Amino acid dipepetide frequency for Oscillatoria acuminata PCC 6304

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.083AlaAla: 7.083 ± 0.084	0.79AlaCys: 0.79 ± 0.019	3.962AlaAsp: 3.962 ± 0.05	5.621AlaGlu: 5.621 ± 0.06	2.767AlaPhe: 2.767 ± 0.041	5.564AlaGly: 5.564 ± 0.06	1.308AlaHis: 1.308 ± 0.029	7.533AlaIle: 7.533 ± 0.073	3.337AlaLys: 3.337 ± 0.045	8.787AlaLeu: 8.787 ± 0.08	1.636AlaMet: 1.636 ± 0.029	3.233AlaAsn: 3.233 ± 0.058	3.063AlaPro: 3.063 ± 0.048	4.394AlaGln: 4.394 ± 0.061	3.61AlaArg: 3.61 ± 0.048	4.713AlaSer: 4.713 ± 0.062	4.786AlaThr: 4.786 ± 0.068	5.538AlaVal: 5.538 ± 0.069	0.98AlaTrp: 0.98 ± 0.023	2.297AlaTyr: 2.297 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.625CysAla: 0.625 ± 0.018	0.149CysCys: 0.149 ± 0.009	0.639CysAsp: 0.639 ± 0.02	0.538CysGlu: 0.538 ± 0.017	0.406CysPhe: 0.406 ± 0.016	0.762CysGly: 0.762 ± 0.021	0.29CysHis: 0.29 ± 0.013	0.54CysIle: 0.54 ± 0.017	0.301CysLys: 0.301 ± 0.013	1.166CysLeu: 1.166 ± 0.029	0.129CysMet: 0.129 ± 0.008	0.329CysAsn: 0.329 ± 0.013	0.561CysPro: 0.561 ± 0.018	0.639CysGln: 0.639 ± 0.02	0.552CysArg: 0.552 ± 0.019	0.571CysSer: 0.571 ± 0.017	0.453CysThr: 0.453 ± 0.014	0.504CysVal: 0.504 ± 0.018	0.16CysTrp: 0.16 ± 0.009	0.38CysTyr: 0.38 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.627AspAla: 3.627 ± 0.051	0.632AspCys: 0.632 ± 0.018	2.243AspAsp: 2.243 ± 0.058	3.137AspGlu: 3.137 ± 0.042	2.265AspPhe: 2.265 ± 0.036	3.522AspGly: 3.522 ± 0.066	0.685AspHis: 0.685 ± 0.021	3.364AspIle: 3.364 ± 0.044	1.766AspLys: 1.766 ± 0.039	6.058AspLeu: 6.058 ± 0.063	0.784AspMet: 0.784 ± 0.023	1.837AspAsn: 1.837 ± 0.037	2.937AspPro: 2.937 ± 0.045	1.613AspGln: 1.613 ± 0.032	4.81AspArg: 4.81 ± 0.05	3.085AspSer: 3.085 ± 0.045	2.342AspThr: 2.342 ± 0.051	2.664AspVal: 2.664 ± 0.038	0.987AspTrp: 0.987 ± 0.022	1.86AspTyr: 1.86 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.169GluAla: 6.169 ± 0.062	0.513GluCys: 0.513 ± 0.018	2.993GluAsp: 2.993 ± 0.042	4.897GluGlu: 4.897 ± 0.068	2.687GluPhe: 2.687 ± 0.035	4.236GluGly: 4.236 ± 0.053	0.984GluHis: 0.984 ± 0.021	5.097GluIle: 5.097 ± 0.058	3.12GluLys: 3.12 ± 0.046	7.628GluLeu: 7.628 ± 0.071	1.573GluMet: 1.573 ± 0.026	2.861GluAsn: 2.861 ± 0.044	2.975GluPro: 2.975 ± 0.057	3.8GluGln: 3.8 ± 0.058	3.76GluArg: 3.76 ± 0.054	4.115GluSer: 4.115 ± 0.053	4.245GluThr: 4.245 ± 0.055	4.439GluVal: 4.439 ± 0.05	0.919GluTrp: 0.919 ± 0.023	1.802GluTyr: 1.802 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	2.858PheAla: 2.858 ± 0.046	0.507PheCys: 0.507 ± 0.016	2.11PheAsp: 2.11 ± 0.037	2.354PheGlu: 2.354 ± 0.036	1.624PhePhe: 1.624 ± 0.034	2.807PheGly: 2.807 ± 0.043	0.719PheHis: 0.719 ± 0.02	2.216PheIle: 2.216 ± 0.039	1.385PheLys: 1.385 ± 0.032	3.967PheLeu: 3.967 ± 0.052	0.727PheMet: 0.727 ± 0.018	1.695PheAsn: 1.695 ± 0.029	1.934PhePro: 1.934 ± 0.037	1.842PheGln: 1.842 ± 0.03	1.811PheArg: 1.811 ± 0.032	2.913PheSer: 2.913 ± 0.047	2.276PheThr: 2.276 ± 0.036	2.225PheVal: 2.225 ± 0.036	0.654PheTrp: 0.654 ± 0.018	1.384PheTyr: 1.384 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	4.722GlyAla: 4.722 ± 0.073	0.725GlyCys: 0.725 ± 0.021	4.142GlyAsp: 4.142 ± 0.075	5.013GlyGlu: 5.013 ± 0.064	2.964GlyPhe: 2.964 ± 0.039	5.321GlyGly: 5.321 ± 0.107	1.293GlyHis: 1.293 ± 0.034	5.059GlyIle: 5.059 ± 0.056	3.492GlyLys: 3.492 ± 0.05	7.157GlyLeu: 7.157 ± 0.072	1.674GlyMet: 1.674 ± 0.033	3.617GlyAsn: 3.617 ± 0.1	1.993GlyPro: 1.993 ± 0.035	3.336GlyGln: 3.336 ± 0.048	3.528GlyArg: 3.528 ± 0.043	4.444GlySer: 4.444 ± 0.063	4.433GlyThr: 4.433 ± 0.084	4.784GlyVal: 4.784 ± 0.054	1.173GlyTrp: 1.173 ± 0.026	2.274GlyTyr: 2.274 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.029HisAla: 1.029 ± 0.024	0.286HisCys: 0.286 ± 0.013	0.733HisAsp: 0.733 ± 0.019	1.016HisGlu: 1.016 ± 0.025	0.756HisPhe: 0.756 ± 0.022	1.063HisGly: 1.063 ± 0.023	0.62HisHis: 0.62 ± 0.02	0.934HisIle: 0.934 ± 0.023	0.618HisLys: 0.618 ± 0.018	2.405HisLeu: 2.405 ± 0.038	0.143HisMet: 0.143 ± 0.009	0.605HisAsn: 0.605 ± 0.019	1.625HisPro: 1.625 ± 0.028	1.347HisGln: 1.347 ± 0.028	1.257HisArg: 1.257 ± 0.026	1.225HisSer: 1.225 ± 0.028	0.816HisThr: 0.816 ± 0.021	0.648HisVal: 0.648 ± 0.019	0.36HisTrp: 0.36 ± 0.013	0.697HisTyr: 0.697 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.359IleAla: 7.359 ± 0.067	0.69IleCys: 0.69 ± 0.019	3.367IleAsp: 3.367 ± 0.047	4.467IleGlu: 4.467 ± 0.05	2.327IlePhe: 2.327 ± 0.04	4.486IleGly: 4.486 ± 0.059	1.279IleHis: 1.279 ± 0.027	3.137IleIle: 3.137 ± 0.044	2.443IleLys: 2.443 ± 0.041	6.643IleLeu: 6.643 ± 0.068	0.78IleMet: 0.78 ± 0.021	2.477IleAsn: 2.477 ± 0.047	3.702IlePro: 3.702 ± 0.049	3.194IleGln: 3.194 ± 0.044	3.205IleArg: 3.205 ± 0.043	4.173IleSer: 4.173 ± 0.052	3.506IleThr: 3.506 ± 0.061	3.849IleVal: 3.849 ± 0.047	0.838IleTrp: 0.838 ± 0.022	1.809IleTyr: 1.809 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.376LysAla: 3.376 ± 0.05	0.286LysCys: 0.286 ± 0.012	1.657LysAsp: 1.657 ± 0.032	2.372LysGlu: 2.372 ± 0.042	1.448LysPhe: 1.448 ± 0.03	2.416LysGly: 2.416 ± 0.038	0.67LysHis: 0.67 ± 0.018	2.943LysIle: 2.943 ± 0.051	1.863LysLys: 1.863 ± 0.042	4.434LysLeu: 4.434 ± 0.057	0.86LysMet: 0.86 ± 0.021	1.656LysAsn: 1.656 ± 0.03	2.226LysPro: 2.226 ± 0.039	2.314LysGln: 2.314 ± 0.044	2.159LysArg: 2.159 ± 0.034	2.478LysSer: 2.478 ± 0.041	2.697LysThr: 2.697 ± 0.039	2.404LysVal: 2.404 ± 0.04	0.472LysTrp: 0.472 ± 0.015	1.024LysTyr: 1.024 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	9.434LeuAla: 9.434 ± 0.087	1.072LeuCys: 1.072 ± 0.026	5.764LeuAsp: 5.764 ± 0.059	8.183LeuGlu: 8.183 ± 0.088	3.887LeuPhe: 3.887 ± 0.055	7.899LeuGly: 7.899 ± 0.079	1.936LeuHis: 1.936 ± 0.035	6.346LeuIle: 6.346 ± 0.071	4.993LeuLys: 4.993 ± 0.065	11.079LeuLeu: 11.079 ± 0.099	2.268LeuMet: 2.268 ± 0.038	4.794LeuAsn: 4.794 ± 0.05	5.763LeuPro: 5.763 ± 0.073	5.797LeuGln: 5.797 ± 0.057	5.65LeuArg: 5.65 ± 0.063	7.822LeuSer: 7.822 ± 0.072	6.722LeuThr: 6.722 ± 0.072	6.683LeuVal: 6.683 ± 0.057	1.611LeuTrp: 1.611 ± 0.039	2.875LeuTyr: 2.875 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	1.781MetAla: 1.781 ± 0.03	0.089MetCys: 0.089 ± 0.007	0.868MetAsp: 0.868 ± 0.025	1.246MetGlu: 1.246 ± 0.027	0.543MetPhe: 0.543 ± 0.017	1.586MetGly: 1.586 ± 0.034	0.258MetHis: 0.258 ± 0.013	1.009MetIle: 1.009 ± 0.026	0.937MetLys: 0.937 ± 0.019	1.809MetLeu: 1.809 ± 0.031	0.49MetMet: 0.49 ± 0.013	0.923MetAsn: 0.923 ± 0.022	1.023MetPro: 1.023 ± 0.02	0.935MetGln: 0.935 ± 0.023	1.006MetArg: 1.006 ± 0.023	1.332MetSer: 1.332 ± 0.026	1.343MetThr: 1.343 ± 0.026	1.315MetVal: 1.315 ± 0.027	0.152MetTrp: 0.152 ± 0.009	0.311MetTyr: 0.311 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.986AsnAla: 2.986 ± 0.049	0.425AsnCys: 0.425 ± 0.019	1.596AsnAsp: 1.596 ± 0.046	1.849AsnGlu: 1.849 ± 0.031	1.729AsnPhe: 1.729 ± 0.034	2.745AsnGly: 2.745 ± 0.056	0.819AsnHis: 0.819 ± 0.019	2.289AsnIle: 2.289 ± 0.042	1.104AsnLys: 1.104 ± 0.026	5.617AsnLeu: 5.617 ± 0.067	0.521AsnMet: 0.521 ± 0.018	1.641AsnAsn: 1.641 ± 0.039	3.526AsnPro: 3.526 ± 0.049	2.623AsnGln: 2.623 ± 0.04	2.609AsnArg: 2.609 ± 0.043	2.807AsnSer: 2.807 ± 0.047	1.971AsnThr: 1.971 ± 0.043	1.921AsnVal: 1.921 ± 0.035	0.726AsnTrp: 0.726 ± 0.02	1.249AsnTyr: 1.249 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	3.577ProAla: 3.577 ± 0.053	0.366ProCys: 0.366 ± 0.014	3.618ProAsp: 3.618 ± 0.05	5.083ProGlu: 5.083 ± 0.064	1.827ProPhe: 1.827 ± 0.034	3.8ProGly: 3.8 ± 0.045	0.973ProHis: 0.973 ± 0.022	3.068ProIle: 3.068 ± 0.038	1.87ProLys: 1.87 ± 0.03	5.338ProLeu: 5.338 ± 0.058	0.93ProMet: 0.93 ± 0.024	2.333ProAsn: 2.333 ± 0.042	3.228ProPro: 3.228 ± 0.086	2.728ProGln: 2.728 ± 0.042	2.064ProArg: 2.064 ± 0.04	3.345ProSer: 3.345 ± 0.047	3.197ProThr: 3.197 ± 0.049	3.687ProVal: 3.687 ± 0.053	0.637ProTrp: 0.637 ± 0.019	1.279ProTyr: 1.279 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.654GlnAla: 4.654 ± 0.067	0.375GlnCys: 0.375 ± 0.015	2.166GlnAsp: 2.166 ± 0.03	3.779GlnGlu: 3.779 ± 0.053	1.98GlnPhe: 1.98 ± 0.033	3.907GlnGly: 3.907 ± 0.05	0.842GlnHis: 0.842 ± 0.02	3.623GlnIle: 3.623 ± 0.042	2.308GlnLys: 2.308 ± 0.036	6.143GlnLeu: 6.143 ± 0.075	1.125GlnMet: 1.125 ± 0.027	2.081GlnAsn: 2.081 ± 0.035	2.761GlnPro: 2.761 ± 0.044	3.76GlnGln: 3.76 ± 0.066	2.86GlnArg: 2.86 ± 0.044	3.211GlnSer: 3.211 ± 0.044	3.258GlnThr: 3.258 ± 0.045	3.893GlnVal: 3.893 ± 0.047	0.82GlnTrp: 0.82 ± 0.021	1.166GlnTyr: 1.166 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	3.559ArgAla: 3.559 ± 0.053	0.546ArgCys: 0.546 ± 0.018	3.013ArgAsp: 3.013 ± 0.044	3.836ArgGlu: 3.836 ± 0.055	2.285ArgPhe: 2.285 ± 0.038	3.463ArgGly: 3.463 ± 0.05	1.071ArgHis: 1.071 ± 0.026	3.553ArgIle: 3.553 ± 0.046	2.069ArgLys: 2.069 ± 0.037	6.359ArgLeu: 6.359 ± 0.062	1.146ArgMet: 1.146 ± 0.028	2.035ArgAsn: 2.035 ± 0.03	2.263ArgPro: 2.263 ± 0.037	3.493ArgGln: 3.493 ± 0.049	3.11ArgArg: 3.11 ± 0.046	3.499ArgSer: 3.499 ± 0.046	2.791ArgThr: 2.791 ± 0.051	3.562ArgVal: 3.562 ± 0.048	0.893ArgTrp: 0.893 ± 0.02	1.863ArgTyr: 1.863 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	4.682SerAla: 4.682 ± 0.053	0.609SerCys: 0.609 ± 0.016	3.414SerAsp: 3.414 ± 0.051	4.275SerGlu: 4.275 ± 0.05	2.377SerPhe: 2.377 ± 0.044	5.174SerGly: 5.174 ± 0.07	1.319SerHis: 1.319 ± 0.025	3.436SerIle: 3.436 ± 0.045	2.212SerLys: 2.212 ± 0.039	7.398SerLeu: 7.398 ± 0.074	1.188SerMet: 1.188 ± 0.024	2.356SerAsn: 2.356 ± 0.038	4.23SerPro: 4.23 ± 0.056	3.637SerGln: 3.637 ± 0.047	3.462SerArg: 3.462 ± 0.044	4.338SerSer: 4.338 ± 0.051	3.289SerThr: 3.289 ± 0.046	3.847SerVal: 3.847 ± 0.041	0.964SerTrp: 0.964 ± 0.024	1.75SerTyr: 1.75 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	4.893ThrAla: 4.893 ± 0.089	0.489ThrCys: 0.489 ± 0.015	2.744ThrAsp: 2.744 ± 0.045	3.755ThrGlu: 3.755 ± 0.049	2.015ThrPhe: 2.015 ± 0.038	4.922ThrGly: 4.922 ± 0.089	1.116ThrHis: 1.116 ± 0.025	3.516ThrIle: 3.516 ± 0.05	1.612ThrLys: 1.612 ± 0.029	7.273ThrLeu: 7.273 ± 0.083	0.752ThrMet: 0.752 ± 0.021	1.811ThrAsn: 1.811 ± 0.036	4.08ThrPro: 4.08 ± 0.054	3.024ThrGln: 3.024 ± 0.049	2.602ThrArg: 2.602 ± 0.04	3.146ThrSer: 3.146 ± 0.045	3.199ThrThr: 3.199 ± 0.064	4.028ThrVal: 4.028 ± 0.058	0.727ThrTrp: 0.727 ± 0.021	1.485ThrTyr: 1.485 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	5.696ValAla: 5.696 ± 0.066	0.623ValCys: 0.623 ± 0.018	3.004ValAsp: 3.004 ± 0.047	4.659ValGlu: 4.659 ± 0.053	2.287ValPhe: 2.287 ± 0.038	4.397ValGly: 4.397 ± 0.051	0.982ValHis: 0.982 ± 0.022	3.635ValIle: 3.635 ± 0.049	2.809ValLys: 2.809 ± 0.042	6.202ValLeu: 6.202 ± 0.059	1.454ValMet: 1.454 ± 0.028	2.705ValAsn: 2.705 ± 0.037	2.98ValPro: 2.98 ± 0.039	3.023ValGln: 3.023 ± 0.044	3.38ValArg: 3.38 ± 0.048	4.115ValSer: 4.115 ± 0.048	3.918ValThr: 3.918 ± 0.054	4.315ValVal: 4.315 ± 0.055	0.853ValTrp: 0.853 ± 0.023	1.684ValTyr: 1.684 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	0.937TrpAla: 0.937 ± 0.027	0.144TrpCys: 0.144 ± 0.008	0.787TrpAsp: 0.787 ± 0.032	1.035TrpGlu: 1.035 ± 0.025	0.575TrpPhe: 0.575 ± 0.013	1.044TrpGly: 1.044 ± 0.026	0.323TrpHis: 0.323 ± 0.013	0.946TrpIle: 0.946 ± 0.025	0.577TrpLys: 0.577 ± 0.019	1.641TrpLeu: 1.641 ± 0.03	0.395TrpMet: 0.395 ± 0.013	0.678TrpAsn: 0.678 ± 0.021	0.444TrpPro: 0.444 ± 0.018	1.111TrpGln: 1.111 ± 0.025	0.862TrpArg: 0.862 ± 0.025	0.796TrpSer: 0.796 ± 0.02	0.675TrpThr: 0.675 ± 0.021	1.074TrpVal: 1.074 ± 0.024	0.233TrpTrp: 0.233 ± 0.011	0.39TrpTyr: 0.39 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.952TyrAla: 1.952 ± 0.036	0.38TyrCys: 0.38 ± 0.017	1.397TyrAsp: 1.397 ± 0.03	1.698TyrGlu: 1.698 ± 0.035	1.259TyrPhe: 1.259 ± 0.03	2.03TyrGly: 2.03 ± 0.035	0.694TyrHis: 0.694 ± 0.02	1.487TyrIle: 1.487 ± 0.028	0.942TyrLys: 0.942 ± 0.023	3.471TyrLeu: 3.471 ± 0.048	0.381TyrMet: 0.381 ± 0.016	1.086TyrAsn: 1.086 ± 0.027	1.634TyrPro: 1.634 ± 0.031	2.104TyrGln: 2.104 ± 0.035	2.112TyrArg: 2.112 ± 0.035	1.83TyrSer: 1.83 ± 0.03	1.272TyrThr: 1.272 ± 0.029	1.341TyrVal: 1.341 ± 0.026	0.509TyrTrp: 0.509 ± 0.017	0.981TyrTyr: 0.981 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5755 proteins (2048953 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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