Amino acid dipepetide frequency for Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Clostridium phytofermentans)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.777AlaAla: 4.777 ± 0.091
0.869AlaCys: 0.869 ± 0.027
3.175AlaAsp: 3.175 ± 0.048
3.743AlaGlu: 3.743 ± 0.059
2.89AlaPhe: 2.89 ± 0.051
4.417AlaGly: 4.417 ± 0.066
0.867AlaHis: 0.867 ± 0.027
5.585AlaIle: 5.585 ± 0.086
5.058AlaLys: 5.058 ± 0.074
5.977AlaLeu: 5.977 ± 0.086
2.025AlaMet: 2.025 ± 0.034
2.977AlaAsn: 2.977 ± 0.053
1.745AlaPro: 1.745 ± 0.044
1.638AlaGln: 1.638 ± 0.039
2.214AlaArg: 2.214 ± 0.053
3.876AlaSer: 3.876 ± 0.071
3.752AlaThr: 3.752 ± 0.11
4.664AlaVal: 4.664 ± 0.081
0.525AlaTrp: 0.525 ± 0.019
2.547AlaTyr: 2.547 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.756CysAla: 0.756 ± 0.022
0.26CysCys: 0.26 ± 0.016
0.737CysAsp: 0.737 ± 0.026
0.812CysGlu: 0.812 ± 0.024
0.628CysPhe: 0.628 ± 0.022
1.193CysGly: 1.193 ± 0.04
0.263CysHis: 0.263 ± 0.019
1.159CysIle: 1.159 ± 0.024
0.895CysLys: 0.895 ± 0.032
1.117CysLeu: 1.117 ± 0.03
0.386CysMet: 0.386 ± 0.02
0.666CysAsn: 0.666 ± 0.023
0.536CysPro: 0.536 ± 0.026
0.332CysGln: 0.332 ± 0.018
0.415CysArg: 0.415 ± 0.017
0.882CysSer: 0.882 ± 0.024
0.669CysThr: 0.669 ± 0.025
0.799CysVal: 0.799 ± 0.027
0.106CysTrp: 0.106 ± 0.009
0.602CysTyr: 0.602 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.283AspAla: 3.283 ± 0.044
0.73AspCys: 0.73 ± 0.023
2.461AspAsp: 2.461 ± 0.047
4.013AspGlu: 4.013 ± 0.048
2.648AspPhe: 2.648 ± 0.037
3.86AspGly: 3.86 ± 0.063
0.81AspHis: 0.81 ± 0.029
4.874AspIle: 4.874 ± 0.055
3.877AspLys: 3.877 ± 0.071
4.55AspLeu: 4.55 ± 0.061
1.564AspMet: 1.564 ± 0.039
2.741AspAsn: 2.741 ± 0.047
1.44AspPro: 1.44 ± 0.033
1.317AspGln: 1.317 ± 0.034
1.971AspArg: 1.971 ± 0.042
3.336AspSer: 3.336 ± 0.049
3.109AspThr: 3.109 ± 0.093
3.506AspVal: 3.506 ± 0.059
0.539AspTrp: 0.539 ± 0.023
2.976AspTyr: 2.976 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
4.743GluAla: 4.743 ± 0.07
0.832GluCys: 0.832 ± 0.027
4.132GluAsp: 4.132 ± 0.072
7.027GluGlu: 7.027 ± 0.118
2.922GluPhe: 2.922 ± 0.058
4.147GluGly: 4.147 ± 0.05
1.286GluHis: 1.286 ± 0.034
5.967GluIle: 5.967 ± 0.097
5.945GluLys: 5.945 ± 0.105
6.87GluLeu: 6.87 ± 0.094
2.081GluMet: 2.081 ± 0.043
4.279GluAsn: 4.279 ± 0.064
1.699GluPro: 1.699 ± 0.039
2.78GluGln: 2.78 ± 0.058
2.706GluArg: 2.706 ± 0.047
3.678GluSer: 3.678 ± 0.055
3.514GluThr: 3.514 ± 0.108
4.795GluVal: 4.795 ± 0.068
0.62GluTrp: 0.62 ± 0.027
3.149GluTyr: 3.149 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
2.633PheAla: 2.633 ± 0.046
0.652PheCys: 0.652 ± 0.022
2.623PheAsp: 2.623 ± 0.05
2.809PheGlu: 2.809 ± 0.045
1.972PhePhe: 1.972 ± 0.045
2.977PheGly: 2.977 ± 0.044
0.927PheHis: 0.927 ± 0.026
3.506PheIle: 3.506 ± 0.063
2.453PheLys: 2.453 ± 0.043
4.299PheLeu: 4.299 ± 0.075
1.177PheMet: 1.177 ± 0.033
1.893PheAsn: 1.893 ± 0.045
1.343PhePro: 1.343 ± 0.027
1.442PheGln: 1.442 ± 0.031
1.569PheArg: 1.569 ± 0.035
3.107PheSer: 3.107 ± 0.06
2.64PheThr: 2.64 ± 0.051
2.825PheVal: 2.825 ± 0.055
0.418PheTrp: 0.418 ± 0.019
1.927PheTyr: 1.927 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
4.33GlyAla: 4.33 ± 0.105
1.089GlyCys: 1.089 ± 0.035
3.185GlyAsp: 3.185 ± 0.05
4.284GlyGlu: 4.284 ± 0.065
3.091GlyPhe: 3.091 ± 0.042
4.257GlyGly: 4.257 ± 0.076
1.07GlyHis: 1.07 ± 0.03
6.41GlyIle: 6.41 ± 0.066
5.035GlyLys: 5.035 ± 0.083
5.666GlyLeu: 5.666 ± 0.091
2.062GlyMet: 2.062 ± 0.046
3.361GlyAsn: 3.361 ± 0.065
1.279GlyPro: 1.279 ± 0.043
1.724GlyGln: 1.724 ± 0.042
2.331GlyArg: 2.331 ± 0.05
3.935GlySer: 3.935 ± 0.064
3.993GlyThr: 3.993 ± 0.064
4.565GlyVal: 4.565 ± 0.058
0.596GlyTrp: 0.596 ± 0.019
3.193GlyTyr: 3.193 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
0.924HisAla: 0.924 ± 0.024
0.279HisCys: 0.279 ± 0.015
0.857HisAsp: 0.857 ± 0.025
1.047HisGlu: 1.047 ± 0.028
0.771HisPhe: 0.771 ± 0.026
1.2HisGly: 1.2 ± 0.023
0.366HisHis: 0.366 ± 0.016
1.413HisIle: 1.413 ± 0.031
1.101HisLys: 1.101 ± 0.026
1.403HisLeu: 1.403 ± 0.032
0.473HisMet: 0.473 ± 0.021
0.835HisAsn: 0.835 ± 0.026
0.714HisPro: 0.714 ± 0.027
0.555HisGln: 0.555 ± 0.02
0.726HisArg: 0.726 ± 0.022
1.041HisSer: 1.041 ± 0.032
0.892HisThr: 0.892 ± 0.027
0.936HisVal: 0.936 ± 0.025
0.161HisTrp: 0.161 ± 0.012
0.776HisTyr: 0.776 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.808IleAla: 5.808 ± 0.087
1.194IleCys: 1.194 ± 0.035
4.649IleAsp: 4.649 ± 0.076
5.799IleGlu: 5.799 ± 0.137
3.293IlePhe: 3.293 ± 0.069
5.406IleGly: 5.406 ± 0.08
1.481IleHis: 1.481 ± 0.032
6.886IleIle: 6.886 ± 0.08
5.686IleLys: 5.686 ± 0.077
8.131IleLeu: 8.131 ± 0.105
2.119IleMet: 2.119 ± 0.048
4.106IleAsn: 4.106 ± 0.055
3.369IlePro: 3.369 ± 0.051
2.453IleGln: 2.453 ± 0.059
3.256IleArg: 3.256 ± 0.051
6.021IleSer: 6.021 ± 0.08
5.356IleThr: 5.356 ± 0.053
5.57IleVal: 5.57 ± 0.07
0.637IleTrp: 0.637 ± 0.026
3.232IleTyr: 3.232 ± 0.052
0.0IleXaa: 0.0 ± 0.0
Lys
4.557LysAla: 4.557 ± 0.061
0.645LysCys: 0.645 ± 0.019
4.575LysAsp: 4.575 ± 0.077
7.694LysGlu: 7.694 ± 0.09
2.237LysPhe: 2.237 ± 0.047
4.108LysGly: 4.108 ± 0.067
1.089LysHis: 1.089 ± 0.027
5.545LysIle: 5.545 ± 0.069
6.495LysLys: 6.495 ± 0.099
6.472LysLeu: 6.472 ± 0.077
2.089LysMet: 2.089 ± 0.038
4.413LysAsn: 4.413 ± 0.071
2.026LysPro: 2.026 ± 0.043
2.765LysGln: 2.765 ± 0.053
2.989LysArg: 2.989 ± 0.045
4.121LysSer: 4.121 ± 0.066
3.857LysThr: 3.857 ± 0.06
5.025LysVal: 5.025 ± 0.068
0.559LysTrp: 0.559 ± 0.025
2.919LysTyr: 2.919 ± 0.052
0.0LysXaa: 0.0 ± 0.0
Leu
5.896LeuAla: 5.896 ± 0.074
1.384LeuCys: 1.384 ± 0.036
4.806LeuAsp: 4.806 ± 0.056
6.226LeuGlu: 6.226 ± 0.097
4.167LeuPhe: 4.167 ± 0.074
5.816LeuGly: 5.816 ± 0.087
1.487LeuHis: 1.487 ± 0.034
7.177LeuIle: 7.177 ± 0.08
6.756LeuLys: 6.756 ± 0.074
9.103LeuLeu: 9.103 ± 0.121
2.469LeuMet: 2.469 ± 0.045
4.695LeuAsn: 4.695 ± 0.06
3.482LeuPro: 3.482 ± 0.065
2.663LeuGln: 2.663 ± 0.051
3.574LeuArg: 3.574 ± 0.046
7.35LeuSer: 7.35 ± 0.091
5.376LeuThr: 5.376 ± 0.064
5.586LeuVal: 5.586 ± 0.057
0.761LeuTrp: 0.761 ± 0.026
3.727LeuTyr: 3.727 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
1.802MetAla: 1.802 ± 0.036
0.296MetCys: 0.296 ± 0.015
1.689MetAsp: 1.689 ± 0.042
2.291MetGlu: 2.291 ± 0.045
1.039MetPhe: 1.039 ± 0.028
1.699MetGly: 1.699 ± 0.038
0.373MetHis: 0.373 ± 0.019
2.336MetIle: 2.336 ± 0.045
2.668MetLys: 2.668 ± 0.047
2.643MetLeu: 2.643 ± 0.049
0.837MetMet: 0.837 ± 0.026
1.656MetAsn: 1.656 ± 0.031
0.961MetPro: 0.961 ± 0.03
0.914MetGln: 0.914 ± 0.024
1.082MetArg: 1.082 ± 0.028
1.699MetSer: 1.699 ± 0.046
1.527MetThr: 1.527 ± 0.032
1.904MetVal: 1.904 ± 0.046
0.21MetTrp: 0.21 ± 0.015
0.879MetTyr: 0.879 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.208AsnAla: 3.208 ± 0.043
0.613AsnCys: 0.613 ± 0.024
2.574AsnAsp: 2.574 ± 0.046
3.59AsnGlu: 3.59 ± 0.055
2.092AsnPhe: 2.092 ± 0.042
3.683AsnGly: 3.683 ± 0.072
0.984AsnHis: 0.984 ± 0.025
4.394AsnIle: 4.394 ± 0.055
3.73AsnLys: 3.73 ± 0.063
4.612AsnLeu: 4.612 ± 0.068
1.384AsnMet: 1.384 ± 0.034
2.991AsnAsn: 2.991 ± 0.071
2.084AsnPro: 2.084 ± 0.044
2.19AsnGln: 2.19 ± 0.053
2.019AsnArg: 2.019 ± 0.041
3.398AsnSer: 3.398 ± 0.067
3.006AsnThr: 3.006 ± 0.052
3.298AsnVal: 3.298 ± 0.08
0.421AsnTrp: 0.421 ± 0.021
2.349AsnTyr: 2.349 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
1.815ProAla: 1.815 ± 0.048
0.405ProCys: 0.405 ± 0.017
1.769ProAsp: 1.769 ± 0.034
2.538ProGlu: 2.538 ± 0.054
1.472ProPhe: 1.472 ± 0.033
1.845ProGly: 1.845 ± 0.047
0.538ProHis: 0.538 ± 0.023
2.574ProIle: 2.574 ± 0.047
2.083ProLys: 2.083 ± 0.048
2.685ProLeu: 2.685 ± 0.043
0.939ProMet: 0.939 ± 0.025
1.666ProAsn: 1.666 ± 0.037
0.636ProPro: 0.636 ± 0.03
0.885ProGln: 0.885 ± 0.035
0.922ProArg: 0.922 ± 0.031
2.042ProSer: 2.042 ± 0.032
2.06ProThr: 2.06 ± 0.064
2.409ProVal: 2.409 ± 0.04
0.312ProTrp: 0.312 ± 0.015
1.474ProTyr: 1.474 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
1.9GlnAla: 1.9 ± 0.04
0.377GlnCys: 0.377 ± 0.013
1.428GlnAsp: 1.428 ± 0.029
2.261GlnGlu: 2.261 ± 0.055
1.254GlnPhe: 1.254 ± 0.03
1.985GlnGly: 1.985 ± 0.051
0.402GlnHis: 0.402 ± 0.018
2.677GlnIle: 2.677 ± 0.041
2.569GlnLys: 2.569 ± 0.042
2.949GlnLeu: 2.949 ± 0.048
1.0GlnMet: 1.0 ± 0.027
1.779GlnAsn: 1.779 ± 0.041
0.815GlnPro: 0.815 ± 0.026
1.003GlnGln: 1.003 ± 0.027
1.18GlnArg: 1.18 ± 0.033
1.804GlnSer: 1.804 ± 0.031
1.721GlnThr: 1.721 ± 0.05
2.039GlnVal: 2.039 ± 0.073
0.256GlnTrp: 0.256 ± 0.019
1.414GlnTyr: 1.414 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
2.019ArgAla: 2.019 ± 0.037
0.465ArgCys: 0.465 ± 0.021
1.839ArgAsp: 1.839 ± 0.046
3.007ArgGlu: 3.007 ± 0.052
1.723ArgPhe: 1.723 ± 0.039
2.126ArgGly: 2.126 ± 0.036
0.599ArgHis: 0.599 ± 0.022
3.399ArgIle: 3.399 ± 0.063
3.085ArgLys: 3.085 ± 0.04
3.355ArgLeu: 3.355 ± 0.048
1.268ArgMet: 1.268 ± 0.032
2.127ArgAsn: 2.127 ± 0.039
0.987ArgPro: 0.987 ± 0.04
1.104ArgGln: 1.104 ± 0.034
1.614ArgArg: 1.614 ± 0.041
1.865ArgSer: 1.865 ± 0.039
1.948ArgThr: 1.948 ± 0.03
2.383ArgVal: 2.383 ± 0.041
0.29ArgTrp: 0.29 ± 0.014
1.788ArgTyr: 1.788 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
3.673SerAla: 3.673 ± 0.06
0.771SerCys: 0.771 ± 0.028
3.421SerAsp: 3.421 ± 0.061
4.289SerGlu: 4.289 ± 0.061
3.189SerPhe: 3.189 ± 0.059
4.734SerGly: 4.734 ± 0.081
1.027SerHis: 1.027 ± 0.03
5.738SerIle: 5.738 ± 0.083
4.658SerLys: 4.658 ± 0.068
6.014SerLeu: 6.014 ± 0.07
1.87SerMet: 1.87 ± 0.035
3.42SerAsn: 3.42 ± 0.063
1.749SerPro: 1.749 ± 0.04
1.763SerGln: 1.763 ± 0.041
2.099SerArg: 2.099 ± 0.031
4.311SerSer: 4.311 ± 0.083
3.482SerThr: 3.482 ± 0.061
4.36SerVal: 4.36 ± 0.085
0.555SerTrp: 0.555 ± 0.023
3.039SerTyr: 3.039 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
3.742ThrAla: 3.742 ± 0.063
0.65ThrCys: 0.65 ± 0.024
2.89ThrAsp: 2.89 ± 0.053
3.676ThrGlu: 3.676 ± 0.055
2.433ThrPhe: 2.433 ± 0.046
4.384ThrGly: 4.384 ± 0.188
0.85ThrHis: 0.85 ± 0.022
5.106ThrIle: 5.106 ± 0.074
4.204ThrLys: 4.204 ± 0.058
5.298ThrLeu: 5.298 ± 0.067
1.569ThrMet: 1.569 ± 0.032
2.907ThrAsn: 2.907 ± 0.062
2.253ThrPro: 2.253 ± 0.06
1.514ThrGln: 1.514 ± 0.076
1.737ThrArg: 1.737 ± 0.041
3.569ThrSer: 3.569 ± 0.064
3.359ThrThr: 3.359 ± 0.068
4.322ThrVal: 4.322 ± 0.067
0.514ThrTrp: 0.514 ± 0.022
2.449ThrTyr: 2.449 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
4.494ValAla: 4.494 ± 0.131
0.946ValCys: 0.946 ± 0.028
3.709ValAsp: 3.709 ± 0.065
4.331ValGlu: 4.331 ± 0.058
2.913ValPhe: 2.913 ± 0.045
4.101ValGly: 4.101 ± 0.063
0.958ValHis: 0.958 ± 0.025
5.865ValIle: 5.865 ± 0.085
4.663ValLys: 4.663 ± 0.078
6.376ValLeu: 6.376 ± 0.075
1.826ValMet: 1.826 ± 0.037
3.339ValAsn: 3.339 ± 0.044
2.207ValPro: 2.207 ± 0.042
1.585ValGln: 1.585 ± 0.041
2.414ValArg: 2.414 ± 0.037
4.848ValSer: 4.848 ± 0.063
4.375ValThr: 4.375 ± 0.064
4.694ValVal: 4.694 ± 0.069
0.537ValTrp: 0.537 ± 0.022
2.565ValTyr: 2.565 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
0.472TrpAla: 0.472 ± 0.021
0.145TrpCys: 0.145 ± 0.013
0.488TrpAsp: 0.488 ± 0.021
0.542TrpGlu: 0.542 ± 0.023
0.439TrpPhe: 0.439 ± 0.022
0.596TrpGly: 0.596 ± 0.017
0.17TrpHis: 0.17 ± 0.011
0.625TrpIle: 0.625 ± 0.026
0.584TrpLys: 0.584 ± 0.027
0.793TrpLeu: 0.793 ± 0.028
0.283TrpMet: 0.283 ± 0.015
0.565TrpAsn: 0.565 ± 0.023
0.202TrpPro: 0.202 ± 0.013
0.288TrpGln: 0.288 ± 0.013
0.323TrpArg: 0.323 ± 0.016
0.523TrpSer: 0.523 ± 0.026
0.414TrpThr: 0.414 ± 0.018
0.49TrpVal: 0.49 ± 0.023
0.13TrpTrp: 0.13 ± 0.011
0.428TrpTyr: 0.428 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.488TyrAla: 2.488 ± 0.046
0.612TyrCys: 0.612 ± 0.021
2.597TyrAsp: 2.597 ± 0.04
3.193TyrGlu: 3.193 ± 0.05
2.02TyrPhe: 2.02 ± 0.041
2.919TyrGly: 2.919 ± 0.053
0.921TyrHis: 0.921 ± 0.024
3.218TyrIle: 3.218 ± 0.05
2.635TyrLys: 2.635 ± 0.05
4.189TyrLeu: 4.189 ± 0.068
1.087TyrMet: 1.087 ± 0.027
2.204TyrAsn: 2.204 ± 0.048
1.542TyrPro: 1.542 ± 0.034
1.895TyrGln: 1.895 ± 0.053
1.852TyrArg: 1.852 ± 0.033
2.755TyrSer: 2.755 ± 0.047
2.376TyrThr: 2.376 ± 0.052
2.574TyrVal: 2.574 ± 0.053
0.354TyrTrp: 0.354 ± 0.017
2.178TyrTyr: 2.178 ± 0.058
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3891 proteins (1314630 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski