Amino acid dipepetide frequency for Lausannevirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.431AlaAla: 3.431 ± 0.227
1.156AlaCys: 1.156 ± 0.1
2.218AlaAsp: 2.218 ± 0.14
3.835AlaGlu: 3.835 ± 0.189
2.688AlaPhe: 2.688 ± 0.151
2.322AlaGly: 2.322 ± 0.162
0.874AlaHis: 0.874 ± 0.098
2.745AlaIle: 2.745 ± 0.196
4.643AlaLys: 4.643 ± 0.218
5.273AlaLeu: 5.273 ± 0.247
1.128AlaMet: 1.128 ± 0.106
2.021AlaAsn: 2.021 ± 0.136
2.049AlaPro: 2.049 ± 0.155
1.664AlaGln: 1.664 ± 0.129
2.698AlaArg: 2.698 ± 0.177
4.436AlaSer: 4.436 ± 0.228
3.299AlaThr: 3.299 ± 0.242
3.656AlaVal: 3.656 ± 0.19
0.545AlaTrp: 0.545 ± 0.078
1.579AlaTyr: 1.579 ± 0.13
0.0AlaXaa: 0.0 ± 0.0
Cys
1.316CysAla: 1.316 ± 0.141
0.714CysCys: 0.714 ± 0.082
1.353CysAsp: 1.353 ± 0.136
1.72CysGlu: 1.72 ± 0.136
1.494CysPhe: 1.494 ± 0.113
1.927CysGly: 1.927 ± 0.145
0.461CysHis: 0.461 ± 0.061
1.1CysIle: 1.1 ± 0.1
1.635CysLys: 1.635 ± 0.12
2.087CysLeu: 2.087 ± 0.15
0.395CysMet: 0.395 ± 0.065
0.855CysAsn: 0.855 ± 0.099
1.306CysPro: 1.306 ± 0.123
0.78CysGln: 0.78 ± 0.098
1.118CysArg: 1.118 ± 0.093
1.993CysSer: 1.993 ± 0.166
1.006CysThr: 1.006 ± 0.107
1.523CysVal: 1.523 ± 0.125
0.385CysTrp: 0.385 ± 0.065
0.808CysTyr: 0.808 ± 0.092
0.0CysXaa: 0.0 ± 0.0
Asp
2.735AspAla: 2.735 ± 0.156
1.156AspCys: 1.156 ± 0.115
2.594AspAsp: 2.594 ± 0.175
4.079AspGlu: 4.079 ± 0.237
2.979AspPhe: 2.979 ± 0.146
4.183AspGly: 4.183 ± 0.209
0.639AspHis: 0.639 ± 0.064
3.647AspIle: 3.647 ± 0.192
3.581AspLys: 3.581 ± 0.213
3.525AspLeu: 3.525 ± 0.207
0.959AspMet: 0.959 ± 0.096
1.946AspAsn: 1.946 ± 0.164
2.04AspPro: 2.04 ± 0.165
1.156AspGln: 1.156 ± 0.11
2.077AspArg: 2.077 ± 0.155
3.44AspSer: 3.44 ± 0.191
2.209AspThr: 2.209 ± 0.149
3.656AspVal: 3.656 ± 0.159
0.761AspTrp: 0.761 ± 0.09
1.551AspTyr: 1.551 ± 0.12
0.0AspXaa: 0.0 ± 0.0
Glu
3.948GluAla: 3.948 ± 0.221
1.541GluCys: 1.541 ± 0.137
4.239GluAsp: 4.239 ± 0.237
9.126GluGlu: 9.126 ± 0.557
4.643GluPhe: 4.643 ± 0.202
4.258GluGly: 4.258 ± 0.201
1.56GluHis: 1.56 ± 0.135
4.173GluIle: 4.173 ± 0.182
9.267GluLys: 9.267 ± 0.415
6.326GluLeu: 6.326 ± 0.287
2.199GluMet: 2.199 ± 0.151
4.07GluAsn: 4.07 ± 0.211
1.964GluPro: 1.964 ± 0.131
2.867GluGln: 2.867 ± 0.194
5.31GluArg: 5.31 ± 0.272
4.07GluSer: 4.07 ± 0.2
4.972GluThr: 4.972 ± 0.244
4.136GluVal: 4.136 ± 0.198
1.212GluTrp: 1.212 ± 0.098
2.773GluTyr: 2.773 ± 0.148
0.0GluXaa: 0.0 ± 0.0
Phe
3.346PheAla: 3.346 ± 0.189
1.899PheCys: 1.899 ± 0.142
2.932PheAsp: 2.932 ± 0.163
4.502PheGlu: 4.502 ± 0.214
3.036PhePhe: 3.036 ± 0.175
4.051PheGly: 4.051 ± 0.249
0.949PheHis: 0.949 ± 0.085
2.115PheIle: 2.115 ± 0.146
2.068PheLys: 2.068 ± 0.132
6.156PheLeu: 6.156 ± 0.308
1.288PheMet: 1.288 ± 0.129
1.128PheAsn: 1.128 ± 0.112
2.284PhePro: 2.284 ± 0.145
1.852PheGln: 1.852 ± 0.143
2.876PheArg: 2.876 ± 0.197
5.019PheSer: 5.019 ± 0.276
2.04PheThr: 2.04 ± 0.151
4.859PheVal: 4.859 ± 0.213
1.137PheTrp: 1.137 ± 0.103
1.805PheTyr: 1.805 ± 0.116
0.0PheXaa: 0.0 ± 0.0
Gly
3.149GlyAla: 3.149 ± 0.223
1.391GlyCys: 1.391 ± 0.126
2.66GlyAsp: 2.66 ± 0.168
4.615GlyGlu: 4.615 ± 0.222
2.679GlyPhe: 2.679 ± 0.174
3.224GlyGly: 3.224 ± 0.252
0.959GlyHis: 0.959 ± 0.089
3.929GlyIle: 3.929 ± 0.178
6.955GlyLys: 6.955 ± 0.322
4.239GlyLeu: 4.239 ± 0.221
1.391GlyMet: 1.391 ± 0.119
2.763GlyAsn: 2.763 ± 0.171
1.494GlyPro: 1.494 ± 0.142
2.237GlyGln: 2.237 ± 0.217
3.374GlyArg: 3.374 ± 0.185
4.399GlySer: 4.399 ± 0.252
4.718GlyThr: 4.718 ± 0.28
4.042GlyVal: 4.042 ± 0.223
0.837GlyTrp: 0.837 ± 0.091
2.434GlyTyr: 2.434 ± 0.146
0.0GlyXaa: 0.0 ± 0.0
His
0.639HisAla: 0.639 ± 0.069
0.442HisCys: 0.442 ± 0.067
0.517HisAsp: 0.517 ± 0.073
1.231HisGlu: 1.231 ± 0.112
0.968HisPhe: 0.968 ± 0.098
1.889HisGly: 1.889 ± 0.191
0.282HisHis: 0.282 ± 0.053
1.203HisIle: 1.203 ± 0.114
1.41HisLys: 1.41 ± 0.13
1.476HisLeu: 1.476 ± 0.118
0.31HisMet: 0.31 ± 0.052
0.658HisAsn: 0.658 ± 0.076
0.799HisPro: 0.799 ± 0.086
0.677HisGln: 0.677 ± 0.089
1.081HisArg: 1.081 ± 0.112
1.391HisSer: 1.391 ± 0.115
0.837HisThr: 0.837 ± 0.082
0.865HisVal: 0.865 ± 0.079
0.254HisTrp: 0.254 ± 0.053
0.489HisTyr: 0.489 ± 0.074
0.0HisXaa: 0.0 ± 0.0
Ile
3.167IleAla: 3.167 ± 0.192
1.306IleCys: 1.306 ± 0.114
2.35IleAsp: 2.35 ± 0.144
2.904IleGlu: 2.904 ± 0.178
3.158IlePhe: 3.158 ± 0.175
3.111IleGly: 3.111 ± 0.226
0.959IleHis: 0.959 ± 0.092
2.622IleIle: 2.622 ± 0.176
3.525IleLys: 3.525 ± 0.195
5.47IleLeu: 5.47 ± 0.25
1.043IleMet: 1.043 ± 0.112
1.513IleAsn: 1.513 ± 0.133
2.773IlePro: 2.773 ± 0.165
1.983IleGln: 1.983 ± 0.158
2.829IleArg: 2.829 ± 0.169
4.822IleSer: 4.822 ± 0.22
2.077IleThr: 2.077 ± 0.151
3.703IleVal: 3.703 ± 0.195
0.874IleTrp: 0.874 ± 0.09
1.429IleTyr: 1.429 ± 0.111
0.0IleXaa: 0.0 ± 0.0
Lys
4.305LysAla: 4.305 ± 0.246
1.429LysCys: 1.429 ± 0.125
4.671LysAsp: 4.671 ± 0.189
9.126LysGlu: 9.126 ± 0.329
3.647LysPhe: 3.647 ± 0.191
4.436LysGly: 4.436 ± 0.214
1.786LysHis: 1.786 ± 0.158
4.493LysIle: 4.493 ± 0.205
11.41LysLys: 11.41 ± 0.696
6.307LysLeu: 6.307 ± 0.236
1.814LysMet: 1.814 ± 0.139
4.859LysAsn: 4.859 ± 0.272
2.011LysPro: 2.011 ± 0.198
2.369LysGln: 2.369 ± 0.155
5.583LysArg: 5.583 ± 0.253
4.549LysSer: 4.549 ± 0.253
5.376LysThr: 5.376 ± 0.278
4.934LysVal: 4.934 ± 0.238
0.893LysTrp: 0.893 ± 0.087
3.543LysTyr: 3.543 ± 0.199
0.0LysXaa: 0.0 ± 0.0
Leu
4.784LeuAla: 4.784 ± 0.233
2.707LeuCys: 2.707 ± 0.182
4.465LeuAsp: 4.465 ± 0.204
7.858LeuGlu: 7.858 ± 0.377
5.245LeuPhe: 5.245 ± 0.274
5.292LeuGly: 5.292 ± 0.258
1.466LeuHis: 1.466 ± 0.099
2.895LeuIle: 2.895 ± 0.182
5.903LeuLys: 5.903 ± 0.259
9.202LeuLeu: 9.202 ± 0.343
1.673LeuMet: 1.673 ± 0.145
2.679LeuAsn: 2.679 ± 0.184
4.69LeuPro: 4.69 ± 0.179
3.778LeuGln: 3.778 ± 0.337
4.662LeuArg: 4.662 ± 0.19
7.735LeuSer: 7.735 ± 0.292
3.158LeuThr: 3.158 ± 0.18
5.893LeuVal: 5.893 ± 0.219
1.673LeuTrp: 1.673 ± 0.135
2.604LeuTyr: 2.604 ± 0.141
0.0LeuXaa: 0.0 ± 0.0
Met
1.231MetAla: 1.231 ± 0.109
0.517MetCys: 0.517 ± 0.076
1.165MetAsp: 1.165 ± 0.112
1.87MetGlu: 1.87 ± 0.124
1.1MetPhe: 1.1 ± 0.101
1.288MetGly: 1.288 ± 0.106
0.461MetHis: 0.461 ± 0.063
0.846MetIle: 0.846 ± 0.081
1.532MetLys: 1.532 ± 0.128
1.457MetLeu: 1.457 ± 0.128
0.526MetMet: 0.526 ± 0.065
1.053MetAsn: 1.053 ± 0.091
0.573MetPro: 0.573 ± 0.075
1.071MetGln: 1.071 ± 0.107
1.043MetArg: 1.043 ± 0.085
2.058MetSer: 2.058 ± 0.123
1.382MetThr: 1.382 ± 0.117
1.043MetVal: 1.043 ± 0.106
0.179MetTrp: 0.179 ± 0.04
0.508MetTyr: 0.508 ± 0.062
0.0MetXaa: 0.0 ± 0.0
Asn
2.369AsnAla: 2.369 ± 0.164
0.837AsnCys: 0.837 ± 0.103
1.523AsnAsp: 1.523 ± 0.112
2.246AsnGlu: 2.246 ± 0.163
2.491AsnPhe: 2.491 ± 0.144
3.299AsnGly: 3.299 ± 0.183
0.658AsnHis: 0.658 ± 0.092
4.164AsnIle: 4.164 ± 0.207
3.308AsnLys: 3.308 ± 0.201
3.149AsnLeu: 3.149 ± 0.189
0.893AsnMet: 0.893 ± 0.103
1.692AsnAsn: 1.692 ± 0.158
2.087AsnPro: 2.087 ± 0.21
0.79AsnGln: 0.79 ± 0.078
1.523AsnArg: 1.523 ± 0.113
3.026AsnSer: 3.026 ± 0.177
2.284AsnThr: 2.284 ± 0.237
2.951AsnVal: 2.951 ± 0.19
0.489AsnTrp: 0.489 ± 0.056
1.353AsnTyr: 1.353 ± 0.1
0.0AsnXaa: 0.0 ± 0.0
Pro
1.41ProAla: 1.41 ± 0.135
0.733ProCys: 0.733 ± 0.106
1.993ProAsp: 1.993 ± 0.147
4.23ProGlu: 4.23 ± 0.198
2.152ProPhe: 2.152 ± 0.139
1.983ProGly: 1.983 ± 0.145
0.714ProHis: 0.714 ± 0.077
1.964ProIle: 1.964 ± 0.139
3.384ProLys: 3.384 ± 0.249
3.13ProLeu: 3.13 ± 0.175
0.686ProMet: 0.686 ± 0.08
1.899ProAsn: 1.899 ± 0.139
1.551ProPro: 1.551 ± 0.177
1.57ProGln: 1.57 ± 0.117
1.795ProArg: 1.795 ± 0.139
3.158ProSer: 3.158 ± 0.449
2.199ProThr: 2.199 ± 0.235
2.35ProVal: 2.35 ± 0.166
0.526ProTrp: 0.526 ± 0.069
1.288ProTyr: 1.288 ± 0.126
0.0ProXaa: 0.0 ± 0.0
Gln
1.57GlnAla: 1.57 ± 0.164
0.526GlnCys: 0.526 ± 0.089
1.617GlnAsp: 1.617 ± 0.131
3.299GlnGlu: 3.299 ± 0.175
0.949GlnPhe: 0.949 ± 0.08
2.002GlnGly: 2.002 ± 0.253
0.555GlnHis: 0.555 ± 0.071
1.729GlnIle: 1.729 ± 0.121
4.624GlnLys: 4.624 ± 0.213
2.246GlnLeu: 2.246 ± 0.132
1.081GlnMet: 1.081 ± 0.106
1.964GlnAsn: 1.964 ± 0.129
0.855GlnPro: 0.855 ± 0.089
1.476GlnGln: 1.476 ± 0.165
2.782GlnArg: 2.782 ± 0.166
1.645GlnSer: 1.645 ± 0.135
2.293GlnThr: 2.293 ± 0.208
2.416GlnVal: 2.416 ± 0.207
0.489GlnTrp: 0.489 ± 0.072
0.94GlnTyr: 0.94 ± 0.092
0.0GlnXaa: 0.0 ± 0.0
Arg
2.472ArgAla: 2.472 ± 0.176
1.034ArgCys: 1.034 ± 0.092
2.707ArgAsp: 2.707 ± 0.181
5.433ArgGlu: 5.433 ± 0.235
2.369ArgPhe: 2.369 ± 0.139
2.792ArgGly: 2.792 ± 0.176
1.269ArgHis: 1.269 ± 0.12
3.186ArgIle: 3.186 ± 0.156
5.461ArgLys: 5.461 ± 0.276
4.84ArgLeu: 4.84 ± 0.242
1.175ArgMet: 1.175 ± 0.111
2.707ArgAsn: 2.707 ± 0.16
1.626ArgPro: 1.626 ± 0.122
2.115ArgGln: 2.115 ± 0.165
2.867ArgArg: 2.867 ± 0.179
3.026ArgSer: 3.026 ± 0.183
2.923ArgThr: 2.923 ± 0.199
3.835ArgVal: 3.835 ± 0.175
0.649ArgTrp: 0.649 ± 0.066
1.72ArgTyr: 1.72 ± 0.117
0.0ArgXaa: 0.0 ± 0.0
Ser
3.722SerAla: 3.722 ± 0.218
2.162SerCys: 2.162 ± 0.14
3.59SerAsp: 3.59 ± 0.181
5.386SerGlu: 5.386 ± 0.258
5.226SerPhe: 5.226 ± 0.268
5.48SerGly: 5.48 ± 0.253
1.071SerHis: 1.071 ± 0.104
2.979SerIle: 2.979 ± 0.181
5.893SerLys: 5.893 ± 0.27
7.594SerLeu: 7.594 ± 0.284
1.306SerMet: 1.306 ± 0.101
2.698SerAsn: 2.698 ± 0.171
3.064SerPro: 3.064 ± 0.36
3.102SerGln: 3.102 ± 0.184
3.985SerArg: 3.985 ± 0.216
6.72SerSer: 6.72 ± 0.377
3.29SerThr: 3.29 ± 0.208
4.85SerVal: 4.85 ± 0.244
1.1SerTrp: 1.1 ± 0.101
2.011SerTyr: 2.011 ± 0.122
0.0SerXaa: 0.0 ± 0.0
Thr
2.66ThrAla: 2.66 ± 0.191
1.241ThrCys: 1.241 ± 0.103
2.209ThrAsp: 2.209 ± 0.162
3.44ThrGlu: 3.44 ± 0.191
2.923ThrPhe: 2.923 ± 0.165
3.402ThrGly: 3.402 ± 0.231
0.865ThrHis: 0.865 ± 0.083
2.481ThrIle: 2.481 ± 0.147
5.019ThrLys: 5.019 ± 0.23
5.357ThrLeu: 5.357 ± 0.344
0.865ThrMet: 0.865 ± 0.092
2.453ThrAsn: 2.453 ± 0.267
2.613ThrPro: 2.613 ± 0.314
1.795ThrGln: 1.795 ± 0.152
2.914ThrArg: 2.914 ± 0.19
3.694ThrSer: 3.694 ± 0.207
3.337ThrThr: 3.337 ± 0.281
3.083ThrVal: 3.083 ± 0.166
0.733ThrTrp: 0.733 ± 0.085
1.541ThrTyr: 1.541 ± 0.105
0.0ThrXaa: 0.0 ± 0.0
Val
3.684ValAla: 3.684 ± 0.247
1.823ValCys: 1.823 ± 0.155
3.271ValAsp: 3.271 ± 0.166
4.286ValGlu: 4.286 ± 0.273
4.474ValPhe: 4.474 ± 0.229
3.365ValGly: 3.365 ± 0.222
1.156ValHis: 1.156 ± 0.118
3.045ValIle: 3.045 ± 0.162
4.013ValLys: 4.013 ± 0.21
6.749ValLeu: 6.749 ± 0.261
1.175ValMet: 1.175 ± 0.094
2.03ValAsn: 2.03 ± 0.116
3.487ValPro: 3.487 ± 0.177
2.275ValGln: 2.275 ± 0.138
3.214ValArg: 3.214 ± 0.17
6.316ValSer: 6.316 ± 0.291
2.886ValThr: 2.886 ± 0.16
4.925ValVal: 4.925 ± 0.222
1.109ValTrp: 1.109 ± 0.109
2.312ValTyr: 2.312 ± 0.132
0.0ValXaa: 0.0 ± 0.0
Trp
0.555TrpAla: 0.555 ± 0.08
0.489TrpCys: 0.489 ± 0.074
0.837TrpAsp: 0.837 ± 0.098
1.006TrpGlu: 1.006 ± 0.1
1.071TrpPhe: 1.071 ± 0.103
0.573TrpGly: 0.573 ± 0.094
0.235TrpHis: 0.235 ± 0.042
0.686TrpIle: 0.686 ± 0.079
1.532TrpLys: 1.532 ± 0.149
1.241TrpLeu: 1.241 ± 0.135
0.282TrpMet: 0.282 ± 0.05
0.79TrpAsn: 0.79 ± 0.093
0.263TrpPro: 0.263 ± 0.052
0.414TrpGln: 0.414 ± 0.05
0.977TrpArg: 0.977 ± 0.096
1.325TrpSer: 1.325 ± 0.124
0.724TrpThr: 0.724 ± 0.078
0.743TrpVal: 0.743 ± 0.083
0.263TrpTrp: 0.263 ± 0.048
0.658TrpTyr: 0.658 ± 0.088
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.767TyrAla: 1.767 ± 0.134
0.874TyrCys: 0.874 ± 0.096
2.002TyrAsp: 2.002 ± 0.154
2.463TyrGlu: 2.463 ± 0.149
2.049TyrPhe: 2.049 ± 0.142
2.622TyrGly: 2.622 ± 0.176
0.498TyrHis: 0.498 ± 0.066
1.617TyrIle: 1.617 ± 0.116
2.378TyrLys: 2.378 ± 0.137
2.538TyrLeu: 2.538 ± 0.144
0.705TyrMet: 0.705 ± 0.085
1.353TyrAsn: 1.353 ± 0.095
1.184TyrPro: 1.184 ± 0.091
1.09TyrGln: 1.09 ± 0.113
1.494TyrArg: 1.494 ± 0.126
2.406TyrSer: 2.406 ± 0.163
1.617TyrThr: 1.617 ± 0.11
2.134TyrVal: 2.134 ± 0.134
0.555TyrTrp: 0.555 ± 0.078
0.959TyrTyr: 0.959 ± 0.091
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 444 proteins (106395 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski