Amino acid dipepetide frequency for Pseudoxanthomonas wuyuanensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.616AlaAla: 18.616 ± 0.177	1.188AlaCys: 1.188 ± 0.033	7.246AlaAsp: 7.246 ± 0.086	7.076AlaGlu: 7.076 ± 0.091	4.044AlaPhe: 4.044 ± 0.063	11.608AlaGly: 11.608 ± 0.112	2.376AlaHis: 2.376 ± 0.049	5.545AlaIle: 5.545 ± 0.067	3.058AlaLys: 3.058 ± 0.068	15.127AlaLeu: 15.127 ± 0.163	3.225AlaMet: 3.225 ± 0.051	2.981AlaAsn: 2.981 ± 0.06	6.177AlaPro: 6.177 ± 0.085	5.542AlaGln: 5.542 ± 0.063	9.239AlaArg: 9.239 ± 0.11	7.034AlaSer: 7.034 ± 0.097	6.045AlaThr: 6.045 ± 0.092	8.943AlaVal: 8.943 ± 0.087	1.965AlaTrp: 1.965 ± 0.042	2.661AlaTyr: 2.661 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.024CysAla: 1.024 ± 0.031	0.096CysCys: 0.096 ± 0.007	0.454CysAsp: 0.454 ± 0.019	0.419CysGlu: 0.419 ± 0.021	0.241CysPhe: 0.241 ± 0.013	0.909CysGly: 0.909 ± 0.027	0.202CysHis: 0.202 ± 0.01	0.334CysIle: 0.334 ± 0.016	0.19CysLys: 0.19 ± 0.013	0.808CysLeu: 0.808 ± 0.026	0.134CysMet: 0.134 ± 0.01	0.219CysAsn: 0.219 ± 0.012	0.395CysPro: 0.395 ± 0.018	0.261CysGln: 0.261 ± 0.014	0.602CysArg: 0.602 ± 0.024	0.446CysSer: 0.446 ± 0.018	0.407CysThr: 0.407 ± 0.037	0.596CysVal: 0.596 ± 0.018	0.124CysTrp: 0.124 ± 0.009	0.182CysTyr: 0.182 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.056AspAla: 8.056 ± 0.086	0.453AspCys: 0.453 ± 0.02	3.237AspAsp: 3.237 ± 0.066	3.308AspGlu: 3.308 ± 0.055	2.164AspPhe: 2.164 ± 0.042	6.019AspGly: 6.019 ± 0.086	1.119AspHis: 1.119 ± 0.033	2.552AspIle: 2.552 ± 0.044	1.465AspLys: 1.465 ± 0.041	5.412AspLeu: 5.412 ± 0.071	1.061AspMet: 1.061 ± 0.027	1.465AspAsn: 1.465 ± 0.037	3.351AspPro: 3.351 ± 0.048	1.692AspGln: 1.692 ± 0.036	3.918AspArg: 3.918 ± 0.049	2.84AspSer: 2.84 ± 0.048	2.678AspThr: 2.678 ± 0.057	3.795AspVal: 3.795 ± 0.057	1.161AspTrp: 1.161 ± 0.029	1.816AspTyr: 1.816 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.603GluAla: 6.603 ± 0.097	0.326GluCys: 0.326 ± 0.019	2.552GluAsp: 2.552 ± 0.044	2.564GluGlu: 2.564 ± 0.05	1.846GluPhe: 1.846 ± 0.038	3.81GluGly: 3.81 ± 0.061	1.228GluHis: 1.228 ± 0.031	2.564GluIle: 2.564 ± 0.048	1.6GluLys: 1.6 ± 0.038	6.077GluLeu: 6.077 ± 0.075	1.091GluMet: 1.091 ± 0.031	1.34GluAsn: 1.34 ± 0.034	2.681GluPro: 2.681 ± 0.046	2.698GluGln: 2.698 ± 0.056	4.97GluArg: 4.97 ± 0.074	2.732GluSer: 2.732 ± 0.042	2.81GluThr: 2.81 ± 0.051	3.688GluVal: 3.688 ± 0.06	0.738GluTrp: 0.738 ± 0.025	1.237GluTyr: 1.237 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.394PheAla: 4.394 ± 0.065	0.328PheCys: 0.328 ± 0.015	2.667PheAsp: 2.667 ± 0.046	1.906PheGlu: 1.906 ± 0.037	1.261PhePhe: 1.261 ± 0.036	3.473PheGly: 3.473 ± 0.064	0.745PheHis: 0.745 ± 0.023	1.288PheIle: 1.288 ± 0.037	0.918PheLys: 0.918 ± 0.028	3.0PheLeu: 3.0 ± 0.044	0.63PheMet: 0.63 ± 0.025	1.141PheAsn: 1.141 ± 0.034	1.485PhePro: 1.485 ± 0.03	1.04PheGln: 1.04 ± 0.028	2.182PheArg: 2.182 ± 0.042	2.141PheSer: 2.141 ± 0.045	1.615PheThr: 1.615 ± 0.042	2.572PheVal: 2.572 ± 0.043	0.537PheTrp: 0.537 ± 0.023	0.881PheTyr: 0.881 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.057GlyAla: 9.057 ± 0.136	0.816GlyCys: 0.816 ± 0.026	4.862GlyAsp: 4.862 ± 0.069	4.82GlyGlu: 4.82 ± 0.066	3.421GlyPhe: 3.421 ± 0.059	7.414GlyGly: 7.414 ± 0.123	1.98GlyHis: 1.98 ± 0.042	4.107GlyIle: 4.107 ± 0.053	3.015GlyLys: 3.015 ± 0.047	8.73GlyLeu: 8.73 ± 0.084	2.245GlyMet: 2.245 ± 0.046	2.72GlyAsn: 2.72 ± 0.06	3.162GlyPro: 3.162 ± 0.053	3.617GlyGln: 3.617 ± 0.06	6.212GlyArg: 6.212 ± 0.071	5.14GlySer: 5.14 ± 0.081	4.458GlyThr: 4.458 ± 0.121	6.175GlyVal: 6.175 ± 0.073	1.725GlyTrp: 1.725 ± 0.041	2.631GlyTyr: 2.631 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.838HisAla: 2.838 ± 0.053	0.219HisCys: 0.219 ± 0.014	1.201HisAsp: 1.201 ± 0.033	1.038HisGlu: 1.038 ± 0.032	0.778HisPhe: 0.778 ± 0.022	2.214HisGly: 2.214 ± 0.041	0.558HisHis: 0.558 ± 0.023	0.755HisIle: 0.755 ± 0.024	0.432HisLys: 0.432 ± 0.02	2.072HisLeu: 2.072 ± 0.045	0.38HisMet: 0.38 ± 0.016	0.491HisAsn: 0.491 ± 0.019	1.46HisPro: 1.46 ± 0.034	0.692HisGln: 0.692 ± 0.02	1.681HisArg: 1.681 ± 0.038	1.055HisSer: 1.055 ± 0.031	0.915HisThr: 0.915 ± 0.025	1.315HisVal: 1.315 ± 0.032	0.439HisTrp: 0.439 ± 0.017	0.613HisTyr: 0.613 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.637IleAla: 6.637 ± 0.073	0.398IleCys: 0.398 ± 0.016	3.35IleAsp: 3.35 ± 0.051	2.949IleGlu: 2.949 ± 0.049	1.132IlePhe: 1.132 ± 0.03	4.497IleGly: 4.497 ± 0.07	0.828IleHis: 0.828 ± 0.025	1.423IleIle: 1.423 ± 0.035	1.113IleLys: 1.113 ± 0.032	3.016IleLeu: 3.016 ± 0.052	0.515IleMet: 0.515 ± 0.019	1.314IleAsn: 1.314 ± 0.032	2.131IlePro: 2.131 ± 0.046	1.144IleGln: 1.144 ± 0.028	2.891IleArg: 2.891 ± 0.046	2.329IleSer: 2.329 ± 0.048	2.086IleThr: 2.086 ± 0.037	3.26IleVal: 3.26 ± 0.052	0.51IleTrp: 0.51 ± 0.019	0.935IleTyr: 0.935 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.158LysAla: 3.158 ± 0.063	0.124LysCys: 0.124 ± 0.012	1.359LysAsp: 1.359 ± 0.042	1.155LysGlu: 1.155 ± 0.035	0.775LysPhe: 0.775 ± 0.029	1.859LysGly: 1.859 ± 0.045	0.596LysHis: 0.596 ± 0.02	1.13LysIle: 1.13 ± 0.033	0.984LysLys: 0.984 ± 0.049	3.078LysLeu: 3.078 ± 0.059	0.564LysMet: 0.564 ± 0.02	0.694LysAsn: 0.694 ± 0.024	1.961LysPro: 1.961 ± 0.041	1.198LysGln: 1.198 ± 0.033	2.23LysArg: 2.23 ± 0.046	1.376LysSer: 1.376 ± 0.036	1.521LysThr: 1.521 ± 0.036	2.004LysVal: 2.004 ± 0.041	0.295LysTrp: 0.295 ± 0.015	0.631LysTyr: 0.631 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	15.071LeuAla: 15.071 ± 0.127	0.901LeuCys: 0.901 ± 0.029	6.375LeuAsp: 6.375 ± 0.083	5.288LeuGlu: 5.288 ± 0.077	3.445LeuPhe: 3.445 ± 0.058	8.514LeuGly: 8.514 ± 0.088	2.294LeuHis: 2.294 ± 0.043	4.183LeuIle: 4.183 ± 0.059	3.068LeuLys: 3.068 ± 0.055	12.169LeuLeu: 12.169 ± 0.139	2.171LeuMet: 2.171 ± 0.043	2.508LeuAsn: 2.508 ± 0.044	6.662LeuPro: 6.662 ± 0.092	4.432LeuGln: 4.432 ± 0.057	8.702LeuArg: 8.702 ± 0.095	6.293LeuSer: 6.293 ± 0.075	5.067LeuThr: 5.067 ± 0.071	6.995LeuVal: 6.995 ± 0.074	1.506LeuTrp: 1.506 ± 0.043	2.255LeuTyr: 2.255 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.753MetAla: 2.753 ± 0.047	0.118MetCys: 0.118 ± 0.009	1.041MetAsp: 1.041 ± 0.033	0.941MetGlu: 0.941 ± 0.029	0.668MetPhe: 0.668 ± 0.025	1.438MetGly: 1.438 ± 0.036	0.439MetHis: 0.439 ± 0.017	0.812MetIle: 0.812 ± 0.027	0.834MetLys: 0.834 ± 0.025	2.317MetLeu: 2.317 ± 0.046	0.468MetMet: 0.468 ± 0.018	0.708MetAsn: 0.708 ± 0.02	1.407MetPro: 1.407 ± 0.03	0.9MetGln: 0.9 ± 0.025	1.709MetArg: 1.709 ± 0.033	1.425MetSer: 1.425 ± 0.032	1.303MetThr: 1.303 ± 0.028	1.362MetVal: 1.362 ± 0.031	0.189MetTrp: 0.189 ± 0.012	0.342MetTyr: 0.342 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.374AsnAla: 3.374 ± 0.059	0.214AsnCys: 0.214 ± 0.012	1.439AsnAsp: 1.439 ± 0.037	1.236AsnGlu: 1.236 ± 0.032	0.944AsnPhe: 0.944 ± 0.031	2.657AsnGly: 2.657 ± 0.062	0.532AsnHis: 0.532 ± 0.019	1.169AsnIle: 1.169 ± 0.033	0.584AsnLys: 0.584 ± 0.024	2.679AsnLeu: 2.679 ± 0.051	0.412AsnMet: 0.412 ± 0.016	0.759AsnAsn: 0.759 ± 0.039	1.896AsnPro: 1.896 ± 0.04	0.88AsnGln: 0.88 ± 0.027	1.934AsnArg: 1.934 ± 0.04	1.222AsnSer: 1.222 ± 0.038	1.354AsnThr: 1.354 ± 0.043	1.841AsnVal: 1.841 ± 0.042	0.409AsnTrp: 0.409 ± 0.021	0.76AsnTyr: 0.76 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	7.721ProAla: 7.721 ± 0.111	0.312ProCys: 0.312 ± 0.017	3.491ProAsp: 3.491 ± 0.051	3.404ProGlu: 3.404 ± 0.049	1.62ProPhe: 1.62 ± 0.038	4.88ProGly: 4.88 ± 0.058	1.095ProHis: 1.095 ± 0.03	1.854ProIle: 1.854 ± 0.038	1.294ProLys: 1.294 ± 0.037	5.617ProLeu: 5.617 ± 0.071	1.262ProMet: 1.262 ± 0.031	1.228ProAsn: 1.228 ± 0.031	3.019ProPro: 3.019 ± 0.073	2.389ProGln: 2.389 ± 0.05	3.357ProArg: 3.357 ± 0.054	2.742ProSer: 2.742 ± 0.044	2.247ProThr: 2.247 ± 0.046	4.179ProVal: 4.179 ± 0.059	0.851ProTrp: 0.851 ± 0.024	1.249ProTyr: 1.249 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	5.83GlnAla: 5.83 ± 0.081	0.257GlnCys: 0.257 ± 0.015	1.752GlnAsp: 1.752 ± 0.036	1.605GlnGlu: 1.605 ± 0.038	1.192GlnPhe: 1.192 ± 0.03	2.854GlnGly: 2.854 ± 0.048	0.89GlnHis: 0.89 ± 0.026	1.655GlnIle: 1.655 ± 0.037	0.917GlnLys: 0.917 ± 0.029	4.394GlnLeu: 4.394 ± 0.069	0.885GlnMet: 0.885 ± 0.024	0.851GlnAsn: 0.851 ± 0.033	2.512GlnPro: 2.512 ± 0.056	2.157GlnGln: 2.157 ± 0.043	4.07GlnArg: 4.07 ± 0.066	2.038GlnSer: 2.038 ± 0.041	1.82GlnThr: 1.82 ± 0.038	3.04GlnVal: 3.04 ± 0.049	0.73GlnTrp: 0.73 ± 0.025	0.873GlnTyr: 0.873 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	8.002ArgAla: 8.002 ± 0.104	0.549ArgCys: 0.549 ± 0.022	4.366ArgAsp: 4.366 ± 0.066	4.544ArgGlu: 4.544 ± 0.071	3.08ArgPhe: 3.08 ± 0.05	5.204ArgGly: 5.204 ± 0.067	1.875ArgHis: 1.875 ± 0.04	4.187ArgIle: 4.187 ± 0.047	2.11ArgLys: 2.11 ± 0.043	8.824ArgLeu: 8.824 ± 0.112	1.914ArgMet: 1.914 ± 0.045	2.123ArgAsn: 2.123 ± 0.039	3.452ArgPro: 3.452 ± 0.053	3.502ArgGln: 3.502 ± 0.057	5.948ArgArg: 5.948 ± 0.085	3.969ArgSer: 3.969 ± 0.053	3.441ArgThr: 3.441 ± 0.044	5.026ArgVal: 5.026 ± 0.06	1.531ArgTrp: 1.531 ± 0.031	2.441ArgTyr: 2.441 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.873SerAla: 6.873 ± 0.09	0.416SerCys: 0.416 ± 0.023	3.01SerAsp: 3.01 ± 0.042	2.805SerGlu: 2.805 ± 0.046	1.985SerPhe: 1.985 ± 0.033	5.741SerGly: 5.741 ± 0.078	1.164SerHis: 1.164 ± 0.033	2.301SerIle: 2.301 ± 0.043	1.396SerLys: 1.396 ± 0.037	5.746SerLeu: 5.746 ± 0.068	1.044SerMet: 1.044 ± 0.027	1.479SerAsn: 1.479 ± 0.036	3.041SerPro: 3.041 ± 0.051	2.072SerGln: 2.072 ± 0.045	3.924SerArg: 3.924 ± 0.061	3.05SerSer: 3.05 ± 0.052	2.625SerThr: 2.625 ± 0.049	3.889SerVal: 3.889 ± 0.074	0.8SerTrp: 0.8 ± 0.024	1.471SerTyr: 1.471 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.204ThrAla: 6.204 ± 0.089	0.359ThrCys: 0.359 ± 0.019	2.658ThrAsp: 2.658 ± 0.049	2.126ThrGlu: 2.126 ± 0.041	1.577ThrPhe: 1.577 ± 0.039	4.726ThrGly: 4.726 ± 0.097	0.996ThrHis: 0.996 ± 0.028	2.051ThrIle: 2.051 ± 0.045	0.886ThrLys: 0.886 ± 0.03	6.02ThrLeu: 6.02 ± 0.103	0.862ThrMet: 0.862 ± 0.025	1.087ThrAsn: 1.087 ± 0.036	3.136ThrPro: 3.136 ± 0.051	1.642ThrGln: 1.642 ± 0.032	3.433ThrArg: 3.433 ± 0.05	2.438ThrSer: 2.438 ± 0.045	2.477ThrThr: 2.477 ± 0.069	4.048ThrVal: 4.048 ± 0.097	0.635ThrTrp: 0.635 ± 0.027	1.236ThrTyr: 1.236 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	9.166ValAla: 9.166 ± 0.095	0.622ValCys: 0.622 ± 0.022	4.197ValAsp: 4.197 ± 0.062	4.079ValGlu: 4.079 ± 0.06	2.52ValPhe: 2.52 ± 0.042	5.254ValGly: 5.254 ± 0.07	1.404ValHis: 1.404 ± 0.035	3.125ValIle: 3.125 ± 0.05	1.776ValLys: 1.776 ± 0.042	7.799ValLeu: 7.799 ± 0.095	1.48ValMet: 1.48 ± 0.036	1.982ValAsn: 1.982 ± 0.046	3.824ValPro: 3.824 ± 0.056	2.584ValGln: 2.584 ± 0.046	5.207ValArg: 5.207 ± 0.072	4.226ValSer: 4.226 ± 0.062	3.617ValThr: 3.617 ± 0.056	5.528ValVal: 5.528 ± 0.069	0.932ValTrp: 0.932 ± 0.032	1.6ValTyr: 1.6 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.301TrpAla: 1.301 ± 0.036	0.132TrpCys: 0.132 ± 0.009	0.708TrpAsp: 0.708 ± 0.024	0.624TrpGlu: 0.624 ± 0.019	0.579TrpPhe: 0.579 ± 0.023	0.972TrpGly: 0.972 ± 0.029	0.373TrpHis: 0.373 ± 0.015	0.663TrpIle: 0.663 ± 0.024	0.482TrpLys: 0.482 ± 0.019	2.36TrpLeu: 2.36 ± 0.043	0.439TrpMet: 0.439 ± 0.02	0.542TrpAsn: 0.542 ± 0.019	0.809TrpPro: 0.809 ± 0.028	0.902TrpGln: 0.902 ± 0.03	1.549TrpArg: 1.549 ± 0.036	0.947TrpSer: 0.947 ± 0.025	0.771TrpThr: 0.771 ± 0.027	0.996TrpVal: 0.996 ± 0.03	0.352TrpTrp: 0.352 ± 0.019	0.373TrpTyr: 0.373 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.019TyrAla: 3.019 ± 0.062	0.214TyrCys: 0.214 ± 0.012	1.599TyrAsp: 1.599 ± 0.05	1.265TyrGlu: 1.265 ± 0.031	0.932TyrPhe: 0.932 ± 0.025	2.265TyrGly: 2.265 ± 0.053	0.455TyrHis: 0.455 ± 0.018	0.761TyrIle: 0.761 ± 0.025	0.568TyrLys: 0.568 ± 0.026	2.653TyrLeu: 2.653 ± 0.043	0.39TyrMet: 0.39 ± 0.018	0.661TyrAsn: 0.661 ± 0.027	1.253TyrPro: 1.253 ± 0.031	0.975TyrGln: 0.975 ± 0.028	2.332TyrArg: 2.332 ± 0.042	1.389TyrSer: 1.389 ± 0.039	1.343TyrThr: 1.343 ± 0.058	1.671TyrVal: 1.671 ± 0.036	0.443TyrTrp: 0.443 ± 0.019	0.742TyrTyr: 0.742 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3989 proteins (1357910 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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