Amino acid dipepetide frequency for Paenibacillus baekrokdamisoli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.283AlaAla: 8.283 ± 0.107	0.661AlaCys: 0.661 ± 0.019	4.214AlaAsp: 4.214 ± 0.05	4.97AlaGlu: 4.97 ± 0.065	3.32AlaPhe: 3.32 ± 0.043	6.042AlaGly: 6.042 ± 0.076	1.404AlaHis: 1.404 ± 0.03	5.799AlaIle: 5.799 ± 0.058	4.256AlaLys: 4.256 ± 0.063	7.787AlaLeu: 7.787 ± 0.095	2.17AlaMet: 2.17 ± 0.035	2.858AlaAsn: 2.858 ± 0.049	2.514AlaPro: 2.514 ± 0.044	2.633AlaGln: 2.633 ± 0.035	3.136AlaArg: 3.136 ± 0.045	5.205AlaSer: 5.205 ± 0.049	3.819AlaThr: 3.819 ± 0.145	5.985AlaVal: 5.985 ± 0.103	0.951AlaTrp: 0.951 ± 0.024	2.7AlaTyr: 2.7 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.505CysAla: 0.505 ± 0.016	0.113CysCys: 0.113 ± 0.008	0.379CysAsp: 0.379 ± 0.015	0.451CysGlu: 0.451 ± 0.014	0.33CysPhe: 0.33 ± 0.013	0.729CysGly: 0.729 ± 0.022	0.197CysHis: 0.197 ± 0.011	0.501CysIle: 0.501 ± 0.017	0.355CysLys: 0.355 ± 0.013	0.716CysLeu: 0.716 ± 0.018	0.212CysMet: 0.212 ± 0.009	0.282CysAsn: 0.282 ± 0.013	0.345CysPro: 0.345 ± 0.015	0.213CysGln: 0.213 ± 0.01	0.383CysArg: 0.383 ± 0.014	0.584CysSer: 0.584 ± 0.017	0.402CysThr: 0.402 ± 0.016	0.452CysVal: 0.452 ± 0.016	0.099CysTrp: 0.099 ± 0.007	0.285CysTyr: 0.285 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.837AspAla: 3.837 ± 0.049	0.382AspCys: 0.382 ± 0.014	2.496AspAsp: 2.496 ± 0.039	3.569AspGlu: 3.569 ± 0.047	2.22AspPhe: 2.22 ± 0.034	4.122AspGly: 4.122 ± 0.064	1.223AspHis: 1.223 ± 0.023	3.697AspIle: 3.697 ± 0.044	2.953AspLys: 2.953 ± 0.043	4.904AspLeu: 4.904 ± 0.052	1.396AspMet: 1.396 ± 0.025	2.041AspAsn: 2.041 ± 0.035	2.309AspPro: 2.309 ± 0.036	1.984AspGln: 1.984 ± 0.035	2.597AspArg: 2.597 ± 0.038	3.12AspSer: 3.12 ± 0.048	2.6AspThr: 2.6 ± 0.046	3.557AspVal: 3.557 ± 0.049	0.914AspTrp: 0.914 ± 0.022	2.204AspTyr: 2.204 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	5.685GluAla: 5.685 ± 0.077	0.397GluCys: 0.397 ± 0.015	2.987GluAsp: 2.987 ± 0.042	4.797GluGlu: 4.797 ± 0.067	2.136GluPhe: 2.136 ± 0.032	4.145GluGly: 4.145 ± 0.05	1.472GluHis: 1.472 ± 0.031	4.308GluIle: 4.308 ± 0.051	3.792GluLys: 3.792 ± 0.055	6.862GluLeu: 6.862 ± 0.085	1.995GluMet: 1.995 ± 0.035	2.476GluAsn: 2.476 ± 0.036	2.082GluPro: 2.082 ± 0.035	3.491GluGln: 3.491 ± 0.049	3.688GluArg: 3.688 ± 0.061	3.61GluSer: 3.61 ± 0.039	3.237GluThr: 3.237 ± 0.049	4.205GluVal: 4.205 ± 0.048	1.018GluTrp: 1.018 ± 0.027	1.85GluTyr: 1.85 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.124PheAla: 3.124 ± 0.048	0.364PheCys: 0.364 ± 0.013	2.372PheAsp: 2.372 ± 0.036	2.482PheGlu: 2.482 ± 0.037	1.875PhePhe: 1.875 ± 0.039	3.177PheGly: 3.177 ± 0.045	0.949PheHis: 0.949 ± 0.024	3.234PheIle: 3.234 ± 0.05	2.128PheLys: 2.128 ± 0.036	3.891PheLeu: 3.891 ± 0.057	1.163PheMet: 1.163 ± 0.028	1.803PheAsn: 1.803 ± 0.031	1.692PhePro: 1.692 ± 0.037	1.49PheGln: 1.49 ± 0.026	1.989PheArg: 1.989 ± 0.032	2.919PheSer: 2.919 ± 0.041	2.57PheThr: 2.57 ± 0.038	3.052PheVal: 3.052 ± 0.047	0.557PheTrp: 0.557 ± 0.017	1.52PheTyr: 1.52 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	5.271GlyAla: 5.271 ± 0.171	0.701GlyCys: 0.701 ± 0.019	3.448GlyAsp: 3.448 ± 0.047	4.254GlyGlu: 4.254 ± 0.06	3.318GlyPhe: 3.318 ± 0.037	5.235GlyGly: 5.235 ± 0.093	1.402GlyHis: 1.402 ± 0.03	5.743GlyIle: 5.743 ± 0.059	4.511GlyLys: 4.511 ± 0.055	7.002GlyLeu: 7.002 ± 0.061	2.267GlyMet: 2.267 ± 0.036	2.998GlyAsn: 2.998 ± 0.05	1.844GlyPro: 1.844 ± 0.038	2.582GlyGln: 2.582 ± 0.037	3.055GlyArg: 3.055 ± 0.047	4.873GlySer: 4.873 ± 0.066	4.531GlyThr: 4.531 ± 0.068	5.013GlyVal: 5.013 ± 0.094	1.096GlyTrp: 1.096 ± 0.029	2.962GlyTyr: 2.962 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.613HisAla: 1.613 ± 0.028	0.201HisCys: 0.201 ± 0.01	1.003HisAsp: 1.003 ± 0.028	1.232HisGlu: 1.232 ± 0.027	1.049HisPhe: 1.049 ± 0.025	1.467HisGly: 1.467 ± 0.032	0.612HisHis: 0.612 ± 0.021	1.421HisIle: 1.421 ± 0.029	0.917HisLys: 0.917 ± 0.023	2.1HisLeu: 2.1 ± 0.032	0.568HisMet: 0.568 ± 0.015	0.778HisAsn: 0.778 ± 0.02	1.193HisPro: 1.193 ± 0.029	0.773HisGln: 0.773 ± 0.022	1.019HisArg: 1.019 ± 0.022	1.341HisSer: 1.341 ± 0.028	1.101HisThr: 1.101 ± 0.023	1.394HisVal: 1.394 ± 0.03	0.357HisTrp: 0.357 ± 0.014	0.899HisTyr: 0.899 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.987IleAla: 5.987 ± 0.062	0.646IleCys: 0.646 ± 0.019	4.119IleAsp: 4.119 ± 0.051	4.54IleGlu: 4.54 ± 0.046	2.561IlePhe: 2.561 ± 0.044	5.545IleGly: 5.545 ± 0.062	1.629IleHis: 1.629 ± 0.031	4.998IleIle: 4.998 ± 0.059	3.403IleLys: 3.403 ± 0.048	5.997IleLeu: 5.997 ± 0.077	1.758IleMet: 1.758 ± 0.03	2.909IleAsn: 2.909 ± 0.04	3.274IlePro: 3.274 ± 0.042	2.699IleGln: 2.699 ± 0.036	3.736IleArg: 3.736 ± 0.049	4.808IleSer: 4.808 ± 0.054	4.157IleThr: 4.157 ± 0.046	5.521IleVal: 5.521 ± 0.06	0.782IleTrp: 0.782 ± 0.019	2.257IleTyr: 2.257 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.313LysAla: 4.313 ± 0.051	0.255LysCys: 0.255 ± 0.012	3.117LysAsp: 3.117 ± 0.047	4.182LysGlu: 4.182 ± 0.046	1.725LysPhe: 1.725 ± 0.029	3.744LysGly: 3.744 ± 0.044	1.143LysHis: 1.143 ± 0.025	3.249LysIle: 3.249 ± 0.046	3.451LysLys: 3.451 ± 0.049	5.869LysLeu: 5.869 ± 0.062	1.711LysMet: 1.711 ± 0.031	2.246LysAsn: 2.246 ± 0.036	2.328LysPro: 2.328 ± 0.034	2.77LysGln: 2.77 ± 0.041	2.845LysArg: 2.845 ± 0.04	3.347LysSer: 3.347 ± 0.047	2.844LysThr: 2.844 ± 0.038	3.799LysVal: 3.799 ± 0.058	0.835LysTrp: 0.835 ± 0.022	1.749LysTyr: 1.749 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	7.784LeuAla: 7.784 ± 0.088	0.785LeuCys: 0.785 ± 0.019	4.964LeuAsp: 4.964 ± 0.043	5.979LeuGlu: 5.979 ± 0.061	4.719LeuPhe: 4.719 ± 0.063	6.471LeuGly: 6.471 ± 0.068	2.137LeuHis: 2.137 ± 0.036	6.8LeuIle: 6.8 ± 0.074	5.411LeuLys: 5.411 ± 0.056	10.844LeuLeu: 10.844 ± 0.108	2.593LeuMet: 2.593 ± 0.035	4.071LeuAsn: 4.071 ± 0.047	4.412LeuPro: 4.412 ± 0.052	4.182LeuGln: 4.182 ± 0.05	4.677LeuArg: 4.677 ± 0.055	7.145LeuSer: 7.145 ± 0.074	5.884LeuThr: 5.884 ± 0.06	6.214LeuVal: 6.214 ± 0.059	1.097LeuTrp: 1.097 ± 0.025	3.21LeuTyr: 3.21 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.067MetAla: 2.067 ± 0.036	0.168MetCys: 0.168 ± 0.009	1.523MetAsp: 1.523 ± 0.025	1.799MetGlu: 1.799 ± 0.029	1.053MetPhe: 1.053 ± 0.024	1.725MetGly: 1.725 ± 0.034	0.478MetHis: 0.478 ± 0.016	2.006MetIle: 2.006 ± 0.028	2.167MetLys: 2.167 ± 0.032	2.921MetLeu: 2.921 ± 0.043	0.857MetMet: 0.857 ± 0.022	1.586MetAsn: 1.586 ± 0.027	1.155MetPro: 1.155 ± 0.023	1.016MetGln: 1.016 ± 0.02	1.329MetArg: 1.329 ± 0.028	1.851MetSer: 1.851 ± 0.026	1.702MetThr: 1.702 ± 0.029	1.676MetVal: 1.676 ± 0.027	0.244MetTrp: 0.244 ± 0.01	0.781MetTyr: 0.781 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.001AsnAla: 3.001 ± 0.042	0.285AsnCys: 0.285 ± 0.013	2.243AsnAsp: 2.243 ± 0.036	2.813AsnGlu: 2.813 ± 0.041	1.498AsnPhe: 1.498 ± 0.029	3.602AsnGly: 3.602 ± 0.059	0.956AsnHis: 0.956 ± 0.023	2.611AsnIle: 2.611 ± 0.042	2.513AsnLys: 2.513 ± 0.045	3.476AsnLeu: 3.476 ± 0.04	1.091AsnMet: 1.091 ± 0.025	2.005AsnAsn: 2.005 ± 0.04	2.107AsnPro: 2.107 ± 0.038	1.725AsnGln: 1.725 ± 0.033	2.207AsnArg: 2.207 ± 0.038	2.485AsnSer: 2.485 ± 0.045	2.181AsnThr: 2.181 ± 0.04	2.819AsnVal: 2.819 ± 0.043	0.628AsnTrp: 0.628 ± 0.017	1.551AsnTyr: 1.551 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	3.005ProAla: 3.005 ± 0.04	0.242ProCys: 0.242 ± 0.01	2.459ProAsp: 2.459 ± 0.039	2.95ProGlu: 2.95 ± 0.042	1.93ProPhe: 1.93 ± 0.031	2.683ProGly: 2.683 ± 0.054	0.867ProHis: 0.867 ± 0.02	2.91ProIle: 2.91 ± 0.041	1.863ProLys: 1.863 ± 0.03	3.937ProLeu: 3.937 ± 0.049	0.936ProMet: 0.936 ± 0.02	1.729ProAsn: 1.729 ± 0.032	1.163ProPro: 1.163 ± 0.029	1.325ProGln: 1.325 ± 0.029	1.326ProArg: 1.326 ± 0.03	2.756ProSer: 2.756 ± 0.038	2.178ProThr: 2.178 ± 0.04	2.934ProVal: 2.934 ± 0.046	0.529ProTrp: 0.529 ± 0.016	1.522ProTyr: 1.522 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.289GlnAla: 3.289 ± 0.041	0.217GlnCys: 0.217 ± 0.011	1.646GlnAsp: 1.646 ± 0.033	2.474GlnGlu: 2.474 ± 0.038	1.577GlnPhe: 1.577 ± 0.026	2.503GlnGly: 2.503 ± 0.042	0.832GlnHis: 0.832 ± 0.021	2.661GlnIle: 2.661 ± 0.035	1.946GlnLys: 1.946 ± 0.032	4.405GlnLeu: 4.405 ± 0.058	1.18GlnMet: 1.18 ± 0.023	1.419GlnAsn: 1.419 ± 0.03	1.486GlnPro: 1.486 ± 0.025	1.912GlnGln: 1.912 ± 0.037	1.82GlnArg: 1.82 ± 0.029	2.582GlnSer: 2.582 ± 0.032	2.193GlnThr: 2.193 ± 0.03	2.578GlnVal: 2.578 ± 0.035	0.62GlnTrp: 0.62 ± 0.018	1.378GlnTyr: 1.378 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	3.09ArgAla: 3.09 ± 0.047	0.334ArgCys: 0.334 ± 0.014	2.315ArgAsp: 2.315 ± 0.034	3.386ArgGlu: 3.386 ± 0.052	2.231ArgPhe: 2.231 ± 0.03	2.777ArgGly: 2.777 ± 0.046	0.953ArgHis: 0.953 ± 0.026	3.81ArgIle: 3.81 ± 0.054	2.967ArgLys: 2.967 ± 0.043	4.906ArgLeu: 4.906 ± 0.062	1.634ArgMet: 1.634 ± 0.028	2.088ArgAsn: 2.088 ± 0.031	1.507ArgPro: 1.507 ± 0.031	1.801ArgGln: 1.801 ± 0.029	2.373ArgArg: 2.373 ± 0.044	3.027ArgSer: 3.027 ± 0.046	2.554ArgThr: 2.554 ± 0.039	2.985ArgVal: 2.985 ± 0.043	0.645ArgTrp: 0.645 ± 0.017	1.78ArgTyr: 1.78 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	4.802SerAla: 4.802 ± 0.064	0.451SerCys: 0.451 ± 0.015	3.425SerAsp: 3.425 ± 0.05	3.944SerGlu: 3.944 ± 0.051	3.224SerPhe: 3.224 ± 0.039	5.37SerGly: 5.37 ± 0.065	1.35SerHis: 1.35 ± 0.026	4.89SerIle: 4.89 ± 0.05	3.535SerLys: 3.535 ± 0.043	6.617SerLeu: 6.617 ± 0.058	1.825SerMet: 1.825 ± 0.033	2.799SerAsn: 2.799 ± 0.042	2.518SerPro: 2.518 ± 0.045	2.145SerGln: 2.145 ± 0.04	2.948SerArg: 2.948 ± 0.039	4.948SerSer: 4.948 ± 0.068	3.589SerThr: 3.589 ± 0.049	4.64SerVal: 4.64 ± 0.053	0.922SerTrp: 0.922 ± 0.024	2.372SerTyr: 2.372 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.624ThrAla: 4.624 ± 0.068	0.341ThrCys: 0.341 ± 0.015	3.086ThrAsp: 3.086 ± 0.05	3.129ThrGlu: 3.129 ± 0.039	2.473ThrPhe: 2.473 ± 0.041	4.67ThrGly: 4.67 ± 0.223	1.03ThrHis: 1.03 ± 0.023	4.352ThrIle: 4.352 ± 0.057	2.804ThrLys: 2.804 ± 0.036	5.467ThrLeu: 5.467 ± 0.064	1.395ThrMet: 1.395 ± 0.025	2.357ThrAsn: 2.357 ± 0.044	2.454ThrPro: 2.454 ± 0.042	1.645ThrGln: 1.645 ± 0.031	2.21ThrArg: 2.21 ± 0.033	3.612ThrSer: 3.612 ± 0.059	3.221ThrThr: 3.221 ± 0.06	4.442ThrVal: 4.442 ± 0.059	0.693ThrTrp: 0.693 ± 0.02	1.949ThrTyr: 1.949 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	4.976ValAla: 4.976 ± 0.069	0.591ValCys: 0.591 ± 0.018	3.729ValAsp: 3.729 ± 0.047	4.169ValGlu: 4.169 ± 0.046	2.88ValPhe: 2.88 ± 0.042	4.536ValGly: 4.536 ± 0.065	1.394ValHis: 1.394 ± 0.033	5.153ValIle: 5.153 ± 0.06	3.895ValLys: 3.895 ± 0.049	6.766ValLeu: 6.766 ± 0.063	1.922ValMet: 1.922 ± 0.027	3.094ValAsn: 3.094 ± 0.043	2.93ValPro: 2.93 ± 0.042	2.558ValGln: 2.558 ± 0.037	3.214ValArg: 3.214 ± 0.048	4.89ValSer: 4.89 ± 0.064	4.557ValThr: 4.557 ± 0.093	5.039ValVal: 5.039 ± 0.064	0.879ValTrp: 0.879 ± 0.021	2.389ValTyr: 2.389 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.865TrpAla: 0.865 ± 0.023	0.1TrpCys: 0.1 ± 0.007	0.72TrpAsp: 0.72 ± 0.021	0.781TrpGlu: 0.781 ± 0.022	0.612TrpPhe: 0.612 ± 0.018	0.895TrpGly: 0.895 ± 0.024	0.281TrpHis: 0.281 ± 0.012	0.985TrpIle: 0.985 ± 0.023	0.83TrpLys: 0.83 ± 0.022	1.468TrpLeu: 1.468 ± 0.03	0.466TrpMet: 0.466 ± 0.015	0.761TrpAsn: 0.761 ± 0.019	0.4TrpPro: 0.4 ± 0.013	0.537TrpGln: 0.537 ± 0.015	0.651TrpArg: 0.651 ± 0.02	0.93TrpSer: 0.93 ± 0.024	0.771TrpThr: 0.771 ± 0.024	0.877TrpVal: 0.877 ± 0.022	0.196TrpTrp: 0.196 ± 0.009	0.457TrpTyr: 0.457 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.588TyrAla: 2.588 ± 0.042	0.299TyrCys: 0.299 ± 0.013	1.879TyrAsp: 1.879 ± 0.031	2.332TyrGlu: 2.332 ± 0.035	1.619TyrPhe: 1.619 ± 0.032	2.668TyrGly: 2.668 ± 0.042	0.729TyrHis: 0.729 ± 0.021	2.198TyrIle: 2.198 ± 0.035	1.827TyrLys: 1.827 ± 0.035	3.443TyrLeu: 3.443 ± 0.043	0.967TyrMet: 0.967 ± 0.022	1.501TyrAsn: 1.501 ± 0.033	1.53TyrPro: 1.53 ± 0.03	1.237TyrGln: 1.237 ± 0.025	1.962TyrArg: 1.962 ± 0.032	2.278TyrSer: 2.278 ± 0.037	1.862TyrThr: 1.862 ± 0.035	2.38TyrVal: 2.38 ± 0.036	0.519TyrTrp: 0.519 ± 0.017	1.436TyrTyr: 1.436 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6378 proteins (2067881 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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