Amino acid dipepetide frequency for Penicillium oxalicum (strain 114-2 / CGMCC 5302) (Penicillium decumbens)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.914AlaAla: 8.914 ± 0.062	1.05AlaCys: 1.05 ± 0.017	4.323AlaAsp: 4.323 ± 0.034	5.291AlaGlu: 5.291 ± 0.044	3.044AlaPhe: 3.044 ± 0.03	5.8AlaGly: 5.8 ± 0.045	1.944AlaHis: 1.944 ± 0.02	4.152AlaIle: 4.152 ± 0.033	3.869AlaLys: 3.869 ± 0.037	7.797AlaLeu: 7.797 ± 0.044	2.041AlaMet: 2.041 ± 0.024	2.86AlaAsn: 2.86 ± 0.025	4.95AlaPro: 4.95 ± 0.051	3.646AlaGln: 3.646 ± 0.031	5.265AlaArg: 5.265 ± 0.039	7.692AlaSer: 7.692 ± 0.048	5.211AlaThr: 5.211 ± 0.038	5.361AlaVal: 5.361 ± 0.035	1.155AlaTrp: 1.155 ± 0.019	2.064AlaTyr: 2.064 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.959CysAla: 0.959 ± 0.018	0.232CysCys: 0.232 ± 0.009	0.649CysAsp: 0.649 ± 0.014	0.603CysGlu: 0.603 ± 0.013	0.533CysPhe: 0.533 ± 0.013	0.955CysGly: 0.955 ± 0.016	0.351CysHis: 0.351 ± 0.01	0.653CysIle: 0.653 ± 0.013	0.468CysLys: 0.468 ± 0.011	1.291CysLeu: 1.291 ± 0.019	0.267CysMet: 0.267 ± 0.008	0.412CysAsn: 0.412 ± 0.01	0.677CysPro: 0.677 ± 0.017	0.482CysGln: 0.482 ± 0.011	0.762CysArg: 0.762 ± 0.013	0.928CysSer: 0.928 ± 0.018	0.68CysThr: 0.68 ± 0.015	0.796CysVal: 0.796 ± 0.015	0.195CysTrp: 0.195 ± 0.006	0.318CysTyr: 0.318 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.641AspAla: 4.641 ± 0.036	0.621AspCys: 0.621 ± 0.013	3.918AspAsp: 3.918 ± 0.042	4.444AspGlu: 4.444 ± 0.045	2.181AspPhe: 2.181 ± 0.021	3.868AspGly: 3.868 ± 0.032	1.421AspHis: 1.421 ± 0.02	2.797AspIle: 2.797 ± 0.025	2.101AspLys: 2.101 ± 0.026	5.29AspLeu: 5.29 ± 0.035	1.241AspMet: 1.241 ± 0.018	1.664AspAsn: 1.664 ± 0.019	3.369AspPro: 3.369 ± 0.028	2.121AspGln: 2.121 ± 0.024	3.308AspArg: 3.308 ± 0.032	4.298AspSer: 4.298 ± 0.033	2.817AspThr: 2.817 ± 0.032	3.544AspVal: 3.544 ± 0.029	0.867AspTrp: 0.867 ± 0.014	1.512AspTyr: 1.512 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.304GluAla: 5.304 ± 0.046	0.612GluCys: 0.612 ± 0.012	4.159GluAsp: 4.159 ± 0.04	5.299GluGlu: 5.299 ± 0.061	1.952GluPhe: 1.952 ± 0.023	3.554GluGly: 3.554 ± 0.032	1.394GluHis: 1.394 ± 0.021	3.23GluIle: 3.23 ± 0.03	3.584GluLys: 3.584 ± 0.034	5.099GluLeu: 5.099 ± 0.037	1.556GluMet: 1.556 ± 0.02	2.367GluAsn: 2.367 ± 0.024	2.771GluPro: 2.771 ± 0.035	2.52GluGln: 2.52 ± 0.025	3.988GluArg: 3.988 ± 0.038	4.693GluSer: 4.693 ± 0.036	3.609GluThr: 3.609 ± 0.026	3.447GluVal: 3.447 ± 0.03	0.887GluTrp: 0.887 ± 0.012	1.614GluTyr: 1.614 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.09PheAla: 3.09 ± 0.03	0.565PheCys: 0.565 ± 0.012	2.293PheAsp: 2.293 ± 0.022	2.136PheGlu: 2.136 ± 0.025	1.635PhePhe: 1.635 ± 0.022	2.77PheGly: 2.77 ± 0.033	0.948PheHis: 0.948 ± 0.014	1.74PheIle: 1.74 ± 0.023	1.419PheLys: 1.419 ± 0.016	3.467PheLeu: 3.467 ± 0.034	0.793PheMet: 0.793 ± 0.012	1.37PheAsn: 1.37 ± 0.02	1.97PhePro: 1.97 ± 0.021	1.425PheGln: 1.425 ± 0.019	1.981PheArg: 1.981 ± 0.021	3.003PheSer: 3.003 ± 0.028	2.129PheThr: 2.129 ± 0.02	2.401PheVal: 2.401 ± 0.025	0.638PheTrp: 0.638 ± 0.013	1.089PheTyr: 1.089 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.33GlyAla: 5.33 ± 0.039	0.844GlyCys: 0.844 ± 0.017	3.583GlyAsp: 3.583 ± 0.029	3.555GlyGlu: 3.555 ± 0.027	2.72GlyPhe: 2.72 ± 0.028	5.472GlyGly: 5.472 ± 0.054	1.783GlyHis: 1.783 ± 0.022	3.336GlyIle: 3.336 ± 0.03	3.157GlyLys: 3.157 ± 0.033	6.094GlyLeu: 6.094 ± 0.042	1.606GlyMet: 1.606 ± 0.02	2.363GlyAsn: 2.363 ± 0.028	3.528GlyPro: 3.528 ± 0.035	2.688GlyGln: 2.688 ± 0.027	4.166GlyArg: 4.166 ± 0.04	5.975GlySer: 5.975 ± 0.053	3.801GlyThr: 3.801 ± 0.033	4.286GlyVal: 4.286 ± 0.033	1.12GlyTrp: 1.12 ± 0.017	2.01GlyTyr: 2.01 ± 0.027	0.0GlyXaa: 0.0 ± 0.0
His	1.969HisAla: 1.969 ± 0.022	0.334HisCys: 0.334 ± 0.008	1.398HisAsp: 1.398 ± 0.02	1.448HisGlu: 1.448 ± 0.019	0.945HisPhe: 0.945 ± 0.016	1.852HisGly: 1.852 ± 0.022	0.94HisHis: 0.94 ± 0.02	1.155HisIle: 1.155 ± 0.017	0.86HisLys: 0.86 ± 0.013	2.361HisLeu: 2.361 ± 0.025	0.509HisMet: 0.509 ± 0.01	0.834HisAsn: 0.834 ± 0.014	1.784HisPro: 1.784 ± 0.019	1.062HisGln: 1.062 ± 0.016	1.713HisArg: 1.713 ± 0.025	2.023HisSer: 2.023 ± 0.025	1.297HisThr: 1.297 ± 0.018	1.502HisVal: 1.502 ± 0.021	0.338HisTrp: 0.338 ± 0.008	0.7HisTyr: 0.7 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.118IleAla: 4.118 ± 0.037	0.76IleCys: 0.76 ± 0.014	2.825IleAsp: 2.825 ± 0.029	2.839IleGlu: 2.839 ± 0.026	2.01IlePhe: 2.01 ± 0.025	3.062IleGly: 3.062 ± 0.03	1.251IleHis: 1.251 ± 0.018	2.341IleIle: 2.341 ± 0.028	1.991IleLys: 1.991 ± 0.02	4.523IleLeu: 4.523 ± 0.043	1.027IleMet: 1.027 ± 0.016	1.701IleAsn: 1.701 ± 0.023	3.052IlePro: 3.052 ± 0.027	1.935IleGln: 1.935 ± 0.021	2.799IleArg: 2.799 ± 0.027	3.88IleSer: 3.88 ± 0.027	2.666IleThr: 2.666 ± 0.028	3.066IleVal: 3.066 ± 0.027	0.702IleTrp: 0.702 ± 0.014	1.365IleTyr: 1.365 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	3.998LysAla: 3.998 ± 0.039	0.477LysCys: 0.477 ± 0.012	2.53LysAsp: 2.53 ± 0.026	3.101LysGlu: 3.101 ± 0.032	1.389LysPhe: 1.389 ± 0.018	2.698LysGly: 2.698 ± 0.028	1.028LysHis: 1.028 ± 0.015	2.21LysIle: 2.21 ± 0.024	3.175LysLys: 3.175 ± 0.05	3.808LysLeu: 3.808 ± 0.032	1.025LysMet: 1.025 ± 0.018	1.693LysAsn: 1.693 ± 0.019	2.552LysPro: 2.552 ± 0.028	1.758LysGln: 1.758 ± 0.021	3.285LysArg: 3.285 ± 0.032	3.504LysSer: 3.504 ± 0.029	2.703LysThr: 2.703 ± 0.029	2.667LysVal: 2.667 ± 0.03	0.629LysTrp: 0.629 ± 0.011	1.259LysTyr: 1.259 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	7.894LeuAla: 7.894 ± 0.047	1.224LeuCys: 1.224 ± 0.017	5.131LeuAsp: 5.131 ± 0.034	5.519LeuGlu: 5.519 ± 0.044	3.369LeuPhe: 3.369 ± 0.032	5.944LeuGly: 5.944 ± 0.04	2.283LeuHis: 2.283 ± 0.023	3.976LeuIle: 3.976 ± 0.035	3.996LeuLys: 3.996 ± 0.033	8.281LeuLeu: 8.281 ± 0.061	1.858LeuMet: 1.858 ± 0.02	3.19LeuAsn: 3.19 ± 0.027	5.49LeuPro: 5.49 ± 0.039	3.924LeuGln: 3.924 ± 0.033	5.924LeuArg: 5.924 ± 0.044	7.624LeuSer: 7.624 ± 0.045	4.87LeuThr: 4.87 ± 0.034	5.54LeuVal: 5.54 ± 0.043	1.171LeuTrp: 1.171 ± 0.017	2.269LeuTyr: 2.269 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.244MetAla: 2.244 ± 0.025	0.244MetCys: 0.244 ± 0.007	1.317MetAsp: 1.317 ± 0.019	1.322MetGlu: 1.322 ± 0.018	0.73MetPhe: 0.73 ± 0.013	1.526MetGly: 1.526 ± 0.021	0.516MetHis: 0.516 ± 0.011	1.078MetIle: 1.078 ± 0.014	1.004MetLys: 1.004 ± 0.015	1.789MetLeu: 1.789 ± 0.022	0.625MetMet: 0.625 ± 0.012	0.841MetAsn: 0.841 ± 0.014	1.28MetPro: 1.28 ± 0.019	0.928MetGln: 0.928 ± 0.014	1.335MetArg: 1.335 ± 0.016	1.983MetSer: 1.983 ± 0.021	1.398MetThr: 1.398 ± 0.016	1.347MetVal: 1.347 ± 0.018	0.282MetTrp: 0.282 ± 0.007	0.514MetTyr: 0.514 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.073AsnAla: 3.073 ± 0.024	0.428AsnCys: 0.428 ± 0.01	1.892AsnAsp: 1.892 ± 0.023	2.013AsnGlu: 2.013 ± 0.025	1.325AsnPhe: 1.325 ± 0.017	2.783AsnGly: 2.783 ± 0.03	0.861AsnHis: 0.861 ± 0.014	1.81AsnIle: 1.81 ± 0.023	1.383AsnLys: 1.383 ± 0.02	3.217AsnLeu: 3.217 ± 0.027	0.827AsnMet: 0.827 ± 0.014	1.288AsnAsn: 1.288 ± 0.02	2.464AsnPro: 2.464 ± 0.026	1.39AsnGln: 1.39 ± 0.016	1.952AsnArg: 1.952 ± 0.019	2.695AsnSer: 2.695 ± 0.025	2.012AsnThr: 2.012 ± 0.022	2.331AsnVal: 2.331 ± 0.025	0.534AsnTrp: 0.534 ± 0.01	1.013AsnTyr: 1.013 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.474ProAla: 5.474 ± 0.05	0.558ProCys: 0.558 ± 0.012	3.179ProAsp: 3.179 ± 0.025	3.843ProGlu: 3.843 ± 0.034	2.092ProPhe: 2.092 ± 0.023	3.986ProGly: 3.986 ± 0.038	1.427ProHis: 1.427 ± 0.019	2.489ProIle: 2.489 ± 0.028	2.407ProLys: 2.407 ± 0.024	4.826ProLeu: 4.826 ± 0.036	1.127ProMet: 1.127 ± 0.017	2.065ProAsn: 2.065 ± 0.026	5.009ProPro: 5.009 ± 0.07	2.481ProGln: 2.481 ± 0.032	3.714ProArg: 3.714 ± 0.035	6.55ProSer: 6.55 ± 0.056	3.957ProThr: 3.957 ± 0.036	3.838ProVal: 3.838 ± 0.034	0.751ProTrp: 0.751 ± 0.012	1.457ProTyr: 1.457 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.597GlnAla: 3.597 ± 0.032	0.462GlnCys: 0.462 ± 0.013	2.06GlnAsp: 2.06 ± 0.022	2.457GlnGlu: 2.457 ± 0.022	1.365GlnPhe: 1.365 ± 0.02	2.451GlnGly: 2.451 ± 0.025	1.08GlnHis: 1.08 ± 0.016	2.029GlnIle: 2.029 ± 0.023	2.017GlnLys: 2.017 ± 0.024	3.554GlnLeu: 3.554 ± 0.033	0.979GlnMet: 0.979 ± 0.015	1.579GlnAsn: 1.579 ± 0.02	2.658GlnPro: 2.658 ± 0.033	2.371GlnGln: 2.371 ± 0.054	2.773GlnArg: 2.773 ± 0.028	3.581GlnSer: 3.581 ± 0.031	2.418GlnThr: 2.418 ± 0.027	2.334GlnVal: 2.334 ± 0.021	0.6GlnTrp: 0.6 ± 0.012	1.154GlnTyr: 1.154 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.995ArgAla: 4.995 ± 0.039	0.739ArgCys: 0.739 ± 0.015	3.486ArgAsp: 3.486 ± 0.03	4.033ArgGlu: 4.033 ± 0.035	2.23ArgPhe: 2.23 ± 0.02	3.898ArgGly: 3.898 ± 0.037	1.629ArgHis: 1.629 ± 0.019	2.925ArgIle: 2.925 ± 0.028	3.404ArgLys: 3.404 ± 0.028	5.696ArgLeu: 5.696 ± 0.043	1.389ArgMet: 1.389 ± 0.016	2.238ArgAsn: 2.238 ± 0.026	3.756ArgPro: 3.756 ± 0.037	2.783ArgGln: 2.783 ± 0.027	5.361ArgArg: 5.361 ± 0.053	5.181ArgSer: 5.181 ± 0.047	3.363ArgThr: 3.363 ± 0.028	3.602ArgVal: 3.602 ± 0.031	0.962ArgTrp: 0.962 ± 0.016	1.617ArgTyr: 1.617 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	7.193SerAla: 7.193 ± 0.049	0.908SerCys: 0.908 ± 0.017	4.372SerAsp: 4.372 ± 0.034	4.421SerGlu: 4.421 ± 0.034	3.093SerPhe: 3.093 ± 0.025	5.771SerGly: 5.771 ± 0.05	2.244SerHis: 2.244 ± 0.022	3.967SerIle: 3.967 ± 0.031	3.672SerLys: 3.672 ± 0.034	7.653SerLeu: 7.653 ± 0.052	1.847SerMet: 1.847 ± 0.019	3.023SerAsn: 3.023 ± 0.024	5.882SerPro: 5.882 ± 0.065	3.643SerGln: 3.643 ± 0.032	5.505SerArg: 5.505 ± 0.045	9.485SerSer: 9.485 ± 0.082	5.855SerThr: 5.855 ± 0.052	4.918SerVal: 4.918 ± 0.035	1.177SerTrp: 1.177 ± 0.018	2.017SerTyr: 2.017 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	5.178ThrAla: 5.178 ± 0.038	0.742ThrCys: 0.742 ± 0.015	2.819ThrAsp: 2.819 ± 0.027	3.19ThrGlu: 3.19 ± 0.032	2.185ThrPhe: 2.185 ± 0.022	4.221ThrGly: 4.221 ± 0.031	1.362ThrHis: 1.362 ± 0.018	2.943ThrIle: 2.943 ± 0.025	2.438ThrLys: 2.438 ± 0.027	5.233ThrLeu: 5.233 ± 0.034	1.208ThrMet: 1.208 ± 0.016	1.928ThrAsn: 1.928 ± 0.022	4.285ThrPro: 4.285 ± 0.043	2.173ThrGln: 2.173 ± 0.02	3.302ThrArg: 3.302 ± 0.03	5.447ThrSer: 5.447 ± 0.043	4.102ThrThr: 4.102 ± 0.046	3.847ThrVal: 3.847 ± 0.033	0.843ThrTrp: 0.843 ± 0.014	1.491ThrTyr: 1.491 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.246ValAla: 5.246 ± 0.038	0.828ValCys: 0.828 ± 0.016	3.697ValAsp: 3.697 ± 0.031	3.805ValGlu: 3.805 ± 0.034	2.426ValPhe: 2.426 ± 0.029	3.97ValGly: 3.97 ± 0.033	1.466ValHis: 1.466 ± 0.019	3.032ValIle: 3.032 ± 0.028	2.764ValLys: 2.764 ± 0.031	5.534ValLeu: 5.534 ± 0.044	1.384ValMet: 1.384 ± 0.017	2.234ValAsn: 2.234 ± 0.024	3.697ValPro: 3.697 ± 0.031	2.494ValGln: 2.494 ± 0.027	3.555ValArg: 3.555 ± 0.028	4.956ValSer: 4.956 ± 0.034	3.594ValThr: 3.594 ± 0.031	4.25ValVal: 4.25 ± 0.037	0.849ValTrp: 0.849 ± 0.016	1.682ValTyr: 1.682 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.15TrpAla: 1.15 ± 0.02	0.194TrpCys: 0.194 ± 0.006	0.848TrpAsp: 0.848 ± 0.015	0.826TrpGlu: 0.826 ± 0.014	0.506TrpPhe: 0.506 ± 0.011	0.904TrpGly: 0.904 ± 0.014	0.356TrpHis: 0.356 ± 0.01	0.768TrpIle: 0.768 ± 0.013	0.779TrpLys: 0.779 ± 0.013	1.337TrpLeu: 1.337 ± 0.014	0.405TrpMet: 0.405 ± 0.009	0.612TrpAsn: 0.612 ± 0.012	0.589TrpPro: 0.589 ± 0.011	0.568TrpGln: 0.568 ± 0.011	0.951TrpArg: 0.951 ± 0.016	1.133TrpSer: 1.133 ± 0.018	0.944TrpThr: 0.944 ± 0.018	0.843TrpVal: 0.843 ± 0.015	0.274TrpTrp: 0.274 ± 0.008	0.401TrpTyr: 0.401 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.063TyrAla: 2.063 ± 0.022	0.388TyrCys: 0.388 ± 0.009	1.545TyrAsp: 1.545 ± 0.02	1.491TyrGlu: 1.491 ± 0.021	1.135TyrPhe: 1.135 ± 0.016	1.932TyrGly: 1.932 ± 0.022	0.74TyrHis: 0.74 ± 0.014	1.283TyrIle: 1.283 ± 0.017	0.999TyrLys: 0.999 ± 0.014	2.631TyrLeu: 2.631 ± 0.025	0.589TyrMet: 0.589 ± 0.013	1.028TyrAsn: 1.028 ± 0.016	1.465TyrPro: 1.465 ± 0.019	1.128TyrGln: 1.128 ± 0.017	1.645TyrArg: 1.645 ± 0.02	2.014TyrSer: 2.014 ± 0.024	1.512TyrThr: 1.512 ± 0.021	1.544TyrVal: 1.544 ± 0.021	0.413TyrTrp: 0.413 ± 0.01	0.896TyrTyr: 0.896 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9977 proteins (4542051 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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