Amino acid dipepetide frequency for Streptomyces incarnatus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.582AlaAla: 21.582 ± 0.146	1.158AlaCys: 1.158 ± 0.023	8.211AlaAsp: 8.211 ± 0.075	8.939AlaGlu: 8.939 ± 0.088	3.573AlaPhe: 3.573 ± 0.043	13.315AlaGly: 13.315 ± 0.092	3.128AlaHis: 3.128 ± 0.042	3.351AlaIle: 3.351 ± 0.046	2.796AlaLys: 2.796 ± 0.045	14.903AlaLeu: 14.903 ± 0.109	2.449AlaMet: 2.449 ± 0.032	1.875AlaAsn: 1.875 ± 0.027	7.11AlaPro: 7.11 ± 0.088	3.888AlaGln: 3.888 ± 0.044	10.739AlaArg: 10.739 ± 0.093	5.722AlaSer: 5.722 ± 0.053	6.94AlaThr: 6.94 ± 0.052	12.626AlaVal: 12.626 ± 0.093	1.879AlaTrp: 1.879 ± 0.027	2.842AlaTyr: 2.842 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.159CysAla: 1.159 ± 0.025	0.108CysCys: 0.108 ± 0.008	0.464CysAsp: 0.464 ± 0.013	0.393CysGlu: 0.393 ± 0.011	0.235CysPhe: 0.235 ± 0.011	0.975CysGly: 0.975 ± 0.02	0.202CysHis: 0.202 ± 0.009	0.161CysIle: 0.161 ± 0.008	0.119CysLys: 0.119 ± 0.008	0.821CysLeu: 0.821 ± 0.019	0.117CysMet: 0.117 ± 0.008	0.132CysAsn: 0.132 ± 0.008	0.506CysPro: 0.506 ± 0.016	0.168CysGln: 0.168 ± 0.008	0.608CysArg: 0.608 ± 0.018	0.443CysSer: 0.443 ± 0.014	0.542CysThr: 0.542 ± 0.016	0.692CysVal: 0.692 ± 0.017	0.133CysTrp: 0.133 ± 0.007	0.154CysTyr: 0.154 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.458AspAla: 7.458 ± 0.066	0.43AspCys: 0.43 ± 0.014	3.355AspAsp: 3.355 ± 0.046	3.586AspGlu: 3.586 ± 0.045	1.669AspPhe: 1.669 ± 0.023	6.098AspGly: 6.098 ± 0.055	1.473AspHis: 1.473 ± 0.03	1.86AspIle: 1.86 ± 0.031	1.162AspLys: 1.162 ± 0.027	6.167AspLeu: 6.167 ± 0.053	0.797AspMet: 0.797 ± 0.018	0.924AspAsn: 0.924 ± 0.021	4.493AspPro: 4.493 ± 0.043	1.515AspGln: 1.515 ± 0.025	4.872AspArg: 4.872 ± 0.06	2.462AspSer: 2.462 ± 0.034	3.238AspThr: 3.238 ± 0.04	4.605AspVal: 4.605 ± 0.046	1.048AspTrp: 1.048 ± 0.022	1.101AspTyr: 1.101 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	7.307GluAla: 7.307 ± 0.078	0.362GluCys: 0.362 ± 0.013	2.726GluAsp: 2.726 ± 0.038	3.65GluGlu: 3.65 ± 0.054	1.43GluPhe: 1.43 ± 0.025	4.201GluGly: 4.201 ± 0.045	1.543GluHis: 1.543 ± 0.027	2.164GluIle: 2.164 ± 0.04	1.359GluLys: 1.359 ± 0.028	6.749GluLeu: 6.749 ± 0.069	0.822GluMet: 0.822 ± 0.019	0.932GluAsn: 0.932 ± 0.02	3.386GluPro: 3.386 ± 0.047	2.194GluGln: 2.194 ± 0.032	5.505GluArg: 5.505 ± 0.064	2.39GluSer: 2.39 ± 0.03	2.823GluThr: 2.823 ± 0.036	4.493GluVal: 4.493 ± 0.051	0.736GluTrp: 0.736 ± 0.02	1.076GluTyr: 1.076 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.748PheAla: 3.748 ± 0.042	0.286PheCys: 0.286 ± 0.012	1.89PheAsp: 1.89 ± 0.028	1.399PheGlu: 1.399 ± 0.027	0.917PhePhe: 0.917 ± 0.023	3.042PheGly: 3.042 ± 0.038	0.658PheHis: 0.658 ± 0.016	0.677PheIle: 0.677 ± 0.017	0.511PheLys: 0.511 ± 0.017	2.691PheLeu: 2.691 ± 0.045	0.412PheMet: 0.412 ± 0.013	0.561PheAsn: 0.561 ± 0.017	1.432PhePro: 1.432 ± 0.023	0.716PheGln: 0.716 ± 0.016	1.886PheArg: 1.886 ± 0.03	1.464PheSer: 1.464 ± 0.028	2.018PheThr: 2.018 ± 0.032	2.217PheVal: 2.217 ± 0.032	0.429PheTrp: 0.429 ± 0.016	0.578PheTyr: 0.578 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	11.205GlyAla: 11.205 ± 0.084	0.851GlyCys: 0.851 ± 0.018	4.968GlyAsp: 4.968 ± 0.05	4.994GlyGlu: 4.994 ± 0.052	2.932GlyPhe: 2.932 ± 0.039	8.794GlyGly: 8.794 ± 0.091	2.532GlyHis: 2.532 ± 0.035	3.47GlyIle: 3.47 ± 0.043	2.354GlyLys: 2.354 ± 0.038	9.631GlyLeu: 9.631 ± 0.084	1.979GlyMet: 1.979 ± 0.029	1.704GlyAsn: 1.704 ± 0.034	5.218GlyPro: 5.218 ± 0.058	2.685GlyGln: 2.685 ± 0.034	7.934GlyArg: 7.934 ± 0.061	5.251GlySer: 5.251 ± 0.053	6.599GlyThr: 6.599 ± 0.071	7.605GlyVal: 7.605 ± 0.058	1.731GlyTrp: 1.731 ± 0.034	2.349GlyTyr: 2.349 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.911HisAla: 2.911 ± 0.04	0.214HisCys: 0.214 ± 0.009	1.355HisAsp: 1.355 ± 0.025	1.275HisGlu: 1.275 ± 0.023	0.676HisPhe: 0.676 ± 0.017	2.61HisGly: 2.61 ± 0.035	0.725HisHis: 0.725 ± 0.021	0.708HisIle: 0.708 ± 0.016	0.397HisLys: 0.397 ± 0.012	2.557HisLeu: 2.557 ± 0.033	0.341HisMet: 0.341 ± 0.012	0.372HisAsn: 0.372 ± 0.013	1.96HisPro: 1.96 ± 0.031	0.659HisGln: 0.659 ± 0.016	2.202HisArg: 2.202 ± 0.035	1.031HisSer: 1.031 ± 0.021	1.443HisThr: 1.443 ± 0.025	1.784HisVal: 1.784 ± 0.026	0.397HisTrp: 0.397 ± 0.012	0.507HisTyr: 0.507 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.73IleAla: 4.73 ± 0.055	0.283IleCys: 0.283 ± 0.011	2.143IleAsp: 2.143 ± 0.035	1.903IleGlu: 1.903 ± 0.03	0.664IlePhe: 0.664 ± 0.018	3.543IleGly: 3.543 ± 0.051	0.62IleHis: 0.62 ± 0.016	0.859IleIle: 0.859 ± 0.02	0.71IleLys: 0.71 ± 0.018	2.402IleLeu: 2.402 ± 0.037	0.429IleMet: 0.429 ± 0.014	0.675IleAsn: 0.675 ± 0.02	1.772IlePro: 1.772 ± 0.03	0.749IleGln: 0.749 ± 0.021	2.292IleArg: 2.292 ± 0.034	1.584IleSer: 1.584 ± 0.029	2.173IleThr: 2.173 ± 0.032	2.64IleVal: 2.64 ± 0.04	0.381IleTrp: 0.381 ± 0.013	0.507IleTyr: 0.507 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.988LysAla: 2.988 ± 0.042	0.117LysCys: 0.117 ± 0.008	1.359LysAsp: 1.359 ± 0.029	1.164LysGlu: 1.164 ± 0.026	0.454LysPhe: 0.454 ± 0.015	1.841LysGly: 1.841 ± 0.037	0.421LysHis: 0.421 ± 0.015	0.837LysIle: 0.837 ± 0.022	0.843LysLys: 0.843 ± 0.027	1.963LysLeu: 1.963 ± 0.035	0.372LysMet: 0.372 ± 0.016	0.518LysAsn: 0.518 ± 0.017	1.308LysPro: 1.308 ± 0.026	0.719LysGln: 0.719 ± 0.02	1.4LysArg: 1.4 ± 0.026	1.06LysSer: 1.06 ± 0.025	1.213LysThr: 1.213 ± 0.027	1.899LysVal: 1.899 ± 0.03	0.259LysTrp: 0.259 ± 0.012	0.458LysTyr: 0.458 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.49LeuAla: 15.49 ± 0.113	0.879LeuCys: 0.879 ± 0.022	6.73LeuAsp: 6.73 ± 0.063	4.632LeuGlu: 4.632 ± 0.05	2.673LeuPhe: 2.673 ± 0.036	9.493LeuGly: 9.493 ± 0.078	2.441LeuHis: 2.441 ± 0.035	3.288LeuIle: 3.288 ± 0.044	2.11LeuLys: 2.11 ± 0.038	11.728LeuLeu: 11.728 ± 0.111	1.616LeuMet: 1.616 ± 0.027	1.694LeuAsn: 1.694 ± 0.026	6.65LeuPro: 6.65 ± 0.056	2.339LeuGln: 2.339 ± 0.032	8.81LeuArg: 8.81 ± 0.073	5.238LeuSer: 5.238 ± 0.051	7.101LeuThr: 7.101 ± 0.063	8.934LeuVal: 8.934 ± 0.077	1.363LeuTrp: 1.363 ± 0.028	1.974LeuTyr: 1.974 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.245MetAla: 2.245 ± 0.033	0.139MetCys: 0.139 ± 0.008	0.868MetAsp: 0.868 ± 0.019	0.724MetGlu: 0.724 ± 0.017	0.467MetPhe: 0.467 ± 0.017	1.277MetGly: 1.277 ± 0.027	0.367MetHis: 0.367 ± 0.012	0.639MetIle: 0.639 ± 0.018	0.404MetLys: 0.404 ± 0.013	1.614MetLeu: 1.614 ± 0.027	0.283MetMet: 0.283 ± 0.012	0.42MetAsn: 0.42 ± 0.014	1.119MetPro: 1.119 ± 0.022	0.435MetGln: 0.435 ± 0.015	1.389MetArg: 1.389 ± 0.026	1.276MetSer: 1.276 ± 0.021	1.535MetThr: 1.535 ± 0.028	1.202MetVal: 1.202 ± 0.025	0.213MetTrp: 0.213 ± 0.01	0.319MetTyr: 0.319 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.18AsnAla: 2.18 ± 0.033	0.168AsnCys: 0.168 ± 0.01	0.934AsnAsp: 0.934 ± 0.022	0.742AsnGlu: 0.742 ± 0.019	0.484AsnPhe: 0.484 ± 0.014	1.826AsnGly: 1.826 ± 0.034	0.413AsnHis: 0.413 ± 0.015	0.605AsnIle: 0.605 ± 0.019	0.4AsnLys: 0.4 ± 0.014	1.662AsnLeu: 1.662 ± 0.031	0.289AsnMet: 0.289 ± 0.012	0.407AsnAsn: 0.407 ± 0.015	1.344AsnPro: 1.344 ± 0.027	0.532AsnGln: 0.532 ± 0.016	1.21AsnArg: 1.21 ± 0.02	0.904AsnSer: 0.904 ± 0.022	1.074AsnThr: 1.074 ± 0.024	1.352AsnVal: 1.352 ± 0.026	0.277AsnTrp: 0.277 ± 0.011	0.386AsnTyr: 0.386 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.881ProAla: 8.881 ± 0.082	0.354ProCys: 0.354 ± 0.015	4.356ProAsp: 4.356 ± 0.051	4.385ProGlu: 4.385 ± 0.054	1.55ProPhe: 1.55 ± 0.028	6.817ProGly: 6.817 ± 0.067	1.519ProHis: 1.519 ± 0.027	1.201ProIle: 1.201 ± 0.023	1.185ProLys: 1.185 ± 0.029	5.507ProLeu: 5.507 ± 0.054	0.979ProMet: 0.979 ± 0.02	0.88ProAsn: 0.88 ± 0.021	3.467ProPro: 3.467 ± 0.057	1.797ProGln: 1.797 ± 0.043	4.054ProArg: 4.054 ± 0.046	3.054ProSer: 3.054 ± 0.038	3.067ProThr: 3.067 ± 0.043	5.564ProVal: 5.564 ± 0.049	0.914ProTrp: 0.914 ± 0.022	1.543ProTyr: 1.543 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.899GlnAla: 3.899 ± 0.046	0.181GlnCys: 0.181 ± 0.008	1.413GlnAsp: 1.413 ± 0.029	1.456GlnGlu: 1.456 ± 0.023	0.68GlnPhe: 0.68 ± 0.017	2.377GlnGly: 2.377 ± 0.032	0.672GlnHis: 0.672 ± 0.018	1.072GlnIle: 1.072 ± 0.024	0.65GlnLys: 0.65 ± 0.02	3.137GlnLeu: 3.137 ± 0.04	0.48GlnMet: 0.48 ± 0.014	0.514GlnAsn: 0.514 ± 0.017	1.764GlnPro: 1.764 ± 0.047	1.268GlnGln: 1.268 ± 0.038	2.387GlnArg: 2.387 ± 0.035	1.275GlnSer: 1.275 ± 0.021	1.353GlnThr: 1.353 ± 0.026	2.424GlnVal: 2.424 ± 0.031	0.483GlnTrp: 0.483 ± 0.016	0.628GlnTyr: 0.628 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.272ArgAla: 10.272 ± 0.087	0.617ArgCys: 0.617 ± 0.017	4.169ArgAsp: 4.169 ± 0.049	4.805ArgGlu: 4.805 ± 0.063	2.354ArgPhe: 2.354 ± 0.036	5.74ArgGly: 5.74 ± 0.062	2.265ArgHis: 2.265 ± 0.034	3.288ArgIle: 3.288 ± 0.044	1.575ArgLys: 1.575 ± 0.031	9.25ArgLeu: 9.25 ± 0.09	1.734ArgMet: 1.734 ± 0.028	1.299ArgAsn: 1.299 ± 0.024	5.061ArgPro: 5.061 ± 0.054	2.362ArgGln: 2.362 ± 0.034	7.937ArgArg: 7.937 ± 0.076	3.926ArgSer: 3.926 ± 0.041	5.468ArgThr: 5.468 ± 0.057	5.911ArgVal: 5.911 ± 0.06	1.365ArgTrp: 1.365 ± 0.025	1.851ArgTyr: 1.851 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	6.693SerAla: 6.693 ± 0.059	0.402SerCys: 0.402 ± 0.013	2.512SerAsp: 2.512 ± 0.036	2.162SerGlu: 2.162 ± 0.03	1.483SerPhe: 1.483 ± 0.024	6.002SerGly: 6.002 ± 0.07	1.002SerHis: 1.002 ± 0.021	1.325SerIle: 1.325 ± 0.025	0.967SerLys: 0.967 ± 0.024	4.837SerLeu: 4.837 ± 0.044	1.039SerMet: 1.039 ± 0.021	0.837SerAsn: 0.837 ± 0.019	3.07SerPro: 3.07 ± 0.037	1.203SerGln: 1.203 ± 0.025	3.524SerArg: 3.524 ± 0.042	2.765SerSer: 2.765 ± 0.045	2.949SerThr: 2.949 ± 0.045	4.213SerVal: 4.213 ± 0.04	0.889SerTrp: 0.889 ± 0.02	1.262SerTyr: 1.262 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	9.069ThrAla: 9.069 ± 0.071	0.468ThrCys: 0.468 ± 0.015	3.649ThrAsp: 3.649 ± 0.044	3.208ThrGlu: 3.208 ± 0.041	1.612ThrPhe: 1.612 ± 0.031	6.932ThrGly: 6.932 ± 0.059	1.263ThrHis: 1.263 ± 0.027	1.657ThrIle: 1.657 ± 0.03	1.156ThrLys: 1.156 ± 0.027	5.82ThrLeu: 5.82 ± 0.053	0.89ThrMet: 0.89 ± 0.018	0.985ThrAsn: 0.985 ± 0.024	4.124ThrPro: 4.124 ± 0.048	1.385ThrGln: 1.385 ± 0.024	3.913ThrArg: 3.913 ± 0.047	3.084ThrSer: 3.084 ± 0.042	3.802ThrThr: 3.802 ± 0.052	6.09ThrVal: 6.09 ± 0.051	0.937ThrTrp: 0.937 ± 0.021	1.361ThrTyr: 1.361 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	10.64ValAla: 10.64 ± 0.085	0.79ValCys: 0.79 ± 0.021	4.75ValAsp: 4.75 ± 0.049	4.474ValGlu: 4.474 ± 0.051	2.507ValPhe: 2.507 ± 0.039	6.394ValGly: 6.394 ± 0.053	2.074ValHis: 2.074 ± 0.029	2.84ValIle: 2.84 ± 0.041	1.721ValLys: 1.721 ± 0.029	9.769ValLeu: 9.769 ± 0.072	1.384ValMet: 1.384 ± 0.026	1.675ValAsn: 1.675 ± 0.031	5.404ValPro: 5.404 ± 0.047	2.223ValGln: 2.223 ± 0.029	7.385ValArg: 7.385 ± 0.06	4.315ValSer: 4.315 ± 0.037	5.796ValThr: 5.796 ± 0.051	7.974ValVal: 7.974 ± 0.067	1.17ValTrp: 1.17 ± 0.021	1.662ValTyr: 1.662 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.699TrpAla: 1.699 ± 0.031	0.156TrpCys: 0.156 ± 0.008	0.805TrpAsp: 0.805 ± 0.02	0.708TrpGlu: 0.708 ± 0.02	0.506TrpPhe: 0.506 ± 0.017	1.074TrpGly: 1.074 ± 0.022	0.398TrpHis: 0.398 ± 0.015	0.577TrpIle: 0.577 ± 0.015	0.364TrpLys: 0.364 ± 0.012	1.827TrpLeu: 1.827 ± 0.028	0.27TrpMet: 0.27 ± 0.011	0.38TrpAsn: 0.38 ± 0.012	0.79TrpPro: 0.79 ± 0.015	0.651TrpGln: 0.651 ± 0.018	1.364TrpArg: 1.364 ± 0.025	0.944TrpSer: 0.944 ± 0.023	1.039TrpThr: 1.039 ± 0.021	1.006TrpVal: 1.006 ± 0.022	0.347TrpTrp: 0.347 ± 0.015	0.408TrpTyr: 0.408 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.868TyrAla: 2.868 ± 0.033	0.172TyrCys: 0.172 ± 0.009	1.655TyrAsp: 1.655 ± 0.03	1.247TyrGlu: 1.247 ± 0.023	0.666TyrPhe: 0.666 ± 0.015	2.437TyrGly: 2.437 ± 0.038	0.407TyrHis: 0.407 ± 0.014	0.48TyrIle: 0.48 ± 0.015	0.41TyrLys: 0.41 ± 0.015	2.149TyrLeu: 2.149 ± 0.028	0.255TyrMet: 0.255 ± 0.012	0.405TyrAsn: 0.405 ± 0.015	1.098TyrPro: 1.098 ± 0.025	0.625TyrGln: 0.625 ± 0.019	1.838TyrArg: 1.838 ± 0.029	0.945TyrSer: 0.945 ± 0.02	1.232TyrThr: 1.232 ± 0.025	1.716TyrVal: 1.716 ± 0.029	0.361TyrTrp: 0.361 ± 0.013	0.47TyrTyr: 0.47 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7427 proteins (2392873 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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