Amino acid dipepetide frequency for La Joya virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.387AlaAla: 2.387 ± 0.863
0.995AlaCys: 0.995 ± 0.347
1.989AlaAsp: 1.989 ± 0.832
0.398AlaGlu: 0.398 ± 0.23
0.796AlaPhe: 0.796 ± 0.334
2.586AlaGly: 2.586 ± 0.747
1.392AlaHis: 1.392 ± 0.416
3.183AlaIle: 3.183 ± 0.852
3.581AlaLys: 3.581 ± 0.742
4.575AlaLeu: 4.575 ± 0.829
1.194AlaMet: 1.194 ± 0.633
0.796AlaAsn: 0.796 ± 0.337
2.188AlaPro: 2.188 ± 1.307
1.392AlaGln: 1.392 ± 0.647
1.194AlaArg: 1.194 ± 0.347
2.188AlaSer: 2.188 ± 0.674
3.382AlaThr: 3.382 ± 1.387
0.995AlaVal: 0.995 ± 0.48
1.392AlaTrp: 1.392 ± 0.522
2.387AlaTyr: 2.387 ± 0.827
0.0AlaXaa: 0.0 ± 0.0
Cys
0.995CysAla: 0.995 ± 0.366
0.0CysCys: 0.0 ± 0.0
1.194CysAsp: 1.194 ± 0.423
0.597CysGlu: 0.597 ± 0.4
0.398CysPhe: 0.398 ± 0.26
1.194CysGly: 1.194 ± 0.783
1.392CysHis: 1.392 ± 0.745
0.796CysIle: 0.796 ± 0.396
0.995CysLys: 0.995 ± 0.574
0.796CysLeu: 0.796 ± 0.573
0.0CysMet: 0.0 ± 0.0
0.597CysAsn: 0.597 ± 0.338
1.591CysPro: 1.591 ± 0.453
0.597CysGln: 0.597 ± 0.322
0.995CysArg: 0.995 ± 0.471
1.591CysSer: 1.591 ± 0.755
0.597CysThr: 0.597 ± 0.24
0.995CysVal: 0.995 ± 0.484
0.597CysTrp: 0.597 ± 0.27
1.194CysTyr: 1.194 ± 0.715
0.0CysXaa: 0.0 ± 0.0
Asp
0.995AspAla: 0.995 ± 0.282
0.995AspCys: 0.995 ± 0.336
3.382AspAsp: 3.382 ± 0.964
1.989AspGlu: 1.989 ± 0.623
2.984AspPhe: 2.984 ± 0.812
3.382AspGly: 3.382 ± 0.431
1.392AspHis: 1.392 ± 0.585
4.973AspIle: 4.973 ± 1.85
3.78AspLys: 3.78 ± 0.816
8.156AspLeu: 8.156 ± 1.359
2.387AspMet: 2.387 ± 0.485
1.79AspAsn: 1.79 ± 0.46
4.376AspPro: 4.376 ± 0.663
1.591AspGln: 1.591 ± 0.469
0.995AspArg: 0.995 ± 0.656
3.581AspSer: 3.581 ± 1.319
1.194AspThr: 1.194 ± 0.464
1.989AspVal: 1.989 ± 0.855
1.194AspTrp: 1.194 ± 0.455
3.581AspTyr: 3.581 ± 1.237
0.0AspXaa: 0.0 ± 0.0
Glu
1.79GluAla: 1.79 ± 0.55
0.995GluCys: 0.995 ± 0.6
2.188GluAsp: 2.188 ± 0.862
3.78GluGlu: 3.78 ± 0.743
2.984GluPhe: 2.984 ± 0.942
2.785GluGly: 2.785 ± 1.022
2.387GluHis: 2.387 ± 0.758
3.78GluIle: 3.78 ± 0.841
3.78GluLys: 3.78 ± 0.959
4.376GluLeu: 4.376 ± 0.992
0.597GluMet: 0.597 ± 0.389
2.188GluAsn: 2.188 ± 0.538
2.387GluPro: 2.387 ± 0.419
0.597GluGln: 0.597 ± 0.389
1.79GluArg: 1.79 ± 0.447
4.575GluSer: 4.575 ± 1.053
2.785GluThr: 2.785 ± 0.763
3.183GluVal: 3.183 ± 0.816
0.995GluTrp: 0.995 ± 0.479
3.183GluTyr: 3.183 ± 0.678
0.0GluXaa: 0.0 ± 0.0
Phe
2.188PheAla: 2.188 ± 0.648
0.995PheCys: 0.995 ± 0.331
3.581PheAsp: 3.581 ± 0.978
3.183PheGlu: 3.183 ± 0.762
2.387PhePhe: 2.387 ± 0.484
3.382PheGly: 3.382 ± 0.845
1.591PheHis: 1.591 ± 0.52
2.387PheIle: 2.387 ± 0.753
3.382PheLys: 3.382 ± 0.746
4.774PheLeu: 4.774 ± 1.297
0.995PheMet: 0.995 ± 0.385
2.188PheAsn: 2.188 ± 1.091
2.586PhePro: 2.586 ± 0.704
2.387PheGln: 2.387 ± 0.644
2.785PheArg: 2.785 ± 0.836
3.78PheSer: 3.78 ± 1.171
3.78PheThr: 3.78 ± 0.687
2.785PheVal: 2.785 ± 0.639
0.398PheTrp: 0.398 ± 0.261
0.995PheTyr: 0.995 ± 0.328
0.0PheXaa: 0.0 ± 0.0
Gly
1.194GlyAla: 1.194 ± 0.768
0.796GlyCys: 0.796 ± 0.511
3.183GlyAsp: 3.183 ± 0.775
4.177GlyGlu: 4.177 ± 1.239
4.177GlyPhe: 4.177 ± 1.191
2.586GlyGly: 2.586 ± 0.751
1.392GlyHis: 1.392 ± 0.551
3.183GlyIle: 3.183 ± 0.799
3.581GlyLys: 3.581 ± 0.818
7.559GlyLeu: 7.559 ± 1.043
1.392GlyMet: 1.392 ± 0.735
2.785GlyAsn: 2.785 ± 0.588
3.78GlyPro: 3.78 ± 0.87
2.785GlyGln: 2.785 ± 0.649
1.989GlyArg: 1.989 ± 0.525
4.973GlySer: 4.973 ± 0.765
2.984GlyThr: 2.984 ± 0.694
3.979GlyVal: 3.979 ± 0.538
0.995GlyTrp: 0.995 ± 0.484
2.984GlyTyr: 2.984 ± 0.768
0.0GlyXaa: 0.0 ± 0.0
His
1.591HisAla: 1.591 ± 0.379
0.398HisCys: 0.398 ± 0.383
1.392HisAsp: 1.392 ± 0.401
1.989HisGlu: 1.989 ± 0.647
1.591HisPhe: 1.591 ± 0.584
1.194HisGly: 1.194 ± 0.434
0.995HisHis: 0.995 ± 0.469
2.785HisIle: 2.785 ± 0.683
1.591HisLys: 1.591 ± 0.686
3.78HisLeu: 3.78 ± 1.029
0.796HisMet: 0.796 ± 0.511
0.199HisAsn: 0.199 ± 0.13
2.387HisPro: 2.387 ± 0.878
0.995HisGln: 0.995 ± 0.491
0.796HisArg: 0.796 ± 0.351
2.785HisSer: 2.785 ± 0.687
1.79HisThr: 1.79 ± 0.583
2.188HisVal: 2.188 ± 0.729
0.597HisTrp: 0.597 ± 0.296
1.392HisTyr: 1.392 ± 0.47
0.0HisXaa: 0.0 ± 0.0
Ile
2.785IleAla: 2.785 ± 0.799
1.392IleCys: 1.392 ± 0.424
3.183IleAsp: 3.183 ± 0.721
3.78IleGlu: 3.78 ± 0.753
3.183IlePhe: 3.183 ± 0.475
4.973IleGly: 4.973 ± 0.938
2.984IleHis: 2.984 ± 0.73
5.371IleIle: 5.371 ± 1.355
5.57IleLys: 5.57 ± 1.299
6.763IleLeu: 6.763 ± 1.707
1.392IleMet: 1.392 ± 0.526
3.979IleAsn: 3.979 ± 0.825
4.177IlePro: 4.177 ± 0.691
2.188IleGln: 2.188 ± 0.576
5.172IleArg: 5.172 ± 0.935
5.172IleSer: 5.172 ± 0.55
3.78IleThr: 3.78 ± 1.02
2.387IleVal: 2.387 ± 0.725
0.796IleTrp: 0.796 ± 0.35
4.575IleTyr: 4.575 ± 1.358
0.0IleXaa: 0.0 ± 0.0
Lys
2.984LysAla: 2.984 ± 0.845
0.995LysCys: 0.995 ± 0.579
3.183LysAsp: 3.183 ± 0.776
2.387LysGlu: 2.387 ± 0.698
2.984LysPhe: 2.984 ± 0.623
3.979LysGly: 3.979 ± 1.218
1.194LysHis: 1.194 ± 0.441
6.366LysIle: 6.366 ± 1.278
5.172LysLys: 5.172 ± 1.148
6.366LysLeu: 6.366 ± 1.654
1.591LysMet: 1.591 ± 0.487
4.575LysAsn: 4.575 ± 0.57
3.581LysPro: 3.581 ± 0.722
1.392LysGln: 1.392 ± 0.538
3.382LysArg: 3.382 ± 0.873
6.565LysSer: 6.565 ± 0.827
2.984LysThr: 2.984 ± 0.992
3.183LysVal: 3.183 ± 0.538
1.79LysTrp: 1.79 ± 0.625
0.796LysTyr: 0.796 ± 0.563
0.0LysXaa: 0.0 ± 0.0
Leu
3.78LeuAla: 3.78 ± 0.848
1.194LeuCys: 1.194 ± 0.398
8.156LeuAsp: 8.156 ± 1.024
6.962LeuGlu: 6.962 ± 0.839
4.376LeuPhe: 4.376 ± 0.936
8.355LeuGly: 8.355 ± 1.715
2.586LeuHis: 2.586 ± 0.927
8.156LeuIle: 8.156 ± 1.124
6.167LeuLys: 6.167 ± 1.616
10.344LeuLeu: 10.344 ± 1.258
4.177LeuMet: 4.177 ± 1.371
5.371LeuAsn: 5.371 ± 1.382
3.183LeuPro: 3.183 ± 0.924
2.984LeuGln: 2.984 ± 1.049
4.575LeuArg: 4.575 ± 0.902
8.554LeuSer: 8.554 ± 1.385
6.565LeuThr: 6.565 ± 1.224
6.565LeuVal: 6.565 ± 1.16
1.591LeuTrp: 1.591 ± 0.826
1.989LeuTyr: 1.989 ± 0.654
0.0LeuXaa: 0.0 ± 0.0
Met
1.79MetAla: 1.79 ± 0.53
0.597MetCys: 0.597 ± 0.283
1.591MetAsp: 1.591 ± 0.548
1.392MetGlu: 1.392 ± 0.445
1.79MetPhe: 1.79 ± 0.587
1.392MetGly: 1.392 ± 0.537
0.199MetHis: 0.199 ± 0.279
2.586MetIle: 2.586 ± 1.155
1.392MetLys: 1.392 ± 0.564
1.989MetLeu: 1.989 ± 0.643
0.597MetMet: 0.597 ± 0.309
0.796MetAsn: 0.796 ± 0.299
0.398MetPro: 0.398 ± 0.514
0.398MetGln: 0.398 ± 0.27
0.597MetArg: 0.597 ± 0.538
2.387MetSer: 2.387 ± 0.688
1.591MetThr: 1.591 ± 0.543
2.387MetVal: 2.387 ± 0.486
0.796MetTrp: 0.796 ± 0.494
0.995MetTyr: 0.995 ± 0.442
0.0MetXaa: 0.0 ± 0.0
Asn
2.188AsnAla: 2.188 ± 0.773
0.995AsnCys: 0.995 ± 0.361
2.188AsnAsp: 2.188 ± 0.91
1.989AsnGlu: 1.989 ± 0.658
2.188AsnPhe: 2.188 ± 0.653
2.586AsnGly: 2.586 ± 0.896
1.591AsnHis: 1.591 ± 0.584
3.78AsnIle: 3.78 ± 0.501
2.586AsnLys: 2.586 ± 0.635
8.156AsnLeu: 8.156 ± 1.314
0.796AsnMet: 0.796 ± 0.485
2.188AsnAsn: 2.188 ± 0.42
3.78AsnPro: 3.78 ± 0.703
1.79AsnGln: 1.79 ± 0.429
1.194AsnArg: 1.194 ± 0.427
3.979AsnSer: 3.979 ± 0.623
0.995AsnThr: 0.995 ± 0.51
2.586AsnVal: 2.586 ± 1.605
0.796AsnTrp: 0.796 ± 0.413
2.387AsnTyr: 2.387 ± 0.743
0.0AsnXaa: 0.0 ± 0.0
Pro
2.586ProAla: 2.586 ± 0.762
0.199ProCys: 0.199 ± 0.13
2.984ProAsp: 2.984 ± 0.574
2.188ProGlu: 2.188 ± 0.481
1.79ProPhe: 1.79 ± 0.684
2.188ProGly: 2.188 ± 0.641
2.188ProHis: 2.188 ± 0.668
4.575ProIle: 4.575 ± 1.088
3.183ProLys: 3.183 ± 0.734
4.376ProLeu: 4.376 ± 0.76
1.392ProMet: 1.392 ± 1.022
2.984ProAsn: 2.984 ± 0.76
3.382ProPro: 3.382 ± 0.897
2.188ProGln: 2.188 ± 0.863
1.989ProArg: 1.989 ± 0.555
6.167ProSer: 6.167 ± 1.054
3.183ProThr: 3.183 ± 0.951
2.188ProVal: 2.188 ± 1.027
0.995ProTrp: 0.995 ± 0.524
1.79ProTyr: 1.79 ± 0.786
0.0ProXaa: 0.0 ± 0.0
Gln
1.194GlnAla: 1.194 ± 0.404
0.597GlnCys: 0.597 ± 0.313
1.989GlnAsp: 1.989 ± 0.809
1.989GlnGlu: 1.989 ± 0.73
1.591GlnPhe: 1.591 ± 0.495
1.591GlnGly: 1.591 ± 0.485
0.597GlnHis: 0.597 ± 0.267
3.183GlnIle: 3.183 ± 0.904
1.79GlnLys: 1.79 ± 0.538
2.387GlnLeu: 2.387 ± 0.703
1.591GlnMet: 1.591 ± 0.593
1.79GlnAsn: 1.79 ± 0.747
1.79GlnPro: 1.79 ± 0.602
0.0GlnGln: 0.0 ± 0.0
1.194GlnArg: 1.194 ± 0.44
2.188GlnSer: 2.188 ± 0.469
2.188GlnThr: 2.188 ± 0.644
2.188GlnVal: 2.188 ± 0.697
0.995GlnTrp: 0.995 ± 0.447
0.597GlnTyr: 0.597 ± 0.283
0.0GlnXaa: 0.0 ± 0.0
Arg
1.392ArgAla: 1.392 ± 0.705
0.995ArgCys: 0.995 ± 0.282
1.989ArgAsp: 1.989 ± 0.61
2.387ArgGlu: 2.387 ± 0.467
2.785ArgPhe: 2.785 ± 0.53
2.387ArgGly: 2.387 ± 0.562
1.194ArgHis: 1.194 ± 0.572
2.586ArgIle: 2.586 ± 0.369
1.989ArgLys: 1.989 ± 0.617
2.785ArgLeu: 2.785 ± 0.758
1.392ArgMet: 1.392 ± 0.667
1.79ArgAsn: 1.79 ± 0.628
2.586ArgPro: 2.586 ± 0.68
1.591ArgGln: 1.591 ± 0.592
0.995ArgArg: 0.995 ± 0.486
3.581ArgSer: 3.581 ± 0.685
2.586ArgThr: 2.586 ± 0.937
2.984ArgVal: 2.984 ± 1.028
0.398ArgTrp: 0.398 ± 0.26
1.79ArgTyr: 1.79 ± 0.455
0.0ArgXaa: 0.0 ± 0.0
Ser
2.984SerAla: 2.984 ± 0.794
1.989SerCys: 1.989 ± 0.615
3.382SerAsp: 3.382 ± 0.91
3.382SerGlu: 3.382 ± 0.81
5.371SerPhe: 5.371 ± 0.773
4.774SerGly: 4.774 ± 0.765
2.586SerHis: 2.586 ± 0.723
4.973SerIle: 4.973 ± 0.879
4.774SerLys: 4.774 ± 1.283
13.129SerLeu: 13.129 ± 1.149
1.194SerMet: 1.194 ± 0.483
4.973SerAsn: 4.973 ± 0.665
4.177SerPro: 4.177 ± 1.059
1.989SerGln: 1.989 ± 0.66
2.785SerArg: 2.785 ± 0.497
7.559SerSer: 7.559 ± 1.818
5.968SerThr: 5.968 ± 1.345
3.78SerVal: 3.78 ± 0.683
1.591SerTrp: 1.591 ± 0.558
3.382SerTyr: 3.382 ± 0.487
0.0SerXaa: 0.0 ± 0.0
Thr
1.989ThrAla: 1.989 ± 0.583
0.597ThrCys: 0.597 ± 0.282
3.183ThrAsp: 3.183 ± 0.816
2.785ThrGlu: 2.785 ± 0.746
2.785ThrPhe: 2.785 ± 0.519
3.78ThrGly: 3.78 ± 0.83
2.586ThrHis: 2.586 ± 0.526
3.979ThrIle: 3.979 ± 0.732
3.979ThrLys: 3.979 ± 0.935
4.376ThrLeu: 4.376 ± 0.884
1.591ThrMet: 1.591 ± 0.693
2.586ThrAsn: 2.586 ± 0.685
1.591ThrPro: 1.591 ± 0.852
2.586ThrGln: 2.586 ± 0.739
2.387ThrArg: 2.387 ± 0.789
5.371ThrSer: 5.371 ± 1.183
2.984ThrThr: 2.984 ± 0.981
2.984ThrVal: 2.984 ± 1.297
1.591ThrTrp: 1.591 ± 0.48
1.591ThrTyr: 1.591 ± 0.44
0.0ThrXaa: 0.0 ± 0.0
Val
1.392ValAla: 1.392 ± 0.726
1.194ValCys: 1.194 ± 0.607
2.387ValAsp: 2.387 ± 0.66
2.387ValGlu: 2.387 ± 1.174
2.785ValPhe: 2.785 ± 0.889
3.581ValGly: 3.581 ± 1.373
1.392ValHis: 1.392 ± 0.724
3.979ValIle: 3.979 ± 0.673
3.979ValLys: 3.979 ± 1.078
5.769ValLeu: 5.769 ± 1.172
0.995ValMet: 0.995 ± 0.398
3.581ValAsn: 3.581 ± 0.793
2.586ValPro: 2.586 ± 0.736
1.194ValGln: 1.194 ± 0.462
1.989ValArg: 1.989 ± 0.829
4.774ValSer: 4.774 ± 1.138
3.183ValThr: 3.183 ± 1.158
2.586ValVal: 2.586 ± 0.93
0.796ValTrp: 0.796 ± 0.399
2.188ValTyr: 2.188 ± 0.67
0.0ValXaa: 0.0 ± 0.0
Trp
1.194TrpAla: 1.194 ± 0.786
0.0TrpCys: 0.0 ± 0.0
1.79TrpAsp: 1.79 ± 0.627
1.591TrpGlu: 1.591 ± 0.558
1.194TrpPhe: 1.194 ± 0.356
2.188TrpGly: 2.188 ± 0.793
0.597TrpHis: 0.597 ± 0.4
0.995TrpIle: 0.995 ± 0.56
0.995TrpLys: 0.995 ± 0.332
0.597TrpLeu: 0.597 ± 0.459
0.796TrpMet: 0.796 ± 0.284
1.591TrpAsn: 1.591 ± 0.435
0.199TrpPro: 0.199 ± 0.13
0.199TrpGln: 0.199 ± 0.13
0.597TrpArg: 0.597 ± 0.353
1.79TrpSer: 1.79 ± 0.806
0.199TrpThr: 0.199 ± 0.22
0.796TrpVal: 0.796 ± 0.397
0.597TrpTrp: 0.597 ± 0.4
1.194TrpTyr: 1.194 ± 0.62
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.591TyrAla: 1.591 ± 0.511
1.194TyrCys: 1.194 ± 0.652
1.79TyrAsp: 1.79 ± 0.758
1.79TyrGlu: 1.79 ± 0.52
2.387TyrPhe: 2.387 ± 0.637
1.591TyrGly: 1.591 ± 0.486
1.194TyrHis: 1.194 ± 0.506
1.989TyrIle: 1.989 ± 0.56
3.183TyrLys: 3.183 ± 1.133
4.575TyrLeu: 4.575 ± 0.877
0.597TyrMet: 0.597 ± 0.467
1.989TyrAsn: 1.989 ± 0.827
1.79TyrPro: 1.79 ± 0.676
2.586TyrGln: 2.586 ± 0.868
2.785TyrArg: 2.785 ± 0.935
3.183TyrSer: 3.183 ± 1.072
2.586TyrThr: 2.586 ± 0.772
1.989TyrVal: 1.989 ± 0.516
0.199TyrTrp: 0.199 ± 0.22
1.79TyrTyr: 1.79 ± 0.509
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 14 proteins (5028 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski