Amino acid dipepetide frequency for Muribaculaceae bacterium Isolate-110 (HZI)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.223AlaAla: 7.223 ± 0.125	0.987AlaCys: 0.987 ± 0.034	5.662AlaAsp: 5.662 ± 0.085	5.12AlaGlu: 5.12 ± 0.085	2.832AlaPhe: 2.832 ± 0.055	6.008AlaGly: 6.008 ± 0.09	1.325AlaHis: 1.325 ± 0.037	5.238AlaIle: 5.238 ± 0.088	3.711AlaLys: 3.711 ± 0.075	7.38AlaLeu: 7.38 ± 0.099	2.551AlaMet: 2.551 ± 0.049	3.103AlaAsn: 3.103 ± 0.058	3.119AlaPro: 3.119 ± 0.058	2.457AlaGln: 2.457 ± 0.055	4.534AlaArg: 4.534 ± 0.077	5.378AlaSer: 5.378 ± 0.083	4.898AlaThr: 4.898 ± 0.076	5.817AlaVal: 5.817 ± 0.108	0.949AlaTrp: 0.949 ± 0.029	2.947AlaTyr: 2.947 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.944CysAla: 0.944 ± 0.032	0.21CysCys: 0.21 ± 0.015	0.819CysAsp: 0.819 ± 0.029	0.71CysGlu: 0.71 ± 0.029	0.467CysPhe: 0.467 ± 0.021	1.125CysGly: 1.125 ± 0.041	0.363CysHis: 0.363 ± 0.018	0.827CysIle: 0.827 ± 0.036	0.499CysLys: 0.499 ± 0.02	1.017CysLeu: 1.017 ± 0.034	0.306CysMet: 0.306 ± 0.015	0.607CysAsn: 0.607 ± 0.027	0.599CysPro: 0.599 ± 0.03	0.324CysGln: 0.324 ± 0.019	0.851CysArg: 0.851 ± 0.034	0.824CysSer: 0.824 ± 0.032	0.643CysThr: 0.643 ± 0.028	0.845CysVal: 0.845 ± 0.029	0.139CysTrp: 0.139 ± 0.011	0.52CysTyr: 0.52 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	4.745AspAla: 4.745 ± 0.068	0.774AspCys: 0.774 ± 0.029	3.52AspAsp: 3.52 ± 0.07	3.836AspGlu: 3.836 ± 0.07	2.871AspPhe: 2.871 ± 0.059	5.0AspGly: 5.0 ± 0.106	0.945AspHis: 0.945 ± 0.032	4.82AspIle: 4.82 ± 0.066	3.224AspLys: 3.224 ± 0.072	4.574AspLeu: 4.574 ± 0.075	1.978AspMet: 1.978 ± 0.045	3.267AspAsn: 3.267 ± 0.061	2.523AspPro: 2.523 ± 0.054	1.046AspGln: 1.046 ± 0.036	3.596AspArg: 3.596 ± 0.062	4.01AspSer: 4.01 ± 0.079	3.486AspThr: 3.486 ± 0.065	3.866AspVal: 3.866 ± 0.067	0.798AspTrp: 0.798 ± 0.028	3.145AspTyr: 3.145 ± 0.066	0.0AspXaa: 0.0 ± 0.0
Glu	4.992GluAla: 4.992 ± 0.096	0.674GluCys: 0.674 ± 0.026	2.773GluAsp: 2.773 ± 0.056	3.716GluGlu: 3.716 ± 0.095	2.231GluPhe: 2.231 ± 0.055	3.93GluGly: 3.93 ± 0.067	1.13GluHis: 1.13 ± 0.038	4.236GluIle: 4.236 ± 0.071	3.466GluLys: 3.466 ± 0.072	5.32GluLeu: 5.32 ± 0.072	1.965GluMet: 1.965 ± 0.044	2.691GluAsn: 2.691 ± 0.057	1.973GluPro: 1.973 ± 0.044	2.044GluGln: 2.044 ± 0.05	3.514GluArg: 3.514 ± 0.066	3.283GluSer: 3.283 ± 0.055	3.184GluThr: 3.184 ± 0.062	3.882GluVal: 3.882 ± 0.063	0.836GluTrp: 0.836 ± 0.031	2.436GluTyr: 2.436 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.109PheAla: 3.109 ± 0.055	0.556PheCys: 0.556 ± 0.026	2.929PheAsp: 2.929 ± 0.058	2.03PheGlu: 2.03 ± 0.044	1.726PhePhe: 1.726 ± 0.053	3.05PheGly: 3.05 ± 0.061	0.823PheHis: 0.823 ± 0.028	2.835PheIle: 2.835 ± 0.058	1.74PheLys: 1.74 ± 0.042	3.128PheLeu: 3.128 ± 0.057	1.277PheMet: 1.277 ± 0.041	2.126PheAsn: 2.126 ± 0.047	1.597PhePro: 1.597 ± 0.038	0.878PheGln: 0.878 ± 0.031	2.168PheArg: 2.168 ± 0.049	3.036PheSer: 3.036 ± 0.063	2.675PheThr: 2.675 ± 0.057	2.586PheVal: 2.586 ± 0.052	0.501PheTrp: 0.501 ± 0.024	1.652PheTyr: 1.652 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	5.243GlyAla: 5.243 ± 0.085	1.152GlyCys: 1.152 ± 0.038	4.036GlyAsp: 4.036 ± 0.074	4.021GlyGlu: 4.021 ± 0.065	2.958GlyPhe: 2.958 ± 0.053	5.107GlyGly: 5.107 ± 0.097	1.579GlyHis: 1.579 ± 0.046	5.109GlyIle: 5.109 ± 0.076	4.16GlyLys: 4.16 ± 0.068	6.141GlyLeu: 6.141 ± 0.093	2.216GlyMet: 2.216 ± 0.049	3.324GlyAsn: 3.324 ± 0.074	1.748GlyPro: 1.748 ± 0.043	1.999GlyGln: 1.999 ± 0.048	4.221GlyArg: 4.221 ± 0.073	4.586GlySer: 4.586 ± 0.081	4.046GlyThr: 4.046 ± 0.079	5.367GlyVal: 5.367 ± 0.091	1.072GlyTrp: 1.072 ± 0.038	3.286GlyTyr: 3.286 ± 0.072	0.0GlyXaa: 0.0 ± 0.0
His	1.293HisAla: 1.293 ± 0.032	0.294HisCys: 0.294 ± 0.016	1.276HisAsp: 1.276 ± 0.04	1.045HisGlu: 1.045 ± 0.031	0.885HisPhe: 0.885 ± 0.029	1.483HisGly: 1.483 ± 0.042	0.545HisHis: 0.545 ± 0.031	1.58HisIle: 1.58 ± 0.036	0.909HisLys: 0.909 ± 0.026	1.76HisLeu: 1.76 ± 0.046	0.46HisMet: 0.46 ± 0.021	1.044HisAsn: 1.044 ± 0.031	1.108HisPro: 1.108 ± 0.034	0.45HisGln: 0.45 ± 0.022	1.161HisArg: 1.161 ± 0.037	1.229HisSer: 1.229 ± 0.035	1.196HisThr: 1.196 ± 0.042	1.096HisVal: 1.096 ± 0.035	0.238HisTrp: 0.238 ± 0.014	0.823HisTyr: 0.823 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.861IleAla: 5.861 ± 0.085	0.888IleCys: 0.888 ± 0.033	4.926IleAsp: 4.926 ± 0.076	4.126IleGlu: 4.126 ± 0.074	2.557IlePhe: 2.557 ± 0.051	4.568IleGly: 4.568 ± 0.08	1.27IleHis: 1.27 ± 0.037	4.598IleIle: 4.598 ± 0.088	3.361IleLys: 3.361 ± 0.06	5.341IleLeu: 5.341 ± 0.083	1.541IleMet: 1.541 ± 0.042	3.228IleAsn: 3.228 ± 0.062	3.188IlePro: 3.188 ± 0.057	1.621IleGln: 1.621 ± 0.044	3.407IleArg: 3.407 ± 0.054	4.594IleSer: 4.594 ± 0.077	4.063IleThr: 4.063 ± 0.057	4.434IleVal: 4.434 ± 0.066	0.668IleTrp: 0.668 ± 0.028	2.499IleTyr: 2.499 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.271LysAla: 4.271 ± 0.076	0.543LysCys: 0.543 ± 0.029	2.922LysAsp: 2.922 ± 0.065	3.463LysGlu: 3.463 ± 0.079	1.822LysPhe: 1.822 ± 0.05	3.594LysGly: 3.594 ± 0.066	0.939LysHis: 0.939 ± 0.029	3.369LysIle: 3.369 ± 0.068	3.056LysLys: 3.056 ± 0.075	3.794LysLeu: 3.794 ± 0.067	1.621LysMet: 1.621 ± 0.045	2.341LysAsn: 2.341 ± 0.047	1.876LysPro: 1.876 ± 0.045	1.447LysGln: 1.447 ± 0.04	2.683LysArg: 2.683 ± 0.059	3.117LysSer: 3.117 ± 0.056	2.777LysThr: 2.777 ± 0.053	3.499LysVal: 3.499 ± 0.063	0.691LysTrp: 0.691 ± 0.024	2.275LysTyr: 2.275 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	7.158LeuAla: 7.158 ± 0.097	1.302LeuCys: 1.302 ± 0.038	5.398LeuAsp: 5.398 ± 0.076	4.411LeuGlu: 4.411 ± 0.084	3.484LeuPhe: 3.484 ± 0.072	5.971LeuGly: 5.971 ± 0.09	1.873LeuHis: 1.873 ± 0.046	5.137LeuIle: 5.137 ± 0.086	4.574LeuLys: 4.574 ± 0.06	7.999LeuLeu: 7.999 ± 0.12	2.591LeuMet: 2.591 ± 0.055	4.002LeuAsn: 4.002 ± 0.07	4.21LeuPro: 4.21 ± 0.069	2.444LeuGln: 2.444 ± 0.055	5.502LeuArg: 5.502 ± 0.073	6.985LeuSer: 6.985 ± 0.088	5.872LeuThr: 5.872 ± 0.091	5.07LeuVal: 5.07 ± 0.087	1.07LeuTrp: 1.07 ± 0.037	3.396LeuTyr: 3.396 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.612MetAla: 2.612 ± 0.05	0.296MetCys: 0.296 ± 0.018	1.48MetAsp: 1.48 ± 0.042	1.609MetGlu: 1.609 ± 0.042	1.031MetPhe: 1.031 ± 0.032	1.786MetGly: 1.786 ± 0.043	0.565MetHis: 0.565 ± 0.024	1.607MetIle: 1.607 ± 0.033	1.947MetLys: 1.947 ± 0.041	2.863MetLeu: 2.863 ± 0.052	0.8MetMet: 0.8 ± 0.03	1.235MetAsn: 1.235 ± 0.036	1.408MetPro: 1.408 ± 0.035	0.932MetGln: 0.932 ± 0.031	1.821MetArg: 1.821 ± 0.045	1.992MetSer: 1.992 ± 0.047	1.897MetThr: 1.897 ± 0.047	1.72MetVal: 1.72 ± 0.051	0.32MetTrp: 0.32 ± 0.018	0.866MetTyr: 0.866 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.48AsnAla: 3.48 ± 0.06	0.482AsnCys: 0.482 ± 0.024	2.575AsnAsp: 2.575 ± 0.056	2.316AsnGlu: 2.316 ± 0.055	1.884AsnPhe: 1.884 ± 0.047	3.676AsnGly: 3.676 ± 0.068	0.906AsnHis: 0.906 ± 0.029	3.456AsnIle: 3.456 ± 0.064	2.078AsnLys: 2.078 ± 0.051	3.827AsnLeu: 3.827 ± 0.065	1.152AsnMet: 1.152 ± 0.036	2.327AsnAsn: 2.327 ± 0.064	2.721AsnPro: 2.721 ± 0.055	1.177AsnGln: 1.177 ± 0.042	2.483AsnArg: 2.483 ± 0.053	2.695AsnSer: 2.695 ± 0.06	2.599AsnThr: 2.599 ± 0.058	3.108AsnVal: 3.108 ± 0.067	0.534AsnTrp: 0.534 ± 0.023	2.043AsnTyr: 2.043 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	3.966ProAla: 3.966 ± 0.073	0.384ProCys: 0.384 ± 0.02	3.385ProAsp: 3.385 ± 0.063	3.499ProGlu: 3.499 ± 0.061	1.708ProPhe: 1.708 ± 0.044	3.041ProGly: 3.041 ± 0.057	0.794ProHis: 0.794 ± 0.027	2.146ProIle: 2.146 ± 0.049	1.751ProLys: 1.751 ± 0.044	3.639ProLeu: 3.639 ± 0.059	1.12ProMet: 1.12 ± 0.031	1.387ProAsn: 1.387 ± 0.037	0.993ProPro: 0.993 ± 0.033	1.38ProGln: 1.38 ± 0.038	2.041ProArg: 2.041 ± 0.045	3.023ProSer: 3.023 ± 0.057	2.313ProThr: 2.313 ± 0.049	3.47ProVal: 3.47 ± 0.06	0.556ProTrp: 0.556 ± 0.026	1.697ProTyr: 1.697 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	2.354GlnAla: 2.354 ± 0.049	0.317GlnCys: 0.317 ± 0.019	1.263GlnAsp: 1.263 ± 0.038	1.546GlnGlu: 1.546 ± 0.033	1.17GlnPhe: 1.17 ± 0.04	1.899GlnGly: 1.899 ± 0.045	0.534GlnHis: 0.534 ± 0.024	1.755GlnIle: 1.755 ± 0.045	1.463GlnLys: 1.463 ± 0.042	2.911GlnLeu: 2.911 ± 0.059	0.871GlnMet: 0.871 ± 0.029	1.176GlnAsn: 1.176 ± 0.038	1.259GlnPro: 1.259 ± 0.039	1.172GlnGln: 1.172 ± 0.041	1.655GlnArg: 1.655 ± 0.046	1.823GlnSer: 1.823 ± 0.04	1.601GlnThr: 1.601 ± 0.042	1.693GlnVal: 1.693 ± 0.038	0.487GlnTrp: 0.487 ± 0.029	1.232GlnTyr: 1.232 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.969ArgAla: 3.969 ± 0.072	0.621ArgCys: 0.621 ± 0.028	3.184ArgAsp: 3.184 ± 0.052	3.673ArgGlu: 3.673 ± 0.069	2.505ArgPhe: 2.505 ± 0.051	3.357ArgGly: 3.357 ± 0.059	1.496ArgHis: 1.496 ± 0.037	3.861ArgIle: 3.861 ± 0.066	2.997ArgLys: 2.997 ± 0.056	5.945ArgLeu: 5.945 ± 0.086	1.755ArgMet: 1.755 ± 0.042	2.656ArgAsn: 2.656 ± 0.047	2.436ArgPro: 2.436 ± 0.058	2.143ArgGln: 2.143 ± 0.053	3.859ArgArg: 3.859 ± 0.088	2.97ArgSer: 2.97 ± 0.061	2.752ArgThr: 2.752 ± 0.059	3.448ArgVal: 3.448 ± 0.072	0.8ArgTrp: 0.8 ± 0.026	2.744ArgTyr: 2.744 ± 0.063	0.0ArgXaa: 0.0 ± 0.0
Ser	5.195SerAla: 5.195 ± 0.081	0.826SerCys: 0.826 ± 0.033	4.248SerAsp: 4.248 ± 0.07	3.441SerGlu: 3.441 ± 0.059	2.853SerPhe: 2.853 ± 0.054	4.938SerGly: 4.938 ± 0.08	1.433SerHis: 1.433 ± 0.04	4.179SerIle: 4.179 ± 0.066	2.731SerLys: 2.731 ± 0.054	6.664SerLeu: 6.664 ± 0.09	1.802SerMet: 1.802 ± 0.036	2.502SerAsn: 2.502 ± 0.051	2.913SerPro: 2.913 ± 0.067	2.035SerGln: 2.035 ± 0.046	3.941SerArg: 3.941 ± 0.068	4.236SerSer: 4.236 ± 0.081	3.813SerThr: 3.813 ± 0.074	4.565SerVal: 4.565 ± 0.067	0.85SerTrp: 0.85 ± 0.035	2.74SerTyr: 2.74 ± 0.068	0.0SerXaa: 0.0 ± 0.0
Thr	5.1ThrAla: 5.1 ± 0.082	0.599ThrCys: 0.599 ± 0.028	3.937ThrAsp: 3.937 ± 0.062	2.876ThrGlu: 2.876 ± 0.055	2.629ThrPhe: 2.629 ± 0.057	4.586ThrGly: 4.586 ± 0.076	1.084ThrHis: 1.084 ± 0.034	3.851ThrIle: 3.851 ± 0.071	2.069ThrLys: 2.069 ± 0.048	5.977ThrLeu: 5.977 ± 0.081	1.305ThrMet: 1.305 ± 0.037	2.139ThrAsn: 2.139 ± 0.055	3.727ThrPro: 3.727 ± 0.073	1.573ThrGln: 1.573 ± 0.037	3.011ThrArg: 3.011 ± 0.056	3.784ThrSer: 3.784 ± 0.074	3.542ThrThr: 3.542 ± 0.065	4.735ThrVal: 4.735 ± 0.09	0.687ThrTrp: 0.687 ± 0.034	2.428ThrTyr: 2.428 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	5.68ValAla: 5.68 ± 0.09	0.915ValCys: 0.915 ± 0.032	4.08ValAsp: 4.08 ± 0.067	3.956ValGlu: 3.956 ± 0.077	2.421ValPhe: 2.421 ± 0.048	4.238ValGly: 4.238 ± 0.088	1.085ValHis: 1.085 ± 0.035	4.681ValIle: 4.681 ± 0.078	3.842ValLys: 3.842 ± 0.069	5.339ValLeu: 5.339 ± 0.083	1.982ValMet: 1.982 ± 0.049	3.308ValAsn: 3.308 ± 0.055	2.698ValPro: 2.698 ± 0.046	1.483ValGln: 1.483 ± 0.036	3.497ValArg: 3.497 ± 0.065	4.827ValSer: 4.827 ± 0.08	4.97ValThr: 4.97 ± 0.092	4.445ValVal: 4.445 ± 0.075	0.773ValTrp: 0.773 ± 0.028	2.617ValTyr: 2.617 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.904TrpAla: 0.904 ± 0.027	0.231TrpCys: 0.231 ± 0.016	0.771TrpAsp: 0.771 ± 0.032	0.679TrpGlu: 0.679 ± 0.024	0.49TrpPhe: 0.49 ± 0.023	0.998TrpGly: 0.998 ± 0.034	0.314TrpHis: 0.314 ± 0.018	0.76TrpIle: 0.76 ± 0.031	0.607TrpLys: 0.607 ± 0.025	1.281TrpLeu: 1.281 ± 0.043	0.403TrpMet: 0.403 ± 0.02	0.681TrpAsn: 0.681 ± 0.032	0.326TrpPro: 0.326 ± 0.019	0.493TrpGln: 0.493 ± 0.022	0.766TrpArg: 0.766 ± 0.034	0.769TrpSer: 0.769 ± 0.031	0.745TrpThr: 0.745 ± 0.028	0.752TrpVal: 0.752 ± 0.024	0.239TrpTrp: 0.239 ± 0.018	0.511TrpTyr: 0.511 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.141TyrAla: 3.141 ± 0.057	0.587TyrCys: 0.587 ± 0.025	2.841TyrAsp: 2.841 ± 0.058	2.202TyrGlu: 2.202 ± 0.048	1.898TyrPhe: 1.898 ± 0.041	3.017TyrGly: 3.017 ± 0.059	0.87TyrHis: 0.87 ± 0.029	2.694TyrIle: 2.694 ± 0.051	1.913TyrLys: 1.913 ± 0.049	3.55TyrLeu: 3.55 ± 0.057	1.09TyrMet: 1.09 ± 0.034	2.375TyrAsn: 2.375 ± 0.059	1.871TyrPro: 1.871 ± 0.041	1.082TyrGln: 1.082 ± 0.036	2.462TyrArg: 2.462 ± 0.043	2.741TyrSer: 2.741 ± 0.06	2.568TyrThr: 2.568 ± 0.055	2.438TyrVal: 2.438 ± 0.057	0.514TyrTrp: 0.514 ± 0.022	1.953TyrTyr: 1.953 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2771 proteins (1005138 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---