Amino acid dipepetide frequency for Corynebacterium epidermidicanis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.844AlaAla: 14.844 ± 0.247	0.971AlaCys: 0.971 ± 0.038	6.684AlaAsp: 6.684 ± 0.099	8.033AlaGlu: 8.033 ± 0.134	3.631AlaPhe: 3.631 ± 0.081	9.995AlaGly: 9.995 ± 0.125	2.473AlaHis: 2.473 ± 0.056	5.68AlaIle: 5.68 ± 0.083	4.091AlaLys: 4.091 ± 0.093	11.663AlaLeu: 11.663 ± 0.161	2.805AlaMet: 2.805 ± 0.067	3.021AlaAsn: 3.021 ± 0.067	5.22AlaPro: 5.22 ± 0.109	4.655AlaGln: 4.655 ± 0.092	6.683AlaArg: 6.683 ± 0.099	6.016AlaSer: 6.016 ± 0.097	7.489AlaThr: 7.489 ± 0.122	9.455AlaVal: 9.455 ± 0.122	1.486AlaTrp: 1.486 ± 0.052	2.276AlaTyr: 2.276 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.982CysAla: 0.982 ± 0.042	0.106CysCys: 0.106 ± 0.014	0.467CysAsp: 0.467 ± 0.025	0.389CysGlu: 0.389 ± 0.023	0.309CysPhe: 0.309 ± 0.017	0.825CysGly: 0.825 ± 0.036	0.166CysHis: 0.166 ± 0.014	0.356CysIle: 0.356 ± 0.023	0.157CysLys: 0.157 ± 0.014	0.687CysLeu: 0.687 ± 0.028	0.165CysMet: 0.165 ± 0.017	0.197CysAsn: 0.197 ± 0.016	0.435CysPro: 0.435 ± 0.026	0.237CysGln: 0.237 ± 0.017	0.401CysArg: 0.401 ± 0.027	0.523CysSer: 0.523 ± 0.026	0.508CysThr: 0.508 ± 0.029	0.616CysVal: 0.616 ± 0.031	0.111CysTrp: 0.111 ± 0.013	0.158CysTyr: 0.158 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.585AspAla: 6.585 ± 0.116	0.437AspCys: 0.437 ± 0.022	3.153AspAsp: 3.153 ± 0.081	3.622AspGlu: 3.622 ± 0.075	2.204AspPhe: 2.204 ± 0.052	4.698AspGly: 4.698 ± 0.092	1.202AspHis: 1.202 ± 0.044	3.155AspIle: 3.155 ± 0.068	1.917AspLys: 1.917 ± 0.053	5.355AspLeu: 5.355 ± 0.085	1.187AspMet: 1.187 ± 0.038	1.58AspAsn: 1.58 ± 0.05	3.56AspPro: 3.56 ± 0.073	1.834AspGln: 1.834 ± 0.048	3.297AspArg: 3.297 ± 0.069	2.905AspSer: 2.905 ± 0.07	2.963AspThr: 2.963 ± 0.073	4.618AspVal: 4.618 ± 0.086	0.763AspTrp: 0.763 ± 0.038	1.407AspTyr: 1.407 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.606GluAla: 6.606 ± 0.116	0.373GluCys: 0.373 ± 0.021	2.996GluAsp: 2.996 ± 0.067	3.667GluGlu: 3.667 ± 0.083	2.376GluPhe: 2.376 ± 0.056	3.8GluGly: 3.8 ± 0.087	1.51GluHis: 1.51 ± 0.046	3.579GluIle: 3.579 ± 0.072	2.534GluLys: 2.534 ± 0.057	7.102GluLeu: 7.102 ± 0.117	1.316GluMet: 1.316 ± 0.048	1.896GluAsn: 1.896 ± 0.051	2.634GluPro: 2.634 ± 0.072	2.61GluGln: 2.61 ± 0.06	3.767GluArg: 3.767 ± 0.074	2.957GluSer: 2.957 ± 0.065	3.198GluThr: 3.198 ± 0.072	5.029GluVal: 5.029 ± 0.078	0.757GluTrp: 0.757 ± 0.037	1.319GluTyr: 1.319 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	4.139PheAla: 4.139 ± 0.076	0.295PheCys: 0.295 ± 0.02	2.491PheAsp: 2.491 ± 0.048	1.911PheGlu: 1.911 ± 0.047	1.21PhePhe: 1.21 ± 0.048	3.563PheGly: 3.563 ± 0.07	0.768PheHis: 0.768 ± 0.033	1.692PheIle: 1.692 ± 0.052	0.954PheLys: 0.954 ± 0.039	3.211PheLeu: 3.211 ± 0.078	0.677PheMet: 0.677 ± 0.034	1.102PheAsn: 1.102 ± 0.045	1.644PhePro: 1.644 ± 0.04	1.024PheGln: 1.024 ± 0.035	1.758PheArg: 1.758 ± 0.048	2.278PheSer: 2.278 ± 0.056	2.22PheThr: 2.22 ± 0.061	2.835PheVal: 2.835 ± 0.067	0.429PheTrp: 0.429 ± 0.026	0.863PheTyr: 0.863 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	8.505GlyAla: 8.505 ± 0.122	0.71GlyCys: 0.71 ± 0.029	4.078GlyAsp: 4.078 ± 0.074	4.774GlyGlu: 4.774 ± 0.087	3.254GlyPhe: 3.254 ± 0.064	6.357GlyGly: 6.357 ± 0.109	1.906GlyHis: 1.906 ± 0.054	4.63GlyIle: 4.63 ± 0.091	3.362GlyLys: 3.362 ± 0.071	8.202GlyLeu: 8.202 ± 0.123	2.185GlyMet: 2.185 ± 0.058	2.382GlyAsn: 2.382 ± 0.075	3.207GlyPro: 3.207 ± 0.066	2.822GlyGln: 2.822 ± 0.068	4.579GlyArg: 4.579 ± 0.075	4.866GlySer: 4.866 ± 0.084	5.263GlyThr: 5.263 ± 0.125	6.997GlyVal: 6.997 ± 0.11	1.339GlyTrp: 1.339 ± 0.043	2.135GlyTyr: 2.135 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.272HisAla: 2.272 ± 0.063	0.181HisCys: 0.181 ± 0.016	1.306HisAsp: 1.306 ± 0.044	1.201HisGlu: 1.201 ± 0.042	0.737HisPhe: 0.737 ± 0.029	1.828HisGly: 1.828 ± 0.053	0.578HisHis: 0.578 ± 0.032	1.162HisIle: 1.162 ± 0.043	0.544HisLys: 0.544 ± 0.027	2.011HisLeu: 2.011 ± 0.052	0.47HisMet: 0.47 ± 0.026	0.667HisAsn: 0.667 ± 0.029	1.511HisPro: 1.511 ± 0.05	0.737HisGln: 0.737 ± 0.029	1.464HisArg: 1.464 ± 0.043	1.226HisSer: 1.226 ± 0.044	1.3HisThr: 1.3 ± 0.034	1.585HisVal: 1.585 ± 0.05	0.292HisTrp: 0.292 ± 0.019	0.518HisTyr: 0.518 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.565IleAla: 6.565 ± 0.105	0.429IleCys: 0.429 ± 0.024	3.759IleAsp: 3.759 ± 0.074	3.193IleGlu: 3.193 ± 0.076	1.754IlePhe: 1.754 ± 0.053	4.488IleGly: 4.488 ± 0.085	1.032IleHis: 1.032 ± 0.039	2.519IleIle: 2.519 ± 0.075	1.674IleLys: 1.674 ± 0.053	4.232IleLeu: 4.232 ± 0.088	1.032IleMet: 1.032 ± 0.036	1.725IleAsn: 1.725 ± 0.045	2.771IlePro: 2.771 ± 0.068	1.345IleGln: 1.345 ± 0.044	2.658IleArg: 2.658 ± 0.059	3.345IleSer: 3.345 ± 0.072	3.16IleThr: 3.16 ± 0.072	4.456IleVal: 4.456 ± 0.079	0.497IleTrp: 0.497 ± 0.024	1.111IleTyr: 1.111 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	3.634LysAla: 3.634 ± 0.078	0.159LysCys: 0.159 ± 0.015	1.835LysAsp: 1.835 ± 0.056	1.995LysGlu: 1.995 ± 0.056	1.19LysPhe: 1.19 ± 0.036	2.191LysGly: 2.191 ± 0.063	0.749LysHis: 0.749 ± 0.033	1.752LysIle: 1.752 ± 0.054	1.644LysLys: 1.644 ± 0.054	3.431LysLeu: 3.431 ± 0.061	0.833LysMet: 0.833 ± 0.034	1.228LysAsn: 1.228 ± 0.042	1.92LysPro: 1.92 ± 0.055	1.412LysGln: 1.412 ± 0.041	2.128LysArg: 2.128 ± 0.057	1.931LysSer: 1.931 ± 0.055	2.019LysThr: 2.019 ± 0.06	2.843LysVal: 2.843 ± 0.07	0.421LysTrp: 0.421 ± 0.02	0.792LysTyr: 0.792 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	12.674LeuAla: 12.674 ± 0.149	0.749LeuCys: 0.749 ± 0.034	5.708LeuAsp: 5.708 ± 0.105	4.98LeuGlu: 4.98 ± 0.09	3.003LeuPhe: 3.003 ± 0.07	8.585LeuGly: 8.585 ± 0.139	1.936LeuHis: 1.936 ± 0.064	5.098LeuIle: 5.098 ± 0.097	2.964LeuLys: 2.964 ± 0.061	9.548LeuLeu: 9.548 ± 0.148	1.953LeuMet: 1.953 ± 0.051	2.762LeuAsn: 2.762 ± 0.059	5.341LeuPro: 5.341 ± 0.09	2.983LeuGln: 2.983 ± 0.063	6.254LeuArg: 6.254 ± 0.094	6.349LeuSer: 6.349 ± 0.091	6.041LeuThr: 6.041 ± 0.091	8.285LeuVal: 8.285 ± 0.114	1.191LeuTrp: 1.191 ± 0.044	1.7LeuTyr: 1.7 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.584MetAla: 2.584 ± 0.057	0.186MetCys: 0.186 ± 0.015	1.006MetAsp: 1.006 ± 0.036	1.005MetGlu: 1.005 ± 0.035	0.786MetPhe: 0.786 ± 0.027	1.68MetGly: 1.68 ± 0.05	0.501MetHis: 0.501 ± 0.025	1.215MetIle: 1.215 ± 0.041	0.842MetLys: 0.842 ± 0.034	2.324MetLeu: 2.324 ± 0.063	0.515MetMet: 0.515 ± 0.033	0.761MetAsn: 0.761 ± 0.035	1.172MetPro: 1.172 ± 0.038	0.74MetGln: 0.74 ± 0.03	1.431MetArg: 1.431 ± 0.043	1.647MetSer: 1.647 ± 0.048	1.65MetThr: 1.65 ± 0.05	1.704MetVal: 1.704 ± 0.044	0.334MetTrp: 0.334 ± 0.021	0.428MetTyr: 0.428 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.081AsnAla: 3.081 ± 0.068	0.271AsnCys: 0.271 ± 0.021	1.49AsnAsp: 1.49 ± 0.053	1.669AsnGlu: 1.669 ± 0.049	1.085AsnPhe: 1.085 ± 0.038	2.355AsnGly: 2.355 ± 0.074	0.606AsnHis: 0.606 ± 0.025	1.518AsnIle: 1.518 ± 0.041	1.057AsnLys: 1.057 ± 0.04	2.75AsnLeu: 2.75 ± 0.059	0.628AsnMet: 0.628 ± 0.028	0.991AsnAsn: 0.991 ± 0.041	2.2AsnPro: 2.2 ± 0.05	1.045AsnGln: 1.045 ± 0.039	1.73AsnArg: 1.73 ± 0.048	1.862AsnSer: 1.862 ± 0.049	1.695AsnThr: 1.695 ± 0.049	2.136AsnVal: 2.136 ± 0.059	0.433AsnTrp: 0.433 ± 0.021	0.824AsnTyr: 0.824 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	6.285ProAla: 6.285 ± 0.142	0.272ProCys: 0.272 ± 0.019	3.029ProAsp: 3.029 ± 0.069	4.159ProGlu: 4.159 ± 0.08	1.62ProPhe: 1.62 ± 0.049	4.601ProGly: 4.601 ± 0.111	1.134ProHis: 1.134 ± 0.035	2.369ProIle: 2.369 ± 0.06	1.771ProLys: 1.771 ± 0.055	4.386ProLeu: 4.386 ± 0.078	1.094ProMet: 1.094 ± 0.035	1.649ProAsn: 1.649 ± 0.048	1.862ProPro: 1.862 ± 0.078	1.904ProGln: 1.904 ± 0.047	2.678ProArg: 2.678 ± 0.055	2.84ProSer: 2.84 ± 0.064	3.391ProThr: 3.391 ± 0.08	4.444ProVal: 4.444 ± 0.108	0.713ProTrp: 0.713 ± 0.029	1.048ProTyr: 1.048 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.137GlnAla: 4.137 ± 0.084	0.2GlnCys: 0.2 ± 0.019	1.578GlnAsp: 1.578 ± 0.051	1.986GlnGlu: 1.986 ± 0.053	1.126GlnPhe: 1.126 ± 0.041	2.33GlnGly: 2.33 ± 0.051	0.858GlnHis: 0.858 ± 0.029	1.769GlnIle: 1.769 ± 0.051	1.099GlnLys: 1.099 ± 0.041	4.279GlnLeu: 4.279 ± 0.087	0.79GlnMet: 0.79 ± 0.036	0.852GlnAsn: 0.852 ± 0.04	2.026GlnPro: 2.026 ± 0.063	1.785GlnGln: 1.785 ± 0.05	2.803GlnArg: 2.803 ± 0.064	1.706GlnSer: 1.706 ± 0.042	1.691GlnThr: 1.691 ± 0.05	2.895GlnVal: 2.895 ± 0.061	0.596GlnTrp: 0.596 ± 0.029	0.659GlnTyr: 0.659 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	6.442ArgAla: 6.442 ± 0.111	0.397ArgCys: 0.397 ± 0.023	3.272ArgAsp: 3.272 ± 0.07	3.968ArgGlu: 3.968 ± 0.068	2.059ArgPhe: 2.059 ± 0.056	4.324ArgGly: 4.324 ± 0.07	1.19ArgHis: 1.19 ± 0.04	3.362ArgIle: 3.362 ± 0.072	2.234ArgLys: 2.234 ± 0.055	5.65ArgLeu: 5.65 ± 0.098	1.601ArgMet: 1.601 ± 0.047	1.872ArgAsn: 1.872 ± 0.048	2.803ArgPro: 2.803 ± 0.065	2.117ArgGln: 2.117 ± 0.052	4.618ArgArg: 4.618 ± 0.095	3.364ArgSer: 3.364 ± 0.07	3.531ArgThr: 3.531 ± 0.067	4.554ArgVal: 4.554 ± 0.081	0.853ArgTrp: 0.853 ± 0.032	1.445ArgTyr: 1.445 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.589SerAla: 6.589 ± 0.1	0.461SerCys: 0.461 ± 0.027	3.117SerAsp: 3.117 ± 0.07	3.349SerGlu: 3.349 ± 0.064	2.243SerPhe: 2.243 ± 0.062	5.411SerGly: 5.411 ± 0.092	1.223SerHis: 1.223 ± 0.038	2.936SerIle: 2.936 ± 0.071	1.896SerLys: 1.896 ± 0.055	5.451SerLeu: 5.451 ± 0.091	1.562SerMet: 1.562 ± 0.044	1.685SerAsn: 1.685 ± 0.047	3.048SerPro: 3.048 ± 0.064	2.053SerGln: 2.053 ± 0.063	3.187SerArg: 3.187 ± 0.069	3.622SerSer: 3.622 ± 0.093	3.693SerThr: 3.693 ± 0.071	4.58SerVal: 4.58 ± 0.086	0.93SerTrp: 0.93 ± 0.039	1.405SerTyr: 1.405 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	6.983ThrAla: 6.983 ± 0.111	0.505ThrCys: 0.505 ± 0.031	3.303ThrAsp: 3.303 ± 0.08	3.215ThrGlu: 3.215 ± 0.066	2.177ThrPhe: 2.177 ± 0.062	5.24ThrGly: 5.24 ± 0.095	1.294ThrHis: 1.294 ± 0.04	3.149ThrIle: 3.149 ± 0.07	2.009ThrLys: 2.009 ± 0.056	5.699ThrLeu: 5.699 ± 0.1	1.333ThrMet: 1.333 ± 0.046	1.688ThrAsn: 1.688 ± 0.066	3.887ThrPro: 3.887 ± 0.083	2.005ThrGln: 2.005 ± 0.051	3.116ThrArg: 3.116 ± 0.072	3.753ThrSer: 3.753 ± 0.078	4.259ThrThr: 4.259 ± 0.158	5.446ThrVal: 5.446 ± 0.169	0.867ThrTrp: 0.867 ± 0.035	1.462ThrTyr: 1.462 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	10.461ValAla: 10.461 ± 0.112	0.789ValCys: 0.789 ± 0.026	5.153ValAsp: 5.153 ± 0.094	4.942ValGlu: 4.942 ± 0.09	2.798ValPhe: 2.798 ± 0.062	6.385ValGly: 6.385 ± 0.101	1.685ValHis: 1.685 ± 0.049	4.22ValIle: 4.22 ± 0.068	2.386ValLys: 2.386 ± 0.062	8.16ValLeu: 8.16 ± 0.129	1.687ValMet: 1.687 ± 0.049	2.291ValAsn: 2.291 ± 0.057	4.175ValPro: 4.175 ± 0.1	2.307ValGln: 2.307 ± 0.057	4.665ValArg: 4.665 ± 0.085	5.135ValSer: 5.135 ± 0.088	5.423ValThr: 5.423 ± 0.153	7.799ValVal: 7.799 ± 0.154	1.024ValTrp: 1.024 ± 0.035	1.523ValTyr: 1.523 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.473TrpAla: 1.473 ± 0.045	0.124TrpCys: 0.124 ± 0.012	0.692TrpAsp: 0.692 ± 0.029	0.685TrpGlu: 0.685 ± 0.032	0.554TrpPhe: 0.554 ± 0.026	0.962TrpGly: 0.962 ± 0.036	0.352TrpHis: 0.352 ± 0.021	0.702TrpIle: 0.702 ± 0.03	0.437TrpLys: 0.437 ± 0.025	1.607TrpLeu: 1.607 ± 0.054	0.339TrpMet: 0.339 ± 0.021	0.434TrpAsn: 0.434 ± 0.024	0.633TrpPro: 0.633 ± 0.028	0.653TrpGln: 0.653 ± 0.032	0.906TrpArg: 0.906 ± 0.033	0.744TrpSer: 0.744 ± 0.029	0.73TrpThr: 0.73 ± 0.034	1.063TrpVal: 1.063 ± 0.039	0.333TrpTrp: 0.333 ± 0.021	0.29TrpTyr: 0.29 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.328TyrAla: 2.328 ± 0.056	0.18TyrCys: 0.18 ± 0.016	1.326TyrAsp: 1.326 ± 0.042	1.28TyrGlu: 1.28 ± 0.041	0.949TyrPhe: 0.949 ± 0.034	1.936TyrGly: 1.936 ± 0.051	0.427TyrHis: 0.427 ± 0.024	0.883TyrIle: 0.883 ± 0.037	0.537TyrLys: 0.537 ± 0.028	2.357TyrLeu: 2.357 ± 0.063	0.34TyrMet: 0.34 ± 0.022	0.643TyrAsn: 0.643 ± 0.03	1.197TyrPro: 1.197 ± 0.047	0.897TyrGln: 0.897 ± 0.036	1.533TyrArg: 1.533 ± 0.049	1.372TyrSer: 1.372 ± 0.045	1.164TyrThr: 1.164 ± 0.047	1.668TyrVal: 1.668 ± 0.046	0.346TyrTrp: 0.346 ± 0.024	0.477TyrTyr: 0.477 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2448 proteins (790097 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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