Amino acid dipepetide frequency for Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.711AlaAla: 13.711 ± 0.178	1.366AlaCys: 1.366 ± 0.049	5.928AlaAsp: 5.928 ± 0.086	6.395AlaGlu: 6.395 ± 0.111	3.773AlaPhe: 3.773 ± 0.076	9.427AlaGly: 9.427 ± 0.122	2.462AlaHis: 2.462 ± 0.061	5.566AlaIle: 5.566 ± 0.085	3.206AlaLys: 3.206 ± 0.063	13.03AlaLeu: 13.03 ± 0.155	3.092AlaMet: 3.092 ± 0.066	2.538AlaAsn: 2.538 ± 0.062	6.073AlaPro: 6.073 ± 0.103	4.28AlaGln: 4.28 ± 0.076	7.909AlaArg: 7.909 ± 0.121	6.735AlaSer: 6.735 ± 0.108	5.932AlaThr: 5.932 ± 0.093	7.534AlaVal: 7.534 ± 0.104	1.413AlaTrp: 1.413 ± 0.045	2.268AlaTyr: 2.268 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.177CysAla: 1.177 ± 0.042	0.18CysCys: 0.18 ± 0.012	0.563CysAsp: 0.563 ± 0.028	0.521CysGlu: 0.521 ± 0.026	0.383CysPhe: 0.383 ± 0.022	1.054CysGly: 1.054 ± 0.033	0.299CysHis: 0.299 ± 0.023	0.462CysIle: 0.462 ± 0.023	0.2CysLys: 0.2 ± 0.015	1.08CysLeu: 1.08 ± 0.039	0.202CysMet: 0.202 ± 0.013	0.236CysAsn: 0.236 ± 0.018	0.612CysPro: 0.612 ± 0.031	0.319CysGln: 0.319 ± 0.021	0.778CysArg: 0.778 ± 0.03	0.621CysSer: 0.621 ± 0.029	0.53CysThr: 0.53 ± 0.025	0.73CysVal: 0.73 ± 0.027	0.145CysTrp: 0.145 ± 0.014	0.193CysTyr: 0.193 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	6.4AspAla: 6.4 ± 0.092	0.54AspCys: 0.54 ± 0.024	2.919AspAsp: 2.919 ± 0.067	3.063AspGlu: 3.063 ± 0.073	2.017AspPhe: 2.017 ± 0.056	5.111AspGly: 5.111 ± 0.088	1.373AspHis: 1.373 ± 0.044	3.019AspIle: 3.019 ± 0.06	1.199AspLys: 1.199 ± 0.035	5.971AspLeu: 5.971 ± 0.086	1.557AspMet: 1.557 ± 0.042	1.294AspAsn: 1.294 ± 0.039	3.452AspPro: 3.452 ± 0.064	1.807AspGln: 1.807 ± 0.045	4.301AspArg: 4.301 ± 0.073	2.532AspSer: 2.532 ± 0.058	2.779AspThr: 2.779 ± 0.068	4.227AspVal: 4.227 ± 0.081	1.043AspTrp: 1.043 ± 0.038	1.359AspTyr: 1.359 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	6.692GluAla: 6.692 ± 0.1	0.39GluCys: 0.39 ± 0.024	2.947GluAsp: 2.947 ± 0.061	3.012GluGlu: 3.012 ± 0.083	1.429GluPhe: 1.429 ± 0.045	4.252GluGly: 4.252 ± 0.094	1.369GluHis: 1.369 ± 0.043	3.036GluIle: 3.036 ± 0.069	2.324GluLys: 2.324 ± 0.059	4.74GluLeu: 4.74 ± 0.088	1.366GluMet: 1.366 ± 0.045	1.84GluAsn: 1.84 ± 0.048	2.212GluPro: 2.212 ± 0.062	2.333GluGln: 2.333 ± 0.058	4.736GluArg: 4.736 ± 0.092	2.442GluSer: 2.442 ± 0.048	3.683GluThr: 3.683 ± 0.069	3.093GluVal: 3.093 ± 0.069	0.69GluTrp: 0.69 ± 0.027	0.977GluTyr: 0.977 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.553PheAla: 3.553 ± 0.065	0.494PheCys: 0.494 ± 0.026	2.203PheAsp: 2.203 ± 0.054	1.808PheGlu: 1.808 ± 0.049	1.278PhePhe: 1.278 ± 0.041	3.378PheGly: 3.378 ± 0.065	0.92PheHis: 0.92 ± 0.031	1.435PheIle: 1.435 ± 0.038	0.737PheLys: 0.737 ± 0.03	3.417PheLeu: 3.417 ± 0.067	0.916PheMet: 0.916 ± 0.035	1.043PheAsn: 1.043 ± 0.035	1.678PhePro: 1.678 ± 0.05	1.118PheGln: 1.118 ± 0.032	2.5PheArg: 2.5 ± 0.051	2.619PheSer: 2.619 ± 0.06	1.913PheThr: 1.913 ± 0.048	2.471PheVal: 2.471 ± 0.062	0.5PheTrp: 0.5 ± 0.024	0.847PheTyr: 0.847 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	8.142GlyAla: 8.142 ± 0.111	0.932GlyCys: 0.932 ± 0.032	3.944GlyAsp: 3.944 ± 0.066	4.132GlyGlu: 4.132 ± 0.079	3.354GlyPhe: 3.354 ± 0.069	6.915GlyGly: 6.915 ± 0.151	2.207GlyHis: 2.207 ± 0.054	4.502GlyIle: 4.502 ± 0.08	3.077GlyLys: 3.077 ± 0.06	8.911GlyLeu: 8.911 ± 0.113	2.411GlyMet: 2.411 ± 0.054	2.353GlyAsn: 2.353 ± 0.061	3.592GlyPro: 3.592 ± 0.073	3.316GlyGln: 3.316 ± 0.061	6.064GlyArg: 6.064 ± 0.089	5.081GlySer: 5.081 ± 0.097	5.331GlyThr: 5.331 ± 0.097	5.704GlyVal: 5.704 ± 0.084	1.412GlyTrp: 1.412 ± 0.043	2.118GlyTyr: 2.118 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.69HisAla: 2.69 ± 0.06	0.24HisCys: 0.24 ± 0.015	1.501HisAsp: 1.501 ± 0.044	1.228HisGlu: 1.228 ± 0.038	0.925HisPhe: 0.925 ± 0.032	2.235HisGly: 2.235 ± 0.052	0.822HisHis: 0.822 ± 0.034	1.129HisIle: 1.129 ± 0.04	0.549HisLys: 0.549 ± 0.03	2.461HisLeu: 2.461 ± 0.058	0.52HisMet: 0.52 ± 0.023	0.645HisAsn: 0.645 ± 0.028	1.593HisPro: 1.593 ± 0.04	0.784HisGln: 0.784 ± 0.03	1.68HisArg: 1.68 ± 0.043	1.161HisSer: 1.161 ± 0.041	1.106HisThr: 1.106 ± 0.035	1.844HisVal: 1.844 ± 0.051	0.39HisTrp: 0.39 ± 0.021	0.675HisTyr: 0.675 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.048IleAla: 6.048 ± 0.098	0.576IleCys: 0.576 ± 0.023	2.926IleAsp: 2.926 ± 0.058	3.032IleGlu: 3.032 ± 0.061	1.475IlePhe: 1.475 ± 0.042	4.573IleGly: 4.573 ± 0.076	1.079IleHis: 1.079 ± 0.035	2.143IleIle: 2.143 ± 0.061	1.155IleLys: 1.155 ± 0.039	4.804IleLeu: 4.804 ± 0.081	1.045IleMet: 1.045 ± 0.037	1.411IleAsn: 1.411 ± 0.042	2.735IlePro: 2.735 ± 0.059	1.444IleGln: 1.444 ± 0.04	3.662IleArg: 3.662 ± 0.059	3.136IleSer: 3.136 ± 0.068	2.799IleThr: 2.799 ± 0.063	3.695IleVal: 3.695 ± 0.069	0.613IleTrp: 0.613 ± 0.024	0.945IleTyr: 0.945 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.856LysAla: 3.856 ± 0.078	0.157LysCys: 0.157 ± 0.013	1.657LysAsp: 1.657 ± 0.056	1.44LysGlu: 1.44 ± 0.048	0.754LysPhe: 0.754 ± 0.03	2.454LysGly: 2.454 ± 0.056	0.599LysHis: 0.599 ± 0.027	1.634LysIle: 1.634 ± 0.053	1.175LysLys: 1.175 ± 0.049	2.871LysLeu: 2.871 ± 0.058	0.721LysMet: 0.721 ± 0.03	0.904LysAsn: 0.904 ± 0.037	1.864LysPro: 1.864 ± 0.043	1.023LysGln: 1.023 ± 0.035	2.232LysArg: 2.232 ± 0.056	1.727LysSer: 1.727 ± 0.049	2.161LysThr: 2.161 ± 0.051	1.935LysVal: 1.935 ± 0.053	0.365LysTrp: 0.365 ± 0.019	0.535LysTyr: 0.535 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	11.847LeuAla: 11.847 ± 0.134	1.24LeuCys: 1.24 ± 0.041	5.997LeuAsp: 5.997 ± 0.094	5.343LeuGlu: 5.343 ± 0.098	3.568LeuPhe: 3.568 ± 0.083	7.835LeuGly: 7.835 ± 0.124	2.514LeuHis: 2.514 ± 0.058	4.446LeuIle: 4.446 ± 0.081	3.555LeuLys: 3.555 ± 0.072	10.094LeuLeu: 10.094 ± 0.148	2.552LeuMet: 2.552 ± 0.057	2.875LeuAsn: 2.875 ± 0.06	6.556LeuPro: 6.556 ± 0.093	3.225LeuGln: 3.225 ± 0.06	7.574LeuArg: 7.574 ± 0.105	7.37LeuSer: 7.37 ± 0.103	6.437LeuThr: 6.437 ± 0.087	6.768LeuVal: 6.768 ± 0.099	1.237LeuTrp: 1.237 ± 0.037	2.139LeuTyr: 2.139 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	2.955MetAla: 2.955 ± 0.051	0.169MetCys: 0.169 ± 0.015	1.269MetAsp: 1.269 ± 0.044	1.158MetGlu: 1.158 ± 0.039	0.755MetPhe: 0.755 ± 0.029	1.94MetGly: 1.94 ± 0.052	0.474MetHis: 0.474 ± 0.023	1.379MetIle: 1.379 ± 0.037	0.916MetLys: 0.916 ± 0.033	2.543MetLeu: 2.543 ± 0.062	0.69MetMet: 0.69 ± 0.031	0.734MetAsn: 0.734 ± 0.033	1.639MetPro: 1.639 ± 0.039	0.864MetGln: 0.864 ± 0.032	1.797MetArg: 1.797 ± 0.05	1.877MetSer: 1.877 ± 0.043	2.129MetThr: 2.129 ± 0.051	1.591MetVal: 1.591 ± 0.043	0.204MetTrp: 0.204 ± 0.017	0.302MetTyr: 0.302 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.207AsnAla: 3.207 ± 0.061	0.259AsnCys: 0.259 ± 0.018	1.423AsnAsp: 1.423 ± 0.034	1.178AsnGlu: 1.178 ± 0.037	0.904AsnPhe: 0.904 ± 0.035	2.87AsnGly: 2.87 ± 0.078	0.612AsnHis: 0.612 ± 0.028	1.45AsnIle: 1.45 ± 0.047	0.568AsnLys: 0.568 ± 0.023	2.496AsnLeu: 2.496 ± 0.056	0.652AsnMet: 0.652 ± 0.028	0.743AsnAsn: 0.743 ± 0.037	1.865AsnPro: 1.865 ± 0.047	0.819AsnGln: 0.819 ± 0.031	2.022AsnArg: 2.022 ± 0.05	1.433AsnSer: 1.433 ± 0.045	1.633AsnThr: 1.633 ± 0.057	2.032AsnVal: 2.032 ± 0.051	0.462AsnTrp: 0.462 ± 0.026	0.657AsnTyr: 0.657 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	6.501ProAla: 6.501 ± 0.11	0.448ProCys: 0.448 ± 0.022	4.242ProAsp: 4.242 ± 0.079	4.096ProGlu: 4.096 ± 0.075	2.034ProPhe: 2.034 ± 0.05	4.61ProGly: 4.61 ± 0.072	1.427ProHis: 1.427 ± 0.043	2.075ProIle: 2.075 ± 0.051	1.649ProLys: 1.649 ± 0.049	5.181ProLeu: 5.181 ± 0.088	1.265ProMet: 1.265 ± 0.037	1.344ProAsn: 1.344 ± 0.038	2.811ProPro: 2.811 ± 0.085	2.032ProGln: 2.032 ± 0.052	2.976ProArg: 2.976 ± 0.066	3.574ProSer: 3.574 ± 0.067	2.749ProThr: 2.749 ± 0.056	4.906ProVal: 4.906 ± 0.075	0.801ProTrp: 0.801 ± 0.03	1.298ProTyr: 1.298 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	4.532GlnAla: 4.532 ± 0.086	0.24GlnCys: 0.24 ± 0.015	2.156GlnAsp: 2.156 ± 0.056	1.692GlnGlu: 1.692 ± 0.052	1.128GlnPhe: 1.128 ± 0.033	2.662GlnGly: 2.662 ± 0.058	0.708GlnHis: 0.708 ± 0.025	2.124GlnIle: 2.124 ± 0.054	1.408GlnLys: 1.408 ± 0.043	2.781GlnLeu: 2.781 ± 0.058	0.973GlnMet: 0.973 ± 0.035	1.123GlnAsn: 1.123 ± 0.04	1.983GlnPro: 1.983 ± 0.052	1.461GlnGln: 1.461 ± 0.052	2.324GlnArg: 2.324 ± 0.059	2.231GlnSer: 2.231 ± 0.055	2.496GlnThr: 2.496 ± 0.056	2.415GlnVal: 2.415 ± 0.054	0.44GlnTrp: 0.44 ± 0.02	0.757GlnTyr: 0.757 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	7.036ArgAla: 7.036 ± 0.115	0.657ArgCys: 0.657 ± 0.032	3.926ArgAsp: 3.926 ± 0.07	4.031ArgGlu: 4.031 ± 0.072	2.934ArgPhe: 2.934 ± 0.057	4.546ArgGly: 4.546 ± 0.082	2.083ArgHis: 2.083 ± 0.057	3.924ArgIle: 3.924 ± 0.072	2.524ArgLys: 2.524 ± 0.056	8.306ArgLeu: 8.306 ± 0.125	1.858ArgMet: 1.858 ± 0.052	2.221ArgAsn: 2.221 ± 0.047	3.931ArgPro: 3.931 ± 0.071	3.006ArgGln: 3.006 ± 0.057	5.866ArgArg: 5.866 ± 0.1	4.19ArgSer: 4.19 ± 0.074	3.905ArgThr: 3.905 ± 0.068	4.41ArgVal: 4.41 ± 0.082	0.993ArgTrp: 0.993 ± 0.041	1.787ArgTyr: 1.787 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.614SerAla: 6.614 ± 0.092	0.607SerCys: 0.607 ± 0.028	3.328SerAsp: 3.328 ± 0.066	3.0SerGlu: 3.0 ± 0.056	2.335SerPhe: 2.335 ± 0.055	6.137SerGly: 6.137 ± 0.103	1.464SerHis: 1.464 ± 0.039	2.925SerIle: 2.925 ± 0.072	1.441SerLys: 1.441 ± 0.049	6.272SerLeu: 6.272 ± 0.097	1.498SerMet: 1.498 ± 0.042	1.486SerAsn: 1.486 ± 0.047	3.375SerPro: 3.375 ± 0.06	2.0SerGln: 2.0 ± 0.048	4.309SerArg: 4.309 ± 0.075	3.894SerSer: 3.894 ± 0.107	3.328SerThr: 3.328 ± 0.078	4.629SerVal: 4.629 ± 0.078	0.901SerTrp: 0.901 ± 0.033	1.46SerTyr: 1.46 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	6.423ThrAla: 6.423 ± 0.091	0.536ThrCys: 0.536 ± 0.025	3.28ThrAsp: 3.28 ± 0.06	2.7ThrGlu: 2.7 ± 0.061	1.984ThrPhe: 1.984 ± 0.051	5.494ThrGly: 5.494 ± 0.094	1.333ThrHis: 1.333 ± 0.037	2.952ThrIle: 2.952 ± 0.069	1.456ThrLys: 1.456 ± 0.039	6.777ThrLeu: 6.777 ± 0.102	1.278ThrMet: 1.278 ± 0.039	1.54ThrAsn: 1.54 ± 0.046	4.048ThrPro: 4.048 ± 0.084	1.999ThrGln: 1.999 ± 0.051	3.641ThrArg: 3.641 ± 0.064	3.332ThrSer: 3.332 ± 0.088	3.438ThrThr: 3.438 ± 0.07	4.765ThrVal: 4.765 ± 0.088	0.681ThrTrp: 0.681 ± 0.031	1.318ThrTyr: 1.318 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	7.721ValAla: 7.721 ± 0.105	0.842ValCys: 0.842 ± 0.03	3.553ValAsp: 3.553 ± 0.07	3.934ValGlu: 3.934 ± 0.079	2.512ValPhe: 2.512 ± 0.054	4.891ValGly: 4.891 ± 0.08	1.476ValHis: 1.476 ± 0.043	3.53ValIle: 3.53 ± 0.066	1.863ValLys: 1.863 ± 0.048	7.742ValLeu: 7.742 ± 0.108	1.965ValMet: 1.965 ± 0.053	1.783ValAsn: 1.783 ± 0.051	4.17ValPro: 4.17 ± 0.069	2.36ValGln: 2.36 ± 0.06	4.825ValArg: 4.825 ± 0.081	5.02ValSer: 5.02 ± 0.079	4.644ValThr: 4.644 ± 0.076	5.344ValVal: 5.344 ± 0.107	0.947ValTrp: 0.947 ± 0.034	1.325ValTyr: 1.325 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.147TrpAla: 1.147 ± 0.036	0.181TrpCys: 0.181 ± 0.014	0.7TrpAsp: 0.7 ± 0.03	0.625TrpGlu: 0.625 ± 0.029	0.483TrpPhe: 0.483 ± 0.027	0.918TrpGly: 0.918 ± 0.04	0.434TrpHis: 0.434 ± 0.022	0.688TrpIle: 0.688 ± 0.029	0.574TrpLys: 0.574 ± 0.025	1.667TrpLeu: 1.667 ± 0.041	0.415TrpMet: 0.415 ± 0.021	0.461TrpAsn: 0.461 ± 0.024	0.679TrpPro: 0.679 ± 0.031	0.609TrpGln: 0.609 ± 0.026	1.232TrpArg: 1.232 ± 0.048	0.855TrpSer: 0.855 ± 0.036	0.832TrpThr: 0.832 ± 0.034	0.779TrpVal: 0.779 ± 0.033	0.23TrpTrp: 0.23 ± 0.017	0.301TrpTyr: 0.301 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.386TyrAla: 2.386 ± 0.055	0.233TyrCys: 0.233 ± 0.017	1.501TyrAsp: 1.501 ± 0.04	1.173TyrGlu: 1.173 ± 0.037	0.807TyrPhe: 0.807 ± 0.029	2.194TyrGly: 2.194 ± 0.051	0.522TyrHis: 0.522 ± 0.025	0.879TyrIle: 0.879 ± 0.033	0.487TyrLys: 0.487 ± 0.027	2.029TyrLeu: 2.029 ± 0.048	0.405TyrMet: 0.405 ± 0.022	0.712TyrAsn: 0.712 ± 0.036	1.151TyrPro: 1.151 ± 0.037	0.835TyrGln: 0.835 ± 0.037	1.707TyrArg: 1.707 ± 0.047	1.175TyrSer: 1.175 ± 0.045	1.148TyrThr: 1.148 ± 0.04	1.572TyrVal: 1.572 ± 0.045	0.342TyrTrp: 0.342 ± 0.021	0.573TyrTyr: 0.573 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2626 proteins (859884 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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