Amino acid dipepetide frequency for Campylobacter virus CP220

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.441AlaAla: 2.441 ± 0.343
0.904AlaCys: 0.904 ± 0.148
2.499AlaAsp: 2.499 ± 0.237
2.614AlaGlu: 2.614 ± 0.239
1.672AlaPhe: 1.672 ± 0.186
2.345AlaGly: 2.345 ± 0.247
0.596AlaHis: 0.596 ± 0.116
3.326AlaIle: 3.326 ± 0.215
4.229AlaLys: 4.229 ± 0.333
4.46AlaLeu: 4.46 ± 0.334
1.115AlaMet: 1.115 ± 0.12
3.383AlaAsn: 3.383 ± 0.315
1.038AlaPro: 1.038 ± 0.164
1.23AlaGln: 1.23 ± 0.17
1.519AlaArg: 1.519 ± 0.171
3.576AlaSer: 3.576 ± 0.305
2.307AlaThr: 2.307 ± 0.266
2.787AlaVal: 2.787 ± 0.266
0.346AlaTrp: 0.346 ± 0.072
1.807AlaTyr: 1.807 ± 0.207
0.0AlaXaa: 0.0 ± 0.0
Cys
0.5CysAla: 0.5 ± 0.102
0.308CysCys: 0.308 ± 0.078
1.019CysAsp: 1.019 ± 0.18
1.057CysGlu: 1.057 ± 0.153
0.942CysPhe: 0.942 ± 0.158
0.98CysGly: 0.98 ± 0.163
0.231CysHis: 0.231 ± 0.081
1.403CysIle: 1.403 ± 0.207
1.096CysLys: 1.096 ± 0.182
1.269CysLeu: 1.269 ± 0.155
0.308CysMet: 0.308 ± 0.077
1.346CysAsn: 1.346 ± 0.236
0.404CysPro: 0.404 ± 0.113
0.442CysGln: 0.442 ± 0.11
0.577CysArg: 0.577 ± 0.118
0.865CysSer: 0.865 ± 0.123
0.75CysThr: 0.75 ± 0.18
0.75CysVal: 0.75 ± 0.137
0.115CysTrp: 0.115 ± 0.046
0.769CysTyr: 0.769 ± 0.145
0.0CysXaa: 0.0 ± 0.0
Asp
3.095AspAla: 3.095 ± 0.222
1.288AspCys: 1.288 ± 0.282
3.172AspAsp: 3.172 ± 0.303
3.23AspGlu: 3.23 ± 0.331
5.536AspPhe: 5.536 ± 0.405
3.114AspGly: 3.114 ± 0.275
0.673AspHis: 0.673 ± 0.105
6.575AspIle: 6.575 ± 0.354
4.075AspLys: 4.075 ± 0.26
8.151AspLeu: 8.151 ± 0.539
0.865AspMet: 0.865 ± 0.139
4.229AspAsn: 4.229 ± 0.322
2.153AspPro: 2.153 ± 0.216
1.038AspGln: 1.038 ± 0.156
1.749AspArg: 1.749 ± 0.195
6.863AspSer: 6.863 ± 0.47
4.479AspThr: 4.479 ± 0.276
3.076AspVal: 3.076 ± 0.217
0.577AspTrp: 0.577 ± 0.097
4.729AspTyr: 4.729 ± 0.348
0.0AspXaa: 0.0 ± 0.0
Glu
3.806GluAla: 3.806 ± 0.323
1.096GluCys: 1.096 ± 0.195
3.287GluAsp: 3.287 ± 0.247
3.249GluGlu: 3.249 ± 0.305
4.114GluPhe: 4.114 ± 0.261
2.461GluGly: 2.461 ± 0.255
0.98GluHis: 0.98 ± 0.144
6.075GluIle: 6.075 ± 0.382
4.037GluLys: 4.037 ± 0.294
6.882GluLeu: 6.882 ± 0.435
0.884GluMet: 0.884 ± 0.124
4.537GluAsn: 4.537 ± 0.333
2.249GluPro: 2.249 ± 0.26
1.519GluGln: 1.519 ± 0.17
1.692GluArg: 1.692 ± 0.189
5.229GluSer: 5.229 ± 0.312
4.114GluThr: 4.114 ± 0.318
4.018GluVal: 4.018 ± 0.26
0.365GluTrp: 0.365 ± 0.076
3.96GluTyr: 3.96 ± 0.301
0.0GluXaa: 0.0 ± 0.0
Phe
1.557PheAla: 1.557 ± 0.185
0.731PheCys: 0.731 ± 0.13
4.364PheAsp: 4.364 ± 0.285
4.095PheGlu: 4.095 ± 0.336
1.922PhePhe: 1.922 ± 0.215
2.595PheGly: 2.595 ± 0.236
0.538PheHis: 0.538 ± 0.116
4.364PheIle: 4.364 ± 0.283
6.575PheLys: 6.575 ± 0.393
4.383PheLeu: 4.383 ± 0.292
0.884PheMet: 0.884 ± 0.128
4.921PheAsn: 4.921 ± 0.311
0.827PhePro: 0.827 ± 0.15
1.326PheGln: 1.326 ± 0.157
1.73PheArg: 1.73 ± 0.174
3.095PheSer: 3.095 ± 0.246
2.634PheThr: 2.634 ± 0.247
2.211PheVal: 2.211 ± 0.197
0.288PheTrp: 0.288 ± 0.092
2.614PheTyr: 2.614 ± 0.291
0.0PheXaa: 0.0 ± 0.0
Gly
2.614GlyAla: 2.614 ± 0.248
0.865GlyCys: 0.865 ± 0.148
2.941GlyAsp: 2.941 ± 0.241
2.403GlyGlu: 2.403 ± 0.241
2.691GlyPhe: 2.691 ± 0.278
1.692GlyGly: 1.692 ± 0.232
0.538GlyHis: 0.538 ± 0.123
4.383GlyIle: 4.383 ± 0.28
3.403GlyLys: 3.403 ± 0.265
3.902GlyLeu: 3.902 ± 0.299
0.884GlyMet: 0.884 ± 0.118
3.095GlyAsn: 3.095 ± 0.211
0.731GlyPro: 0.731 ± 0.116
1.173GlyGln: 1.173 ± 0.182
1.096GlyArg: 1.096 ± 0.154
4.402GlySer: 4.402 ± 0.31
2.768GlyThr: 2.768 ± 0.273
3.018GlyVal: 3.018 ± 0.231
0.288GlyTrp: 0.288 ± 0.066
2.192GlyTyr: 2.192 ± 0.186
0.0GlyXaa: 0.0 ± 0.0
His
0.269HisAla: 0.269 ± 0.067
0.327HisCys: 0.327 ± 0.084
0.577HisAsp: 0.577 ± 0.098
0.519HisGlu: 0.519 ± 0.107
0.769HisPhe: 0.769 ± 0.121
0.442HisGly: 0.442 ± 0.096
0.365HisHis: 0.365 ± 0.089
1.615HisIle: 1.615 ± 0.183
1.942HisLys: 1.942 ± 0.245
1.307HisLeu: 1.307 ± 0.18
0.135HisMet: 0.135 ± 0.053
1.173HisAsn: 1.173 ± 0.154
0.423HisPro: 0.423 ± 0.086
0.404HisGln: 0.404 ± 0.102
0.461HisArg: 0.461 ± 0.115
1.211HisSer: 1.211 ± 0.194
0.731HisThr: 0.731 ± 0.12
0.25HisVal: 0.25 ± 0.068
0.038HisTrp: 0.038 ± 0.034
0.807HisTyr: 0.807 ± 0.119
0.0HisXaa: 0.0 ± 0.0
Ile
3.691IleAla: 3.691 ± 0.284
1.346IleCys: 1.346 ± 0.168
7.478IleAsp: 7.478 ± 0.409
6.19IleGlu: 6.19 ± 0.397
4.248IlePhe: 4.248 ± 0.3
3.095IleGly: 3.095 ± 0.281
1.307IleHis: 1.307 ± 0.175
6.459IleIle: 6.459 ± 0.428
10.035IleLys: 10.035 ± 0.479
7.17IleLeu: 7.17 ± 0.366
1.442IleMet: 1.442 ± 0.176
7.766IleAsn: 7.766 ± 0.413
2.307IlePro: 2.307 ± 0.219
3.518IleGln: 3.518 ± 0.3
2.864IleArg: 2.864 ± 0.214
5.306IleSer: 5.306 ± 0.38
4.479IleThr: 4.479 ± 0.269
4.133IleVal: 4.133 ± 0.262
0.519IleTrp: 0.519 ± 0.083
3.479IleTyr: 3.479 ± 0.303
0.0IleXaa: 0.0 ± 0.0
Lys
3.999LysAla: 3.999 ± 0.35
1.211LysCys: 1.211 ± 0.207
7.728LysAsp: 7.728 ± 0.427
6.286LysGlu: 6.286 ± 0.344
4.402LysPhe: 4.402 ± 0.254
3.806LysGly: 3.806 ± 0.25
1.538LysHis: 1.538 ± 0.192
8.728LysIle: 8.728 ± 0.474
7.536LysLys: 7.536 ± 0.434
8.612LysLeu: 8.612 ± 0.464
1.692LysMet: 1.692 ± 0.187
7.536LysAsn: 7.536 ± 0.392
2.999LysPro: 2.999 ± 0.254
2.999LysGln: 2.999 ± 0.255
2.653LysArg: 2.653 ± 0.225
6.978LysSer: 6.978 ± 0.389
5.402LysThr: 5.402 ± 0.387
4.421LysVal: 4.421 ± 0.292
0.923LysTrp: 0.923 ± 0.148
6.402LysTyr: 6.402 ± 0.372
0.0LysXaa: 0.0 ± 0.0
Leu
3.979LeuAla: 3.979 ± 0.284
0.942LeuCys: 0.942 ± 0.121
7.555LeuAsp: 7.555 ± 0.375
6.69LeuGlu: 6.69 ± 0.423
3.422LeuPhe: 3.422 ± 0.243
4.191LeuGly: 4.191 ± 0.314
1.211LeuHis: 1.211 ± 0.172
6.632LeuIle: 6.632 ± 0.404
10.227LeuLys: 10.227 ± 0.374
5.633LeuLeu: 5.633 ± 0.355
1.538LeuMet: 1.538 ± 0.191
8.343LeuAsn: 8.343 ± 0.44
2.749LeuPro: 2.749 ± 0.2
2.192LeuGln: 2.192 ± 0.177
2.96LeuArg: 2.96 ± 0.24
6.075LeuSer: 6.075 ± 0.345
4.46LeuThr: 4.46 ± 0.336
4.172LeuVal: 4.172 ± 0.378
0.615LeuTrp: 0.615 ± 0.089
4.018LeuTyr: 4.018 ± 0.338
0.0LeuXaa: 0.0 ± 0.0
Met
0.923MetAla: 0.923 ± 0.116
0.288MetCys: 0.288 ± 0.079
1.0MetAsp: 1.0 ± 0.129
0.731MetGlu: 0.731 ± 0.115
0.904MetPhe: 0.904 ± 0.114
0.884MetGly: 0.884 ± 0.158
0.192MetHis: 0.192 ± 0.061
1.499MetIle: 1.499 ± 0.142
1.711MetLys: 1.711 ± 0.183
1.807MetLeu: 1.807 ± 0.166
0.115MetMet: 0.115 ± 0.042
1.634MetAsn: 1.634 ± 0.187
0.615MetPro: 0.615 ± 0.126
0.538MetGln: 0.538 ± 0.101
0.615MetArg: 0.615 ± 0.108
1.211MetSer: 1.211 ± 0.142
0.923MetThr: 0.923 ± 0.13
0.788MetVal: 0.788 ± 0.119
0.096MetTrp: 0.096 ± 0.039
0.961MetTyr: 0.961 ± 0.142
0.0MetXaa: 0.0 ± 0.0
Asn
3.172AsnAla: 3.172 ± 0.277
1.134AsnCys: 1.134 ± 0.253
4.575AsnAsp: 4.575 ± 0.298
4.941AsnGlu: 4.941 ± 0.269
4.191AsnPhe: 4.191 ± 0.275
3.537AsnGly: 3.537 ± 0.247
1.192AsnHis: 1.192 ± 0.171
8.343AsnIle: 8.343 ± 0.395
8.093AsnLys: 8.093 ± 0.419
6.805AsnLeu: 6.805 ± 0.38
1.499AsnMet: 1.499 ± 0.17
6.036AsnAsn: 6.036 ± 0.401
3.018AsnPro: 3.018 ± 0.292
2.595AsnGln: 2.595 ± 0.233
2.288AsnArg: 2.288 ± 0.237
4.71AsnSer: 4.71 ± 0.348
4.883AsnThr: 4.883 ± 0.287
4.229AsnVal: 4.229 ± 0.318
0.384AsnTrp: 0.384 ± 0.084
4.71AsnTyr: 4.71 ± 0.347
0.0AsnXaa: 0.0 ± 0.0
Pro
0.942ProAla: 0.942 ± 0.114
0.25ProCys: 0.25 ± 0.07
2.153ProAsp: 2.153 ± 0.206
2.864ProGlu: 2.864 ± 0.254
1.23ProPhe: 1.23 ± 0.156
1.845ProGly: 1.845 ± 0.187
0.365ProHis: 0.365 ± 0.096
2.115ProIle: 2.115 ± 0.185
2.826ProLys: 2.826 ± 0.235
2.211ProLeu: 2.211 ± 0.201
0.577ProMet: 0.577 ± 0.106
1.903ProAsn: 1.903 ± 0.2
0.423ProPro: 0.423 ± 0.1
0.654ProGln: 0.654 ± 0.119
1.096ProArg: 1.096 ± 0.161
2.211ProSer: 2.211 ± 0.197
1.442ProThr: 1.442 ± 0.193
1.634ProVal: 1.634 ± 0.181
0.231ProTrp: 0.231 ± 0.058
1.23ProTyr: 1.23 ± 0.162
0.0ProXaa: 0.0 ± 0.0
Gln
2.095GlnAla: 2.095 ± 0.241
0.25GlnCys: 0.25 ± 0.063
2.095GlnAsp: 2.095 ± 0.186
2.441GlnGlu: 2.441 ± 0.244
1.288GlnPhe: 1.288 ± 0.154
1.596GlnGly: 1.596 ± 0.211
0.384GlnHis: 0.384 ± 0.079
2.614GlnIle: 2.614 ± 0.269
2.326GlnLys: 2.326 ± 0.217
2.48GlnLeu: 2.48 ± 0.244
0.442GlnMet: 0.442 ± 0.069
2.422GlnAsn: 2.422 ± 0.231
0.538GlnPro: 0.538 ± 0.111
0.5GlnGln: 0.5 ± 0.101
0.942GlnArg: 0.942 ± 0.149
1.634GlnSer: 1.634 ± 0.166
1.634GlnThr: 1.634 ± 0.185
1.807GlnVal: 1.807 ± 0.231
0.25GlnTrp: 0.25 ± 0.064
1.672GlnTyr: 1.672 ± 0.173
0.0GlnXaa: 0.0 ± 0.0
Arg
1.442ArgAla: 1.442 ± 0.129
0.519ArgCys: 0.519 ± 0.113
1.692ArgAsp: 1.692 ± 0.171
1.845ArgGlu: 1.845 ± 0.206
2.307ArgPhe: 2.307 ± 0.206
1.615ArgGly: 1.615 ± 0.174
0.577ArgHis: 0.577 ± 0.112
3.076ArgIle: 3.076 ± 0.226
2.134ArgLys: 2.134 ± 0.232
3.018ArgLeu: 3.018 ± 0.259
0.481ArgMet: 0.481 ± 0.079
2.076ArgAsn: 2.076 ± 0.178
0.731ArgPro: 0.731 ± 0.1
0.788ArgGln: 0.788 ± 0.126
1.096ArgArg: 1.096 ± 0.136
2.115ArgSer: 2.115 ± 0.187
1.922ArgThr: 1.922 ± 0.18
2.038ArgVal: 2.038 ± 0.221
0.211ArgTrp: 0.211 ± 0.062
1.788ArgTyr: 1.788 ± 0.193
0.0ArgXaa: 0.0 ± 0.0
Ser
3.153SerAla: 3.153 ± 0.328
0.827SerCys: 0.827 ± 0.124
4.46SerAsp: 4.46 ± 0.303
4.479SerGlu: 4.479 ± 0.322
3.441SerPhe: 3.441 ± 0.298
3.71SerGly: 3.71 ± 0.365
0.923SerHis: 0.923 ± 0.121
6.152SerIle: 6.152 ± 0.379
8.478SerLys: 8.478 ± 0.464
6.075SerLeu: 6.075 ± 0.361
1.576SerMet: 1.576 ± 0.195
5.536SerAsn: 5.536 ± 0.355
1.442SerPro: 1.442 ± 0.159
2.384SerGln: 2.384 ± 0.199
2.288SerArg: 2.288 ± 0.189
4.806SerSer: 4.806 ± 0.452
3.883SerThr: 3.883 ± 0.284
4.21SerVal: 4.21 ± 0.293
0.404SerTrp: 0.404 ± 0.094
2.787SerTyr: 2.787 ± 0.212
0.0SerXaa: 0.0 ± 0.0
Thr
2.153ThrAla: 2.153 ± 0.236
0.827ThrCys: 0.827 ± 0.164
3.364ThrAsp: 3.364 ± 0.265
4.172ThrGlu: 4.172 ± 0.352
2.691ThrPhe: 2.691 ± 0.233
2.941ThrGly: 2.941 ± 0.249
0.692ThrHis: 0.692 ± 0.119
4.575ThrIle: 4.575 ± 0.35
6.228ThrLys: 6.228 ± 0.34
4.345ThrLeu: 4.345 ± 0.261
0.961ThrMet: 0.961 ± 0.115
4.825ThrAsn: 4.825 ± 0.285
2.23ThrPro: 2.23 ± 0.203
2.403ThrGln: 2.403 ± 0.279
1.999ThrArg: 1.999 ± 0.194
3.364ThrSer: 3.364 ± 0.252
3.441ThrThr: 3.441 ± 0.335
2.499ThrVal: 2.499 ± 0.275
0.481ThrTrp: 0.481 ± 0.098
2.826ThrTyr: 2.826 ± 0.245
0.0ThrXaa: 0.0 ± 0.0
Val
2.076ValAla: 2.076 ± 0.235
0.673ValCys: 0.673 ± 0.147
4.383ValAsp: 4.383 ± 0.323
3.364ValGlu: 3.364 ± 0.319
2.518ValPhe: 2.518 ± 0.25
2.249ValGly: 2.249 ± 0.256
0.673ValHis: 0.673 ± 0.106
3.691ValIle: 3.691 ± 0.231
4.748ValLys: 4.748 ± 0.345
4.652ValLeu: 4.652 ± 0.311
0.942ValMet: 0.942 ± 0.137
3.999ValAsn: 3.999 ± 0.336
1.634ValPro: 1.634 ± 0.232
1.769ValGln: 1.769 ± 0.217
1.865ValArg: 1.865 ± 0.167
3.864ValSer: 3.864 ± 0.356
2.884ValThr: 2.884 ± 0.266
3.095ValVal: 3.095 ± 0.263
0.384ValTrp: 0.384 ± 0.073
2.826ValTyr: 2.826 ± 0.281
0.0ValXaa: 0.0 ± 0.0
Trp
0.365TrpAla: 0.365 ± 0.072
0.231TrpCys: 0.231 ± 0.066
0.596TrpAsp: 0.596 ± 0.093
0.423TrpGlu: 0.423 ± 0.092
0.365TrpPhe: 0.365 ± 0.08
0.365TrpGly: 0.365 ± 0.083
0.019TrpHis: 0.019 ± 0.018
0.538TrpIle: 0.538 ± 0.097
0.461TrpLys: 0.461 ± 0.113
0.538TrpLeu: 0.538 ± 0.099
0.173TrpMet: 0.173 ± 0.053
0.711TrpAsn: 0.711 ± 0.115
0.115TrpPro: 0.115 ± 0.046
0.269TrpGln: 0.269 ± 0.075
0.173TrpArg: 0.173 ± 0.059
0.461TrpSer: 0.461 ± 0.1
0.308TrpThr: 0.308 ± 0.084
0.442TrpVal: 0.442 ± 0.1
0.058TrpTrp: 0.058 ± 0.036
0.404TrpTyr: 0.404 ± 0.066
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.922TyrAla: 1.922 ± 0.205
1.115TyrCys: 1.115 ± 0.18
3.729TyrAsp: 3.729 ± 0.25
2.96TyrGlu: 2.96 ± 0.233
2.999TyrPhe: 2.999 ± 0.307
1.615TyrGly: 1.615 ± 0.158
0.769TyrHis: 0.769 ± 0.119
4.671TyrIle: 4.671 ± 0.33
5.69TyrLys: 5.69 ± 0.37
3.902TyrLeu: 3.902 ± 0.249
0.904TyrMet: 0.904 ± 0.128
4.864TyrAsn: 4.864 ± 0.32
1.576TyrPro: 1.576 ± 0.19
1.672TyrGln: 1.672 ± 0.198
1.807TyrArg: 1.807 ± 0.211
3.057TyrSer: 3.057 ± 0.284
3.576TyrThr: 3.576 ± 0.233
2.711TyrVal: 2.711 ± 0.303
0.442TyrTrp: 0.442 ± 0.096
2.499TyrTyr: 2.499 ± 0.231
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 194 proteins (52020 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski