
1.226AsnAsp: 1.226 ± 0.025
1.237AsnGlu: 1.237 ± 0.026
0.888AsnPhe: 0.888 ± 0.021
2.175AsnGly: 2.175 ± 0.04
0.502AsnHis: 0.502 ± 0.015
1.117AsnIle: 1.117 ± 0.027
0.799AsnLys: 0.799 ± 0.022
2.75AsnLeu: 2.75 ± 0.039
0.537AsnMet: 0.537 ± 0.017
0.766AsnAsn: 0.766 ± 0.026
1.738AsnPro: 1.738 ± 0.03
0.927AsnGln: 0.927 ± 0.022
1.587AsnArg: 1.587 ± 0.03
1.253AsnSer: 1.253 ± 0.027
1.44AsnThr: 1.44 ± 0.029
1.771AsnVal: 1.771 ± 0.034
0.415AsnTrp: 0.415 ± 0.017
0.675AsnTyr: 0.675 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
7.145ProAla: 7.145 ± 0.074
0.358ProCys: 0.358 ± 0.013
2.989ProAsp: 2.989 ± 0.045
3.415ProGlu: 3.415 ± 0.047
1.704ProPhe: 1.704 ± 0.033
4.788ProGly: 4.788 ± 0.056
1.039ProHis: 1.039 ± 0.025
1.757ProIle: 1.757 ± 0.028
1.534ProLys: 1.534 ± 0.032
5.498ProLeu: 5.498 ± 0.06
1.297ProMet: 1.297 ± 0.027
1.225ProAsn: 1.225 ± 0.028
2.65ProPro: 2.65 ± 0.05
2.189ProGln: 2.189 ± 0.031
2.978ProArg: 2.978 ± 0.047
2.789ProSer: 2.789 ± 0.038
2.554ProThr: 2.554 ± 0.059
4.096ProVal: 4.096 ± 0.046
0.801ProTrp: 0.801 ± 0.019
1.059ProTyr: 1.059 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
6.697GlnAla: 6.697 ± 0.08
0.315GlnCys: 0.315 ± 0.014
1.731GlnAsp: 1.731 ± 0.03
1.562GlnGlu: 1.562 ± 0.035
1.339GlnPhe: 1.339 ± 0.028
3.6GlnGly: 3.6 ± 0.046
1.034GlnHis: 1.034 ± 0.026
1.919GlnIle: 1.919 ± 0.044
0.904GlnLys: 0.904 ± 0.026
5.083GlnLeu: 5.083 ± 0.064
1.088GlnMet: 1.088 ± 0.028
0.772GlnAsn: 0.772 ± 0.021
2.297GlnPro: 2.297 ± 0.038
2.341GlnGln: 2.341 ± 0.045
3.979GlnArg: 3.979 ± 0.049
2.102GlnSer: 2.102 ± 0.034
2.096GlnThr: 2.096 ± 0.036
3.284GlnVal: 3.284 ± 0.04
0.694GlnTrp: 0.694 ± 0.017
0.749GlnTyr: 0.749 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
7.989ArgAla: 7.989 ± 0.069
0.66ArgCys: 0.66 ± 0.019
3.458ArgAsp: 3.458 ± 0.05
4.188ArgGlu: 4.188 ± 0.057
2.765ArgPhe: 2.765 ± 0.044
4.629ArgGly: 4.629 ± 0.047
1.795ArgHis: 1.795 ± 0.032
3.21ArgIle: 3.21 ± 0.043
1.891ArgLys: 1.891 ± 0.036
8.722ArgLeu: 8.722 ± 0.083
1.862ArgMet: 1.862 ± 0.031
1.715ArgAsn: 1.715 ± 0.031
3.319ArgPro: 3.319 ± 0.042
3.173ArgGln: 3.173 ± 0.052
5.174ArgArg: 5.174 ± 0.063
3.854ArgSer: 3.854 ± 0.051
2.875ArgThr: 2.875 ± 0.043
5.095ArgVal: 5.095 ± 0.058
1.245ArgTrp: 1.245 ± 0.026
1.791ArgTyr: 1.791 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
6.991SerAla: 6.991 ± 0.069
0.475SerCys: 0.475 ± 0.018
2.724SerAsp: 2.724 ± 0.043
2.605SerGlu: 2.605 ± 0.036
2.212SerPhe: 2.212 ± 0.038
5.542SerGly: 5.542 ± 0.067
1.188SerHis: 1.188 ± 0.024
2.327SerIle: 2.327 ± 0.041
1.609SerLys: 1.609 ± 0.031
6.593SerLeu: 6.593 ± 0.071
1.338SerMet: 1.338 ± 0.029
1.483SerAsn: 1.483 ± 0.029
2.886SerPro: 2.886 ± 0.043
2.064SerGln: 2.064 ± 0.037
3.527SerArg: 3.527 ± 0.045
3.48SerSer: 3.48 ± 0.057
2.996SerThr: 2.996 ± 0.052
3.99SerVal: 3.99 ± 0.053
0.829SerTrp: 0.829 ± 0.023
1.376SerTyr: 1.376 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
6.005ThrAla: 6.005 ± 0.075
0.351ThrCys: 0.351 ± 0.015
2.357ThrAsp: 2.357 ± 0.032
2.494ThrGlu: 2.494 ± 0.03
1.472ThrPhe: 1.472 ± 0.028
4.59ThrGly: 4.59 ± 0.058
1.089ThrHis: 1.089 ± 0.027
1.852ThrIle: 1.852 ± 0.037
1.225ThrLys: 1.225 ± 0.029
6.329ThrLeu: 6.329 ± 0.064
1.106ThrMet: 1.106 ± 0.028
1.143ThrAsn: 1.143 ± 0.029
3.437ThrPro: 3.437 ± 0.06
2.042ThrGln: 2.042 ± 0.034
3.255ThrArg: 3.255 ± 0.043
2.63ThrSer: 2.63 ± 0.052
2.582ThrThr: 2.582 ± 0.052
4.005ThrVal: 4.005 ± 0.054
0.676ThrTrp: 0.676 ± 0.02
0.94ThrTyr: 0.94 ± 0.024
0.0ThrXaa: 0.0 ± 0.0
Val
9.324ValAla: 9.324 ± 0.084
0.687ValCys: 0.687 ± 0.019
3.814ValAsp: 3.814 ± 0.046
3.996ValGlu: 3.996 ± 0.045
2.62ValPhe: 2.62 ± 0.038
5.504ValGly: 5.504 ± 0.067
1.501ValHis: 1.501 ± 0.031
3.116ValIle: 3.116 ± 0.042
2.344ValLys: 2.344 ± 0.039
8.546ValLeu: 8.546 ± 0.081
1.825ValMet: 1.825 ± 0.036
2.085ValAsn: 2.085 ± 0.036
3.715ValPro: 3.715 ± 0.048
3.022ValGln: 3.022 ± 0.046
4.779ValArg: 4.779 ± 0.056
4.188ValSer: 4.188 ± 0.056
3.765ValThr: 3.765 ± 0.057
5.664ValVal: 5.664 ± 0.065
0.986ValTrp: 0.986 ± 0.022
1.397ValTyr: 1.397 ± 0.027
0.0ValXaa: 0.0 ± 0.0
Trp
1.592TrpAla: 1.592 ± 0.03
0.168TrpCys: 0.168 ± 0.011
0.613TrpAsp: 0.613 ± 0.021
0.538TrpGlu: 0.538 ± 0.017
0.52TrpPhe: 0.52 ± 0.016
0.984TrpGly: 0.984 ± 0.025
0.37TrpHis: 0.37 ± 0.013
0.577TrpIle: 0.577 ± 0.016
0.41TrpLys: 0.41 ± 0.015
2.246TrpLeu: 2.246 ± 0.039
0.401TrpMet: 0.401 ± 0.013
0.401TrpAsn: 0.401 ± 0.016
0.774TrpPro: 0.774 ± 0.024
0.84TrpGln: 0.84 ± 0.023
1.266TrpArg: 1.266 ± 0.027
0.837TrpSer: 0.837 ± 0.022
0.755TrpThr: 0.755 ± 0.021
1.085TrpVal: 1.085 ± 0.023
0.283TrpTrp: 0.283 ± 0.013
0.289TrpTyr: 0.289 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.6TyrAla: 2.6 ± 0.034
0.218TyrCys: 0.218 ± 0.012
1.128TyrAsp: 1.128 ± 0.041
1.082TyrGlu: 1.082 ± 0.027
0.855TyrPhe: 0.855 ± 0.023
1.931TyrGly: 1.931 ± 0.032
0.39TyrHis: 0.39 ± 0.014
0.736TyrIle: 0.736 ± 0.02
0.668TyrLys: 0.668 ± 0.021
2.401TyrLeu: 2.401 ± 0.037
0.398TyrMet: 0.398 ± 0.016
0.56TyrAsn: 0.56 ± 0.018
1.024TyrPro: 1.024 ± 0.023
0.885TyrGln: 0.885 ± 0.021
1.648TyrArg: 1.648 ± 0.028
1.156TyrSer: 1.156 ± 0.025
1.143TyrThr: 1.143 ± 0.024
1.508TyrVal: 1.508 ± 0.029
0.366TyrTrp: 0.366 ± 0.013
0.516TyrTyr: 0.516 ± 0.016
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5633 proteins (1933284 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski