Amino acid dipepetide frequency for Streptococcus phage Javan481

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.161AlaAla: 5.161 ± 1.112
0.287AlaCys: 0.287 ± 0.156
4.874AlaAsp: 4.874 ± 0.628
6.403AlaGlu: 6.403 ± 0.74
2.294AlaPhe: 2.294 ± 0.659
4.205AlaGly: 4.205 ± 0.963
0.956AlaHis: 0.956 ± 0.32
7.263AlaIle: 7.263 ± 1.152
8.314AlaLys: 8.314 ± 0.906
5.638AlaLeu: 5.638 ± 0.706
1.72AlaMet: 1.72 ± 0.417
4.683AlaAsn: 4.683 ± 0.73
1.147AlaPro: 1.147 ± 0.309
3.058AlaGln: 3.058 ± 0.465
2.198AlaArg: 2.198 ± 0.483
4.778AlaSer: 4.778 ± 0.736
4.492AlaThr: 4.492 ± 0.663
5.256AlaVal: 5.256 ± 0.579
1.147AlaTrp: 1.147 ± 0.318
2.198AlaTyr: 2.198 ± 0.508
0.0AlaXaa: 0.0 ± 0.0
Cys
0.287CysAla: 0.287 ± 0.154
0.382CysCys: 0.382 ± 0.172
0.382CysAsp: 0.382 ± 0.184
0.573CysGlu: 0.573 ± 0.254
0.478CysPhe: 0.478 ± 0.203
0.86CysGly: 0.86 ± 0.324
0.096CysHis: 0.096 ± 0.091
0.0CysIle: 0.0 ± 0.0
0.382CysLys: 0.382 ± 0.216
0.669CysLeu: 0.669 ± 0.233
0.287CysMet: 0.287 ± 0.175
0.287CysAsn: 0.287 ± 0.187
0.0CysPro: 0.0 ± 0.0
0.191CysGln: 0.191 ± 0.144
0.478CysArg: 0.478 ± 0.23
0.478CysSer: 0.478 ± 0.26
0.096CysThr: 0.096 ± 0.09
0.382CysVal: 0.382 ± 0.255
0.096CysTrp: 0.096 ± 0.098
0.287CysTyr: 0.287 ± 0.209
0.0CysXaa: 0.0 ± 0.0
Asp
4.205AspAla: 4.205 ± 0.696
0.956AspCys: 0.956 ± 0.371
4.396AspAsp: 4.396 ± 0.71
4.587AspGlu: 4.587 ± 0.754
2.676AspPhe: 2.676 ± 0.483
4.3AspGly: 4.3 ± 0.658
0.478AspHis: 0.478 ± 0.241
5.256AspIle: 5.256 ± 0.519
5.734AspLys: 5.734 ± 1.051
6.403AspLeu: 6.403 ± 0.881
1.242AspMet: 1.242 ± 0.296
4.3AspAsn: 4.3 ± 0.616
2.485AspPro: 2.485 ± 0.524
1.433AspGln: 1.433 ± 0.351
1.911AspArg: 1.911 ± 0.376
3.918AspSer: 3.918 ± 0.697
3.918AspThr: 3.918 ± 1.105
4.587AspVal: 4.587 ± 0.61
0.956AspTrp: 0.956 ± 0.343
2.771AspTyr: 2.771 ± 0.532
0.0AspXaa: 0.0 ± 0.0
Glu
6.116GluAla: 6.116 ± 0.836
0.382GluCys: 0.382 ± 0.201
3.823GluAsp: 3.823 ± 0.682
4.969GluGlu: 4.969 ± 0.93
3.345GluPhe: 3.345 ± 0.567
3.631GluGly: 3.631 ± 0.596
1.816GluHis: 1.816 ± 0.375
5.161GluIle: 5.161 ± 0.759
5.83GluLys: 5.83 ± 0.683
6.976GluLeu: 6.976 ± 1.138
2.198GluMet: 2.198 ± 0.512
3.536GluAsn: 3.536 ± 0.527
2.294GluPro: 2.294 ± 0.477
3.44GluGln: 3.44 ± 0.776
2.294GluArg: 2.294 ± 0.466
3.918GluSer: 3.918 ± 0.653
4.014GluThr: 4.014 ± 0.524
3.536GluVal: 3.536 ± 0.805
0.956GluTrp: 0.956 ± 0.326
1.816GluTyr: 1.816 ± 0.493
0.0GluXaa: 0.0 ± 0.0
Phe
3.44PheAla: 3.44 ± 0.728
0.287PheCys: 0.287 ± 0.136
3.727PheAsp: 3.727 ± 0.505
3.918PheGlu: 3.918 ± 0.915
1.529PhePhe: 1.529 ± 0.394
2.294PheGly: 2.294 ± 0.43
0.669PheHis: 0.669 ± 0.328
2.294PheIle: 2.294 ± 0.459
3.44PheLys: 3.44 ± 0.468
2.294PheLeu: 2.294 ± 0.466
1.242PheMet: 1.242 ± 0.386
2.485PheAsn: 2.485 ± 0.51
0.956PhePro: 0.956 ± 0.278
1.051PheGln: 1.051 ± 0.289
1.72PheArg: 1.72 ± 0.373
2.58PheSer: 2.58 ± 0.729
2.198PheThr: 2.198 ± 0.44
2.771PheVal: 2.771 ± 0.487
0.573PheTrp: 0.573 ± 0.254
0.86PheTyr: 0.86 ± 0.214
0.0PheXaa: 0.0 ± 0.0
Gly
5.065GlyAla: 5.065 ± 0.923
0.191GlyCys: 0.191 ± 0.157
4.205GlyAsp: 4.205 ± 0.565
4.683GlyGlu: 4.683 ± 0.766
3.249GlyPhe: 3.249 ± 0.53
4.587GlyGly: 4.587 ± 0.821
0.765GlyHis: 0.765 ± 0.257
5.83GlyIle: 5.83 ± 0.847
5.447GlyLys: 5.447 ± 0.684
5.638GlyLeu: 5.638 ± 0.884
2.102GlyMet: 2.102 ± 0.432
3.154GlyAsn: 3.154 ± 0.469
1.242GlyPro: 1.242 ± 0.573
2.58GlyGln: 2.58 ± 0.612
1.911GlyArg: 1.911 ± 0.549
3.727GlySer: 3.727 ± 0.602
4.109GlyThr: 4.109 ± 0.643
3.44GlyVal: 3.44 ± 0.624
0.669GlyTrp: 0.669 ± 0.291
3.536GlyTyr: 3.536 ± 0.599
0.0GlyXaa: 0.0 ± 0.0
His
1.147HisAla: 1.147 ± 0.3
0.096HisCys: 0.096 ± 0.098
1.051HisAsp: 1.051 ± 0.383
1.529HisGlu: 1.529 ± 0.37
0.669HisPhe: 0.669 ± 0.219
1.051HisGly: 1.051 ± 0.321
0.096HisHis: 0.096 ± 0.087
0.669HisIle: 0.669 ± 0.254
0.573HisLys: 0.573 ± 0.211
1.433HisLeu: 1.433 ± 0.39
0.287HisMet: 0.287 ± 0.152
0.478HisAsn: 0.478 ± 0.224
0.956HisPro: 0.956 ± 0.394
0.382HisGln: 0.382 ± 0.163
0.86HisArg: 0.86 ± 0.251
0.86HisSer: 0.86 ± 0.27
0.669HisThr: 0.669 ± 0.279
0.573HisVal: 0.573 ± 0.271
0.287HisTrp: 0.287 ± 0.18
0.478HisTyr: 0.478 ± 0.244
0.0HisXaa: 0.0 ± 0.0
Ile
4.969IleAla: 4.969 ± 0.734
0.382IleCys: 0.382 ± 0.25
6.69IleAsp: 6.69 ± 0.838
4.396IleGlu: 4.396 ± 0.654
3.249IlePhe: 3.249 ± 0.597
3.918IleGly: 3.918 ± 1.072
0.86IleHis: 0.86 ± 0.226
3.536IleIle: 3.536 ± 0.466
7.55IleLys: 7.55 ± 0.893
5.161IleLeu: 5.161 ± 0.586
2.389IleMet: 2.389 ± 0.5
4.014IleAsn: 4.014 ± 0.753
2.294IlePro: 2.294 ± 0.549
2.485IleGln: 2.485 ± 0.463
2.58IleArg: 2.58 ± 0.506
5.734IleSer: 5.734 ± 1.171
4.587IleThr: 4.587 ± 0.645
3.918IleVal: 3.918 ± 0.767
0.382IleTrp: 0.382 ± 0.172
1.816IleTyr: 1.816 ± 0.438
0.0IleXaa: 0.0 ± 0.0
Lys
6.785LysAla: 6.785 ± 0.894
0.287LysCys: 0.287 ± 0.183
6.69LysAsp: 6.69 ± 0.942
5.543LysGlu: 5.543 ± 0.9
2.771LysPhe: 2.771 ± 0.485
5.065LysGly: 5.065 ± 0.604
1.433LysHis: 1.433 ± 0.324
5.734LysIle: 5.734 ± 0.819
9.652LysLys: 9.652 ± 1.163
6.403LysLeu: 6.403 ± 0.742
2.389LysMet: 2.389 ± 0.472
4.396LysAsn: 4.396 ± 0.557
3.154LysPro: 3.154 ± 0.547
3.44LysGln: 3.44 ± 0.568
4.3LysArg: 4.3 ± 0.737
6.116LysSer: 6.116 ± 0.829
5.925LysThr: 5.925 ± 0.814
7.072LysVal: 7.072 ± 0.808
0.956LysTrp: 0.956 ± 0.281
3.249LysTyr: 3.249 ± 0.443
0.0LysXaa: 0.0 ± 0.0
Leu
7.167LeuAla: 7.167 ± 0.987
0.191LeuCys: 0.191 ± 0.138
5.638LeuAsp: 5.638 ± 0.872
6.307LeuGlu: 6.307 ± 1.13
3.058LeuPhe: 3.058 ± 0.394
4.969LeuGly: 4.969 ± 0.74
1.051LeuHis: 1.051 ± 0.371
4.969LeuIle: 4.969 ± 0.642
8.888LeuLys: 8.888 ± 0.981
6.594LeuLeu: 6.594 ± 0.821
1.242LeuMet: 1.242 ± 0.357
4.778LeuAsn: 4.778 ± 0.608
2.485LeuPro: 2.485 ± 0.477
3.058LeuGln: 3.058 ± 0.656
3.536LeuArg: 3.536 ± 0.61
6.021LeuSer: 6.021 ± 1.078
3.727LeuThr: 3.727 ± 0.674
4.683LeuVal: 4.683 ± 0.71
0.669LeuTrp: 0.669 ± 0.238
2.198LeuTyr: 2.198 ± 0.418
0.0LeuXaa: 0.0 ± 0.0
Met
2.294MetAla: 2.294 ± 0.636
0.191MetCys: 0.191 ± 0.123
1.625MetAsp: 1.625 ± 0.384
1.433MetGlu: 1.433 ± 0.48
0.573MetPhe: 0.573 ± 0.236
2.294MetGly: 2.294 ± 0.635
0.478MetHis: 0.478 ± 0.249
1.72MetIle: 1.72 ± 0.395
1.338MetLys: 1.338 ± 0.317
1.529MetLeu: 1.529 ± 0.317
0.287MetMet: 0.287 ± 0.163
1.338MetAsn: 1.338 ± 0.316
0.765MetPro: 0.765 ± 0.269
1.147MetGln: 1.147 ± 0.32
0.86MetArg: 0.86 ± 0.284
1.625MetSer: 1.625 ± 0.372
2.198MetThr: 2.198 ± 0.392
1.529MetVal: 1.529 ± 0.454
0.382MetTrp: 0.382 ± 0.175
0.956MetTyr: 0.956 ± 0.285
0.0MetXaa: 0.0 ± 0.0
Asn
4.3AsnAla: 4.3 ± 0.975
0.478AsnCys: 0.478 ± 0.194
2.007AsnAsp: 2.007 ± 0.393
3.345AsnGlu: 3.345 ± 0.502
2.771AsnPhe: 2.771 ± 0.496
4.969AsnGly: 4.969 ± 0.65
1.051AsnHis: 1.051 ± 0.31
3.631AsnIle: 3.631 ± 0.456
5.352AsnLys: 5.352 ± 0.877
4.778AsnLeu: 4.778 ± 0.661
1.242AsnMet: 1.242 ± 0.259
2.294AsnAsn: 2.294 ± 0.591
1.816AsnPro: 1.816 ± 0.427
2.007AsnGln: 2.007 ± 0.46
2.198AsnArg: 2.198 ± 0.525
3.44AsnSer: 3.44 ± 0.641
2.294AsnThr: 2.294 ± 0.445
2.867AsnVal: 2.867 ± 0.542
0.765AsnTrp: 0.765 ± 0.239
2.867AsnTyr: 2.867 ± 0.596
0.0AsnXaa: 0.0 ± 0.0
Pro
2.58ProAla: 2.58 ± 0.46
0.191ProCys: 0.191 ± 0.131
2.58ProAsp: 2.58 ± 0.547
1.72ProGlu: 1.72 ± 0.514
1.242ProPhe: 1.242 ± 0.406
1.051ProGly: 1.051 ± 0.285
0.382ProHis: 0.382 ± 0.252
2.676ProIle: 2.676 ± 0.469
3.823ProLys: 3.823 ± 0.565
1.816ProLeu: 1.816 ± 0.373
0.669ProMet: 0.669 ± 0.194
1.051ProAsn: 1.051 ± 0.395
0.478ProPro: 0.478 ± 0.176
0.956ProGln: 0.956 ± 0.234
0.765ProArg: 0.765 ± 0.266
2.389ProSer: 2.389 ± 0.468
1.433ProThr: 1.433 ± 0.394
1.242ProVal: 1.242 ± 0.486
0.287ProTrp: 0.287 ± 0.166
1.147ProTyr: 1.147 ± 0.326
0.0ProXaa: 0.0 ± 0.0
Gln
1.816GlnAla: 1.816 ± 0.439
0.287GlnCys: 0.287 ± 0.18
1.72GlnAsp: 1.72 ± 0.38
2.771GlnGlu: 2.771 ± 0.685
1.433GlnPhe: 1.433 ± 0.384
2.294GlnGly: 2.294 ± 0.405
0.382GlnHis: 0.382 ± 0.2
2.963GlnIle: 2.963 ± 0.695
2.58GlnLys: 2.58 ± 0.616
3.631GlnLeu: 3.631 ± 0.595
0.573GlnMet: 0.573 ± 0.26
2.389GlnAsn: 2.389 ± 0.49
1.338GlnPro: 1.338 ± 0.388
1.338GlnGln: 1.338 ± 0.347
2.007GlnArg: 2.007 ± 0.467
2.867GlnSer: 2.867 ± 0.643
2.198GlnThr: 2.198 ± 0.724
2.389GlnVal: 2.389 ± 0.418
0.573GlnTrp: 0.573 ± 0.322
0.669GlnTyr: 0.669 ± 0.218
0.0GlnXaa: 0.0 ± 0.0
Arg
2.676ArgAla: 2.676 ± 0.572
0.573ArgCys: 0.573 ± 0.289
1.911ArgAsp: 1.911 ± 0.429
3.345ArgGlu: 3.345 ± 0.531
0.86ArgPhe: 0.86 ± 0.288
2.676ArgGly: 2.676 ± 0.41
0.573ArgHis: 0.573 ± 0.21
3.154ArgIle: 3.154 ± 0.507
2.485ArgLys: 2.485 ± 0.517
4.396ArgLeu: 4.396 ± 0.59
0.765ArgMet: 0.765 ± 0.264
2.771ArgAsn: 2.771 ± 0.56
1.051ArgPro: 1.051 ± 0.266
1.147ArgGln: 1.147 ± 0.342
0.86ArgArg: 0.86 ± 0.369
1.72ArgSer: 1.72 ± 0.391
1.816ArgThr: 1.816 ± 0.407
2.58ArgVal: 2.58 ± 0.396
0.573ArgTrp: 0.573 ± 0.213
1.72ArgTyr: 1.72 ± 0.42
0.0ArgXaa: 0.0 ± 0.0
Ser
5.161SerAla: 5.161 ± 1.644
0.573SerCys: 0.573 ± 0.231
4.587SerAsp: 4.587 ± 0.679
3.631SerGlu: 3.631 ± 0.626
3.536SerPhe: 3.536 ± 0.705
5.734SerGly: 5.734 ± 0.881
0.382SerHis: 0.382 ± 0.214
4.396SerIle: 4.396 ± 0.589
5.256SerLys: 5.256 ± 0.791
5.734SerLeu: 5.734 ± 0.902
1.338SerMet: 1.338 ± 0.317
3.631SerAsn: 3.631 ± 0.597
1.433SerPro: 1.433 ± 0.315
2.58SerGln: 2.58 ± 0.485
2.389SerArg: 2.389 ± 0.853
5.638SerSer: 5.638 ± 1.181
3.727SerThr: 3.727 ± 0.572
4.205SerVal: 4.205 ± 0.515
0.573SerTrp: 0.573 ± 0.282
2.676SerTyr: 2.676 ± 0.651
0.0SerXaa: 0.0 ± 0.0
Thr
5.065ThrAla: 5.065 ± 0.688
0.287ThrCys: 0.287 ± 0.153
2.963ThrAsp: 2.963 ± 0.523
3.727ThrGlu: 3.727 ± 0.576
2.485ThrPhe: 2.485 ± 0.396
5.161ThrGly: 5.161 ± 0.895
1.147ThrHis: 1.147 ± 0.347
4.3ThrIle: 4.3 ± 0.637
4.969ThrLys: 4.969 ± 0.581
4.587ThrLeu: 4.587 ± 0.692
1.147ThrMet: 1.147 ± 0.309
2.963ThrAsn: 2.963 ± 0.508
1.338ThrPro: 1.338 ± 0.355
2.198ThrGln: 2.198 ± 0.587
1.529ThrArg: 1.529 ± 0.478
4.3ThrSer: 4.3 ± 0.542
3.918ThrThr: 3.918 ± 0.619
4.3ThrVal: 4.3 ± 0.488
0.669ThrTrp: 0.669 ± 0.277
2.007ThrTyr: 2.007 ± 0.405
0.0ThrXaa: 0.0 ± 0.0
Val
3.918ValAla: 3.918 ± 0.58
0.382ValCys: 0.382 ± 0.195
3.918ValAsp: 3.918 ± 0.691
4.587ValGlu: 4.587 ± 0.715
2.102ValPhe: 2.102 ± 0.45
4.205ValGly: 4.205 ± 0.558
0.765ValHis: 0.765 ± 0.276
4.3ValIle: 4.3 ± 0.628
5.161ValLys: 5.161 ± 0.535
4.778ValLeu: 4.778 ± 0.631
1.911ValMet: 1.911 ± 0.372
3.249ValAsn: 3.249 ± 0.514
1.816ValPro: 1.816 ± 0.411
2.389ValGln: 2.389 ± 0.463
2.389ValArg: 2.389 ± 0.495
4.3ValSer: 4.3 ± 0.528
5.638ValThr: 5.638 ± 0.791
4.778ValVal: 4.778 ± 0.79
0.287ValTrp: 0.287 ± 0.144
1.625ValTyr: 1.625 ± 0.351
0.0ValXaa: 0.0 ± 0.0
Trp
0.956TrpAla: 0.956 ± 0.376
0.096TrpCys: 0.096 ± 0.09
0.382TrpAsp: 0.382 ± 0.192
0.956TrpGlu: 0.956 ± 0.36
0.382TrpPhe: 0.382 ± 0.194
1.147TrpGly: 1.147 ± 0.405
0.191TrpHis: 0.191 ± 0.205
0.765TrpIle: 0.765 ± 0.286
0.956TrpLys: 0.956 ± 0.323
0.478TrpLeu: 0.478 ± 0.239
0.382TrpMet: 0.382 ± 0.219
0.478TrpAsn: 0.478 ± 0.208
0.191TrpPro: 0.191 ± 0.136
0.573TrpGln: 0.573 ± 0.225
0.765TrpArg: 0.765 ± 0.301
1.051TrpSer: 1.051 ± 0.265
0.478TrpThr: 0.478 ± 0.168
0.287TrpVal: 0.287 ± 0.146
0.096TrpTrp: 0.096 ± 0.11
0.669TrpTyr: 0.669 ± 0.2
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.963TyrAla: 2.963 ± 0.544
0.191TyrCys: 0.191 ± 0.143
3.345TyrAsp: 3.345 ± 0.62
1.625TyrGlu: 1.625 ± 0.387
1.625TyrPhe: 1.625 ± 0.412
1.72TyrGly: 1.72 ± 0.37
0.573TyrHis: 0.573 ± 0.234
2.294TyrIle: 2.294 ± 0.371
3.631TyrLys: 3.631 ± 0.629
2.294TyrLeu: 2.294 ± 0.482
1.051TyrMet: 1.051 ± 0.335
2.198TyrAsn: 2.198 ± 0.468
1.242TyrPro: 1.242 ± 0.325
0.86TyrGln: 0.86 ± 0.243
2.102TyrArg: 2.102 ± 0.587
1.72TyrSer: 1.72 ± 0.511
1.625TyrThr: 1.625 ± 0.403
2.102TyrVal: 2.102 ± 0.4
0.382TyrTrp: 0.382 ± 0.179
1.625TyrTyr: 1.625 ± 0.425
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (10465 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski