Amino acid dipepetide frequency for Cnuella takakiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.839AlaAla: 9.839 ± 0.109
0.791AlaCys: 0.791 ± 0.025
4.596AlaAsp: 4.596 ± 0.052
4.629AlaGlu: 4.629 ± 0.062
4.012AlaPhe: 4.012 ± 0.054
7.184AlaGly: 7.184 ± 0.077
1.627AlaHis: 1.627 ± 0.031
5.278AlaIle: 5.278 ± 0.055
4.209AlaLys: 4.209 ± 0.055
8.489AlaLeu: 8.489 ± 0.096
2.011AlaMet: 2.011 ± 0.04
3.892AlaAsn: 3.892 ± 0.058
3.563AlaPro: 3.563 ± 0.055
4.067AlaGln: 4.067 ± 0.056
3.68AlaArg: 3.68 ± 0.048
5.035AlaSer: 5.035 ± 0.048
5.342AlaThr: 5.342 ± 0.068
5.651AlaVal: 5.651 ± 0.07
1.001AlaTrp: 1.001 ± 0.027
3.104AlaTyr: 3.104 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.628CysAla: 0.628 ± 0.021
0.178CysCys: 0.178 ± 0.01
0.347CysAsp: 0.347 ± 0.018
0.358CysGlu: 0.358 ± 0.014
0.45CysPhe: 0.45 ± 0.018
0.719CysGly: 0.719 ± 0.023
0.218CysHis: 0.218 ± 0.013
0.551CysIle: 0.551 ± 0.017
0.402CysLys: 0.402 ± 0.015
0.786CysLeu: 0.786 ± 0.026
0.22CysMet: 0.22 ± 0.012
0.405CysAsn: 0.405 ± 0.017
0.351CysPro: 0.351 ± 0.017
0.262CysGln: 0.262 ± 0.014
0.398CysArg: 0.398 ± 0.018
0.607CysSer: 0.607 ± 0.022
0.566CysThr: 0.566 ± 0.021
0.469CysVal: 0.469 ± 0.018
0.113CysTrp: 0.113 ± 0.009
0.294CysTyr: 0.294 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
4.662AspAla: 4.662 ± 0.057
0.379AspCys: 0.379 ± 0.017
2.172AspAsp: 2.172 ± 0.041
2.788AspGlu: 2.788 ± 0.05
2.572AspPhe: 2.572 ± 0.045
4.131AspGly: 4.131 ± 0.077
0.929AspHis: 0.929 ± 0.026
3.151AspIle: 3.151 ± 0.047
2.806AspLys: 2.806 ± 0.047
4.829AspLeu: 4.829 ± 0.06
1.123AspMet: 1.123 ± 0.029
2.206AspAsn: 2.206 ± 0.038
2.25AspPro: 2.25 ± 0.043
1.715AspGln: 1.715 ± 0.034
2.415AspArg: 2.415 ± 0.038
2.741AspSer: 2.741 ± 0.048
2.669AspThr: 2.669 ± 0.042
3.312AspVal: 3.312 ± 0.053
0.739AspTrp: 0.739 ± 0.027
2.117AspTyr: 2.117 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
5.287GluAla: 5.287 ± 0.073
0.311GluCys: 0.311 ± 0.014
2.52GluAsp: 2.52 ± 0.042
3.571GluGlu: 3.571 ± 0.057
1.956GluPhe: 1.956 ± 0.037
4.004GluGly: 4.004 ± 0.048
1.159GluHis: 1.159 ± 0.028
3.107GluIle: 3.107 ± 0.051
3.827GluLys: 3.827 ± 0.059
5.777GluLeu: 5.777 ± 0.064
1.371GluMet: 1.371 ± 0.033
2.481GluAsn: 2.481 ± 0.04
1.924GluPro: 1.924 ± 0.036
3.143GluGln: 3.143 ± 0.047
2.89GluArg: 2.89 ± 0.049
2.505GluSer: 2.505 ± 0.044
2.728GluThr: 2.728 ± 0.045
4.02GluVal: 4.02 ± 0.057
0.786GluTrp: 0.786 ± 0.022
1.762GluTyr: 1.762 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.942PheAla: 3.942 ± 0.051
0.471PheCys: 0.471 ± 0.018
2.648PheAsp: 2.648 ± 0.043
2.423PheGlu: 2.423 ± 0.045
2.404PhePhe: 2.404 ± 0.049
3.481PheGly: 3.481 ± 0.05
0.915PheHis: 0.915 ± 0.028
2.643PheIle: 2.643 ± 0.05
2.209PheLys: 2.209 ± 0.039
4.271PheLeu: 4.271 ± 0.06
0.975PheMet: 0.975 ± 0.025
2.48PheAsn: 2.48 ± 0.038
1.766PhePro: 1.766 ± 0.031
1.685PheGln: 1.685 ± 0.031
2.46PheArg: 2.46 ± 0.039
3.323PheSer: 3.323 ± 0.052
3.135PheThr: 3.135 ± 0.045
3.03PheVal: 3.03 ± 0.053
0.602PheTrp: 0.602 ± 0.02
1.862PheTyr: 1.862 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
6.162GlyAla: 6.162 ± 0.069
0.73GlyCys: 0.73 ± 0.028
3.411GlyAsp: 3.411 ± 0.053
3.45GlyGlu: 3.45 ± 0.049
3.758GlyPhe: 3.758 ± 0.055
5.91GlyGly: 5.91 ± 0.098
1.35GlyHis: 1.35 ± 0.03
4.92GlyIle: 4.92 ± 0.063
5.199GlyLys: 5.199 ± 0.059
6.791GlyLeu: 6.791 ± 0.074
2.109GlyMet: 2.109 ± 0.045
3.872GlyAsn: 3.872 ± 0.068
1.924GlyPro: 1.924 ± 0.036
2.813GlyGln: 2.813 ± 0.047
3.558GlyArg: 3.558 ± 0.045
4.767GlySer: 4.767 ± 0.073
4.708GlyThr: 4.708 ± 0.078
5.011GlyVal: 5.011 ± 0.057
1.217GlyTrp: 1.217 ± 0.033
3.02GlyTyr: 3.02 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
1.439HisAla: 1.439 ± 0.035
0.234HisCys: 0.234 ± 0.013
0.901HisAsp: 0.901 ± 0.027
0.96HisGlu: 0.96 ± 0.029
1.249HisPhe: 1.249 ± 0.03
1.308HisGly: 1.308 ± 0.031
0.633HisHis: 0.633 ± 0.024
1.218HisIle: 1.218 ± 0.033
0.974HisLys: 0.974 ± 0.025
2.163HisLeu: 2.163 ± 0.043
0.445HisMet: 0.445 ± 0.017
0.958HisAsn: 0.958 ± 0.026
1.315HisPro: 1.315 ± 0.037
0.948HisGln: 0.948 ± 0.024
1.097HisArg: 1.097 ± 0.029
1.122HisSer: 1.122 ± 0.026
1.154HisThr: 1.154 ± 0.027
1.034HisVal: 1.034 ± 0.025
0.296HisTrp: 0.296 ± 0.014
0.904HisTyr: 0.904 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.294IleAla: 5.294 ± 0.054
0.612IleCys: 0.612 ± 0.021
3.271IleAsp: 3.271 ± 0.045
3.258IleGlu: 3.258 ± 0.045
2.332IlePhe: 2.332 ± 0.04
4.275IleGly: 4.275 ± 0.06
1.2IleHis: 1.2 ± 0.03
3.538IleIle: 3.538 ± 0.049
3.124IleLys: 3.124 ± 0.05
5.015IleLeu: 5.015 ± 0.071
1.151IleMet: 1.151 ± 0.029
3.215IleAsn: 3.215 ± 0.047
2.732IlePro: 2.732 ± 0.043
2.127IleGln: 2.127 ± 0.037
3.253IleArg: 3.253 ± 0.044
3.744IleSer: 3.744 ± 0.052
3.844IleThr: 3.844 ± 0.058
3.56IleVal: 3.56 ± 0.047
0.642IleTrp: 0.642 ± 0.023
1.884IleTyr: 1.884 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
5.277LysAla: 5.277 ± 0.068
0.283LysCys: 0.283 ± 0.014
3.248LysAsp: 3.248 ± 0.045
4.135LysGlu: 4.135 ± 0.056
1.77LysPhe: 1.77 ± 0.037
4.548LysGly: 4.548 ± 0.061
1.016LysHis: 1.016 ± 0.024
3.016LysIle: 3.016 ± 0.047
3.86LysLys: 3.86 ± 0.064
4.907LysLeu: 4.907 ± 0.054
1.548LysMet: 1.548 ± 0.037
2.518LysAsn: 2.518 ± 0.042
2.697LysPro: 2.697 ± 0.042
2.621LysGln: 2.621 ± 0.041
2.59LysArg: 2.59 ± 0.043
2.702LysSer: 2.702 ± 0.043
3.247LysThr: 3.247 ± 0.046
4.02LysVal: 4.02 ± 0.052
0.724LysTrp: 0.724 ± 0.023
1.892LysTyr: 1.892 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
8.278LeuAla: 8.278 ± 0.089
0.923LeuCys: 0.923 ± 0.031
4.639LeuAsp: 4.639 ± 0.058
5.392LeuGlu: 5.392 ± 0.068
4.846LeuPhe: 4.846 ± 0.073
6.283LeuGly: 6.283 ± 0.069
2.278LeuHis: 2.278 ± 0.045
4.755LeuIle: 4.755 ± 0.07
5.45LeuLys: 5.45 ± 0.056
11.107LeuLeu: 11.107 ± 0.146
2.259LeuMet: 2.259 ± 0.042
4.568LeuAsn: 4.568 ± 0.068
4.976LeuPro: 4.976 ± 0.067
5.355LeuGln: 5.355 ± 0.065
4.868LeuArg: 4.868 ± 0.063
6.273LeuSer: 6.273 ± 0.074
5.019LeuThr: 5.019 ± 0.067
6.89LeuVal: 6.89 ± 0.079
1.042LeuTrp: 1.042 ± 0.025
3.404LeuTyr: 3.404 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
2.114MetAla: 2.114 ± 0.045
0.139MetCys: 0.139 ± 0.01
1.275MetAsp: 1.275 ± 0.03
1.504MetGlu: 1.504 ± 0.032
0.764MetPhe: 0.764 ± 0.025
1.73MetGly: 1.73 ± 0.036
0.542MetHis: 0.542 ± 0.021
1.275MetIle: 1.275 ± 0.033
1.64MetLys: 1.64 ± 0.031
2.198MetLeu: 2.198 ± 0.038
0.659MetMet: 0.659 ± 0.021
1.155MetAsn: 1.155 ± 0.03
1.256MetPro: 1.256 ± 0.028
1.347MetGln: 1.347 ± 0.033
1.23MetArg: 1.23 ± 0.027
1.163MetSer: 1.163 ± 0.025
1.01MetThr: 1.01 ± 0.027
1.685MetVal: 1.685 ± 0.034
0.226MetTrp: 0.226 ± 0.011
0.66MetTyr: 0.66 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.934AsnAla: 3.934 ± 0.05
0.373AsnCys: 0.373 ± 0.016
2.288AsnAsp: 2.288 ± 0.038
2.517AsnGlu: 2.517 ± 0.041
2.195AsnPhe: 2.195 ± 0.037
4.022AsnGly: 4.022 ± 0.064
0.894AsnHis: 0.894 ± 0.024
3.01AsnIle: 3.01 ± 0.057
2.823AsnLys: 2.823 ± 0.043
4.61AsnLeu: 4.61 ± 0.067
1.082AsnMet: 1.082 ± 0.027
2.835AsnAsn: 2.835 ± 0.054
2.689AsnPro: 2.689 ± 0.046
1.896AsnGln: 1.896 ± 0.036
2.65AsnArg: 2.65 ± 0.046
2.715AsnSer: 2.715 ± 0.048
3.019AsnThr: 3.019 ± 0.056
2.629AsnVal: 2.629 ± 0.046
0.773AsnTrp: 0.773 ± 0.025
2.054AsnTyr: 2.054 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
4.478ProAla: 4.478 ± 0.067
0.27ProCys: 0.27 ± 0.014
2.587ProAsp: 2.587 ± 0.045
2.985ProGlu: 2.985 ± 0.05
2.163ProPhe: 2.163 ± 0.04
3.287ProGly: 3.287 ± 0.051
0.873ProHis: 0.873 ± 0.024
2.24ProIle: 2.24 ± 0.038
2.021ProLys: 2.021 ± 0.037
3.967ProLeu: 3.967 ± 0.05
0.927ProMet: 0.927 ± 0.024
1.975ProAsn: 1.975 ± 0.038
1.406ProPro: 1.406 ± 0.053
1.957ProGln: 1.957 ± 0.038
1.622ProArg: 1.622 ± 0.035
2.326ProSer: 2.326 ± 0.039
2.229ProThr: 2.229 ± 0.041
3.659ProVal: 3.659 ± 0.048
0.497ProTrp: 0.497 ± 0.019
1.624ProTyr: 1.624 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
3.631GlnAla: 3.631 ± 0.053
0.257GlnCys: 0.257 ± 0.012
1.909GlnAsp: 1.909 ± 0.034
2.577GlnGlu: 2.577 ± 0.038
1.946GlnPhe: 1.946 ± 0.034
2.726GlnGly: 2.726 ± 0.044
1.084GlnHis: 1.084 ± 0.032
2.099GlnIle: 2.099 ± 0.039
2.709GlnLys: 2.709 ± 0.043
4.969GlnLeu: 4.969 ± 0.06
1.133GlnMet: 1.133 ± 0.024
2.0GlnAsn: 2.0 ± 0.036
2.257GlnPro: 2.257 ± 0.042
3.214GlnGln: 3.214 ± 0.058
2.182GlnArg: 2.182 ± 0.041
2.305GlnSer: 2.305 ± 0.043
2.411GlnThr: 2.411 ± 0.039
3.43GlnVal: 3.43 ± 0.056
0.713GlnTrp: 0.713 ± 0.023
1.837GlnTyr: 1.837 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
3.029ArgAla: 3.029 ± 0.047
0.338ArgCys: 0.338 ± 0.014
2.216ArgAsp: 2.216 ± 0.04
2.632ArgGlu: 2.632 ± 0.042
2.764ArgPhe: 2.764 ± 0.046
2.796ArgGly: 2.796 ± 0.039
1.0ArgHis: 1.0 ± 0.024
3.403ArgIle: 3.403 ± 0.044
3.351ArgLys: 3.351 ± 0.051
4.816ArgLeu: 4.816 ± 0.055
1.48ArgMet: 1.48 ± 0.033
2.972ArgAsn: 2.972 ± 0.041
1.801ArgPro: 1.801 ± 0.035
2.371ArgGln: 2.371 ± 0.041
2.465ArgArg: 2.465 ± 0.043
2.916ArgSer: 2.916 ± 0.047
2.745ArgThr: 2.745 ± 0.039
2.963ArgVal: 2.963 ± 0.05
0.756ArgTrp: 0.756 ± 0.022
2.32ArgTyr: 2.32 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
4.705SerAla: 4.705 ± 0.061
0.513SerCys: 0.513 ± 0.019
2.691SerAsp: 2.691 ± 0.04
2.952SerGlu: 2.952 ± 0.039
3.405SerPhe: 3.405 ± 0.047
5.105SerGly: 5.105 ± 0.071
1.001SerHis: 1.001 ± 0.03
3.815SerIle: 3.815 ± 0.052
2.965SerLys: 2.965 ± 0.04
6.165SerLeu: 6.165 ± 0.075
1.368SerMet: 1.368 ± 0.034
2.717SerAsn: 2.717 ± 0.054
2.228SerPro: 2.228 ± 0.038
2.039SerGln: 2.039 ± 0.036
2.881SerArg: 2.881 ± 0.046
3.315SerSer: 3.315 ± 0.055
3.16SerThr: 3.16 ± 0.047
3.837SerVal: 3.837 ± 0.045
0.828SerTrp: 0.828 ± 0.024
2.213SerTyr: 2.213 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
5.433ThrAla: 5.433 ± 0.077
0.407ThrCys: 0.407 ± 0.016
2.999ThrAsp: 2.999 ± 0.05
2.905ThrGlu: 2.905 ± 0.048
2.432ThrPhe: 2.432 ± 0.041
5.101ThrGly: 5.101 ± 0.07
1.038ThrHis: 1.038 ± 0.027
3.821ThrIle: 3.821 ± 0.053
2.538ThrLys: 2.538 ± 0.042
5.518ThrLeu: 5.518 ± 0.06
1.05ThrMet: 1.05 ± 0.03
2.742ThrAsn: 2.742 ± 0.055
2.929ThrPro: 2.929 ± 0.044
2.026ThrGln: 2.026 ± 0.032
2.62ThrArg: 2.62 ± 0.043
3.216ThrSer: 3.216 ± 0.048
3.774ThrThr: 3.774 ± 0.075
3.942ThrVal: 3.942 ± 0.067
0.716ThrTrp: 0.716 ± 0.023
2.154ThrTyr: 2.154 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
6.072ValAla: 6.072 ± 0.073
0.622ValCys: 0.622 ± 0.02
3.383ValAsp: 3.383 ± 0.052
3.479ValGlu: 3.479 ± 0.052
3.094ValPhe: 3.094 ± 0.05
4.342ValGly: 4.342 ± 0.056
1.434ValHis: 1.434 ± 0.034
3.607ValIle: 3.607 ± 0.058
3.722ValLys: 3.722 ± 0.053
7.087ValLeu: 7.087 ± 0.083
1.525ValMet: 1.525 ± 0.031
3.211ValAsn: 3.211 ± 0.056
2.987ValPro: 2.987 ± 0.046
3.232ValGln: 3.232 ± 0.05
3.234ValArg: 3.234 ± 0.046
4.147ValSer: 4.147 ± 0.052
3.612ValThr: 3.612 ± 0.062
5.224ValVal: 5.224 ± 0.067
0.844ValTrp: 0.844 ± 0.025
2.483ValTyr: 2.483 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.909TrpAla: 0.909 ± 0.024
0.119TrpCys: 0.119 ± 0.008
0.652TrpAsp: 0.652 ± 0.021
0.719TrpGlu: 0.719 ± 0.022
0.589TrpPhe: 0.589 ± 0.022
0.941TrpGly: 0.941 ± 0.027
0.306TrpHis: 0.306 ± 0.015
0.722TrpIle: 0.722 ± 0.024
0.818TrpLys: 0.818 ± 0.027
1.34TrpLeu: 1.34 ± 0.032
0.427TrpMet: 0.427 ± 0.019
0.72TrpAsn: 0.72 ± 0.025
0.416TrpPro: 0.416 ± 0.016
0.782TrpGln: 0.782 ± 0.022
0.711TrpArg: 0.711 ± 0.021
0.761TrpSer: 0.761 ± 0.023
0.689TrpThr: 0.689 ± 0.022
0.891TrpVal: 0.891 ± 0.026
0.254TrpTrp: 0.254 ± 0.014
0.529TrpTyr: 0.529 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.888TyrAla: 2.888 ± 0.043
0.371TyrCys: 0.371 ± 0.016
1.952TyrAsp: 1.952 ± 0.037
1.895TyrGlu: 1.895 ± 0.038
2.027TyrPhe: 2.027 ± 0.036
2.786TyrGly: 2.786 ± 0.049
0.855TyrHis: 0.855 ± 0.023
1.903TyrIle: 1.903 ± 0.036
1.971TyrLys: 1.971 ± 0.035
3.8TyrLeu: 3.8 ± 0.049
0.706TyrMet: 0.706 ± 0.022
2.083TyrAsn: 2.083 ± 0.04
1.626TyrPro: 1.626 ± 0.039
1.792TyrGln: 1.792 ± 0.037
2.328TyrArg: 2.328 ± 0.044
2.222TyrSer: 2.222 ± 0.043
2.301TyrThr: 2.301 ± 0.045
2.082TyrVal: 2.082 ± 0.038
0.529TyrTrp: 0.529 ± 0.02
1.581TyrTyr: 1.581 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4753 proteins (1616750 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski