Amino acid dipepetide frequency for Streptococcus phage Javan648

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.619AlaAla: 2.619 ± 1.084
0.409AlaCys: 0.409 ± 0.177
3.11AlaAsp: 3.11 ± 0.545
4.255AlaGlu: 4.255 ± 0.613
2.046AlaPhe: 2.046 ± 0.347
3.764AlaGly: 3.764 ± 0.65
0.573AlaHis: 0.573 ± 0.255
5.074AlaIle: 5.074 ± 0.559
6.137AlaLys: 6.137 ± 0.817
5.319AlaLeu: 5.319 ± 0.795
1.309AlaMet: 1.309 ± 0.454
4.664AlaAsn: 4.664 ± 0.712
1.146AlaPro: 1.146 ± 0.284
2.619AlaGln: 2.619 ± 0.669
1.718AlaArg: 1.718 ± 0.339
4.664AlaSer: 4.664 ± 0.997
4.419AlaThr: 4.419 ± 0.712
3.355AlaVal: 3.355 ± 0.653
0.818AlaTrp: 0.818 ± 0.285
2.373AlaTyr: 2.373 ± 0.47
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.655CysAsp: 0.655 ± 0.225
0.245CysGlu: 0.245 ± 0.156
0.245CysPhe: 0.245 ± 0.187
0.245CysGly: 0.245 ± 0.146
0.164CysHis: 0.164 ± 0.191
0.082CysIle: 0.082 ± 0.085
0.327CysLys: 0.327 ± 0.184
0.491CysLeu: 0.491 ± 0.225
0.164CysMet: 0.164 ± 0.121
0.245CysAsn: 0.245 ± 0.141
0.082CysPro: 0.082 ± 0.089
0.245CysGln: 0.245 ± 0.145
0.245CysArg: 0.245 ± 0.146
0.164CysSer: 0.164 ± 0.121
0.164CysThr: 0.164 ± 0.112
0.164CysVal: 0.164 ± 0.125
0.164CysTrp: 0.164 ± 0.123
0.164CysTyr: 0.164 ± 0.119
0.0CysXaa: 0.0 ± 0.0
Asp
2.946AspAla: 2.946 ± 0.6
0.082AspCys: 0.082 ± 0.096
3.928AspAsp: 3.928 ± 0.665
4.992AspGlu: 4.992 ± 0.853
3.273AspPhe: 3.273 ± 0.514
4.092AspGly: 4.092 ± 0.65
0.573AspHis: 0.573 ± 0.29
3.355AspIle: 3.355 ± 0.517
5.155AspLys: 5.155 ± 0.707
5.483AspLeu: 5.483 ± 0.687
1.8AspMet: 1.8 ± 0.43
3.191AspAsn: 3.191 ± 0.526
1.964AspPro: 1.964 ± 0.382
1.391AspGln: 1.391 ± 0.334
1.555AspArg: 1.555 ± 0.333
4.664AspSer: 4.664 ± 0.594
3.846AspThr: 3.846 ± 0.706
3.437AspVal: 3.437 ± 0.68
1.064AspTrp: 1.064 ± 0.266
3.273AspTyr: 3.273 ± 0.646
0.0AspXaa: 0.0 ± 0.0
Glu
3.928GluAla: 3.928 ± 0.683
0.164GluCys: 0.164 ± 0.113
3.191GluAsp: 3.191 ± 0.587
4.664GluGlu: 4.664 ± 0.805
2.7GluPhe: 2.7 ± 0.479
2.946GluGly: 2.946 ± 0.601
1.227GluHis: 1.227 ± 0.352
6.219GluIle: 6.219 ± 1.062
4.828GluLys: 4.828 ± 0.755
8.02GluLeu: 8.02 ± 1.069
1.8GluMet: 1.8 ± 0.366
5.074GluAsn: 5.074 ± 0.769
1.227GluPro: 1.227 ± 0.443
3.519GluGln: 3.519 ± 0.722
2.619GluArg: 2.619 ± 0.54
3.846GluSer: 3.846 ± 0.608
3.11GluThr: 3.11 ± 0.541
5.237GluVal: 5.237 ± 0.887
0.9GluTrp: 0.9 ± 0.358
3.028GluTyr: 3.028 ± 0.467
0.0GluXaa: 0.0 ± 0.0
Phe
2.782PheAla: 2.782 ± 0.563
0.245PheCys: 0.245 ± 0.152
2.946PheAsp: 2.946 ± 0.647
2.537PheGlu: 2.537 ± 0.453
1.473PhePhe: 1.473 ± 0.338
3.11PheGly: 3.11 ± 0.559
0.573PheHis: 0.573 ± 0.274
2.7PheIle: 2.7 ± 0.524
3.601PheLys: 3.601 ± 0.581
3.437PheLeu: 3.437 ± 0.673
1.391PheMet: 1.391 ± 0.344
2.537PheAsn: 2.537 ± 0.468
1.882PhePro: 1.882 ± 0.407
1.309PheGln: 1.309 ± 0.372
2.046PheArg: 2.046 ± 0.413
4.173PheSer: 4.173 ± 0.548
1.8PheThr: 1.8 ± 0.357
2.046PheVal: 2.046 ± 0.521
0.409PheTrp: 0.409 ± 0.193
2.209PheTyr: 2.209 ± 0.46
0.0PheXaa: 0.0 ± 0.0
Gly
2.619GlyAla: 2.619 ± 0.446
0.0GlyCys: 0.0 ± 0.0
3.519GlyAsp: 3.519 ± 0.489
2.782GlyGlu: 2.782 ± 0.417
2.537GlyPhe: 2.537 ± 0.512
3.846GlyGly: 3.846 ± 0.775
0.736GlyHis: 0.736 ± 0.267
4.664GlyIle: 4.664 ± 0.495
5.728GlyLys: 5.728 ± 0.531
4.992GlyLeu: 4.992 ± 0.612
1.555GlyMet: 1.555 ± 0.366
4.501GlyAsn: 4.501 ± 0.93
0.573GlyPro: 0.573 ± 0.234
2.864GlyGln: 2.864 ± 0.618
2.046GlyArg: 2.046 ± 0.475
4.092GlySer: 4.092 ± 0.828
4.01GlyThr: 4.01 ± 0.791
3.191GlyVal: 3.191 ± 0.653
0.491GlyTrp: 0.491 ± 0.17
2.7GlyTyr: 2.7 ± 0.502
0.0GlyXaa: 0.0 ± 0.0
His
0.736HisAla: 0.736 ± 0.216
0.082HisCys: 0.082 ± 0.087
0.982HisAsp: 0.982 ± 0.328
0.491HisGlu: 0.491 ± 0.262
0.9HisPhe: 0.9 ± 0.336
0.491HisGly: 0.491 ± 0.216
0.409HisHis: 0.409 ± 0.22
1.391HisIle: 1.391 ± 0.376
1.473HisLys: 1.473 ± 0.384
1.309HisLeu: 1.309 ± 0.261
0.491HisMet: 0.491 ± 0.2
1.473HisAsn: 1.473 ± 0.327
0.655HisPro: 0.655 ± 0.206
0.327HisGln: 0.327 ± 0.19
0.409HisArg: 0.409 ± 0.163
1.146HisSer: 1.146 ± 0.366
1.227HisThr: 1.227 ± 0.328
1.064HisVal: 1.064 ± 0.262
0.082HisTrp: 0.082 ± 0.069
0.736HisTyr: 0.736 ± 0.255
0.0HisXaa: 0.0 ± 0.0
Ile
4.91IleAla: 4.91 ± 0.657
0.164IleCys: 0.164 ± 0.116
5.892IleAsp: 5.892 ± 0.976
6.383IleGlu: 6.383 ± 1.018
2.046IlePhe: 2.046 ± 0.39
3.519IleGly: 3.519 ± 0.582
0.982IleHis: 0.982 ± 0.237
5.319IleIle: 5.319 ± 0.759
6.956IleLys: 6.956 ± 1.007
4.746IleLeu: 4.746 ± 0.621
2.209IleMet: 2.209 ± 0.406
5.892IleAsn: 5.892 ± 0.743
3.028IlePro: 3.028 ± 0.531
2.455IleGln: 2.455 ± 0.408
2.373IleArg: 2.373 ± 0.408
6.547IleSer: 6.547 ± 0.815
4.91IleThr: 4.91 ± 0.636
3.601IleVal: 3.601 ± 0.587
0.736IleTrp: 0.736 ± 0.272
2.782IleTyr: 2.782 ± 0.559
0.0IleXaa: 0.0 ± 0.0
Lys
5.155LysAla: 5.155 ± 0.627
0.245LysCys: 0.245 ± 0.134
4.337LysAsp: 4.337 ± 0.608
7.365LysGlu: 7.365 ± 1.135
3.682LysPhe: 3.682 ± 0.662
5.401LysGly: 5.401 ± 0.512
1.555LysHis: 1.555 ± 0.407
7.365LysIle: 7.365 ± 0.791
7.692LysLys: 7.692 ± 1.036
8.674LysLeu: 8.674 ± 0.811
2.373LysMet: 2.373 ± 0.407
6.056LysAsn: 6.056 ± 0.77
2.782LysPro: 2.782 ± 0.603
3.846LysGln: 3.846 ± 0.667
3.11LysArg: 3.11 ± 0.559
5.483LysSer: 5.483 ± 0.72
4.173LysThr: 4.173 ± 0.541
5.319LysVal: 5.319 ± 0.558
0.736LysTrp: 0.736 ± 0.18
3.191LysTyr: 3.191 ± 0.466
0.0LysXaa: 0.0 ± 0.0
Leu
6.137LeuAla: 6.137 ± 0.857
0.491LeuCys: 0.491 ± 0.205
5.81LeuAsp: 5.81 ± 0.909
5.974LeuGlu: 5.974 ± 0.997
3.11LeuPhe: 3.11 ± 0.575
4.746LeuGly: 4.746 ± 0.92
1.882LeuHis: 1.882 ± 0.409
5.483LeuIle: 5.483 ± 0.719
8.511LeuLys: 8.511 ± 0.868
7.283LeuLeu: 7.283 ± 0.841
1.964LeuMet: 1.964 ± 0.409
6.219LeuAsn: 6.219 ± 0.599
2.291LeuPro: 2.291 ± 0.513
2.782LeuGln: 2.782 ± 0.494
3.191LeuArg: 3.191 ± 0.47
6.465LeuSer: 6.465 ± 0.622
5.892LeuThr: 5.892 ± 0.951
4.501LeuVal: 4.501 ± 0.732
1.064LeuTrp: 1.064 ± 0.277
2.537LeuTyr: 2.537 ± 0.501
0.0LeuXaa: 0.0 ± 0.0
Met
1.8MetAla: 1.8 ± 0.414
0.082MetCys: 0.082 ± 0.074
1.227MetAsp: 1.227 ± 0.321
1.146MetGlu: 1.146 ± 0.356
0.982MetPhe: 0.982 ± 0.266
0.9MetGly: 0.9 ± 0.245
0.245MetHis: 0.245 ± 0.17
1.8MetIle: 1.8 ± 0.392
2.619MetLys: 2.619 ± 0.378
2.373MetLeu: 2.373 ± 0.425
0.491MetMet: 0.491 ± 0.184
1.964MetAsn: 1.964 ± 0.279
0.736MetPro: 0.736 ± 0.286
0.818MetGln: 0.818 ± 0.243
1.064MetArg: 1.064 ± 0.245
2.209MetSer: 2.209 ± 0.481
2.537MetThr: 2.537 ± 0.426
1.146MetVal: 1.146 ± 0.368
0.164MetTrp: 0.164 ± 0.108
0.655MetTyr: 0.655 ± 0.221
0.0MetXaa: 0.0 ± 0.0
Asn
5.237AsnAla: 5.237 ± 0.726
0.573AsnCys: 0.573 ± 0.202
3.846AsnAsp: 3.846 ± 0.646
4.583AsnGlu: 4.583 ± 0.668
2.946AsnPhe: 2.946 ± 0.548
6.137AsnGly: 6.137 ± 0.958
0.818AsnHis: 0.818 ± 0.208
4.992AsnIle: 4.992 ± 0.666
5.155AsnLys: 5.155 ± 0.682
4.664AsnLeu: 4.664 ± 0.662
1.473AsnMet: 1.473 ± 0.35
4.664AsnAsn: 4.664 ± 0.632
2.946AsnPro: 2.946 ± 0.467
2.864AsnGln: 2.864 ± 0.619
2.046AsnArg: 2.046 ± 0.436
4.419AsnSer: 4.419 ± 0.694
3.764AsnThr: 3.764 ± 0.456
3.928AsnVal: 3.928 ± 0.661
1.064AsnTrp: 1.064 ± 0.285
2.7AsnTyr: 2.7 ± 0.545
0.0AsnXaa: 0.0 ± 0.0
Pro
1.718ProAla: 1.718 ± 0.44
0.0ProCys: 0.0 ± 0.0
1.8ProAsp: 1.8 ± 0.463
2.128ProGlu: 2.128 ± 0.41
1.718ProPhe: 1.718 ± 0.331
0.491ProGly: 0.491 ± 0.22
0.573ProHis: 0.573 ± 0.187
2.291ProIle: 2.291 ± 0.319
3.11ProLys: 3.11 ± 0.622
2.7ProLeu: 2.7 ± 0.483
0.409ProMet: 0.409 ± 0.234
2.455ProAsn: 2.455 ± 0.428
0.573ProPro: 0.573 ± 0.241
1.391ProGln: 1.391 ± 0.389
1.064ProArg: 1.064 ± 0.355
1.555ProSer: 1.555 ± 0.385
2.291ProThr: 2.291 ± 0.389
1.555ProVal: 1.555 ± 0.46
0.245ProTrp: 0.245 ± 0.126
1.555ProTyr: 1.555 ± 0.35
0.0ProXaa: 0.0 ± 0.0
Gln
3.437GlnAla: 3.437 ± 0.528
0.082GlnCys: 0.082 ± 0.098
2.046GlnAsp: 2.046 ± 0.375
3.11GlnGlu: 3.11 ± 0.467
1.637GlnPhe: 1.637 ± 0.436
1.882GlnGly: 1.882 ± 0.393
0.491GlnHis: 0.491 ± 0.176
2.864GlnIle: 2.864 ± 0.546
4.01GlnLys: 4.01 ± 0.627
3.846GlnLeu: 3.846 ± 0.483
1.064GlnMet: 1.064 ± 0.282
2.946GlnAsn: 2.946 ± 0.445
0.982GlnPro: 0.982 ± 0.287
2.619GlnGln: 2.619 ± 0.625
1.309GlnArg: 1.309 ± 0.327
2.537GlnSer: 2.537 ± 0.472
1.718GlnThr: 1.718 ± 0.365
2.046GlnVal: 2.046 ± 0.402
0.655GlnTrp: 0.655 ± 0.243
1.473GlnTyr: 1.473 ± 0.437
0.0GlnXaa: 0.0 ± 0.0
Arg
1.555ArgAla: 1.555 ± 0.294
0.245ArgCys: 0.245 ± 0.217
1.882ArgAsp: 1.882 ± 0.49
2.946ArgGlu: 2.946 ± 0.518
1.964ArgPhe: 1.964 ± 0.333
2.046ArgGly: 2.046 ± 0.484
0.491ArgHis: 0.491 ± 0.197
2.537ArgIle: 2.537 ± 0.378
3.028ArgLys: 3.028 ± 0.538
3.355ArgLeu: 3.355 ± 0.555
0.9ArgMet: 0.9 ± 0.234
2.209ArgAsn: 2.209 ± 0.456
1.064ArgPro: 1.064 ± 0.286
1.718ArgGln: 1.718 ± 0.339
1.227ArgArg: 1.227 ± 0.405
1.391ArgSer: 1.391 ± 0.399
1.718ArgThr: 1.718 ± 0.408
1.555ArgVal: 1.555 ± 0.277
0.655ArgTrp: 0.655 ± 0.203
1.882ArgTyr: 1.882 ± 0.403
0.0ArgXaa: 0.0 ± 0.0
Ser
3.928SerAla: 3.928 ± 0.696
0.327SerCys: 0.327 ± 0.189
4.828SerAsp: 4.828 ± 0.787
3.846SerGlu: 3.846 ± 0.606
3.437SerPhe: 3.437 ± 0.597
3.437SerGly: 3.437 ± 0.737
1.391SerHis: 1.391 ± 0.325
5.565SerIle: 5.565 ± 0.626
6.137SerLys: 6.137 ± 0.943
5.155SerLeu: 5.155 ± 0.602
2.209SerMet: 2.209 ± 0.415
6.056SerAsn: 6.056 ± 0.67
2.291SerPro: 2.291 ± 0.483
2.782SerGln: 2.782 ± 0.582
2.455SerArg: 2.455 ± 0.378
4.746SerSer: 4.746 ± 0.661
4.992SerThr: 4.992 ± 0.772
3.682SerVal: 3.682 ± 0.538
0.491SerTrp: 0.491 ± 0.165
2.455SerTyr: 2.455 ± 0.704
0.0SerXaa: 0.0 ± 0.0
Thr
4.092ThrAla: 4.092 ± 0.652
0.164ThrCys: 0.164 ± 0.135
3.764ThrAsp: 3.764 ± 0.587
3.764ThrGlu: 3.764 ± 0.627
3.273ThrPhe: 3.273 ± 0.671
3.11ThrGly: 3.11 ± 0.561
1.064ThrHis: 1.064 ± 0.316
5.892ThrIle: 5.892 ± 0.998
5.401ThrLys: 5.401 ± 0.786
5.155ThrLeu: 5.155 ± 0.663
1.064ThrMet: 1.064 ± 0.276
2.864ThrAsn: 2.864 ± 0.642
1.882ThrPro: 1.882 ± 0.462
2.537ThrGln: 2.537 ± 0.511
2.373ThrArg: 2.373 ± 0.498
4.419ThrSer: 4.419 ± 0.733
3.11ThrThr: 3.11 ± 0.523
4.419ThrVal: 4.419 ± 0.945
0.736ThrTrp: 0.736 ± 0.252
3.11ThrTyr: 3.11 ± 0.623
0.0ThrXaa: 0.0 ± 0.0
Val
4.173ValAla: 4.173 ± 1.071
0.245ValCys: 0.245 ± 0.137
3.191ValAsp: 3.191 ± 0.576
3.355ValGlu: 3.355 ± 0.626
2.946ValPhe: 2.946 ± 0.5
3.928ValGly: 3.928 ± 0.692
0.573ValHis: 0.573 ± 0.203
4.255ValIle: 4.255 ± 0.475
4.91ValLys: 4.91 ± 0.626
4.092ValLeu: 4.092 ± 0.562
0.9ValMet: 0.9 ± 0.301
3.028ValAsn: 3.028 ± 0.383
1.8ValPro: 1.8 ± 0.41
2.291ValGln: 2.291 ± 0.416
1.555ValArg: 1.555 ± 0.357
4.173ValSer: 4.173 ± 0.596
4.828ValThr: 4.828 ± 1.05
3.601ValVal: 3.601 ± 0.476
0.655ValTrp: 0.655 ± 0.237
2.209ValTyr: 2.209 ± 0.508
0.0ValXaa: 0.0 ± 0.0
Trp
0.655TrpAla: 0.655 ± 0.221
0.245TrpCys: 0.245 ± 0.198
0.573TrpAsp: 0.573 ± 0.277
0.573TrpGlu: 0.573 ± 0.266
0.573TrpPhe: 0.573 ± 0.177
0.491TrpGly: 0.491 ± 0.203
0.327TrpHis: 0.327 ± 0.142
0.818TrpIle: 0.818 ± 0.268
1.309TrpLys: 1.309 ± 0.376
1.8TrpLeu: 1.8 ± 0.381
0.082TrpMet: 0.082 ± 0.087
0.573TrpAsn: 0.573 ± 0.218
0.0TrpPro: 0.0 ± 0.0
0.573TrpGln: 0.573 ± 0.234
0.573TrpArg: 0.573 ± 0.159
0.818TrpSer: 0.818 ± 0.271
0.655TrpThr: 0.655 ± 0.196
0.491TrpVal: 0.491 ± 0.182
0.245TrpTrp: 0.245 ± 0.116
0.245TrpTyr: 0.245 ± 0.149
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.964TyrAla: 1.964 ± 0.325
0.409TyrCys: 0.409 ± 0.202
2.537TyrAsp: 2.537 ± 0.468
3.11TyrGlu: 3.11 ± 0.532
1.718TyrPhe: 1.718 ± 0.315
2.864TyrGly: 2.864 ± 0.606
1.227TyrHis: 1.227 ± 0.279
2.782TyrIle: 2.782 ± 0.446
2.537TyrLys: 2.537 ± 0.495
3.437TyrLeu: 3.437 ± 0.516
1.227TyrMet: 1.227 ± 0.34
2.209TyrAsn: 2.209 ± 0.474
1.718TyrPro: 1.718 ± 0.444
1.8TyrGln: 1.8 ± 0.343
1.391TyrArg: 1.391 ± 0.277
2.7TyrSer: 2.7 ± 0.614
3.028TyrThr: 3.028 ± 0.619
2.373TyrVal: 2.373 ± 0.485
0.245TyrTrp: 0.245 ± 0.159
1.637TyrTyr: 1.637 ± 0.465
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 64 proteins (12221 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski