Amino acid dipepetide frequency for Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.528AlaAla: 20.528 ± 0.228	1.191AlaCys: 1.191 ± 0.034	7.426AlaAsp: 7.426 ± 0.086	7.82AlaGlu: 7.82 ± 0.091	4.972AlaPhe: 4.972 ± 0.073	11.701AlaGly: 11.701 ± 0.097	2.278AlaHis: 2.278 ± 0.049	5.803AlaIle: 5.803 ± 0.075	5.27AlaLys: 5.27 ± 0.077	14.948AlaLeu: 14.948 ± 0.189	3.634AlaMet: 3.634 ± 0.057	2.987AlaAsn: 2.987 ± 0.062	7.542AlaPro: 7.542 ± 0.109	4.734AlaGln: 4.734 ± 0.064	10.098AlaArg: 10.098 ± 0.136	6.711AlaSer: 6.711 ± 0.089	6.308AlaThr: 6.308 ± 0.104	9.739AlaVal: 9.739 ± 0.105	2.054AlaTrp: 2.054 ± 0.044	2.932AlaTyr: 2.932 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.037CysAla: 1.037 ± 0.029	0.085CysCys: 0.085 ± 0.009	0.492CysAsp: 0.492 ± 0.021	0.402CysGlu: 0.402 ± 0.016	0.278CysPhe: 0.278 ± 0.017	0.83CysGly: 0.83 ± 0.029	0.154CysHis: 0.154 ± 0.012	0.263CysIle: 0.263 ± 0.016	0.19CysLys: 0.19 ± 0.013	0.676CysLeu: 0.676 ± 0.024	0.131CysMet: 0.131 ± 0.01	0.162CysAsn: 0.162 ± 0.011	0.381CysPro: 0.381 ± 0.02	0.212CysGln: 0.212 ± 0.012	0.496CysArg: 0.496 ± 0.021	0.385CysSer: 0.385 ± 0.021	0.283CysThr: 0.283 ± 0.017	0.639CysVal: 0.639 ± 0.02	0.093CysTrp: 0.093 ± 0.009	0.162CysTyr: 0.162 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.646AspAla: 7.646 ± 0.089	0.413AspCys: 0.413 ± 0.017	3.146AspAsp: 3.146 ± 0.059	3.222AspGlu: 3.222 ± 0.058	2.218AspPhe: 2.218 ± 0.041	5.445AspGly: 5.445 ± 0.081	1.273AspHis: 1.273 ± 0.036	2.517AspIle: 2.517 ± 0.049	1.985AspLys: 1.985 ± 0.044	6.464AspLeu: 6.464 ± 0.086	1.186AspMet: 1.186 ± 0.033	1.174AspAsn: 1.174 ± 0.035	3.864AspPro: 3.864 ± 0.061	2.001AspGln: 2.001 ± 0.044	4.216AspArg: 4.216 ± 0.071	2.009AspSer: 2.009 ± 0.045	2.414AspThr: 2.414 ± 0.05	4.063AspVal: 4.063 ± 0.066	1.023AspTrp: 1.023 ± 0.024	1.528AspTyr: 1.528 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	8.743GluAla: 8.743 ± 0.116	0.228GluCys: 0.228 ± 0.013	2.787GluAsp: 2.787 ± 0.049	2.6GluGlu: 2.6 ± 0.061	1.481GluPhe: 1.481 ± 0.035	4.762GluGly: 4.762 ± 0.065	1.006GluHis: 1.006 ± 0.029	3.012GluIle: 3.012 ± 0.056	2.055GluLys: 2.055 ± 0.048	4.701GluLeu: 4.701 ± 0.067	1.238GluMet: 1.238 ± 0.033	1.319GluAsn: 1.319 ± 0.036	2.687GluPro: 2.687 ± 0.054	1.942GluGln: 1.942 ± 0.037	4.785GluArg: 4.785 ± 0.076	2.118GluSer: 2.118 ± 0.037	3.504GluThr: 3.504 ± 0.061	3.816GluVal: 3.816 ± 0.066	0.587GluTrp: 0.587 ± 0.021	0.851GluTyr: 0.851 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.647PheAla: 4.647 ± 0.074	0.333PheCys: 0.333 ± 0.017	2.74PheAsp: 2.74 ± 0.046	2.282PheGlu: 2.282 ± 0.045	1.261PhePhe: 1.261 ± 0.038	3.552PheGly: 3.552 ± 0.063	0.685PheHis: 0.685 ± 0.029	1.437PheIle: 1.437 ± 0.038	1.236PheLys: 1.236 ± 0.034	2.993PheLeu: 2.993 ± 0.059	0.772PheMet: 0.772 ± 0.03	1.121PheAsn: 1.121 ± 0.033	1.466PhePro: 1.466 ± 0.038	1.138PheGln: 1.138 ± 0.034	1.954PheArg: 1.954 ± 0.039	2.062PheSer: 2.062 ± 0.044	2.052PheThr: 2.052 ± 0.041	2.708PheVal: 2.708 ± 0.047	0.55PheTrp: 0.55 ± 0.025	0.84PheTyr: 0.84 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	11.369GlyAla: 11.369 ± 0.133	0.751GlyCys: 0.751 ± 0.024	4.985GlyAsp: 4.985 ± 0.057	5.115GlyGlu: 5.115 ± 0.08	3.743GlyPhe: 3.743 ± 0.053	8.395GlyGly: 8.395 ± 0.101	1.612GlyHis: 1.612 ± 0.046	2.714GlyIle: 2.714 ± 0.054	3.578GlyLys: 3.578 ± 0.059	9.803GlyLeu: 9.803 ± 0.114	2.082GlyMet: 2.082 ± 0.047	1.556GlyAsn: 1.556 ± 0.048	4.101GlyPro: 4.101 ± 0.071	3.247GlyGln: 3.247 ± 0.062	6.377GlyArg: 6.377 ± 0.087	4.0GlySer: 4.0 ± 0.06	3.236GlyThr: 3.236 ± 0.061	8.101GlyVal: 8.101 ± 0.082	1.561GlyTrp: 1.561 ± 0.04	2.237GlyTyr: 2.237 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.291HisAla: 2.291 ± 0.049	0.166HisCys: 0.166 ± 0.012	1.104HisAsp: 1.104 ± 0.034	0.92HisGlu: 0.92 ± 0.028	0.648HisPhe: 0.648 ± 0.025	1.742HisGly: 1.742 ± 0.054	0.484HisHis: 0.484 ± 0.026	0.696HisIle: 0.696 ± 0.022	0.461HisLys: 0.461 ± 0.018	1.753HisLeu: 1.753 ± 0.039	0.421HisMet: 0.421 ± 0.021	0.391HisAsn: 0.391 ± 0.017	1.252HisPro: 1.252 ± 0.035	0.55HisGln: 0.55 ± 0.024	1.28HisArg: 1.28 ± 0.033	0.667HisSer: 0.667 ± 0.025	0.679HisThr: 0.679 ± 0.026	1.275HisVal: 1.275 ± 0.032	0.275HisTrp: 0.275 ± 0.016	0.473HisTyr: 0.473 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.623IleAla: 6.623 ± 0.084	0.387IleCys: 0.387 ± 0.017	3.19IleAsp: 3.19 ± 0.045	3.029IleGlu: 3.029 ± 0.053	1.34IlePhe: 1.34 ± 0.036	4.208IleGly: 4.208 ± 0.072	0.749IleHis: 0.749 ± 0.025	1.692IleIle: 1.692 ± 0.045	1.428IleLys: 1.428 ± 0.037	3.872IleLeu: 3.872 ± 0.061	0.793IleMet: 0.793 ± 0.025	1.209IleAsn: 1.209 ± 0.029	1.974IlePro: 1.974 ± 0.04	1.294IleGln: 1.294 ± 0.032	2.664IleArg: 2.664 ± 0.048	2.331IleSer: 2.331 ± 0.047	2.432IleThr: 2.432 ± 0.047	3.502IleVal: 3.502 ± 0.055	0.562IleTrp: 0.562 ± 0.024	0.894IleTyr: 0.894 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	5.739LysAla: 5.739 ± 0.083	0.124LysCys: 0.124 ± 0.01	1.916LysAsp: 1.916 ± 0.042	1.312LysGlu: 1.312 ± 0.039	0.962LysPhe: 0.962 ± 0.029	3.169LysGly: 3.169 ± 0.064	0.522LysHis: 0.522 ± 0.023	1.743LysIle: 1.743 ± 0.035	1.277LysLys: 1.277 ± 0.039	3.388LysLeu: 3.388 ± 0.067	0.737LysMet: 0.737 ± 0.023	0.864LysAsn: 0.864 ± 0.034	2.499LysPro: 2.499 ± 0.056	0.929LysGln: 0.929 ± 0.027	2.411LysArg: 2.411 ± 0.047	1.827LysSer: 1.827 ± 0.04	2.371LysThr: 2.371 ± 0.048	2.905LysVal: 2.905 ± 0.059	0.349LysTrp: 0.349 ± 0.017	0.567LysTyr: 0.567 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	14.89LeuAla: 14.89 ± 0.153	0.754LeuCys: 0.754 ± 0.027	6.151LeuAsp: 6.151 ± 0.092	5.344LeuGlu: 5.344 ± 0.075	3.362LeuPhe: 3.362 ± 0.061	8.249LeuGly: 8.249 ± 0.092	1.629LeuHis: 1.629 ± 0.042	4.822LeuIle: 4.822 ± 0.072	4.254LeuLys: 4.254 ± 0.067	8.764LeuLeu: 8.764 ± 0.12	2.275LeuMet: 2.275 ± 0.049	2.619LeuAsn: 2.619 ± 0.058	5.08LeuPro: 5.08 ± 0.065	2.539LeuGln: 2.539 ± 0.048	6.611LeuArg: 6.611 ± 0.094	6.545LeuSer: 6.545 ± 0.125	6.003LeuThr: 6.003 ± 0.118	7.24LeuVal: 7.24 ± 0.094	1.217LeuTrp: 1.217 ± 0.036	1.996LeuTyr: 1.996 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.208MetAla: 3.208 ± 0.054	0.132MetCys: 0.132 ± 0.01	1.222MetAsp: 1.222 ± 0.034	0.929MetGlu: 0.929 ± 0.027	0.669MetPhe: 0.669 ± 0.023	1.919MetGly: 1.919 ± 0.04	0.347MetHis: 0.347 ± 0.019	1.216MetIle: 1.216 ± 0.034	0.92MetLys: 0.92 ± 0.029	2.117MetLeu: 2.117 ± 0.049	0.583MetMet: 0.583 ± 0.022	0.691MetAsn: 0.691 ± 0.025	1.207MetPro: 1.207 ± 0.031	0.616MetGln: 0.616 ± 0.025	1.673MetArg: 1.673 ± 0.037	1.626MetSer: 1.626 ± 0.033	1.842MetThr: 1.842 ± 0.041	1.504MetVal: 1.504 ± 0.039	0.196MetTrp: 0.196 ± 0.013	0.236MetTyr: 0.236 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.145AsnAla: 3.145 ± 0.057	0.19AsnCys: 0.19 ± 0.013	1.318AsnAsp: 1.318 ± 0.036	0.99AsnGlu: 0.99 ± 0.03	0.865AsnPhe: 0.865 ± 0.031	2.284AsnGly: 2.284 ± 0.047	0.437AsnHis: 0.437 ± 0.02	1.129AsnIle: 1.129 ± 0.034	0.637AsnLys: 0.637 ± 0.023	2.596AsnLeu: 2.596 ± 0.057	0.502AsnMet: 0.502 ± 0.022	0.632AsnAsn: 0.632 ± 0.029	1.738AsnPro: 1.738 ± 0.04	0.749AsnGln: 0.749 ± 0.026	1.595AsnArg: 1.595 ± 0.04	1.08AsnSer: 1.08 ± 0.031	1.256AsnThr: 1.256 ± 0.037	1.803AsnVal: 1.803 ± 0.045	0.352AsnTrp: 0.352 ± 0.016	0.657AsnTyr: 0.657 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	7.325ProAla: 7.325 ± 0.103	0.345ProCys: 0.345 ± 0.016	3.589ProAsp: 3.589 ± 0.054	3.599ProGlu: 3.599 ± 0.065	2.01ProPhe: 2.01 ± 0.047	4.827ProGly: 4.827 ± 0.066	0.924ProHis: 0.924 ± 0.026	2.333ProIle: 2.333 ± 0.044	1.996ProLys: 1.996 ± 0.047	4.825ProLeu: 4.825 ± 0.064	1.253ProMet: 1.253 ± 0.029	1.38ProAsn: 1.38 ± 0.03	3.326ProPro: 3.326 ± 0.095	1.666ProGln: 1.666 ± 0.042	3.285ProArg: 3.285 ± 0.059	2.951ProSer: 2.951 ± 0.056	2.965ProThr: 2.965 ± 0.049	4.223ProVal: 4.223 ± 0.068	0.757ProTrp: 0.757 ± 0.028	1.131ProTyr: 1.131 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.888GlnAla: 4.888 ± 0.069	0.15GlnCys: 0.15 ± 0.01	1.553GlnAsp: 1.553 ± 0.031	1.316GlnGlu: 1.316 ± 0.032	1.011GlnPhe: 1.011 ± 0.027	2.809GlnGly: 2.809 ± 0.048	0.55GlnHis: 0.55 ± 0.021	1.636GlnIle: 1.636 ± 0.072	1.039GlnLys: 1.039 ± 0.027	2.809GlnLeu: 2.809 ± 0.086	0.777GlnMet: 0.777 ± 0.026	0.732GlnAsn: 0.732 ± 0.025	1.76GlnPro: 1.76 ± 0.04	1.031GlnGln: 1.031 ± 0.033	2.408GlnArg: 2.408 ± 0.051	1.647GlnSer: 1.647 ± 0.042	2.029GlnThr: 2.029 ± 0.041	2.542GlnVal: 2.542 ± 0.081	0.4GlnTrp: 0.4 ± 0.018	0.523GlnTyr: 0.523 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.998ArgAla: 8.998 ± 0.115	0.475ArgCys: 0.475 ± 0.019	4.054ArgAsp: 4.054 ± 0.066	4.043ArgGlu: 4.043 ± 0.066	2.879ArgPhe: 2.879 ± 0.044	5.212ArgGly: 5.212 ± 0.077	1.31ArgHis: 1.31 ± 0.033	3.386ArgIle: 3.386 ± 0.057	2.394ArgLys: 2.394 ± 0.045	8.351ArgLeu: 8.351 ± 0.11	1.788ArgMet: 1.788 ± 0.043	1.49ArgAsn: 1.49 ± 0.038	4.022ArgPro: 4.022 ± 0.058	2.427ArgGln: 2.427 ± 0.053	6.083ArgArg: 6.083 ± 0.092	3.299ArgSer: 3.299 ± 0.061	3.332ArgThr: 3.332 ± 0.049	4.878ArgVal: 4.878 ± 0.067	1.182ArgTrp: 1.182 ± 0.038	1.734ArgTyr: 1.734 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.672SerAla: 6.672 ± 0.105	0.325SerCys: 0.325 ± 0.016	2.862SerAsp: 2.862 ± 0.046	2.405SerGlu: 2.405 ± 0.043	1.991SerPhe: 1.991 ± 0.043	5.036SerGly: 5.036 ± 0.08	0.85SerHis: 0.85 ± 0.026	2.249SerIle: 2.249 ± 0.043	1.62SerLys: 1.62 ± 0.037	5.284SerLeu: 5.284 ± 0.076	1.107SerMet: 1.107 ± 0.032	1.303SerAsn: 1.303 ± 0.035	3.143SerPro: 3.143 ± 0.058	1.645SerGln: 1.645 ± 0.036	3.551SerArg: 3.551 ± 0.056	2.702SerSer: 2.702 ± 0.063	2.698SerThr: 2.698 ± 0.079	3.717SerVal: 3.717 ± 0.05	0.748SerTrp: 0.748 ± 0.027	1.154SerTyr: 1.154 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.764ThrAla: 6.764 ± 0.092	0.367ThrCys: 0.367 ± 0.019	2.704ThrAsp: 2.704 ± 0.058	2.266ThrGlu: 2.266 ± 0.045	1.979ThrPhe: 1.979 ± 0.043	5.079ThrGly: 5.079 ± 0.071	0.94ThrHis: 0.94 ± 0.031	2.355ThrIle: 2.355 ± 0.042	1.532ThrLys: 1.532 ± 0.042	5.93ThrLeu: 5.93 ± 0.079	0.976ThrMet: 0.976 ± 0.028	1.303ThrAsn: 1.303 ± 0.057	3.972ThrPro: 3.972 ± 0.06	1.688ThrGln: 1.688 ± 0.171	3.284ThrArg: 3.284 ± 0.055	2.6ThrSer: 2.6 ± 0.05	3.005ThrThr: 3.005 ± 0.137	4.226ThrVal: 4.226 ± 0.064	0.74ThrTrp: 0.74 ± 0.026	1.234ThrTyr: 1.234 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	9.997ValAla: 9.997 ± 0.107	0.648ValCys: 0.648 ± 0.023	4.345ValAsp: 4.345 ± 0.057	4.927ValGlu: 4.927 ± 0.077	2.782ValPhe: 2.782 ± 0.051	6.166ValGly: 6.166 ± 0.064	1.191ValHis: 1.191 ± 0.029	3.732ValIle: 3.732 ± 0.055	2.496ValLys: 2.496 ± 0.056	7.448ValLeu: 7.448 ± 0.09	1.801ValMet: 1.801 ± 0.042	1.948ValAsn: 1.948 ± 0.045	2.934ValPro: 2.934 ± 0.05	2.128ValGln: 2.128 ± 0.044	5.328ValArg: 5.328 ± 0.075	4.484ValSer: 4.484 ± 0.064	4.555ValThr: 4.555 ± 0.066	6.222ValVal: 6.222 ± 0.089	1.065ValTrp: 1.065 ± 0.032	1.484ValTyr: 1.484 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.428TrpAla: 1.428 ± 0.039	0.105TrpCys: 0.105 ± 0.008	0.7TrpAsp: 0.7 ± 0.025	0.531TrpGlu: 0.531 ± 0.019	0.559TrpPhe: 0.559 ± 0.023	1.028TrpGly: 1.028 ± 0.031	0.208TrpHis: 0.208 ± 0.013	0.7TrpIle: 0.7 ± 0.024	0.563TrpLys: 0.563 ± 0.022	1.635TrpLeu: 1.635 ± 0.039	0.38TrpMet: 0.38 ± 0.02	0.457TrpAsn: 0.457 ± 0.023	0.745TrpPro: 0.745 ± 0.028	0.37TrpGln: 0.37 ± 0.018	1.533TrpArg: 1.533 ± 0.037	0.999TrpSer: 0.999 ± 0.032	0.98TrpThr: 0.98 ± 0.031	0.86TrpVal: 0.86 ± 0.028	0.26TrpTrp: 0.26 ± 0.017	0.269TrpTyr: 0.269 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.737TyrAla: 2.737 ± 0.047	0.185TyrCys: 0.185 ± 0.012	1.519TyrAsp: 1.519 ± 0.041	1.173TyrGlu: 1.173 ± 0.032	0.817TyrPhe: 0.817 ± 0.026	2.15TyrGly: 2.15 ± 0.046	0.379TyrHis: 0.379 ± 0.02	0.737TyrIle: 0.737 ± 0.027	0.682TyrLys: 0.682 ± 0.024	1.984TyrLeu: 1.984 ± 0.05	0.416TyrMet: 0.416 ± 0.019	0.615TyrAsn: 0.615 ± 0.027	1.019TyrPro: 1.019 ± 0.03	0.705TyrGln: 0.705 ± 0.023	1.702TyrArg: 1.702 ± 0.035	1.023TyrSer: 1.023 ± 0.036	0.998TyrThr: 0.998 ± 0.036	1.719TyrVal: 1.719 ± 0.038	0.34TyrTrp: 0.34 ± 0.017	0.536TyrTyr: 0.536 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3859 proteins (1213672 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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