Amino acid dipepetide frequency for Hydrogenophaga sp. T4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.738AlaAla: 12.738 ± 0.158	1.478AlaCys: 1.478 ± 0.045	5.276AlaAsp: 5.276 ± 0.079	5.643AlaGlu: 5.643 ± 0.087	4.057AlaPhe: 4.057 ± 0.078	8.677AlaGly: 8.677 ± 0.107	2.638AlaHis: 2.638 ± 0.064	4.912AlaIle: 4.912 ± 0.079	4.24AlaLys: 4.24 ± 0.075	11.642AlaLeu: 11.642 ± 0.124	3.988AlaMet: 3.988 ± 0.074	2.782AlaAsn: 2.782 ± 0.061	4.929AlaPro: 4.929 ± 0.091	4.813AlaGln: 4.813 ± 0.077	7.258AlaArg: 7.258 ± 0.095	7.04AlaSer: 7.04 ± 0.107	5.862AlaThr: 5.862 ± 0.077	8.143AlaVal: 8.143 ± 0.104	1.806AlaTrp: 1.806 ± 0.043	2.237AlaTyr: 2.237 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.419CysAla: 1.419 ± 0.042	0.367CysCys: 0.367 ± 0.023	0.573CysAsp: 0.573 ± 0.023	0.582CysGlu: 0.582 ± 0.028	0.41CysPhe: 0.41 ± 0.021	1.102CysGly: 1.102 ± 0.04	0.381CysHis: 0.381 ± 0.031	0.504CysIle: 0.504 ± 0.026	0.356CysLys: 0.356 ± 0.018	0.986CysLeu: 0.986 ± 0.031	0.353CysMet: 0.353 ± 0.022	0.302CysAsn: 0.302 ± 0.02	0.716CysPro: 0.716 ± 0.032	0.367CysGln: 0.367 ± 0.02	0.918CysArg: 0.918 ± 0.038	1.038CysSer: 1.038 ± 0.043	0.834CysThr: 0.834 ± 0.034	0.866CysVal: 0.866 ± 0.033	0.316CysTrp: 0.316 ± 0.02	0.233CysTyr: 0.233 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.717AspAla: 5.717 ± 0.087	0.491AspCys: 0.491 ± 0.022	2.55AspAsp: 2.55 ± 0.068	2.989AspGlu: 2.989 ± 0.063	2.126AspPhe: 2.126 ± 0.048	4.245AspGly: 4.245 ± 0.08	1.369AspHis: 1.369 ± 0.041	2.437AspIle: 2.437 ± 0.059	1.89AspLys: 1.89 ± 0.052	5.017AspLeu: 5.017 ± 0.073	1.344AspMet: 1.344 ± 0.041	1.21AspAsn: 1.21 ± 0.039	2.62AspPro: 2.62 ± 0.061	1.949AspGln: 1.949 ± 0.053	3.156AspArg: 3.156 ± 0.068	2.273AspSer: 2.273 ± 0.053	2.443AspThr: 2.443 ± 0.059	3.955AspVal: 3.955 ± 0.068	0.854AspTrp: 0.854 ± 0.033	1.174AspTyr: 1.174 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	5.93GluAla: 5.93 ± 0.081	0.454GluCys: 0.454 ± 0.023	2.257GluAsp: 2.257 ± 0.05	2.604GluGlu: 2.604 ± 0.054	1.89GluPhe: 1.89 ± 0.05	3.606GluGly: 3.606 ± 0.067	1.537GluHis: 1.537 ± 0.046	2.689GluIle: 2.689 ± 0.054	2.353GluLys: 2.353 ± 0.059	5.411GluLeu: 5.411 ± 0.09	1.431GluMet: 1.431 ± 0.043	1.421GluAsn: 1.421 ± 0.042	2.374GluPro: 2.374 ± 0.056	2.629GluGln: 2.629 ± 0.059	4.216GluArg: 4.216 ± 0.065	2.666GluSer: 2.666 ± 0.055	2.604GluThr: 2.604 ± 0.057	4.189GluVal: 4.189 ± 0.076	0.705GluTrp: 0.705 ± 0.026	1.096GluTyr: 1.096 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.865PheAla: 3.865 ± 0.07	0.55PheCys: 0.55 ± 0.025	2.51PheAsp: 2.51 ± 0.062	2.195PheGlu: 2.195 ± 0.051	1.681PhePhe: 1.681 ± 0.043	3.32PheGly: 3.32 ± 0.07	0.855PheHis: 0.855 ± 0.033	1.536PheIle: 1.536 ± 0.046	1.515PheLys: 1.515 ± 0.047	3.221PheLeu: 3.221 ± 0.077	1.087PheMet: 1.087 ± 0.037	1.283PheAsn: 1.283 ± 0.041	1.475PhePro: 1.475 ± 0.045	1.28PheGln: 1.28 ± 0.041	2.027PheArg: 2.027 ± 0.051	2.515PheSer: 2.515 ± 0.054	2.064PheThr: 2.064 ± 0.05	2.903PheVal: 2.903 ± 0.066	0.61PheTrp: 0.61 ± 0.028	0.943PheTyr: 0.943 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	7.473GlyAla: 7.473 ± 0.101	0.982GlyCys: 0.982 ± 0.038	3.759GlyAsp: 3.759 ± 0.073	4.184GlyGlu: 4.184 ± 0.069	3.343GlyPhe: 3.343 ± 0.067	6.346GlyGly: 6.346 ± 0.115	2.287GlyHis: 2.287 ± 0.058	3.798GlyIle: 3.798 ± 0.078	3.598GlyLys: 3.598 ± 0.076	8.414GlyLeu: 8.414 ± 0.102	2.594GlyMet: 2.594 ± 0.049	2.261GlyAsn: 2.261 ± 0.074	2.988GlyPro: 2.988 ± 0.061	3.575GlyGln: 3.575 ± 0.074	5.046GlyArg: 5.046 ± 0.084	4.633GlySer: 4.633 ± 0.074	4.106GlyThr: 4.106 ± 0.071	6.341GlyVal: 6.341 ± 0.087	1.381GlyTrp: 1.381 ± 0.044	2.018GlyTyr: 2.018 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.759HisAla: 2.759 ± 0.061	0.35HisCys: 0.35 ± 0.026	1.227HisAsp: 1.227 ± 0.042	1.292HisGlu: 1.292 ± 0.039	1.042HisPhe: 1.042 ± 0.03	2.194HisGly: 2.194 ± 0.059	0.967HisHis: 0.967 ± 0.04	1.092HisIle: 1.092 ± 0.034	0.727HisLys: 0.727 ± 0.029	2.51HisLeu: 2.51 ± 0.056	0.603HisMet: 0.603 ± 0.026	0.582HisAsn: 0.582 ± 0.026	1.531HisPro: 1.531 ± 0.044	1.076HisGln: 1.076 ± 0.037	1.895HisArg: 1.895 ± 0.062	1.166HisSer: 1.166 ± 0.035	1.21HisThr: 1.21 ± 0.037	1.823HisVal: 1.823 ± 0.052	0.4HisTrp: 0.4 ± 0.023	0.592HisTyr: 0.592 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.243IleAla: 5.243 ± 0.077	0.604IleCys: 0.604 ± 0.023	2.869IleAsp: 2.869 ± 0.054	3.23IleGlu: 3.23 ± 0.06	1.555IlePhe: 1.555 ± 0.045	4.017IleGly: 4.017 ± 0.077	0.996IleHis: 0.996 ± 0.03	1.636IleIle: 1.636 ± 0.054	1.838IleLys: 1.838 ± 0.047	3.376IleLeu: 3.376 ± 0.071	0.997IleMet: 0.997 ± 0.033	1.622IleAsn: 1.622 ± 0.05	2.161IlePro: 2.161 ± 0.054	1.583IleGln: 1.583 ± 0.043	2.566IleArg: 2.566 ± 0.047	2.948IleSer: 2.948 ± 0.062	2.747IleThr: 2.747 ± 0.057	3.356IleVal: 3.356 ± 0.065	0.635IleTrp: 0.635 ± 0.027	1.075IleTyr: 1.075 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.687LysAla: 4.687 ± 0.087	0.3LysCys: 0.3 ± 0.016	2.014LysAsp: 2.014 ± 0.054	1.843LysGlu: 1.843 ± 0.05	1.132LysPhe: 1.132 ± 0.039	2.933LysGly: 2.933 ± 0.057	0.887LysHis: 0.887 ± 0.029	1.798LysIle: 1.798 ± 0.054	1.988LysLys: 1.988 ± 0.058	3.767LysLeu: 3.767 ± 0.074	1.167LysMet: 1.167 ± 0.043	1.277LysAsn: 1.277 ± 0.038	2.438LysPro: 2.438 ± 0.063	1.421LysGln: 1.421 ± 0.048	2.598LysArg: 2.598 ± 0.058	2.323LysSer: 2.323 ± 0.049	2.496LysThr: 2.496 ± 0.056	3.039LysVal: 3.039 ± 0.06	0.442LysTrp: 0.442 ± 0.024	0.865LysTyr: 0.865 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	11.552LeuAla: 11.552 ± 0.113	1.086LeuCys: 1.086 ± 0.036	5.228LeuAsp: 5.228 ± 0.069	4.793LeuGlu: 4.793 ± 0.08	3.513LeuPhe: 3.513 ± 0.082	7.961LeuGly: 7.961 ± 0.113	2.428LeuHis: 2.428 ± 0.055	4.489LeuIle: 4.489 ± 0.089	4.125LeuLys: 4.125 ± 0.066	10.071LeuLeu: 10.071 ± 0.146	2.982LeuMet: 2.982 ± 0.062	2.984LeuAsn: 2.984 ± 0.067	5.592LeuPro: 5.592 ± 0.086	3.976LeuGln: 3.976 ± 0.066	6.562LeuArg: 6.562 ± 0.103	6.079LeuSer: 6.079 ± 0.094	5.204LeuThr: 5.204 ± 0.074	7.625LeuVal: 7.625 ± 0.098	1.28LeuTrp: 1.28 ± 0.046	1.952LeuTyr: 1.952 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.774MetAla: 3.774 ± 0.069	0.299MetCys: 0.299 ± 0.017	1.437MetAsp: 1.437 ± 0.042	1.278MetGlu: 1.278 ± 0.035	0.936MetPhe: 0.936 ± 0.032	2.354MetGly: 2.354 ± 0.063	0.683MetHis: 0.683 ± 0.027	1.289MetIle: 1.289 ± 0.043	1.485MetLys: 1.485 ± 0.045	3.083MetLeu: 3.083 ± 0.053	0.868MetMet: 0.868 ± 0.036	1.125MetAsn: 1.125 ± 0.035	1.971MetPro: 1.971 ± 0.049	1.194MetGln: 1.194 ± 0.04	2.072MetArg: 2.072 ± 0.048	2.113MetSer: 2.113 ± 0.048	1.719MetThr: 1.719 ± 0.04	2.402MetVal: 2.402 ± 0.062	0.323MetTrp: 0.323 ± 0.018	0.452MetTyr: 0.452 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.142AsnAla: 3.142 ± 0.062	0.394AsnCys: 0.394 ± 0.021	1.447AsnAsp: 1.447 ± 0.05	1.435AsnGlu: 1.435 ± 0.042	1.153AsnPhe: 1.153 ± 0.035	2.34AsnGly: 2.34 ± 0.056	0.665AsnHis: 0.665 ± 0.029	1.336AsnIle: 1.336 ± 0.037	0.986AsnLys: 0.986 ± 0.035	2.636AsnLeu: 2.636 ± 0.065	0.812AsnMet: 0.812 ± 0.032	0.933AsnAsn: 0.933 ± 0.039	1.947AsnPro: 1.947 ± 0.047	1.088AsnGln: 1.088 ± 0.034	1.756AsnArg: 1.756 ± 0.038	1.621AsnSer: 1.621 ± 0.047	1.726AsnThr: 1.726 ± 0.049	1.981AsnVal: 1.981 ± 0.052	0.511AsnTrp: 0.511 ± 0.026	0.707AsnTyr: 0.707 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	5.784ProAla: 5.784 ± 0.103	0.675ProCys: 0.675 ± 0.033	2.846ProAsp: 2.846 ± 0.068	3.217ProGlu: 3.217 ± 0.064	1.735ProPhe: 1.735 ± 0.048	4.222ProGly: 4.222 ± 0.07	1.119ProHis: 1.119 ± 0.035	2.02ProIle: 2.02 ± 0.046	1.911ProLys: 1.911 ± 0.043	4.82ProLeu: 4.82 ± 0.073	1.847ProMet: 1.847 ± 0.041	1.403ProAsn: 1.403 ± 0.037	2.521ProPro: 2.521 ± 0.066	1.911ProGln: 1.911 ± 0.045	3.007ProArg: 3.007 ± 0.062	3.596ProSer: 3.596 ± 0.076	2.993ProThr: 2.993 ± 0.061	4.252ProVal: 4.252 ± 0.073	0.891ProTrp: 0.891 ± 0.036	1.089ProTyr: 1.089 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	4.878GlnAla: 4.878 ± 0.086	0.362GlnCys: 0.362 ± 0.021	1.61GlnAsp: 1.61 ± 0.038	1.667GlnGlu: 1.667 ± 0.047	1.322GlnPhe: 1.322 ± 0.043	3.082GlnGly: 3.082 ± 0.065	1.132GlnHis: 1.132 ± 0.038	1.856GlnIle: 1.856 ± 0.044	1.472GlnLys: 1.472 ± 0.046	4.078GlnLeu: 4.078 ± 0.071	1.129GlnMet: 1.129 ± 0.038	1.029GlnAsn: 1.029 ± 0.032	2.191GlnPro: 2.191 ± 0.056	1.985GlnGln: 1.985 ± 0.06	3.502GlnArg: 3.502 ± 0.071	2.122GlnSer: 2.122 ± 0.047	2.086GlnThr: 2.086 ± 0.046	3.198GlnVal: 3.198 ± 0.072	0.601GlnTrp: 0.601 ± 0.031	0.794GlnTyr: 0.794 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	6.414ArgAla: 6.414 ± 0.088	1.126ArgCys: 1.126 ± 0.039	3.148ArgAsp: 3.148 ± 0.059	3.74ArgGlu: 3.74 ± 0.063	2.681ArgPhe: 2.681 ± 0.055	4.158ArgGly: 4.158 ± 0.074	1.915ArgHis: 1.915 ± 0.056	3.324ArgIle: 3.324 ± 0.059	2.555ArgLys: 2.555 ± 0.056	6.817ArgLeu: 6.817 ± 0.102	2.333ArgMet: 2.333 ± 0.056	1.847ArgAsn: 1.847 ± 0.048	3.546ArgPro: 3.546 ± 0.071	2.798ArgGln: 2.798 ± 0.057	4.952ArgArg: 4.952 ± 0.097	4.46ArgSer: 4.46 ± 0.07	3.284ArgThr: 3.284 ± 0.058	4.817ArgVal: 4.817 ± 0.066	1.3ArgTrp: 1.3 ± 0.042	1.675ArgTyr: 1.675 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	6.678SerAla: 6.678 ± 0.095	0.934SerCys: 0.934 ± 0.04	2.677SerAsp: 2.677 ± 0.058	2.839SerGlu: 2.839 ± 0.062	2.296SerPhe: 2.296 ± 0.057	5.222SerGly: 5.222 ± 0.077	1.266SerHis: 1.266 ± 0.038	2.723SerIle: 2.723 ± 0.057	2.135SerLys: 2.135 ± 0.048	5.837SerLeu: 5.837 ± 0.094	2.08SerMet: 2.08 ± 0.049	1.738SerAsn: 1.738 ± 0.049	3.333SerPro: 3.333 ± 0.066	2.077SerGln: 2.077 ± 0.051	4.35SerArg: 4.35 ± 0.077	4.886SerSer: 4.886 ± 0.105	4.126SerThr: 4.126 ± 0.08	4.516SerVal: 4.516 ± 0.079	1.016SerTrp: 1.016 ± 0.035	1.233SerTyr: 1.233 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.928ThrAla: 5.928 ± 0.098	0.701ThrCys: 0.701 ± 0.034	2.512ThrAsp: 2.512 ± 0.054	2.594ThrGlu: 2.594 ± 0.057	1.827ThrPhe: 1.827 ± 0.044	4.766ThrGly: 4.766 ± 0.075	1.243ThrHis: 1.243 ± 0.037	2.33ThrIle: 2.33 ± 0.055	1.762ThrLys: 1.762 ± 0.042	5.918ThrLeu: 5.918 ± 0.091	1.648ThrMet: 1.648 ± 0.047	1.398ThrAsn: 1.398 ± 0.038	3.691ThrPro: 3.691 ± 0.082	1.947ThrGln: 1.947 ± 0.052	3.494ThrArg: 3.494 ± 0.062	3.629ThrSer: 3.629 ± 0.067	3.454ThrThr: 3.454 ± 0.069	4.202ThrVal: 4.202 ± 0.075	0.871ThrTrp: 0.871 ± 0.034	1.141ThrTyr: 1.141 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	8.395ValAla: 8.395 ± 0.105	0.903ValCys: 0.903 ± 0.035	4.153ValAsp: 4.153 ± 0.078	4.18ValGlu: 4.18 ± 0.082	3.181ValPhe: 3.181 ± 0.061	5.83ValGly: 5.83 ± 0.084	1.847ValHis: 1.847 ± 0.054	3.657ValIle: 3.657 ± 0.074	3.022ValLys: 3.022 ± 0.063	7.685ValLeu: 7.685 ± 0.092	2.431ValMet: 2.431 ± 0.056	2.239ValAsn: 2.239 ± 0.048	3.842ValPro: 3.842 ± 0.08	2.924ValGln: 2.924 ± 0.064	4.745ValArg: 4.745 ± 0.071	4.59ValSer: 4.59 ± 0.077	4.01ValThr: 4.01 ± 0.074	6.64ValVal: 6.64 ± 0.111	1.103ValTrp: 1.103 ± 0.032	1.59ValTyr: 1.59 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.523TrpAla: 1.523 ± 0.046	0.306TrpCys: 0.306 ± 0.018	0.62TrpAsp: 0.62 ± 0.028	0.57TrpGlu: 0.57 ± 0.025	0.593TrpPhe: 0.593 ± 0.024	0.944TrpGly: 0.944 ± 0.033	0.354TrpHis: 0.354 ± 0.021	0.72TrpIle: 0.72 ± 0.03	0.628TrpLys: 0.628 ± 0.025	1.853TrpLeu: 1.853 ± 0.047	0.638TrpMet: 0.638 ± 0.03	0.49TrpAsn: 0.49 ± 0.023	0.985TrpPro: 0.985 ± 0.032	0.617TrpGln: 0.617 ± 0.03	1.304TrpArg: 1.304 ± 0.04	0.967TrpSer: 0.967 ± 0.034	0.858TrpThr: 0.858 ± 0.035	1.144TrpVal: 1.144 ± 0.033	0.319TrpTrp: 0.319 ± 0.022	0.312TrpTyr: 0.312 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.26TyrAla: 2.26 ± 0.047	0.26TyrCys: 0.26 ± 0.017	1.095TyrAsp: 1.095 ± 0.04	1.192TyrGlu: 1.192 ± 0.034	0.961TyrPhe: 0.961 ± 0.034	1.806TyrGly: 1.806 ± 0.048	0.468TyrHis: 0.468 ± 0.023	0.908TyrIle: 0.908 ± 0.029	0.829TyrLys: 0.829 ± 0.032	2.34TyrLeu: 2.34 ± 0.048	0.52TyrMet: 0.52 ± 0.027	0.691TyrAsn: 0.691 ± 0.027	1.009TyrPro: 1.009 ± 0.034	0.887TyrGln: 0.887 ± 0.03	1.464TyrArg: 1.464 ± 0.037	1.295TyrSer: 1.295 ± 0.041	1.23TyrThr: 1.23 ± 0.039	1.578TyrVal: 1.578 ± 0.046	0.382TyrTrp: 0.382 ± 0.02	0.571TyrTyr: 0.571 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4866 proteins (880246 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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