Amino acid dipepetide frequency for Bacillus yapensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.026AlaAla: 5.026 ± 0.096	0.572AlaCys: 0.572 ± 0.023	3.16AlaAsp: 3.16 ± 0.052	4.647AlaGlu: 4.647 ± 0.073	3.173AlaPhe: 3.173 ± 0.054	4.981AlaGly: 4.981 ± 0.078	1.252AlaHis: 1.252 ± 0.036	5.928AlaIle: 5.928 ± 0.079	4.634AlaLys: 4.634 ± 0.066	6.895AlaLeu: 6.895 ± 0.095	1.917AlaMet: 1.917 ± 0.043	2.804AlaAsn: 2.804 ± 0.048	2.034AlaPro: 2.034 ± 0.044	2.137AlaGln: 2.137 ± 0.041	2.537AlaArg: 2.537 ± 0.053	3.829AlaSer: 3.829 ± 0.057	3.527AlaThr: 3.527 ± 0.062	5.05AlaVal: 5.05 ± 0.075	0.603AlaTrp: 0.603 ± 0.025	2.252AlaTyr: 2.252 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.448CysAla: 0.448 ± 0.018	0.1CysCys: 0.1 ± 0.01	0.377CysAsp: 0.377 ± 0.017	0.489CysGlu: 0.489 ± 0.021	0.321CysPhe: 0.321 ± 0.018	0.619CysGly: 0.619 ± 0.021	0.195CysHis: 0.195 ± 0.013	0.508CysIle: 0.508 ± 0.021	0.377CysLys: 0.377 ± 0.019	0.685CysLeu: 0.685 ± 0.023	0.16CysMet: 0.16 ± 0.011	0.296CysAsn: 0.296 ± 0.015	0.354CysPro: 0.354 ± 0.019	0.238CysGln: 0.238 ± 0.014	0.274CysArg: 0.274 ± 0.016	0.493CysSer: 0.493 ± 0.019	0.367CysThr: 0.367 ± 0.017	0.448CysVal: 0.448 ± 0.019	0.071CysTrp: 0.071 ± 0.008	0.259CysTyr: 0.259 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.171AspAla: 3.171 ± 0.054	0.402AspCys: 0.402 ± 0.018	2.398AspAsp: 2.398 ± 0.048	4.582AspGlu: 4.582 ± 0.06	2.547AspPhe: 2.547 ± 0.05	3.489AspGly: 3.489 ± 0.061	1.007AspHis: 1.007 ± 0.032	4.132AspIle: 4.132 ± 0.055	3.18AspLys: 3.18 ± 0.055	5.048AspLeu: 5.048 ± 0.067	1.272AspMet: 1.272 ± 0.033	1.798AspAsn: 1.798 ± 0.044	1.863AspPro: 1.863 ± 0.043	1.69AspGln: 1.69 ± 0.035	2.085AspArg: 2.085 ± 0.047	2.729AspSer: 2.729 ± 0.05	2.487AspThr: 2.487 ± 0.042	3.656AspVal: 3.656 ± 0.053	0.651AspTrp: 0.651 ± 0.024	2.159AspTyr: 2.159 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	5.279GluAla: 5.279 ± 0.071	0.387GluCys: 0.387 ± 0.018	3.996GluAsp: 3.996 ± 0.064	7.617GluGlu: 7.617 ± 0.112	2.85GluPhe: 2.85 ± 0.046	4.459GluGly: 4.459 ± 0.063	1.554GluHis: 1.554 ± 0.037	6.217GluIle: 6.217 ± 0.073	7.247GluLys: 7.247 ± 0.086	7.674GluLeu: 7.674 ± 0.083	2.351GluMet: 2.351 ± 0.041	4.093GluAsn: 4.093 ± 0.058	2.067GluPro: 2.067 ± 0.045	3.524GluGln: 3.524 ± 0.061	3.558GluArg: 3.558 ± 0.06	3.74GluSer: 3.74 ± 0.06	3.842GluThr: 3.842 ± 0.06	5.405GluVal: 5.405 ± 0.066	0.867GluTrp: 0.867 ± 0.029	2.451GluTyr: 2.451 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.092PheAla: 3.092 ± 0.055	0.361PheCys: 0.361 ± 0.016	2.445PheAsp: 2.445 ± 0.049	3.176PheGlu: 3.176 ± 0.053	2.413PhePhe: 2.413 ± 0.054	3.436PheGly: 3.436 ± 0.057	1.01PheHis: 1.01 ± 0.029	3.9PheIle: 3.9 ± 0.068	2.537PheLys: 2.537 ± 0.037	4.771PheLeu: 4.771 ± 0.073	1.162PheMet: 1.162 ± 0.03	1.933PheAsn: 1.933 ± 0.037	1.731PhePro: 1.731 ± 0.038	1.726PheGln: 1.726 ± 0.037	1.613PheArg: 1.613 ± 0.041	3.293PheSer: 3.293 ± 0.057	2.538PheThr: 2.538 ± 0.044	3.312PheVal: 3.312 ± 0.052	0.493PheTrp: 0.493 ± 0.022	1.79PheTyr: 1.79 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	4.696GlyAla: 4.696 ± 0.081	0.597GlyCys: 0.597 ± 0.025	3.178GlyAsp: 3.178 ± 0.049	4.774GlyGlu: 4.774 ± 0.065	3.416GlyPhe: 3.416 ± 0.052	4.684GlyGly: 4.684 ± 0.078	1.371GlyHis: 1.371 ± 0.035	6.015GlyIle: 6.015 ± 0.074	5.029GlyLys: 5.029 ± 0.061	6.543GlyLeu: 6.543 ± 0.083	2.032GlyMet: 2.032 ± 0.039	2.798GlyAsn: 2.798 ± 0.053	1.717GlyPro: 1.717 ± 0.043	2.248GlyGln: 2.248 ± 0.042	2.647GlyArg: 2.647 ± 0.051	3.749GlySer: 3.749 ± 0.057	4.053GlyThr: 4.053 ± 0.056	5.055GlyVal: 5.055 ± 0.069	0.829GlyTrp: 0.829 ± 0.03	2.788GlyTyr: 2.788 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.179HisAla: 1.179 ± 0.033	0.192HisCys: 0.192 ± 0.012	0.947HisAsp: 0.947 ± 0.028	1.486HisGlu: 1.486 ± 0.033	1.084HisPhe: 1.084 ± 0.032	1.365HisGly: 1.365 ± 0.033	0.638HisHis: 0.638 ± 0.03	1.472HisIle: 1.472 ± 0.035	1.072HisLys: 1.072 ± 0.031	2.067HisLeu: 2.067 ± 0.042	0.486HisMet: 0.486 ± 0.019	0.783HisAsn: 0.783 ± 0.026	1.027HisPro: 1.027 ± 0.029	0.791HisGln: 0.791 ± 0.025	0.869HisArg: 0.869 ± 0.025	1.199HisSer: 1.199 ± 0.03	0.981HisThr: 0.981 ± 0.026	1.27HisVal: 1.27 ± 0.032	0.22HisTrp: 0.22 ± 0.014	0.848HisTyr: 0.848 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.886IleAla: 5.886 ± 0.089	0.651IleCys: 0.651 ± 0.024	4.347IleAsp: 4.347 ± 0.06	6.349IleGlu: 6.349 ± 0.079	3.469IlePhe: 3.469 ± 0.058	6.007IleGly: 6.007 ± 0.074	1.676IleHis: 1.676 ± 0.038	5.975IleIle: 5.975 ± 0.084	4.859IleLys: 4.859 ± 0.074	7.653IleLeu: 7.653 ± 0.081	1.802IleMet: 1.802 ± 0.04	3.379IleAsn: 3.379 ± 0.061	3.382IlePro: 3.382 ± 0.054	2.979IleGln: 2.979 ± 0.048	3.145IleArg: 3.145 ± 0.045	5.199IleSer: 5.199 ± 0.075	4.343IleThr: 4.343 ± 0.064	5.783IleVal: 5.783 ± 0.077	0.685IleTrp: 0.685 ± 0.027	2.547IleTyr: 2.547 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.581LysAla: 4.581 ± 0.072	0.34LysCys: 0.34 ± 0.016	3.89LysAsp: 3.89 ± 0.05	7.168LysGlu: 7.168 ± 0.083	2.164LysPhe: 2.164 ± 0.039	4.512LysGly: 4.512 ± 0.062	1.232LysHis: 1.232 ± 0.031	5.173LysIle: 5.173 ± 0.068	5.876LysLys: 5.876 ± 0.083	6.199LysLeu: 6.199 ± 0.08	2.21LysMet: 2.21 ± 0.047	3.559LysAsn: 3.559 ± 0.061	2.13LysPro: 2.13 ± 0.043	2.765LysGln: 2.765 ± 0.053	3.219LysArg: 3.219 ± 0.055	3.613LysSer: 3.613 ± 0.053	3.501LysThr: 3.501 ± 0.055	4.836LysVal: 4.836 ± 0.069	0.832LysTrp: 0.832 ± 0.026	2.363LysTyr: 2.363 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	7.095LeuAla: 7.095 ± 0.089	0.646LeuCys: 0.646 ± 0.022	4.924LeuAsp: 4.924 ± 0.065	7.208LeuGlu: 7.208 ± 0.094	5.01LeuPhe: 5.01 ± 0.078	6.459LeuGly: 6.459 ± 0.084	1.916LeuHis: 1.916 ± 0.049	7.466LeuIle: 7.466 ± 0.09	6.689LeuLys: 6.689 ± 0.072	10.133LeuLeu: 10.133 ± 0.103	2.443LeuMet: 2.443 ± 0.039	4.476LeuAsn: 4.476 ± 0.068	3.796LeuPro: 3.796 ± 0.056	3.644LeuGln: 3.644 ± 0.053	3.653LeuArg: 3.653 ± 0.057	6.773LeuSer: 6.773 ± 0.074	5.605LeuThr: 5.605 ± 0.066	6.563LeuVal: 6.563 ± 0.086	0.801LeuTrp: 0.801 ± 0.028	3.193LeuTyr: 3.193 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.877MetAla: 1.877 ± 0.048	0.137MetCys: 0.137 ± 0.01	1.41MetAsp: 1.41 ± 0.03	2.128MetGlu: 2.128 ± 0.047	1.06MetPhe: 1.06 ± 0.031	1.791MetGly: 1.791 ± 0.038	0.389MetHis: 0.389 ± 0.017	2.092MetIle: 2.092 ± 0.046	2.459MetLys: 2.459 ± 0.04	2.401MetLeu: 2.401 ± 0.045	0.794MetMet: 0.794 ± 0.028	1.527MetAsn: 1.527 ± 0.034	0.934MetPro: 0.934 ± 0.044	0.827MetGln: 0.827 ± 0.029	1.039MetArg: 1.039 ± 0.028	1.638MetSer: 1.638 ± 0.037	1.525MetThr: 1.525 ± 0.035	1.739MetVal: 1.739 ± 0.033	0.184MetTrp: 0.184 ± 0.011	0.717MetTyr: 0.717 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.737AsnAla: 2.737 ± 0.048	0.334AsnCys: 0.334 ± 0.017	2.173AsnAsp: 2.173 ± 0.044	3.814AsnGlu: 3.814 ± 0.057	1.816AsnPhe: 1.816 ± 0.043	3.454AsnGly: 3.454 ± 0.059	1.038AsnHis: 1.038 ± 0.031	3.512AsnIle: 3.512 ± 0.067	2.913AsnLys: 2.913 ± 0.057	4.113AsnLeu: 4.113 ± 0.059	1.203AsnMet: 1.203 ± 0.041	2.124AsnAsn: 2.124 ± 0.051	2.236AsnPro: 2.236 ± 0.048	1.97AsnGln: 1.97 ± 0.043	2.066AsnArg: 2.066 ± 0.041	2.408AsnSer: 2.408 ± 0.042	2.129AsnThr: 2.129 ± 0.042	3.073AsnVal: 3.073 ± 0.052	0.585AsnTrp: 0.585 ± 0.022	1.584AsnTyr: 1.584 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	2.091ProAla: 2.091 ± 0.05	0.217ProCys: 0.217 ± 0.014	1.898ProAsp: 1.898 ± 0.042	2.992ProGlu: 2.992 ± 0.047	2.034ProPhe: 2.034 ± 0.038	2.209ProGly: 2.209 ± 0.048	0.757ProHis: 0.757 ± 0.022	2.999ProIle: 2.999 ± 0.051	2.234ProLys: 2.234 ± 0.04	3.354ProLeu: 3.354 ± 0.053	0.775ProMet: 0.775 ± 0.027	1.83ProAsn: 1.83 ± 0.053	0.995ProPro: 0.995 ± 0.032	1.097ProGln: 1.097 ± 0.028	1.14ProArg: 1.14 ± 0.028	2.253ProSer: 2.253 ± 0.044	2.084ProThr: 2.084 ± 0.04	2.627ProVal: 2.627 ± 0.052	0.357ProTrp: 0.357 ± 0.019	1.396ProTyr: 1.396 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.575GlnAla: 2.575 ± 0.048	0.216GlnCys: 0.216 ± 0.014	1.563GlnAsp: 1.563 ± 0.037	3.002GlnGlu: 3.002 ± 0.051	1.733GlnPhe: 1.733 ± 0.037	2.12GlnGly: 2.12 ± 0.042	0.674GlnHis: 0.674 ± 0.024	2.767GlnIle: 2.767 ± 0.052	2.728GlnLys: 2.728 ± 0.049	3.899GlnLeu: 3.899 ± 0.061	1.089GlnMet: 1.089 ± 0.029	1.689GlnAsn: 1.689 ± 0.037	1.123GlnPro: 1.123 ± 0.035	1.683GlnGln: 1.683 ± 0.047	1.418GlnArg: 1.418 ± 0.038	2.075GlnSer: 2.075 ± 0.041	1.892GlnThr: 1.892 ± 0.043	2.446GlnVal: 2.446 ± 0.044	0.385GlnTrp: 0.385 ± 0.018	1.343GlnTyr: 1.343 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.451ArgAla: 2.451 ± 0.042	0.249ArgCys: 0.249 ± 0.015	1.999ArgAsp: 1.999 ± 0.04	3.204ArgGlu: 3.204 ± 0.051	1.977ArgPhe: 1.977 ± 0.044	2.311ArgGly: 2.311 ± 0.041	0.744ArgHis: 0.744 ± 0.026	3.091ArgIle: 3.091 ± 0.057	3.335ArgLys: 3.335 ± 0.058	3.963ArgLeu: 3.963 ± 0.057	1.206ArgMet: 1.206 ± 0.033	1.97ArgAsn: 1.97 ± 0.042	1.278ArgPro: 1.278 ± 0.035	1.43ArgGln: 1.43 ± 0.038	1.85ArgArg: 1.85 ± 0.047	2.117ArgSer: 2.117 ± 0.042	2.061ArgThr: 2.061 ± 0.038	2.678ArgVal: 2.678 ± 0.048	0.42ArgTrp: 0.42 ± 0.018	1.515ArgTyr: 1.515 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	3.493SerAla: 3.493 ± 0.051	0.415SerCys: 0.415 ± 0.017	2.804SerAsp: 2.804 ± 0.054	4.086SerGlu: 4.086 ± 0.058	3.405SerPhe: 3.405 ± 0.048	4.304SerGly: 4.304 ± 0.062	1.176SerHis: 1.176 ± 0.033	5.18SerIle: 5.18 ± 0.067	3.862SerLys: 3.862 ± 0.057	6.21SerLeu: 6.21 ± 0.072	1.621SerMet: 1.621 ± 0.035	2.64SerAsn: 2.64 ± 0.046	2.086SerPro: 2.086 ± 0.043	1.93SerGln: 1.93 ± 0.046	2.226SerArg: 2.226 ± 0.042	3.863SerSer: 3.863 ± 0.059	3.222SerThr: 3.222 ± 0.05	4.129SerVal: 4.129 ± 0.053	0.636SerTrp: 0.636 ± 0.02	2.23SerTyr: 2.23 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	3.701ThrAla: 3.701 ± 0.052	0.331ThrCys: 0.331 ± 0.017	2.698ThrAsp: 2.698 ± 0.049	3.704ThrGlu: 3.704 ± 0.058	2.589ThrPhe: 2.589 ± 0.053	4.1ThrGly: 4.1 ± 0.063	0.995ThrHis: 0.995 ± 0.028	4.66ThrIle: 4.66 ± 0.06	3.485ThrLys: 3.485 ± 0.055	5.276ThrLeu: 5.276 ± 0.062	1.259ThrMet: 1.259 ± 0.037	2.483ThrAsn: 2.483 ± 0.046	2.2ThrPro: 2.2 ± 0.04	1.414ThrGln: 1.414 ± 0.033	1.894ThrArg: 1.894 ± 0.04	3.353ThrSer: 3.353 ± 0.051	3.067ThrThr: 3.067 ± 0.049	4.017ThrVal: 4.017 ± 0.059	0.524ThrTrp: 0.524 ± 0.02	1.938ThrTyr: 1.938 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.992ValAla: 4.992 ± 0.073	0.55ValCys: 0.55 ± 0.021	3.644ValAsp: 3.644 ± 0.059	5.355ValGlu: 5.355 ± 0.072	3.216ValPhe: 3.216 ± 0.062	4.72ValGly: 4.72 ± 0.071	1.305ValHis: 1.305 ± 0.035	5.659ValIle: 5.659 ± 0.073	4.739ValLys: 4.739 ± 0.066	6.947ValLeu: 6.947 ± 0.08	1.762ValMet: 1.762 ± 0.04	3.031ValAsn: 3.031 ± 0.05	2.68ValPro: 2.68 ± 0.047	2.404ValGln: 2.404 ± 0.047	2.608ValArg: 2.608 ± 0.052	4.48ValSer: 4.48 ± 0.072	4.103ValThr: 4.103 ± 0.056	5.202ValVal: 5.202 ± 0.078	0.655ValTrp: 0.655 ± 0.022	2.189ValTyr: 2.189 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.572TrpAla: 0.572 ± 0.028	0.091TrpCys: 0.091 ± 0.008	0.539TrpAsp: 0.539 ± 0.022	0.732TrpGlu: 0.732 ± 0.027	0.536TrpPhe: 0.536 ± 0.021	0.722TrpGly: 0.722 ± 0.027	0.199TrpHis: 0.199 ± 0.013	0.826TrpIle: 0.826 ± 0.03	0.783TrpLys: 0.783 ± 0.025	1.167TrpLeu: 1.167 ± 0.035	0.295TrpMet: 0.295 ± 0.014	0.565TrpAsn: 0.565 ± 0.022	0.256TrpPro: 0.256 ± 0.016	0.356TrpGln: 0.356 ± 0.018	0.371TrpArg: 0.371 ± 0.018	0.598TrpSer: 0.598 ± 0.024	0.547TrpThr: 0.547 ± 0.021	0.676TrpVal: 0.676 ± 0.023	0.152TrpTrp: 0.152 ± 0.011	0.366TrpTyr: 0.366 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.015TyrAla: 2.015 ± 0.041	0.291TyrCys: 0.291 ± 0.015	1.957TyrAsp: 1.957 ± 0.04	2.663TyrGlu: 2.663 ± 0.052	1.918TyrPhe: 1.918 ± 0.041	2.479TyrGly: 2.479 ± 0.048	0.843TyrHis: 0.843 ± 0.028	2.544TyrIle: 2.544 ± 0.048	2.127TyrLys: 2.127 ± 0.045	3.496TyrLeu: 3.496 ± 0.061	0.83TyrMet: 0.83 ± 0.023	1.5TyrAsn: 1.5 ± 0.036	1.45TyrPro: 1.45 ± 0.031	1.566TyrGln: 1.566 ± 0.036	1.64TyrArg: 1.64 ± 0.037	2.117TyrSer: 2.117 ± 0.04	1.812TyrThr: 1.812 ± 0.037	2.277TyrVal: 2.277 ± 0.041	0.401TyrTrp: 0.401 ± 0.017	1.454TyrTyr: 1.454 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4414 proteins (1278922 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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