Amino acid dipepetide frequency for Aphanomyces invadans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.061AlaAla: 11.061 ± 0.059	1.627AlaCys: 1.627 ± 0.015	4.548AlaAsp: 4.548 ± 0.023	4.019AlaGlu: 4.019 ± 0.029	3.477AlaPhe: 3.477 ± 0.024	4.36AlaGly: 4.36 ± 0.037	2.508AlaHis: 2.508 ± 0.021	4.634AlaIle: 4.634 ± 0.025	4.746AlaLys: 4.746 ± 0.032	9.659AlaLeu: 9.659 ± 0.042	2.971AlaMet: 2.971 ± 0.02	3.127AlaAsn: 3.127 ± 0.017	4.947AlaPro: 4.947 ± 0.034	3.528AlaGln: 3.528 ± 0.023	4.66AlaArg: 4.66 ± 0.022	7.906AlaSer: 7.906 ± 0.034	7.343AlaThr: 7.343 ± 0.035	6.957AlaVal: 6.957 ± 0.028	1.193AlaTrp: 1.193 ± 0.013	2.1AlaTyr: 2.1 ± 0.018	0.0AlaXaa: 0.0 ± 0.0
Cys	1.538CysAla: 1.538 ± 0.015	0.421CysCys: 0.421 ± 0.008	1.025CysAsp: 1.025 ± 0.012	0.706CysGlu: 0.706 ± 0.01	0.75CysPhe: 0.75 ± 0.009	1.318CysGly: 1.318 ± 0.013	0.613CysHis: 0.613 ± 0.008	0.914CysIle: 0.914 ± 0.01	0.69CysLys: 0.69 ± 0.012	1.68CysLeu: 1.68 ± 0.015	0.529CysMet: 0.529 ± 0.009	0.589CysAsn: 0.589 ± 0.011	0.994CysPro: 0.994 ± 0.025	0.665CysGln: 0.665 ± 0.01	1.236CysArg: 1.236 ± 0.011	1.288CysSer: 1.288 ± 0.016	1.188CysThr: 1.188 ± 0.014	1.507CysVal: 1.507 ± 0.016	0.233CysTrp: 0.233 ± 0.005	0.415CysTyr: 0.415 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	6.171AspAla: 6.171 ± 0.029	0.876AspCys: 0.876 ± 0.012	5.088AspAsp: 5.088 ± 0.038	3.9AspGlu: 3.9 ± 0.025	1.927AspPhe: 1.927 ± 0.018	3.911AspGly: 3.911 ± 0.024	1.501AspHis: 1.501 ± 0.012	2.709AspIle: 2.709 ± 0.019	2.499AspLys: 2.499 ± 0.019	5.026AspLeu: 5.026 ± 0.027	1.696AspMet: 1.696 ± 0.015	1.843AspAsn: 1.843 ± 0.015	2.664AspPro: 2.664 ± 0.018	1.815AspGln: 1.815 ± 0.016	2.796AspArg: 2.796 ± 0.02	3.614AspSer: 3.614 ± 0.023	3.098AspThr: 3.098 ± 0.019	5.273AspVal: 5.273 ± 0.025	0.615AspTrp: 0.615 ± 0.009	1.183AspTyr: 1.183 ± 0.012	0.0AspXaa: 0.0 ± 0.0
Glu	5.039GluAla: 5.039 ± 0.032	0.928GluCys: 0.928 ± 0.011	2.846GluAsp: 2.846 ± 0.023	3.043GluGlu: 3.043 ± 0.028	1.97GluPhe: 1.97 ± 0.016	2.44GluGly: 2.44 ± 0.017	1.47GluHis: 1.47 ± 0.016	2.189GluIle: 2.189 ± 0.017	2.65GluLys: 2.65 ± 0.025	5.198GluLeu: 5.198 ± 0.033	1.393GluMet: 1.393 ± 0.014	1.697GluAsn: 1.697 ± 0.015	1.968GluPro: 1.968 ± 0.015	1.865GluGln: 1.865 ± 0.018	3.21GluArg: 3.21 ± 0.026	3.692GluSer: 3.692 ± 0.022	2.71GluThr: 2.71 ± 0.019	3.383GluVal: 3.383 ± 0.021	0.83GluTrp: 0.83 ± 0.009	1.458GluTyr: 1.458 ± 0.013	0.0GluXaa: 0.0 ± 0.0
Phe	3.211PheAla: 3.211 ± 0.018	0.734PheCys: 0.734 ± 0.01	2.492PheAsp: 2.492 ± 0.018	1.964PheGlu: 1.964 ± 0.014	1.476PhePhe: 1.476 ± 0.013	2.588PheGly: 2.588 ± 0.024	1.273PheHis: 1.273 ± 0.012	1.32PheIle: 1.32 ± 0.013	1.425PheLys: 1.425 ± 0.013	3.545PheLeu: 3.545 ± 0.026	0.848PheMet: 0.848 ± 0.009	1.312PheAsn: 1.312 ± 0.013	1.725PhePro: 1.725 ± 0.014	1.652PheGln: 1.652 ± 0.015	2.095PheArg: 2.095 ± 0.015	2.532PheSer: 2.532 ± 0.019	2.015PheThr: 2.015 ± 0.017	3.294PheVal: 3.294 ± 0.02	0.443PheTrp: 0.443 ± 0.008	1.04PheTyr: 1.04 ± 0.011	0.0PheXaa: 0.0 ± 0.0
Gly	4.692GlyAla: 4.692 ± 0.038	1.14GlyCys: 1.14 ± 0.014	3.293GlyAsp: 3.293 ± 0.022	2.416GlyGlu: 2.416 ± 0.018	2.264GlyPhe: 2.264 ± 0.017	4.509GlyGly: 4.509 ± 0.066	1.946GlyHis: 1.946 ± 0.017	2.616GlyIle: 2.616 ± 0.019	2.584GlyLys: 2.584 ± 0.019	4.941GlyLeu: 4.941 ± 0.028	1.502GlyMet: 1.502 ± 0.013	2.016GlyAsn: 2.016 ± 0.02	2.233GlyPro: 2.233 ± 0.018	1.997GlyGln: 1.997 ± 0.016	3.313GlyArg: 3.313 ± 0.02	4.244GlySer: 4.244 ± 0.04	3.459GlyThr: 3.459 ± 0.034	4.226GlyVal: 4.226 ± 0.025	0.804GlyTrp: 0.804 ± 0.01	1.625GlyTyr: 1.625 ± 0.015	0.0GlyXaa: 0.0 ± 0.0
His	3.286HisAla: 3.286 ± 0.024	0.58HisCys: 0.58 ± 0.007	2.106HisAsp: 2.106 ± 0.019	1.633HisGlu: 1.633 ± 0.014	1.113HisPhe: 1.113 ± 0.009	2.206HisGly: 2.206 ± 0.016	1.378HisHis: 1.378 ± 0.017	1.249HisIle: 1.249 ± 0.012	1.083HisLys: 1.083 ± 0.01	3.021HisLeu: 3.021 ± 0.021	0.768HisMet: 0.768 ± 0.009	0.926HisAsn: 0.926 ± 0.011	1.853HisPro: 1.853 ± 0.016	1.263HisGln: 1.263 ± 0.015	2.176HisArg: 2.176 ± 0.018	2.009HisSer: 2.009 ± 0.017	1.699HisThr: 1.699 ± 0.015	3.104HisVal: 3.104 ± 0.024	0.374HisTrp: 0.374 ± 0.007	0.716HisTyr: 0.716 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	4.126IleAla: 4.126 ± 0.025	0.73IleCys: 0.73 ± 0.009	2.607IleAsp: 2.607 ± 0.016	2.384IleGlu: 2.384 ± 0.017	1.39IlePhe: 1.39 ± 0.014	2.226IleGly: 2.226 ± 0.018	1.376IleHis: 1.376 ± 0.012	1.268IleIle: 1.268 ± 0.015	1.832IleLys: 1.832 ± 0.015	3.949IleLeu: 3.949 ± 0.028	0.906IleMet: 0.906 ± 0.01	1.245IleAsn: 1.245 ± 0.011	2.278IlePro: 2.278 ± 0.015	2.183IleGln: 2.183 ± 0.017	2.38IleArg: 2.38 ± 0.017	2.664IleSer: 2.664 ± 0.019	2.139IleThr: 2.139 ± 0.019	3.703IleVal: 3.703 ± 0.022	0.442IleTrp: 0.442 ± 0.007	1.016IleTyr: 1.016 ± 0.011	0.0IleXaa: 0.0 ± 0.0
Lys	4.397LysAla: 4.397 ± 0.027	0.797LysCys: 0.797 ± 0.011	2.414LysAsp: 2.414 ± 0.019	2.547LysGlu: 2.547 ± 0.021	1.458LysPhe: 1.458 ± 0.014	2.107LysGly: 2.107 ± 0.017	1.499LysHis: 1.499 ± 0.015	1.705LysIle: 1.705 ± 0.016	3.102LysLys: 3.102 ± 0.03	4.531LysLeu: 4.531 ± 0.027	1.107LysMet: 1.107 ± 0.012	1.396LysAsn: 1.396 ± 0.014	2.326LysPro: 2.326 ± 0.019	2.17LysGln: 2.17 ± 0.017	3.23LysArg: 3.23 ± 0.025	3.184LysSer: 3.184 ± 0.021	2.633LysThr: 2.633 ± 0.018	2.971LysVal: 2.971 ± 0.022	0.679LysTrp: 0.679 ± 0.009	1.282LysTyr: 1.282 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	8.994LeuAla: 8.994 ± 0.039	1.851LeuCys: 1.851 ± 0.018	5.898LeuAsp: 5.898 ± 0.03	5.394LeuGlu: 5.394 ± 0.031	3.53LeuPhe: 3.53 ± 0.025	5.045LeuGly: 5.045 ± 0.028	3.824LeuHis: 3.824 ± 0.024	2.988LeuIle: 2.988 ± 0.021	4.36LeuLys: 4.36 ± 0.026	9.531LeuLeu: 9.531 ± 0.053	2.092LeuMet: 2.092 ± 0.016	3.159LeuAsn: 3.159 ± 0.019	5.252LeuPro: 5.252 ± 0.028	4.887LeuGln: 4.887 ± 0.034	6.106LeuArg: 6.106 ± 0.032	7.057LeuSer: 7.057 ± 0.032	5.504LeuThr: 5.504 ± 0.03	7.611LeuVal: 7.611 ± 0.036	1.216LeuTrp: 1.216 ± 0.014	2.464LeuTyr: 2.464 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	2.687MetAla: 2.687 ± 0.019	0.445MetCys: 0.445 ± 0.008	1.721MetAsp: 1.721 ± 0.014	1.622MetGlu: 1.622 ± 0.018	0.864MetPhe: 0.864 ± 0.01	1.367MetGly: 1.367 ± 0.014	0.916MetHis: 0.916 ± 0.01	0.823MetIle: 0.823 ± 0.01	1.141MetLys: 1.141 ± 0.014	2.582MetLeu: 2.582 ± 0.017	0.667MetMet: 0.667 ± 0.009	0.844MetAsn: 0.844 ± 0.01	1.301MetPro: 1.301 ± 0.013	1.273MetGln: 1.273 ± 0.014	1.405MetArg: 1.405 ± 0.013	1.956MetSer: 1.956 ± 0.014	1.569MetThr: 1.569 ± 0.013	1.681MetVal: 1.681 ± 0.013	0.354MetTrp: 0.354 ± 0.007	0.725MetTyr: 0.725 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.425AsnAla: 3.425 ± 0.019	0.554AsnCys: 0.554 ± 0.008	2.122AsnAsp: 2.122 ± 0.016	1.846AsnGlu: 1.846 ± 0.013	1.112AsnPhe: 1.112 ± 0.013	2.201AsnGly: 2.201 ± 0.019	0.96AsnHis: 0.96 ± 0.011	1.396AsnIle: 1.396 ± 0.015	1.339AsnLys: 1.339 ± 0.014	2.932AsnLeu: 2.932 ± 0.017	0.868AsnMet: 0.868 ± 0.011	1.188AsnAsn: 1.188 ± 0.016	1.838AsnPro: 1.838 ± 0.015	1.331AsnGln: 1.331 ± 0.015	1.663AsnArg: 1.663 ± 0.013	2.209AsnSer: 2.209 ± 0.015	1.81AsnThr: 1.81 ± 0.015	2.901AsnVal: 2.901 ± 0.018	0.395AsnTrp: 0.395 ± 0.007	0.801AsnTyr: 0.801 ± 0.01	0.0AsnXaa: 0.0 ± 0.0
Pro	4.582ProAla: 4.582 ± 0.027	0.788ProCys: 0.788 ± 0.015	2.619ProAsp: 2.619 ± 0.018	2.141ProGlu: 2.141 ± 0.016	1.886ProPhe: 1.886 ± 0.013	2.381ProGly: 2.381 ± 0.022	1.709ProHis: 1.709 ± 0.013	1.974ProIle: 1.974 ± 0.016	2.162ProLys: 2.162 ± 0.018	4.854ProLeu: 4.854 ± 0.028	1.229ProMet: 1.229 ± 0.013	1.772ProAsn: 1.772 ± 0.014	4.94ProPro: 4.94 ± 0.044	1.878ProGln: 1.878 ± 0.016	3.057ProArg: 3.057 ± 0.023	5.818ProSer: 5.818 ± 0.03	4.529ProThr: 4.529 ± 0.034	3.716ProVal: 3.716 ± 0.026	0.686ProTrp: 0.686 ± 0.01	1.145ProTyr: 1.145 ± 0.013	0.0ProXaa: 0.0 ± 0.0
Gln	3.839GlnAla: 3.839 ± 0.023	0.799GlnCys: 0.799 ± 0.011	2.11GlnAsp: 2.11 ± 0.017	1.934GlnGlu: 1.934 ± 0.018	1.476GlnPhe: 1.476 ± 0.013	1.996GlnGly: 1.996 ± 0.017	1.619GlnHis: 1.619 ± 0.016	1.48GlnIle: 1.48 ± 0.012	1.646GlnLys: 1.646 ± 0.016	4.613GlnLeu: 4.613 ± 0.031	0.916GlnMet: 0.916 ± 0.012	1.168GlnAsn: 1.168 ± 0.012	2.147GlnPro: 2.147 ± 0.018	2.157GlnGln: 2.157 ± 0.026	2.96GlnArg: 2.96 ± 0.021	2.902GlnSer: 2.902 ± 0.018	2.318GlnThr: 2.318 ± 0.018	3.259GlnVal: 3.259 ± 0.021	0.664GlnTrp: 0.664 ± 0.01	1.093GlnTyr: 1.093 ± 0.011	0.0GlnXaa: 0.0 ± 0.0
Arg	4.734ArgAla: 4.734 ± 0.028	1.13ArgCys: 1.13 ± 0.013	3.101ArgAsp: 3.101 ± 0.02	2.92ArgGlu: 2.92 ± 0.022	2.157ArgPhe: 2.157 ± 0.015	3.216ArgGly: 3.216 ± 0.02	2.297ArgHis: 2.297 ± 0.019	2.496ArgIle: 2.496 ± 0.018	2.773ArgLys: 2.773 ± 0.018	5.74ArgLeu: 5.74 ± 0.032	1.594ArgMet: 1.594 ± 0.014	1.913ArgAsn: 1.913 ± 0.015	2.947ArgPro: 2.947 ± 0.019	2.909ArgGln: 2.909 ± 0.025	5.082ArgArg: 5.082 ± 0.04	4.284ArgSer: 4.284 ± 0.024	3.189ArgThr: 3.189 ± 0.021	4.275ArgVal: 4.275 ± 0.023	0.889ArgTrp: 0.889 ± 0.012	1.442ArgTyr: 1.442 ± 0.013	0.0ArgXaa: 0.0 ± 0.0
Ser	6.465SerAla: 6.465 ± 0.032	1.367SerCys: 1.367 ± 0.013	3.814SerAsp: 3.814 ± 0.023	2.816SerGlu: 2.816 ± 0.022	3.098SerPhe: 3.098 ± 0.019	4.075SerGly: 4.075 ± 0.044	2.112SerHis: 2.112 ± 0.017	3.797SerIle: 3.797 ± 0.027	3.516SerLys: 3.516 ± 0.023	7.119SerLeu: 7.119 ± 0.029	2.216SerMet: 2.216 ± 0.015	2.723SerAsn: 2.723 ± 0.019	4.74SerPro: 4.74 ± 0.031	2.539SerGln: 2.539 ± 0.018	4.182SerArg: 4.182 ± 0.023	8.081SerSer: 8.081 ± 0.055	6.326SerThr: 6.326 ± 0.034	5.33SerVal: 5.33 ± 0.03	1.024SerTrp: 1.024 ± 0.01	1.716SerTyr: 1.716 ± 0.014	0.0SerXaa: 0.0 ± 0.0
Thr	5.932ThrAla: 5.932 ± 0.035	1.259ThrCys: 1.259 ± 0.015	3.029ThrAsp: 3.029 ± 0.019	2.531ThrGlu: 2.531 ± 0.017	2.422ThrPhe: 2.422 ± 0.019	3.214ThrGly: 3.214 ± 0.039	1.712ThrHis: 1.712 ± 0.015	2.894ThrIle: 2.894 ± 0.019	3.092ThrLys: 3.092 ± 0.022	6.074ThrLeu: 6.074 ± 0.03	1.704ThrMet: 1.704 ± 0.014	2.197ThrAsn: 2.197 ± 0.016	4.032ThrPro: 4.032 ± 0.032	2.165ThrGln: 2.165 ± 0.018	3.144ThrArg: 3.144 ± 0.022	5.916ThrSer: 5.916 ± 0.037	5.478ThrThr: 5.478 ± 0.039	4.286ThrVal: 4.286 ± 0.029	0.974ThrTrp: 0.974 ± 0.01	1.553ThrTyr: 1.553 ± 0.015	0.0ThrXaa: 0.0 ± 0.0
Val	8.088ValAla: 8.088 ± 0.034	1.467ValCys: 1.467 ± 0.014	5.13ValAsp: 5.13 ± 0.025	4.378ValGlu: 4.378 ± 0.024	2.892ValPhe: 2.892 ± 0.018	4.37ValGly: 4.37 ± 0.03	2.664ValHis: 2.664 ± 0.017	2.596ValIle: 2.596 ± 0.016	3.139ValLys: 3.139 ± 0.019	7.95ValLeu: 7.95 ± 0.034	1.802ValMet: 1.802 ± 0.015	2.238ValAsn: 2.238 ± 0.016	4.084ValPro: 4.084 ± 0.025	3.395ValGln: 3.395 ± 0.024	4.082ValArg: 4.082 ± 0.02	4.97ValSer: 4.97 ± 0.03	4.06ValThr: 4.06 ± 0.032	7.506ValVal: 7.506 ± 0.042	1.027ValTrp: 1.027 ± 0.011	1.996ValTyr: 1.996 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	0.933TrpAla: 0.933 ± 0.011	0.268TrpCys: 0.268 ± 0.005	0.711TrpAsp: 0.711 ± 0.01	0.578TrpGlu: 0.578 ± 0.008	0.55TrpPhe: 0.55 ± 0.008	0.664TrpGly: 0.664 ± 0.01	0.445TrpHis: 0.445 ± 0.008	0.659TrpIle: 0.659 ± 0.008	0.716TrpLys: 0.716 ± 0.009	1.327TrpLeu: 1.327 ± 0.014	0.412TrpMet: 0.412 ± 0.007	0.581TrpAsn: 0.581 ± 0.007	0.54TrpPro: 0.54 ± 0.009	0.544TrpGln: 0.544 ± 0.008	0.915TrpArg: 0.915 ± 0.012	1.06TrpSer: 1.06 ± 0.011	1.062TrpThr: 1.062 ± 0.012	0.832TrpVal: 0.832 ± 0.01	0.233TrpTrp: 0.233 ± 0.006	0.351TrpTyr: 0.351 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.169TyrAla: 2.169 ± 0.017	0.537TyrCys: 0.537 ± 0.011	1.531TyrAsp: 1.531 ± 0.014	1.207TyrGlu: 1.207 ± 0.013	1.171TyrPhe: 1.171 ± 0.013	1.624TyrGly: 1.624 ± 0.016	0.723TyrHis: 0.723 ± 0.01	1.136TyrIle: 1.136 ± 0.013	1.04TyrLys: 1.04 ± 0.011	2.492TyrLeu: 2.492 ± 0.018	0.723TyrMet: 0.723 ± 0.009	0.956TyrAsn: 0.956 ± 0.011	1.059TyrPro: 1.059 ± 0.013	0.881TyrGln: 0.881 ± 0.011	1.395TyrArg: 1.395 ± 0.013	1.67TyrSer: 1.67 ± 0.013	1.478TyrThr: 1.478 ± 0.014	2.022TyrVal: 2.022 ± 0.016	0.306TyrTrp: 0.306 ± 0.006	0.769TyrTyr: 0.769 ± 0.01	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 19593 proteins (9628465 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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