Amino acid dipepetide frequency for Chitinophaga eiseniae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.874AlaAla: 9.874 ± 0.092	0.845AlaCys: 0.845 ± 0.02	4.834AlaAsp: 4.834 ± 0.05	4.209AlaGlu: 4.209 ± 0.05	3.692AlaPhe: 3.692 ± 0.039	7.341AlaGly: 7.341 ± 0.079	1.512AlaHis: 1.512 ± 0.028	5.022AlaIle: 5.022 ± 0.053	3.65AlaLys: 3.65 ± 0.051	8.184AlaLeu: 8.184 ± 0.086	2.023AlaMet: 2.023 ± 0.032	3.532AlaAsn: 3.532 ± 0.057	3.389AlaPro: 3.389 ± 0.046	3.275AlaGln: 3.275 ± 0.044	3.668AlaArg: 3.668 ± 0.04	4.738AlaSer: 4.738 ± 0.052	5.184AlaThr: 5.184 ± 0.083	6.069AlaVal: 6.069 ± 0.06	1.08AlaTrp: 1.08 ± 0.022	3.357AlaTyr: 3.357 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.576CysAla: 0.576 ± 0.015	0.166CysCys: 0.166 ± 0.009	0.378CysAsp: 0.378 ± 0.012	0.398CysGlu: 0.398 ± 0.013	0.419CysPhe: 0.419 ± 0.013	0.653CysGly: 0.653 ± 0.017	0.222CysHis: 0.222 ± 0.011	0.609CysIle: 0.609 ± 0.015	0.419CysLys: 0.419 ± 0.013	0.872CysLeu: 0.872 ± 0.021	0.253CysMet: 0.253 ± 0.011	0.383CysAsn: 0.383 ± 0.013	0.366CysPro: 0.366 ± 0.012	0.26CysGln: 0.26 ± 0.011	0.489CysArg: 0.489 ± 0.014	0.549CysSer: 0.549 ± 0.017	0.497CysThr: 0.497 ± 0.013	0.507CysVal: 0.507 ± 0.014	0.132CysTrp: 0.132 ± 0.007	0.375CysTyr: 0.375 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	4.366AspAla: 4.366 ± 0.045	0.379AspCys: 0.379 ± 0.014	2.396AspAsp: 2.396 ± 0.049	2.787AspGlu: 2.787 ± 0.036	2.613AspPhe: 2.613 ± 0.034	3.871AspGly: 3.871 ± 0.051	1.101AspHis: 1.101 ± 0.023	3.784AspIle: 3.784 ± 0.047	3.314AspLys: 3.314 ± 0.038	4.611AspLeu: 4.611 ± 0.054	1.303AspMet: 1.303 ± 0.026	2.727AspAsn: 2.727 ± 0.042	2.329AspPro: 2.329 ± 0.036	1.83AspGln: 1.83 ± 0.027	2.43AspArg: 2.43 ± 0.032	2.847AspSer: 2.847 ± 0.043	3.018AspThr: 3.018 ± 0.038	3.316AspVal: 3.316 ± 0.035	0.763AspTrp: 0.763 ± 0.017	2.49AspTyr: 2.49 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	4.568GluAla: 4.568 ± 0.049	0.331GluCys: 0.331 ± 0.012	2.614GluAsp: 2.614 ± 0.041	3.477GluGlu: 3.477 ± 0.047	1.78GluPhe: 1.78 ± 0.026	3.347GluGly: 3.347 ± 0.038	1.163GluHis: 1.163 ± 0.023	3.449GluIle: 3.449 ± 0.043	4.321GluLys: 4.321 ± 0.053	5.197GluLeu: 5.197 ± 0.054	1.471GluMet: 1.471 ± 0.022	2.692GluAsn: 2.692 ± 0.032	1.628GluPro: 1.628 ± 0.029	2.66GluGln: 2.66 ± 0.038	2.628GluArg: 2.628 ± 0.035	2.324GluSer: 2.324 ± 0.03	2.845GluThr: 2.845 ± 0.037	3.668GluVal: 3.668 ± 0.047	0.697GluTrp: 0.697 ± 0.017	1.869GluTyr: 1.869 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.115PheAla: 3.115 ± 0.041	0.441PheCys: 0.441 ± 0.013	2.607PheAsp: 2.607 ± 0.032	2.304PheGlu: 2.304 ± 0.029	2.321PhePhe: 2.321 ± 0.041	2.926PheGly: 2.926 ± 0.039	0.902PheHis: 0.902 ± 0.019	2.768PheIle: 2.768 ± 0.037	2.235PheLys: 2.235 ± 0.028	4.088PheLeu: 4.088 ± 0.049	1.15PheMet: 1.15 ± 0.022	2.575PheAsn: 2.575 ± 0.029	1.859PhePro: 1.859 ± 0.031	1.395PheGln: 1.395 ± 0.024	2.518PheArg: 2.518 ± 0.031	3.382PheSer: 3.382 ± 0.042	3.063PheThr: 3.063 ± 0.035	2.674PheVal: 2.674 ± 0.034	0.516PheTrp: 0.516 ± 0.016	1.874PheTyr: 1.874 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	5.499GlyAla: 5.499 ± 0.057	0.686GlyCys: 0.686 ± 0.02	3.497GlyAsp: 3.497 ± 0.038	3.385GlyGlu: 3.385 ± 0.04	3.292GlyPhe: 3.292 ± 0.043	5.33GlyGly: 5.33 ± 0.068	1.462GlyHis: 1.462 ± 0.026	5.02GlyIle: 5.02 ± 0.052	4.924GlyLys: 4.924 ± 0.045	6.116GlyLeu: 6.116 ± 0.06	1.939GlyMet: 1.939 ± 0.029	3.891GlyAsn: 3.891 ± 0.049	1.962GlyPro: 1.962 ± 0.035	2.692GlyGln: 2.692 ± 0.034	3.308GlyArg: 3.308 ± 0.04	4.332GlySer: 4.332 ± 0.059	4.607GlyThr: 4.607 ± 0.078	4.763GlyVal: 4.763 ± 0.048	1.12GlyTrp: 1.12 ± 0.021	3.382GlyTyr: 3.382 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.462HisAla: 1.462 ± 0.026	0.234HisCys: 0.234 ± 0.009	0.962HisAsp: 0.962 ± 0.018	1.009HisGlu: 1.009 ± 0.021	1.225HisPhe: 1.225 ± 0.022	1.255HisGly: 1.255 ± 0.023	0.763HisHis: 0.763 ± 0.019	1.436HisIle: 1.436 ± 0.025	0.934HisLys: 0.934 ± 0.02	2.133HisLeu: 2.133 ± 0.037	0.469HisMet: 0.469 ± 0.014	0.897HisAsn: 0.897 ± 0.021	1.258HisPro: 1.258 ± 0.024	1.001HisGln: 1.001 ± 0.022	1.062HisArg: 1.062 ± 0.022	1.056HisSer: 1.056 ± 0.02	1.312HisThr: 1.312 ± 0.025	1.111HisVal: 1.111 ± 0.021	0.312HisTrp: 0.312 ± 0.012	1.029HisTyr: 1.029 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.452IleAla: 5.452 ± 0.052	0.669IleCys: 0.669 ± 0.019	3.429IleAsp: 3.429 ± 0.034	2.843IleGlu: 2.843 ± 0.04	2.551IlePhe: 2.551 ± 0.037	4.223IleGly: 4.223 ± 0.048	1.312IleHis: 1.312 ± 0.027	3.716IleIle: 3.716 ± 0.051	3.14IleLys: 3.14 ± 0.043	5.238IleLeu: 5.238 ± 0.054	1.279IleMet: 1.279 ± 0.023	3.183IleAsn: 3.183 ± 0.036	3.099IlePro: 3.099 ± 0.035	2.168IleGln: 2.168 ± 0.032	3.611IleArg: 3.611 ± 0.041	4.33IleSer: 4.33 ± 0.04	4.512IleThr: 4.512 ± 0.063	3.776IleVal: 3.776 ± 0.046	0.699IleTrp: 0.699 ± 0.017	2.267IleTyr: 2.267 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.872LysAla: 4.872 ± 0.054	0.274LysCys: 0.274 ± 0.01	3.59LysAsp: 3.59 ± 0.045	3.783LysGlu: 3.783 ± 0.053	1.761LysPhe: 1.761 ± 0.027	4.17LysGly: 4.17 ± 0.043	1.06LysHis: 1.06 ± 0.02	3.575LysIle: 3.575 ± 0.038	4.125LysLys: 4.125 ± 0.055	4.757LysLeu: 4.757 ± 0.047	1.656LysMet: 1.656 ± 0.029	2.906LysAsn: 2.906 ± 0.04	2.426LysPro: 2.426 ± 0.032	2.442LysGln: 2.442 ± 0.036	2.492LysArg: 2.492 ± 0.032	2.82LysSer: 2.82 ± 0.041	3.44LysThr: 3.44 ± 0.04	3.849LysVal: 3.849 ± 0.036	0.713LysTrp: 0.713 ± 0.017	2.18LysTyr: 2.18 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	7.584LeuAla: 7.584 ± 0.07	0.934LeuCys: 0.934 ± 0.019	4.672LeuAsp: 4.672 ± 0.05	5.115LeuGlu: 5.115 ± 0.063	4.415LeuPhe: 4.415 ± 0.054	5.721LeuGly: 5.721 ± 0.054	2.176LeuHis: 2.176 ± 0.034	5.052LeuIle: 5.052 ± 0.057	5.864LeuLys: 5.864 ± 0.061	10.982LeuLeu: 10.982 ± 0.113	2.33LeuMet: 2.33 ± 0.034	4.426LeuAsn: 4.426 ± 0.045	5.114LeuPro: 5.114 ± 0.059	5.156LeuGln: 5.156 ± 0.061	4.805LeuArg: 4.805 ± 0.043	6.636LeuSer: 6.636 ± 0.058	5.784LeuThr: 5.784 ± 0.048	5.714LeuVal: 5.714 ± 0.059	1.054LeuTrp: 1.054 ± 0.021	3.58LeuTyr: 3.58 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.174MetAla: 2.174 ± 0.029	0.148MetCys: 0.148 ± 0.008	1.305MetAsp: 1.305 ± 0.021	1.595MetGlu: 1.595 ± 0.025	0.798MetPhe: 0.798 ± 0.018	1.602MetGly: 1.602 ± 0.033	0.525MetHis: 0.525 ± 0.014	1.418MetIle: 1.418 ± 0.024	1.859MetLys: 1.859 ± 0.028	2.492MetLeu: 2.492 ± 0.035	0.685MetMet: 0.685 ± 0.016	1.186MetAsn: 1.186 ± 0.023	1.254MetPro: 1.254 ± 0.022	1.189MetGln: 1.189 ± 0.021	1.097MetArg: 1.097 ± 0.023	1.32MetSer: 1.32 ± 0.024	1.32MetThr: 1.32 ± 0.022	1.578MetVal: 1.578 ± 0.026	0.21MetTrp: 0.21 ± 0.009	0.747MetTyr: 0.747 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.966AsnAla: 3.966 ± 0.046	0.341AsnCys: 0.341 ± 0.011	2.481AsnAsp: 2.481 ± 0.031	2.313AsnGlu: 2.313 ± 0.031	2.053AsnPhe: 2.053 ± 0.03	4.107AsnGly: 4.107 ± 0.057	0.822AsnHis: 0.822 ± 0.018	3.582AsnIle: 3.582 ± 0.045	2.718AsnLys: 2.718 ± 0.034	3.873AsnLeu: 3.873 ± 0.048	1.155AsnMet: 1.155 ± 0.023	2.949AsnAsn: 2.949 ± 0.049	2.508AsnPro: 2.508 ± 0.035	1.647AsnGln: 1.647 ± 0.025	2.407AsnArg: 2.407 ± 0.032	2.677AsnSer: 2.677 ± 0.042	3.337AsnThr: 3.337 ± 0.048	2.98AsnVal: 2.98 ± 0.045	0.639AsnTrp: 0.639 ± 0.017	2.278AsnTyr: 2.278 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	5.104ProAla: 5.104 ± 0.069	0.253ProCys: 0.253 ± 0.01	3.066ProAsp: 3.066 ± 0.042	3.145ProGlu: 3.145 ± 0.039	2.087ProPhe: 2.087 ± 0.031	3.777ProGly: 3.777 ± 0.044	0.809ProHis: 0.809 ± 0.019	1.873ProIle: 1.873 ± 0.028	1.72ProLys: 1.72 ± 0.026	4.132ProLeu: 4.132 ± 0.045	0.869ProMet: 0.869 ± 0.017	1.638ProAsn: 1.638 ± 0.031	1.584ProPro: 1.584 ± 0.035	1.674ProGln: 1.674 ± 0.026	1.554ProArg: 1.554 ± 0.025	2.297ProSer: 2.297 ± 0.029	1.897ProThr: 1.897 ± 0.033	4.323ProVal: 4.323 ± 0.051	0.499ProTrp: 0.499 ± 0.014	1.664ProTyr: 1.664 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.299GlnAla: 3.299 ± 0.042	0.269GlnCys: 0.269 ± 0.012	1.823GlnAsp: 1.823 ± 0.023	2.519GlnGlu: 2.519 ± 0.037	1.656GlnPhe: 1.656 ± 0.023	2.326GlnGly: 2.326 ± 0.031	1.198GlnHis: 1.198 ± 0.021	2.043GlnIle: 2.043 ± 0.029	2.021GlnLys: 2.021 ± 0.03	5.303GlnLeu: 5.303 ± 0.061	0.936GlnMet: 0.936 ± 0.017	1.554GlnAsn: 1.554 ± 0.027	2.14GlnPro: 2.14 ± 0.028	3.514GlnGln: 3.514 ± 0.051	2.192GlnArg: 2.192 ± 0.035	2.088GlnSer: 2.088 ± 0.026	2.227GlnThr: 2.227 ± 0.03	2.856GlnVal: 2.856 ± 0.037	0.596GlnTrp: 0.596 ± 0.015	1.853GlnTyr: 1.853 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	3.03ArgAla: 3.03 ± 0.035	0.333ArgCys: 0.333 ± 0.012	2.278ArgAsp: 2.278 ± 0.03	3.029ArgGlu: 3.029 ± 0.04	2.517ArgPhe: 2.517 ± 0.034	2.504ArgGly: 2.504 ± 0.038	1.139ArgHis: 1.139 ± 0.023	3.41ArgIle: 3.41 ± 0.038	3.19ArgLys: 3.19 ± 0.039	5.002ArgLeu: 5.002 ± 0.055	1.406ArgMet: 1.406 ± 0.023	2.509ArgAsn: 2.509 ± 0.033	1.85ArgPro: 1.85 ± 0.03	2.547ArgGln: 2.547 ± 0.036	2.336ArgArg: 2.336 ± 0.034	2.594ArgSer: 2.594 ± 0.029	2.604ArgThr: 2.604 ± 0.035	2.787ArgVal: 2.787 ± 0.034	0.798ArgTrp: 0.798 ± 0.018	2.424ArgTyr: 2.424 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	4.872SerAla: 4.872 ± 0.051	0.614SerCys: 0.614 ± 0.017	2.717SerAsp: 2.717 ± 0.036	2.414SerGlu: 2.414 ± 0.033	3.112SerPhe: 3.112 ± 0.035	5.143SerGly: 5.143 ± 0.056	1.125SerHis: 1.125 ± 0.022	3.606SerIle: 3.606 ± 0.037	2.714SerLys: 2.714 ± 0.043	6.116SerLeu: 6.116 ± 0.049	1.368SerMet: 1.368 ± 0.024	2.664SerAsn: 2.664 ± 0.037	2.522SerPro: 2.522 ± 0.036	1.983SerGln: 1.983 ± 0.024	3.05SerArg: 3.05 ± 0.035	3.579SerSer: 3.579 ± 0.049	3.3SerThr: 3.3 ± 0.044	4.013SerVal: 4.013 ± 0.05	0.936SerTrp: 0.936 ± 0.02	2.661SerTyr: 2.661 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.118ThrAla: 6.118 ± 0.099	0.443ThrCys: 0.443 ± 0.013	3.515ThrAsp: 3.515 ± 0.044	2.638ThrGlu: 2.638 ± 0.038	2.744ThrPhe: 2.744 ± 0.036	5.618ThrGly: 5.618 ± 0.072	1.085ThrHis: 1.085 ± 0.022	3.892ThrIle: 3.892 ± 0.052	2.441ThrLys: 2.441 ± 0.039	5.996ThrLeu: 5.996 ± 0.055	1.162ThrMet: 1.162 ± 0.019	2.522ThrAsn: 2.522 ± 0.048	3.193ThrPro: 3.193 ± 0.036	1.941ThrGln: 1.941 ± 0.03	2.66ThrArg: 2.66 ± 0.032	3.33ThrSer: 3.33 ± 0.041	3.975ThrThr: 3.975 ± 0.059	4.686ThrVal: 4.686 ± 0.082	0.766ThrTrp: 0.766 ± 0.022	2.38ThrTyr: 2.38 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	5.48ValAla: 5.48 ± 0.055	0.64ValCys: 0.64 ± 0.017	3.135ValAsp: 3.135 ± 0.04	3.062ValGlu: 3.062 ± 0.041	3.025ValPhe: 3.025 ± 0.036	3.546ValGly: 3.546 ± 0.044	1.268ValHis: 1.268 ± 0.024	4.309ValIle: 4.309 ± 0.049	4.267ValLys: 4.267 ± 0.05	6.572ValLeu: 6.572 ± 0.066	1.719ValMet: 1.719 ± 0.029	3.53ValAsn: 3.53 ± 0.041	3.151ValPro: 3.151 ± 0.046	2.504ValGln: 2.504 ± 0.033	3.061ValArg: 3.061 ± 0.033	4.422ValSer: 4.422 ± 0.053	4.707ValThr: 4.707 ± 0.078	4.625ValVal: 4.625 ± 0.064	0.764ValTrp: 0.764 ± 0.017	2.576ValTyr: 2.576 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	0.871TrpAla: 0.871 ± 0.018	0.138TrpCys: 0.138 ± 0.007	0.66TrpAsp: 0.66 ± 0.019	0.748TrpGlu: 0.748 ± 0.017	0.585TrpPhe: 0.585 ± 0.014	0.887TrpGly: 0.887 ± 0.021	0.317TrpHis: 0.317 ± 0.009	0.686TrpIle: 0.686 ± 0.016	0.903TrpLys: 0.903 ± 0.018	1.452TrpLeu: 1.452 ± 0.025	0.431TrpMet: 0.431 ± 0.014	0.671TrpAsn: 0.671 ± 0.017	0.412TrpPro: 0.412 ± 0.013	0.77TrpGln: 0.77 ± 0.019	0.63TrpArg: 0.63 ± 0.016	0.762TrpSer: 0.762 ± 0.019	0.698TrpThr: 0.698 ± 0.02	0.718TrpVal: 0.718 ± 0.019	0.272TrpTrp: 0.272 ± 0.01	0.568TrpTyr: 0.568 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.193TyrAla: 3.193 ± 0.037	0.385TyrCys: 0.385 ± 0.013	2.316TyrAsp: 2.316 ± 0.037	1.954TyrGlu: 1.954 ± 0.029	2.066TyrPhe: 2.066 ± 0.03	2.865TyrGly: 2.865 ± 0.046	0.962TyrHis: 0.962 ± 0.021	2.25TyrIle: 2.25 ± 0.034	2.131TyrLys: 2.131 ± 0.031	3.997TyrLeu: 3.997 ± 0.042	0.897TyrMet: 0.897 ± 0.019	2.4TyrAsn: 2.4 ± 0.042	1.92TyrPro: 1.92 ± 0.033	1.765TyrGln: 1.765 ± 0.025	2.287TyrArg: 2.287 ± 0.028	2.425TyrSer: 2.425 ± 0.035	2.778TyrThr: 2.778 ± 0.045	2.35TyrVal: 2.35 ± 0.034	0.614TyrTrp: 0.614 ± 0.016	1.947TyrTyr: 1.947 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 6844 proteins (2579896 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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