Amino acid dipepetide frequency for Clostridium argentinense CDC 2741

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.614AlaAla: 3.614 ± 0.067	0.686AlaCys: 0.686 ± 0.025	2.401AlaAsp: 2.401 ± 0.046	3.378AlaGlu: 3.378 ± 0.062	2.455AlaPhe: 2.455 ± 0.048	3.425AlaGly: 3.425 ± 0.068	0.829AlaHis: 0.829 ± 0.027	5.834AlaIle: 5.834 ± 0.08	4.425AlaLys: 4.425 ± 0.065	5.847AlaLeu: 5.847 ± 0.078	1.631AlaMet: 1.631 ± 0.036	2.576AlaAsn: 2.576 ± 0.049	1.429AlaPro: 1.429 ± 0.04	1.3AlaGln: 1.3 ± 0.036	1.813AlaArg: 1.813 ± 0.037	3.324AlaSer: 3.324 ± 0.051	2.822AlaThr: 2.822 ± 0.058	3.837AlaVal: 3.837 ± 0.065	0.345AlaTrp: 0.345 ± 0.017	2.139AlaTyr: 2.139 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.545CysAla: 0.545 ± 0.022	0.245CysCys: 0.245 ± 0.025	0.748CysAsp: 0.748 ± 0.026	0.838CysGlu: 0.838 ± 0.03	0.548CysPhe: 0.548 ± 0.022	1.081CysGly: 1.081 ± 0.031	0.236CysHis: 0.236 ± 0.016	1.124CysIle: 1.124 ± 0.032	1.011CysLys: 1.011 ± 0.035	0.857CysLeu: 0.857 ± 0.026	0.281CysMet: 0.281 ± 0.015	0.853CysAsn: 0.853 ± 0.025	0.449CysPro: 0.449 ± 0.024	0.217CysGln: 0.217 ± 0.014	0.428CysArg: 0.428 ± 0.018	0.847CysSer: 0.847 ± 0.03	0.559CysThr: 0.559 ± 0.022	0.595CysVal: 0.595 ± 0.025	0.075CysTrp: 0.075 ± 0.008	0.485CysTyr: 0.485 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	2.49AspAla: 2.49 ± 0.05	0.604AspCys: 0.604 ± 0.019	2.556AspAsp: 2.556 ± 0.049	4.642AspGlu: 4.642 ± 0.067	2.727AspPhe: 2.727 ± 0.053	3.292AspGly: 3.292 ± 0.059	0.642AspHis: 0.642 ± 0.022	6.4AspIle: 6.4 ± 0.076	5.469AspLys: 5.469 ± 0.079	4.687AspLeu: 4.687 ± 0.064	1.549AspMet: 1.549 ± 0.036	3.608AspAsn: 3.608 ± 0.095	1.263AspPro: 1.263 ± 0.033	0.727AspGln: 0.727 ± 0.023	1.767AspArg: 1.767 ± 0.036	3.047AspSer: 3.047 ± 0.05	2.466AspThr: 2.466 ± 0.045	3.43AspVal: 3.43 ± 0.059	0.369AspTrp: 0.369 ± 0.019	2.622AspTyr: 2.622 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	4.193GluAla: 4.193 ± 0.06	0.739GluCys: 0.739 ± 0.029	4.62GluAsp: 4.62 ± 0.068	7.673GluGlu: 7.673 ± 0.093	3.161GluPhe: 3.161 ± 0.059	4.25GluGly: 4.25 ± 0.062	1.033GluHis: 1.033 ± 0.03	7.479GluIle: 7.479 ± 0.086	8.145GluLys: 8.145 ± 0.1	7.01GluLeu: 7.01 ± 0.078	1.948GluMet: 1.948 ± 0.042	5.789GluAsn: 5.789 ± 0.082	1.515GluPro: 1.515 ± 0.043	1.778GluGln: 1.778 ± 0.041	2.737GluArg: 2.737 ± 0.05	3.665GluSer: 3.665 ± 0.051	2.96GluThr: 2.96 ± 0.056	5.026GluVal: 5.026 ± 0.068	0.435GluTrp: 0.435 ± 0.019	3.24GluTyr: 3.24 ± 0.062	0.0GluXaa: 0.0 ± 0.0
Phe	2.141PheAla: 2.141 ± 0.046	0.535PheCys: 0.535 ± 0.018	2.47PheAsp: 2.47 ± 0.046	2.922PheGlu: 2.922 ± 0.06	1.934PhePhe: 1.934 ± 0.049	2.74PheGly: 2.74 ± 0.056	0.601PheHis: 0.601 ± 0.024	4.806PheIle: 4.806 ± 0.079	3.97PheLys: 3.97 ± 0.056	3.975PheLeu: 3.975 ± 0.075	1.135PheMet: 1.135 ± 0.031	3.174PheAsn: 3.174 ± 0.056	1.181PhePro: 1.181 ± 0.035	1.006PheGln: 1.006 ± 0.032	1.268PheArg: 1.268 ± 0.029	3.27PheSer: 3.27 ± 0.051	2.367PheThr: 2.367 ± 0.05	2.364PheVal: 2.364 ± 0.049	0.298PheTrp: 0.298 ± 0.018	1.913PheTyr: 1.913 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.036GlyAla: 4.036 ± 0.073	0.869GlyCys: 0.869 ± 0.026	3.194GlyAsp: 3.194 ± 0.057	4.41GlyGlu: 4.41 ± 0.07	2.968GlyPhe: 2.968 ± 0.054	4.062GlyGly: 4.062 ± 0.082	1.023GlyHis: 1.023 ± 0.028	6.543GlyIle: 6.543 ± 0.081	5.342GlyLys: 5.342 ± 0.08	5.177GlyLeu: 5.177 ± 0.082	1.7GlyMet: 1.7 ± 0.037	3.26GlyAsn: 3.26 ± 0.068	1.384GlyPro: 1.384 ± 0.098	1.434GlyGln: 1.434 ± 0.038	2.16GlyArg: 2.16 ± 0.046	3.558GlySer: 3.558 ± 0.06	3.329GlyThr: 3.329 ± 0.059	4.42GlyVal: 4.42 ± 0.063	0.46GlyTrp: 0.46 ± 0.021	2.94GlyTyr: 2.94 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	0.663HisAla: 0.663 ± 0.022	0.233HisCys: 0.233 ± 0.014	0.751HisAsp: 0.751 ± 0.027	0.922HisGlu: 0.922 ± 0.027	0.669HisPhe: 0.669 ± 0.025	1.003HisGly: 1.003 ± 0.03	0.309HisHis: 0.309 ± 0.015	1.579HisIle: 1.579 ± 0.039	1.105HisLys: 1.105 ± 0.03	1.206HisLeu: 1.206 ± 0.033	0.41HisMet: 0.41 ± 0.019	0.929HisAsn: 0.929 ± 0.026	0.573HisPro: 0.573 ± 0.023	0.332HisGln: 0.332 ± 0.018	0.573HisArg: 0.573 ± 0.021	0.916HisSer: 0.916 ± 0.029	0.661HisThr: 0.661 ± 0.022	0.744HisVal: 0.744 ± 0.025	0.113HisTrp: 0.113 ± 0.009	0.645HisTyr: 0.645 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.885IleAla: 5.885 ± 0.076	1.284IleCys: 1.284 ± 0.029	5.963IleAsp: 5.963 ± 0.078	7.845IleGlu: 7.845 ± 0.089	4.439IlePhe: 4.439 ± 0.078	6.182IleGly: 6.182 ± 0.072	1.338IleHis: 1.338 ± 0.03	9.864IleIle: 9.864 ± 0.118	9.176IleLys: 9.176 ± 0.097	9.581IleLeu: 9.581 ± 0.112	2.379IleMet: 2.379 ± 0.046	6.601IleAsn: 6.601 ± 0.077	3.326IlePro: 3.326 ± 0.057	2.163IleGln: 2.163 ± 0.038	3.088IleArg: 3.088 ± 0.052	7.158IleSer: 7.158 ± 0.08	5.092IleThr: 5.092 ± 0.074	6.281IleVal: 6.281 ± 0.085	0.574IleTrp: 0.574 ± 0.026	3.809IleTyr: 3.809 ± 0.061	0.0IleXaa: 0.0 ± 0.0
Lys	4.851LysAla: 4.851 ± 0.075	0.908LysCys: 0.908 ± 0.032	5.951LysAsp: 5.951 ± 0.083	9.175LysGlu: 9.175 ± 0.1	3.393LysPhe: 3.393 ± 0.057	4.91LysGly: 4.91 ± 0.067	1.194LysHis: 1.194 ± 0.03	8.534LysIle: 8.534 ± 0.087	7.928LysLys: 7.928 ± 0.096	7.798LysLeu: 7.798 ± 0.082	2.33LysMet: 2.33 ± 0.046	6.812LysAsn: 6.812 ± 0.078	2.096LysPro: 2.096 ± 0.043	2.049LysGln: 2.049 ± 0.043	2.965LysArg: 2.965 ± 0.049	5.358LysSer: 5.358 ± 0.069	4.003LysThr: 4.003 ± 0.058	5.647LysVal: 5.647 ± 0.074	0.588LysTrp: 0.588 ± 0.024	4.147LysTyr: 4.147 ± 0.068	0.0LysXaa: 0.0 ± 0.0
Leu	4.958LeuAla: 4.958 ± 0.073	1.191LeuCys: 1.191 ± 0.03	4.972LeuAsp: 4.972 ± 0.065	6.614LeuGlu: 6.614 ± 0.08	3.753LeuPhe: 3.753 ± 0.074	5.958LeuGly: 5.958 ± 0.079	1.156LeuHis: 1.156 ± 0.034	8.586LeuIle: 8.586 ± 0.107	8.606LeuLys: 8.606 ± 0.088	8.194LeuLeu: 8.194 ± 0.124	2.373LeuMet: 2.373 ± 0.053	6.114LeuAsn: 6.114 ± 0.073	2.845LeuPro: 2.845 ± 0.053	2.272LeuGln: 2.272 ± 0.043	3.161LeuArg: 3.161 ± 0.048	6.89LeuSer: 6.89 ± 0.084	4.5LeuThr: 4.5 ± 0.063	4.978LeuVal: 4.978 ± 0.071	0.591LeuTrp: 0.591 ± 0.023	3.454LeuTyr: 3.454 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	1.647MetAla: 1.647 ± 0.038	0.253MetCys: 0.253 ± 0.015	1.544MetAsp: 1.544 ± 0.031	2.06MetGlu: 2.06 ± 0.039	0.987MetPhe: 0.987 ± 0.028	1.722MetGly: 1.722 ± 0.042	0.352MetHis: 0.352 ± 0.013	2.396MetIle: 2.396 ± 0.045	2.636MetLys: 2.636 ± 0.049	2.317MetLeu: 2.317 ± 0.046	0.704MetMet: 0.704 ± 0.027	1.72MetAsn: 1.72 ± 0.04	0.878MetPro: 0.878 ± 0.029	0.606MetGln: 0.606 ± 0.021	0.917MetArg: 0.917 ± 0.027	1.679MetSer: 1.679 ± 0.036	1.197MetThr: 1.197 ± 0.033	1.574MetVal: 1.574 ± 0.032	0.156MetTrp: 0.156 ± 0.011	0.921MetTyr: 0.921 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.849AsnAla: 2.849 ± 0.054	0.795AsnCys: 0.795 ± 0.028	3.047AsnAsp: 3.047 ± 0.096	4.593AsnGlu: 4.593 ± 0.065	2.894AsnPhe: 2.894 ± 0.05	3.672AsnGly: 3.672 ± 0.059	0.947AsnHis: 0.947 ± 0.026	7.542AsnIle: 7.542 ± 0.097	6.426AsnLys: 6.426 ± 0.079	5.93AsnLeu: 5.93 ± 0.077	1.738AsnMet: 1.738 ± 0.035	4.75AsnAsn: 4.75 ± 0.083	2.123AsnPro: 2.123 ± 0.048	1.362AsnGln: 1.362 ± 0.032	2.06AsnArg: 2.06 ± 0.036	4.22AsnSer: 4.22 ± 0.064	3.009AsnThr: 3.009 ± 0.06	3.572AsnVal: 3.572 ± 0.06	0.431AsnTrp: 0.431 ± 0.018	2.923AsnTyr: 2.923 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	1.381ProAla: 1.381 ± 0.038	0.336ProCys: 0.336 ± 0.018	1.315ProAsp: 1.315 ± 0.038	2.218ProGlu: 2.218 ± 0.046	1.351ProPhe: 1.351 ± 0.032	1.593ProGly: 1.593 ± 0.043	0.503ProHis: 0.503 ± 0.021	2.94ProIle: 2.94 ± 0.052	2.287ProLys: 2.287 ± 0.043	2.495ProLeu: 2.495 ± 0.048	0.742ProMet: 0.742 ± 0.026	1.651ProAsn: 1.651 ± 0.043	0.619ProPro: 0.619 ± 0.026	0.841ProGln: 0.841 ± 0.039	0.805ProArg: 0.805 ± 0.025	1.808ProSer: 1.808 ± 0.041	1.551ProThr: 1.551 ± 0.067	1.94ProVal: 1.94 ± 0.045	0.242ProTrp: 0.242 ± 0.015	1.308ProTyr: 1.308 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	1.195GlnAla: 1.195 ± 0.029	0.339GlnCys: 0.339 ± 0.014	1.147GlnAsp: 1.147 ± 0.038	1.588GlnGlu: 1.588 ± 0.034	0.962GlnPhe: 0.962 ± 0.03	1.542GlnGly: 1.542 ± 0.047	0.331GlnHis: 0.331 ± 0.016	2.189GlnIle: 2.189 ± 0.046	1.839GlnLys: 1.839 ± 0.037	2.198GlnLeu: 2.198 ± 0.044	0.64GlnMet: 0.64 ± 0.022	1.394GlnAsn: 1.394 ± 0.033	0.522GlnPro: 0.522 ± 0.023	0.636GlnGln: 0.636 ± 0.025	0.945GlnArg: 0.945 ± 0.029	1.34GlnSer: 1.34 ± 0.033	0.927GlnThr: 0.927 ± 0.029	1.362GlnVal: 1.362 ± 0.038	0.257GlnTrp: 0.257 ± 0.015	1.073GlnTyr: 1.073 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	1.848ArgAla: 1.848 ± 0.037	0.386ArgCys: 0.386 ± 0.02	1.826ArgAsp: 1.826 ± 0.039	2.989ArgGlu: 2.989 ± 0.057	1.416ArgPhe: 1.416 ± 0.035	2.046ArgGly: 2.046 ± 0.041	0.487ArgHis: 0.487 ± 0.019	3.172ArgIle: 3.172 ± 0.049	3.112ArgLys: 3.112 ± 0.048	2.836ArgLeu: 2.836 ± 0.042	0.94ArgMet: 0.94 ± 0.029	2.054ArgAsn: 2.054 ± 0.043	0.855ArgPro: 0.855 ± 0.031	0.831ArgGln: 0.831 ± 0.029	1.409ArgArg: 1.409 ± 0.038	1.534ArgSer: 1.534 ± 0.037	1.595ArgThr: 1.595 ± 0.041	2.221ArgVal: 2.221 ± 0.047	0.227ArgTrp: 0.227 ± 0.016	1.463ArgTyr: 1.463 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	3.064SerAla: 3.064 ± 0.058	0.719SerCys: 0.719 ± 0.024	3.049SerAsp: 3.049 ± 0.055	4.349SerGlu: 4.349 ± 0.061	3.145SerPhe: 3.145 ± 0.06	4.105SerGly: 4.105 ± 0.062	1.012SerHis: 1.012 ± 0.024	6.824SerIle: 6.824 ± 0.079	5.975SerLys: 5.975 ± 0.073	6.21SerLeu: 6.21 ± 0.076	1.797SerMet: 1.797 ± 0.042	3.848SerAsn: 3.848 ± 0.062	1.83SerPro: 1.83 ± 0.041	1.555SerGln: 1.555 ± 0.034	2.019SerArg: 2.019 ± 0.044	4.39SerSer: 4.39 ± 0.071	3.164SerThr: 3.164 ± 0.048	3.453SerVal: 3.453 ± 0.05	0.416SerTrp: 0.416 ± 0.021	2.712SerTyr: 2.712 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	2.789ThrAla: 2.789 ± 0.05	0.48ThrCys: 0.48 ± 0.021	2.196ThrAsp: 2.196 ± 0.043	3.052ThrGlu: 3.052 ± 0.052	2.207ThrPhe: 2.207 ± 0.047	3.529ThrGly: 3.529 ± 0.101	0.74ThrHis: 0.74 ± 0.027	5.194ThrIle: 5.194 ± 0.062	3.559ThrLys: 3.559 ± 0.054	4.916ThrLeu: 4.916 ± 0.063	1.184ThrMet: 1.184 ± 0.034	2.725ThrAsn: 2.725 ± 0.059	1.815ThrPro: 1.815 ± 0.046	1.016ThrGln: 1.016 ± 0.03	1.452ThrArg: 1.452 ± 0.037	3.167ThrSer: 3.167 ± 0.055	2.688ThrThr: 2.688 ± 0.049	3.463ThrVal: 3.463 ± 0.062	0.32ThrTrp: 0.32 ± 0.017	1.895ThrTyr: 1.895 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	3.702ValAla: 3.702 ± 0.066	0.755ValCys: 0.755 ± 0.025	3.623ValAsp: 3.623 ± 0.061	4.608ValGlu: 4.608 ± 0.07	2.754ValPhe: 2.754 ± 0.05	3.956ValGly: 3.956 ± 0.06	0.869ValHis: 0.869 ± 0.028	6.162ValIle: 6.162 ± 0.08	5.252ValLys: 5.252 ± 0.077	5.72ValLeu: 5.72 ± 0.074	1.552ValMet: 1.552 ± 0.034	3.583ValAsn: 3.583 ± 0.051	1.835ValPro: 1.835 ± 0.046	1.334ValGln: 1.334 ± 0.038	1.924ValArg: 1.924 ± 0.04	4.136ValSer: 4.136 ± 0.063	3.16ValThr: 3.16 ± 0.054	4.341ValVal: 4.341 ± 0.07	0.38ValTrp: 0.38 ± 0.018	2.33ValTyr: 2.33 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.36TrpAla: 0.36 ± 0.021	0.105TrpCys: 0.105 ± 0.009	0.383TrpAsp: 0.383 ± 0.016	0.456TrpGlu: 0.456 ± 0.019	0.304TrpPhe: 0.304 ± 0.017	0.496TrpGly: 0.496 ± 0.022	0.126TrpHis: 0.126 ± 0.011	0.625TrpIle: 0.625 ± 0.021	0.503TrpLys: 0.503 ± 0.021	0.594TrpLeu: 0.594 ± 0.022	0.196TrpMet: 0.196 ± 0.014	0.426TrpAsn: 0.426 ± 0.024	0.155TrpPro: 0.155 ± 0.011	0.21TrpGln: 0.21 ± 0.013	0.261TrpArg: 0.261 ± 0.014	0.405TrpSer: 0.405 ± 0.021	0.299TrpThr: 0.299 ± 0.015	0.395TrpVal: 0.395 ± 0.02	0.076TrpTrp: 0.076 ± 0.008	0.29TrpTyr: 0.29 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.898TyrAla: 1.898 ± 0.041	0.559TyrCys: 0.559 ± 0.024	2.602TyrAsp: 2.602 ± 0.063	3.063TyrGlu: 3.063 ± 0.058	2.001TyrPhe: 2.001 ± 0.046	2.706TyrGly: 2.706 ± 0.045	0.609TyrHis: 0.609 ± 0.023	4.233TyrIle: 4.233 ± 0.073	3.871TyrLys: 3.871 ± 0.057	3.617TyrLeu: 3.617 ± 0.059	1.038TyrMet: 1.038 ± 0.03	3.018TyrAsn: 3.018 ± 0.057	1.234TyrPro: 1.234 ± 0.031	0.755TyrGln: 0.755 ± 0.025	1.496TyrArg: 1.496 ± 0.034	2.923TyrSer: 2.923 ± 0.052	2.039TyrThr: 2.039 ± 0.039	2.336TyrVal: 2.336 ± 0.045	0.31TyrTrp: 0.31 ± 0.018	1.89TyrTyr: 1.89 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4273 proteins (1242734 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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