Amino acid dipepetide frequency for Mannheimia phage vB_MhS_1152AP2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.503AlaAla: 4.503 ± 0.824
0.392AlaCys: 0.392 ± 0.2
5.612AlaAsp: 5.612 ± 0.675
6.983AlaGlu: 6.983 ± 0.845
4.111AlaPhe: 4.111 ± 0.69
5.025AlaGly: 5.025 ± 0.71
1.044AlaHis: 1.044 ± 0.283
5.938AlaIle: 5.938 ± 0.779
7.57AlaLys: 7.57 ± 0.759
6.069AlaLeu: 6.069 ± 0.68
2.349AlaMet: 2.349 ± 0.542
4.894AlaAsn: 4.894 ± 0.843
2.48AlaPro: 2.48 ± 0.611
4.307AlaGln: 4.307 ± 0.573
4.176AlaArg: 4.176 ± 0.768
4.176AlaSer: 4.176 ± 0.964
4.699AlaThr: 4.699 ± 0.609
5.547AlaVal: 5.547 ± 0.571
1.175AlaTrp: 1.175 ± 0.258
2.937AlaTyr: 2.937 ± 0.39
0.0AlaXaa: 0.0 ± 0.0
Cys
0.392CysAla: 0.392 ± 0.17
0.196CysCys: 0.196 ± 0.12
0.457CysAsp: 0.457 ± 0.173
0.653CysGlu: 0.653 ± 0.195
0.326CysPhe: 0.326 ± 0.161
1.044CysGly: 1.044 ± 0.34
0.261CysHis: 0.261 ± 0.114
0.522CysIle: 0.522 ± 0.154
0.914CysLys: 0.914 ± 0.279
1.044CysLeu: 1.044 ± 0.385
0.0CysMet: 0.0 ± 0.0
0.718CysAsn: 0.718 ± 0.279
0.522CysPro: 0.522 ± 0.204
0.326CysGln: 0.326 ± 0.153
0.326CysArg: 0.326 ± 0.166
0.522CysSer: 0.522 ± 0.167
0.522CysThr: 0.522 ± 0.201
0.392CysVal: 0.392 ± 0.142
0.131CysTrp: 0.131 ± 0.108
0.457CysTyr: 0.457 ± 0.2
0.0CysXaa: 0.0 ± 0.0
Asp
3.785AspAla: 3.785 ± 0.457
0.587AspCys: 0.587 ± 0.246
2.676AspAsp: 2.676 ± 0.454
3.85AspGlu: 3.85 ± 0.785
3.002AspPhe: 3.002 ± 0.484
4.568AspGly: 4.568 ± 0.557
0.392AspHis: 0.392 ± 0.181
3.002AspIle: 3.002 ± 0.429
4.046AspLys: 4.046 ± 0.538
5.351AspLeu: 5.351 ± 0.567
1.37AspMet: 1.37 ± 0.312
2.806AspAsn: 2.806 ± 0.499
1.305AspPro: 1.305 ± 0.293
1.697AspGln: 1.697 ± 0.393
1.958AspArg: 1.958 ± 0.385
3.524AspSer: 3.524 ± 0.551
2.871AspThr: 2.871 ± 0.396
3.067AspVal: 3.067 ± 0.379
1.044AspTrp: 1.044 ± 0.263
1.827AspTyr: 1.827 ± 0.368
0.0AspXaa: 0.0 ± 0.0
Glu
5.482GluAla: 5.482 ± 0.709
0.783GluCys: 0.783 ± 0.247
3.067GluAsp: 3.067 ± 0.523
5.09GluGlu: 5.09 ± 0.721
3.002GluPhe: 3.002 ± 0.458
2.219GluGly: 2.219 ± 0.353
0.718GluHis: 0.718 ± 0.194
5.612GluIle: 5.612 ± 0.6
6.46GluLys: 6.46 ± 0.849
7.7GluLeu: 7.7 ± 1.122
1.827GluMet: 1.827 ± 0.42
3.459GluAsn: 3.459 ± 0.502
2.48GluPro: 2.48 ± 0.474
5.09GluGln: 5.09 ± 0.821
4.242GluArg: 4.242 ± 0.571
3.459GluSer: 3.459 ± 0.44
5.025GluThr: 5.025 ± 0.496
3.459GluVal: 3.459 ± 0.596
1.697GluTrp: 1.697 ± 0.296
2.153GluTyr: 2.153 ± 0.396
0.0GluXaa: 0.0 ± 0.0
Phe
3.915PheAla: 3.915 ± 0.44
0.326PheCys: 0.326 ± 0.128
2.61PheAsp: 2.61 ± 0.394
3.85PheGlu: 3.85 ± 0.682
1.697PhePhe: 1.697 ± 0.407
3.067PheGly: 3.067 ± 0.412
0.783PheHis: 0.783 ± 0.221
2.545PheIle: 2.545 ± 0.478
2.415PheLys: 2.415 ± 0.295
2.088PheLeu: 2.088 ± 0.33
0.653PheMet: 0.653 ± 0.267
2.741PheAsn: 2.741 ± 0.366
0.979PhePro: 0.979 ± 0.291
0.783PheGln: 0.783 ± 0.301
1.631PheArg: 1.631 ± 0.324
1.958PheSer: 1.958 ± 0.372
2.349PheThr: 2.349 ± 0.557
2.284PheVal: 2.284 ± 0.356
0.326PheTrp: 0.326 ± 0.125
1.37PheTyr: 1.37 ± 0.381
0.0PheXaa: 0.0 ± 0.0
Gly
3.72GlyAla: 3.72 ± 0.795
0.587GlyCys: 0.587 ± 0.213
2.937GlyAsp: 2.937 ± 0.367
4.437GlyGlu: 4.437 ± 0.543
2.415GlyPhe: 2.415 ± 0.329
4.176GlyGly: 4.176 ± 0.72
0.653GlyHis: 0.653 ± 0.198
4.046GlyIle: 4.046 ± 0.485
5.09GlyLys: 5.09 ± 0.499
5.938GlyLeu: 5.938 ± 0.477
1.501GlyMet: 1.501 ± 0.27
3.589GlyAsn: 3.589 ± 0.476
0.653GlyPro: 0.653 ± 0.163
2.349GlyGln: 2.349 ± 0.404
3.067GlyArg: 3.067 ± 0.419
4.111GlySer: 4.111 ± 0.426
4.242GlyThr: 4.242 ± 1.118
4.633GlyVal: 4.633 ± 0.501
1.24GlyTrp: 1.24 ± 0.247
2.741GlyTyr: 2.741 ± 0.414
0.0GlyXaa: 0.0 ± 0.0
His
0.914HisAla: 0.914 ± 0.295
0.261HisCys: 0.261 ± 0.176
0.653HisAsp: 0.653 ± 0.279
0.718HisGlu: 0.718 ± 0.257
0.979HisPhe: 0.979 ± 0.224
0.848HisGly: 0.848 ± 0.193
0.522HisHis: 0.522 ± 0.219
1.044HisIle: 1.044 ± 0.303
1.24HisLys: 1.24 ± 0.363
1.566HisLeu: 1.566 ± 0.27
0.261HisMet: 0.261 ± 0.15
0.653HisAsn: 0.653 ± 0.206
0.979HisPro: 0.979 ± 0.267
0.914HisGln: 0.914 ± 0.235
0.783HisArg: 0.783 ± 0.199
1.436HisSer: 1.436 ± 0.33
0.914HisThr: 0.914 ± 0.236
0.196HisVal: 0.196 ± 0.121
0.326HisTrp: 0.326 ± 0.165
0.718HisTyr: 0.718 ± 0.225
0.0HisXaa: 0.0 ± 0.0
Ile
6.526IleAla: 6.526 ± 0.739
0.522IleCys: 0.522 ± 0.223
4.894IleAsp: 4.894 ± 0.474
5.612IleGlu: 5.612 ± 0.624
1.24IlePhe: 1.24 ± 0.219
4.046IleGly: 4.046 ± 0.46
0.914IleHis: 0.914 ± 0.324
4.372IleIle: 4.372 ± 0.65
5.155IleLys: 5.155 ± 0.708
5.351IleLeu: 5.351 ± 0.793
0.979IleMet: 0.979 ± 0.359
4.307IleAsn: 4.307 ± 0.522
1.892IlePro: 1.892 ± 0.445
2.61IleGln: 2.61 ± 0.379
4.372IleArg: 4.372 ± 0.63
5.743IleSer: 5.743 ± 0.723
5.025IleThr: 5.025 ± 0.805
3.393IleVal: 3.393 ± 0.535
0.848IleTrp: 0.848 ± 0.275
2.676IleTyr: 2.676 ± 0.366
0.0IleXaa: 0.0 ± 0.0
Lys
7.896LysAla: 7.896 ± 0.88
0.979LysCys: 0.979 ± 0.365
3.132LysAsp: 3.132 ± 0.542
5.677LysGlu: 5.677 ± 0.859
2.48LysPhe: 2.48 ± 0.419
3.85LysGly: 3.85 ± 0.622
1.37LysHis: 1.37 ± 0.372
4.568LysIle: 4.568 ± 0.484
3.981LysLys: 3.981 ± 0.513
6.004LysLeu: 6.004 ± 0.443
2.284LysMet: 2.284 ± 0.413
3.85LysAsn: 3.85 ± 0.595
2.871LysPro: 2.871 ± 0.585
4.437LysGln: 4.437 ± 0.727
3.72LysArg: 3.72 ± 0.625
4.307LysSer: 4.307 ± 0.575
4.633LysThr: 4.633 ± 0.535
3.915LysVal: 3.915 ± 0.524
1.044LysTrp: 1.044 ± 0.216
2.219LysTyr: 2.219 ± 0.344
0.0LysXaa: 0.0 ± 0.0
Leu
7.961LeuAla: 7.961 ± 0.62
0.979LeuCys: 0.979 ± 0.29
5.416LeuAsp: 5.416 ± 0.691
6.526LeuGlu: 6.526 ± 0.593
2.545LeuPhe: 2.545 ± 0.39
5.482LeuGly: 5.482 ± 0.63
1.501LeuHis: 1.501 ± 0.405
5.612LeuIle: 5.612 ± 0.708
5.938LeuLys: 5.938 ± 0.887
4.829LeuLeu: 4.829 ± 0.608
1.697LeuMet: 1.697 ± 0.335
6.721LeuAsn: 6.721 ± 0.495
2.741LeuPro: 2.741 ± 0.519
3.198LeuGln: 3.198 ± 0.494
3.785LeuArg: 3.785 ± 0.513
6.199LeuSer: 6.199 ± 0.618
6.069LeuThr: 6.069 ± 0.741
4.111LeuVal: 4.111 ± 0.481
0.914LeuTrp: 0.914 ± 0.283
2.48LeuTyr: 2.48 ± 0.379
0.0LeuXaa: 0.0 ± 0.0
Met
1.958MetAla: 1.958 ± 0.485
0.326MetCys: 0.326 ± 0.154
0.653MetAsp: 0.653 ± 0.238
1.109MetGlu: 1.109 ± 0.329
0.392MetPhe: 0.392 ± 0.157
1.566MetGly: 1.566 ± 0.315
0.196MetHis: 0.196 ± 0.097
1.566MetIle: 1.566 ± 0.423
2.023MetLys: 2.023 ± 0.364
2.153MetLeu: 2.153 ± 0.311
0.457MetMet: 0.457 ± 0.196
1.175MetAsn: 1.175 ± 0.395
0.979MetPro: 0.979 ± 0.293
1.566MetGln: 1.566 ± 0.469
1.175MetArg: 1.175 ± 0.222
1.501MetSer: 1.501 ± 0.334
1.892MetThr: 1.892 ± 0.409
0.653MetVal: 0.653 ± 0.217
0.326MetTrp: 0.326 ± 0.19
0.587MetTyr: 0.587 ± 0.185
0.0MetXaa: 0.0 ± 0.0
Asn
6.656AsnAla: 6.656 ± 1.075
0.065AsnCys: 0.065 ± 0.064
2.48AsnAsp: 2.48 ± 0.457
3.132AsnGlu: 3.132 ± 0.528
1.501AsnPhe: 1.501 ± 0.315
4.699AsnGly: 4.699 ± 0.575
1.044AsnHis: 1.044 ± 0.289
3.785AsnIle: 3.785 ± 0.476
3.785AsnLys: 3.785 ± 0.649
5.286AsnLeu: 5.286 ± 0.609
1.305AsnMet: 1.305 ± 0.246
3.328AsnAsn: 3.328 ± 0.343
2.349AsnPro: 2.349 ± 0.461
3.328AsnGln: 3.328 ± 0.437
3.132AsnArg: 3.132 ± 0.384
3.132AsnSer: 3.132 ± 0.443
2.284AsnThr: 2.284 ± 0.423
3.198AsnVal: 3.198 ± 0.63
0.326AsnTrp: 0.326 ± 0.168
1.762AsnTyr: 1.762 ± 0.367
0.0AsnXaa: 0.0 ± 0.0
Pro
1.958ProAla: 1.958 ± 0.283
0.392ProCys: 0.392 ± 0.202
1.044ProAsp: 1.044 ± 0.303
2.871ProGlu: 2.871 ± 0.504
1.762ProPhe: 1.762 ± 0.356
0.653ProGly: 0.653 ± 0.162
0.392ProHis: 0.392 ± 0.22
2.937ProIle: 2.937 ± 0.393
3.198ProLys: 3.198 ± 0.564
2.349ProLeu: 2.349 ± 0.565
0.914ProMet: 0.914 ± 0.269
2.088ProAsn: 2.088 ± 0.392
1.24ProPro: 1.24 ± 0.356
1.37ProGln: 1.37 ± 0.264
0.848ProArg: 0.848 ± 0.221
1.762ProSer: 1.762 ± 0.352
2.088ProThr: 2.088 ± 0.418
2.088ProVal: 2.088 ± 0.387
0.457ProTrp: 0.457 ± 0.157
1.24ProTyr: 1.24 ± 0.315
0.0ProXaa: 0.0 ± 0.0
Gln
6.004GlnAla: 6.004 ± 0.66
0.457GlnCys: 0.457 ± 0.203
2.284GlnAsp: 2.284 ± 0.251
2.871GlnGlu: 2.871 ± 0.446
1.566GlnPhe: 1.566 ± 0.305
3.524GlnGly: 3.524 ± 0.5
0.979GlnHis: 0.979 ± 0.224
4.437GlnIle: 4.437 ± 0.635
2.676GlnLys: 2.676 ± 0.499
4.242GlnLeu: 4.242 ± 0.554
1.044GlnMet: 1.044 ± 0.308
2.741GlnAsn: 2.741 ± 0.364
1.501GlnPro: 1.501 ± 0.295
3.067GlnGln: 3.067 ± 0.374
2.61GlnArg: 2.61 ± 0.429
2.937GlnSer: 2.937 ± 0.573
2.545GlnThr: 2.545 ± 0.523
2.676GlnVal: 2.676 ± 0.462
0.653GlnTrp: 0.653 ± 0.2
2.088GlnTyr: 2.088 ± 0.314
0.0GlnXaa: 0.0 ± 0.0
Arg
3.198ArgAla: 3.198 ± 0.524
0.587ArgCys: 0.587 ± 0.24
2.676ArgAsp: 2.676 ± 0.476
3.459ArgGlu: 3.459 ± 0.375
2.088ArgPhe: 2.088 ± 0.487
2.284ArgGly: 2.284 ± 0.431
1.37ArgHis: 1.37 ± 0.286
3.85ArgIle: 3.85 ± 0.579
4.307ArgLys: 4.307 ± 0.715
5.025ArgLeu: 5.025 ± 0.687
1.109ArgMet: 1.109 ± 0.227
3.263ArgAsn: 3.263 ± 0.438
1.631ArgPro: 1.631 ± 0.331
2.023ArgGln: 2.023 ± 0.328
2.219ArgArg: 2.219 ± 0.363
2.349ArgSer: 2.349 ± 0.396
2.937ArgThr: 2.937 ± 0.628
2.219ArgVal: 2.219 ± 0.443
0.457ArgTrp: 0.457 ± 0.141
1.697ArgTyr: 1.697 ± 0.322
0.0ArgXaa: 0.0 ± 0.0
Ser
5.482SerAla: 5.482 ± 0.786
0.653SerCys: 0.653 ± 0.263
3.654SerAsp: 3.654 ± 0.458
3.393SerGlu: 3.393 ± 0.443
1.762SerPhe: 1.762 ± 0.396
4.699SerGly: 4.699 ± 0.552
1.175SerHis: 1.175 ± 0.266
4.829SerIle: 4.829 ± 0.714
3.002SerLys: 3.002 ± 0.361
5.221SerLeu: 5.221 ± 0.525
1.37SerMet: 1.37 ± 0.259
3.002SerAsn: 3.002 ± 0.549
1.631SerPro: 1.631 ± 0.285
3.589SerGln: 3.589 ± 0.531
3.459SerArg: 3.459 ± 0.391
4.503SerSer: 4.503 ± 0.766
3.393SerThr: 3.393 ± 0.504
4.176SerVal: 4.176 ± 0.626
0.326SerTrp: 0.326 ± 0.14
2.153SerTyr: 2.153 ± 0.396
0.0SerXaa: 0.0 ± 0.0
Thr
6.526ThrAla: 6.526 ± 1.226
0.457ThrCys: 0.457 ± 0.198
3.72ThrAsp: 3.72 ± 0.514
4.568ThrGlu: 4.568 ± 0.681
2.545ThrPhe: 2.545 ± 0.404
4.046ThrGly: 4.046 ± 0.979
0.979ThrHis: 0.979 ± 0.24
4.633ThrIle: 4.633 ± 1.014
4.699ThrLys: 4.699 ± 0.513
5.351ThrLeu: 5.351 ± 0.541
1.305ThrMet: 1.305 ± 0.332
2.741ThrAsn: 2.741 ± 0.429
2.284ThrPro: 2.284 ± 0.34
4.111ThrGln: 4.111 ± 0.547
1.697ThrArg: 1.697 ± 0.395
2.676ThrSer: 2.676 ± 0.44
3.328ThrThr: 3.328 ± 0.487
3.654ThrVal: 3.654 ± 0.481
0.848ThrTrp: 0.848 ± 0.228
1.827ThrTyr: 1.827 ± 0.604
0.0ThrXaa: 0.0 ± 0.0
Val
4.764ValAla: 4.764 ± 0.684
0.718ValCys: 0.718 ± 0.243
2.349ValAsp: 2.349 ± 0.415
4.894ValGlu: 4.894 ± 0.526
2.219ValPhe: 2.219 ± 0.407
3.132ValGly: 3.132 ± 0.46
0.783ValHis: 0.783 ± 0.321
3.524ValIle: 3.524 ± 0.516
3.654ValLys: 3.654 ± 0.494
2.937ValLeu: 2.937 ± 0.466
1.24ValMet: 1.24 ± 0.306
2.545ValAsn: 2.545 ± 0.426
1.827ValPro: 1.827 ± 0.256
2.806ValGln: 2.806 ± 0.371
3.002ValArg: 3.002 ± 0.336
4.699ValSer: 4.699 ± 0.577
3.981ValThr: 3.981 ± 1.248
2.937ValVal: 2.937 ± 0.449
1.24ValTrp: 1.24 ± 0.247
1.37ValTyr: 1.37 ± 0.279
0.0ValXaa: 0.0 ± 0.0
Trp
0.587TrpAla: 0.587 ± 0.181
0.0TrpCys: 0.0 ± 0.0
0.783TrpAsp: 0.783 ± 0.251
0.914TrpGlu: 0.914 ± 0.209
0.914TrpPhe: 0.914 ± 0.291
0.979TrpGly: 0.979 ± 0.228
0.326TrpHis: 0.326 ± 0.181
0.914TrpIle: 0.914 ± 0.209
0.848TrpLys: 0.848 ± 0.293
2.415TrpLeu: 2.415 ± 0.366
0.131TrpMet: 0.131 ± 0.104
0.783TrpAsn: 0.783 ± 0.189
0.065TrpPro: 0.065 ± 0.059
0.783TrpGln: 0.783 ± 0.2
0.718TrpArg: 0.718 ± 0.217
0.522TrpSer: 0.522 ± 0.179
1.175TrpThr: 1.175 ± 0.388
0.914TrpVal: 0.914 ± 0.263
0.261TrpTrp: 0.261 ± 0.178
0.196TrpTyr: 0.196 ± 0.132
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.762TyrAla: 1.762 ± 0.283
0.457TyrCys: 0.457 ± 0.139
1.631TyrAsp: 1.631 ± 0.316
2.48TyrGlu: 2.48 ± 0.501
1.827TyrPhe: 1.827 ± 0.333
2.219TyrGly: 2.219 ± 0.335
0.522TyrHis: 0.522 ± 0.198
2.741TyrIle: 2.741 ± 0.421
2.219TyrLys: 2.219 ± 0.403
3.785TyrLeu: 3.785 ± 0.438
0.392TyrMet: 0.392 ± 0.174
1.175TyrAsn: 1.175 ± 0.294
1.24TyrPro: 1.24 ± 0.289
2.545TyrGln: 2.545 ± 0.443
1.827TyrArg: 1.827 ± 0.317
1.958TyrSer: 1.958 ± 0.482
2.023TyrThr: 2.023 ± 0.337
1.109TyrVal: 1.109 ± 0.245
0.587TyrTrp: 0.587 ± 0.193
0.783TyrTyr: 0.783 ± 0.199
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 79 proteins (15325 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski