Amino acid dipepetide frequency for Aquimarina intermedia

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.596AlaAla: 4.596 ± 0.104	0.56AlaCys: 0.56 ± 0.03	3.427AlaAsp: 3.427 ± 0.069	3.867AlaGlu: 3.867 ± 0.065	3.131AlaPhe: 3.131 ± 0.063	4.131AlaGly: 4.131 ± 0.095	1.201AlaHis: 1.201 ± 0.037	5.935AlaIle: 5.935 ± 0.094	4.741AlaLys: 4.741 ± 0.084	6.482AlaLeu: 6.482 ± 0.1	1.616AlaMet: 1.616 ± 0.051	3.281AlaAsn: 3.281 ± 0.066	2.03AlaPro: 2.03 ± 0.067	2.504AlaGln: 2.504 ± 0.047	2.179AlaArg: 2.179 ± 0.052	4.385AlaSer: 4.385 ± 0.078	4.151AlaThr: 4.151 ± 0.102	4.249AlaVal: 4.249 ± 0.078	0.579AlaTrp: 0.579 ± 0.022	2.612AlaTyr: 2.612 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.442CysAla: 0.442 ± 0.019	0.109CysCys: 0.109 ± 0.01	0.436CysAsp: 0.436 ± 0.025	0.43CysGlu: 0.43 ± 0.021	0.393CysPhe: 0.393 ± 0.023	0.582CysGly: 0.582 ± 0.029	0.158CysHis: 0.158 ± 0.013	0.615CysIle: 0.615 ± 0.025	0.43CysLys: 0.43 ± 0.021	0.627CysLeu: 0.627 ± 0.028	0.16CysMet: 0.16 ± 0.013	0.375CysAsn: 0.375 ± 0.021	0.326CysPro: 0.326 ± 0.028	0.206CysGln: 0.206 ± 0.014	0.221CysArg: 0.221 ± 0.016	0.559CysSer: 0.559 ± 0.026	0.469CysThr: 0.469 ± 0.033	0.467CysVal: 0.467 ± 0.025	0.057CysTrp: 0.057 ± 0.008	0.313CysTyr: 0.313 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.016AspAla: 4.016 ± 0.088	0.354AspCys: 0.354 ± 0.019	2.995AspAsp: 2.995 ± 0.07	3.639AspGlu: 3.639 ± 0.073	3.426AspPhe: 3.426 ± 0.055	3.649AspGly: 3.649 ± 0.106	1.082AspHis: 1.082 ± 0.033	4.542AspIle: 4.542 ± 0.072	4.115AspLys: 4.115 ± 0.078	5.103AspLeu: 5.103 ± 0.077	1.063AspMet: 1.063 ± 0.034	3.034AspAsn: 3.034 ± 0.069	1.966AspPro: 1.966 ± 0.057	2.081AspGln: 2.081 ± 0.044	2.179AspArg: 2.179 ± 0.051	3.323AspSer: 3.323 ± 0.064	3.469AspThr: 3.469 ± 0.081	3.521AspVal: 3.521 ± 0.072	0.708AspTrp: 0.708 ± 0.025	2.6AspTyr: 2.6 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	4.663GluAla: 4.663 ± 0.085	0.341GluCys: 0.341 ± 0.02	3.681GluAsp: 3.681 ± 0.065	5.186GluGlu: 5.186 ± 0.102	2.865GluPhe: 2.865 ± 0.062	3.754GluGly: 3.754 ± 0.072	1.218GluHis: 1.218 ± 0.039	5.629GluIle: 5.629 ± 0.084	5.385GluLys: 5.385 ± 0.086	6.273GluLeu: 6.273 ± 0.086	1.463GluMet: 1.463 ± 0.039	4.133GluAsn: 4.133 ± 0.058	1.542GluPro: 1.542 ± 0.038	2.52GluGln: 2.52 ± 0.057	2.786GluArg: 2.786 ± 0.064	3.352GluSer: 3.352 ± 0.062	3.735GluThr: 3.735 ± 0.07	4.504GluVal: 4.504 ± 0.065	0.58GluTrp: 0.58 ± 0.02	2.477GluTyr: 2.477 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	2.805PheAla: 2.805 ± 0.058	0.411PheCys: 0.411 ± 0.021	3.408PheAsp: 3.408 ± 0.06	3.602PheGlu: 3.602 ± 0.066	2.6PhePhe: 2.6 ± 0.058	3.405PheGly: 3.405 ± 0.062	0.771PheHis: 0.771 ± 0.03	3.928PheIle: 3.928 ± 0.075	3.578PheLys: 3.578 ± 0.074	4.543PheLeu: 4.543 ± 0.075	1.084PheMet: 1.084 ± 0.034	3.004PheAsn: 3.004 ± 0.07	1.594PhePro: 1.594 ± 0.042	1.409PheGln: 1.409 ± 0.043	1.638PheArg: 1.638 ± 0.04	3.773PheSer: 3.773 ± 0.063	3.182PheThr: 3.182 ± 0.072	2.895PheVal: 2.895 ± 0.05	0.511PheTrp: 0.511 ± 0.02	2.262PheTyr: 2.262 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	4.247GlyAla: 4.247 ± 0.087	0.598GlyCys: 0.598 ± 0.035	3.506GlyAsp: 3.506 ± 0.082	3.608GlyGlu: 3.608 ± 0.058	3.498GlyPhe: 3.498 ± 0.055	4.505GlyGly: 4.505 ± 0.111	1.139GlyHis: 1.139 ± 0.038	5.361GlyIle: 5.361 ± 0.089	4.508GlyLys: 4.508 ± 0.077	5.53GlyLeu: 5.53 ± 0.093	1.528GlyMet: 1.528 ± 0.042	3.416GlyAsn: 3.416 ± 0.085	1.368GlyPro: 1.368 ± 0.047	1.764GlyGln: 1.764 ± 0.043	2.157GlyArg: 2.157 ± 0.051	4.035GlySer: 4.035 ± 0.08	4.071GlyThr: 4.071 ± 0.123	4.471GlyVal: 4.471 ± 0.075	0.719GlyTrp: 0.719 ± 0.028	2.75GlyTyr: 2.75 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.052HisAla: 1.052 ± 0.034	0.203HisCys: 0.203 ± 0.013	0.9HisAsp: 0.9 ± 0.032	1.02HisGlu: 1.02 ± 0.035	1.123HisPhe: 1.123 ± 0.04	1.081HisGly: 1.081 ± 0.04	0.532HisHis: 0.532 ± 0.026	1.525HisIle: 1.525 ± 0.049	1.272HisLys: 1.272 ± 0.038	1.821HisLeu: 1.821 ± 0.039	0.35HisMet: 0.35 ± 0.019	0.969HisAsn: 0.969 ± 0.037	0.944HisPro: 0.944 ± 0.032	0.739HisGln: 0.739 ± 0.029	0.751HisArg: 0.751 ± 0.029	1.127HisSer: 1.127 ± 0.034	1.179HisThr: 1.179 ± 0.037	0.952HisVal: 0.952 ± 0.031	0.209HisTrp: 0.209 ± 0.014	0.876HisTyr: 0.876 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.074IleAla: 6.074 ± 0.086	0.629IleCys: 0.629 ± 0.028	5.034IleAsp: 5.034 ± 0.068	5.757IleGlu: 5.757 ± 0.076	3.657IlePhe: 3.657 ± 0.062	5.128IleGly: 5.128 ± 0.089	1.454IleHis: 1.454 ± 0.037	5.859IleIle: 5.859 ± 0.103	5.869IleLys: 5.869 ± 0.089	7.435IleLeu: 7.435 ± 0.102	1.371IleMet: 1.371 ± 0.037	4.391IleAsn: 4.391 ± 0.071	3.303IlePro: 3.303 ± 0.063	2.866IleGln: 2.866 ± 0.054	2.88IleArg: 2.88 ± 0.051	5.535IleSer: 5.535 ± 0.088	5.174IleThr: 5.174 ± 0.087	4.753IleVal: 4.753 ± 0.079	0.688IleTrp: 0.688 ± 0.026	2.66IleTyr: 2.66 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	4.84LysAla: 4.84 ± 0.085	0.316LysCys: 0.316 ± 0.018	4.3LysAsp: 4.3 ± 0.082	6.279LysGlu: 6.279 ± 0.086	2.902LysPhe: 2.902 ± 0.054	4.26LysGly: 4.26 ± 0.068	1.397LysHis: 1.397 ± 0.044	5.955LysIle: 5.955 ± 0.089	6.714LysLys: 6.714 ± 0.115	6.342LysLeu: 6.342 ± 0.1	1.859LysMet: 1.859 ± 0.052	4.973LysAsn: 4.973 ± 0.081	2.147LysPro: 2.147 ± 0.053	2.796LysGln: 2.796 ± 0.055	3.053LysArg: 3.053 ± 0.063	4.248LysSer: 4.248 ± 0.077	4.404LysThr: 4.404 ± 0.085	4.465LysVal: 4.465 ± 0.075	0.626LysTrp: 0.626 ± 0.026	2.643LysTyr: 2.643 ± 0.054	0.0LysXaa: 0.0 ± 0.0
Leu	5.837LeuAla: 5.837 ± 0.086	0.678LeuCys: 0.678 ± 0.025	5.25LeuAsp: 5.25 ± 0.077	5.861LeuGlu: 5.861 ± 0.091	4.704LeuPhe: 4.704 ± 0.086	5.704LeuGly: 5.704 ± 0.08	1.767LeuHis: 1.767 ± 0.049	7.107LeuIle: 7.107 ± 0.111	7.475LeuLys: 7.475 ± 0.105	9.193LeuLeu: 9.193 ± 0.15	1.959LeuMet: 1.959 ± 0.045	5.188LeuAsn: 5.188 ± 0.08	3.616LeuPro: 3.616 ± 0.057	3.622LeuGln: 3.622 ± 0.066	3.607LeuArg: 3.607 ± 0.068	6.915LeuSer: 6.915 ± 0.093	5.311LeuThr: 5.311 ± 0.083	5.444LeuVal: 5.444 ± 0.088	0.786LeuTrp: 0.786 ± 0.03	3.364LeuTyr: 3.364 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	1.402MetAla: 1.402 ± 0.043	0.141MetCys: 0.141 ± 0.011	1.175MetAsp: 1.175 ± 0.032	1.34MetGlu: 1.34 ± 0.039	0.793MetPhe: 0.793 ± 0.029	1.348MetGly: 1.348 ± 0.045	0.456MetHis: 0.456 ± 0.023	1.678MetIle: 1.678 ± 0.041	1.973MetLys: 1.973 ± 0.046	1.978MetLeu: 1.978 ± 0.055	0.583MetMet: 0.583 ± 0.026	1.24MetAsn: 1.24 ± 0.033	0.772MetPro: 0.772 ± 0.024	0.892MetGln: 0.892 ± 0.033	0.954MetArg: 0.954 ± 0.037	1.445MetSer: 1.445 ± 0.039	1.163MetThr: 1.163 ± 0.039	1.321MetVal: 1.321 ± 0.039	0.143MetTrp: 0.143 ± 0.012	0.724MetTyr: 0.724 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.851AsnAla: 3.851 ± 0.066	0.429AsnCys: 0.429 ± 0.024	3.143AsnAsp: 3.143 ± 0.07	3.61AsnGlu: 3.61 ± 0.07	2.976AsnPhe: 2.976 ± 0.058	3.612AsnGly: 3.612 ± 0.085	1.003AsnHis: 1.003 ± 0.033	4.283AsnIle: 4.283 ± 0.07	3.912AsnLys: 3.912 ± 0.063	4.969AsnLeu: 4.969 ± 0.076	1.233AsnMet: 1.233 ± 0.034	3.137AsnAsn: 3.137 ± 0.084	2.517AsnPro: 2.517 ± 0.057	2.163AsnGln: 2.163 ± 0.05	2.167AsnArg: 2.167 ± 0.049	3.642AsnSer: 3.642 ± 0.073	3.729AsnThr: 3.729 ± 0.075	3.269AsnVal: 3.269 ± 0.059	0.676AsnTrp: 0.676 ± 0.027	2.541AsnTyr: 2.541 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	1.983ProAla: 1.983 ± 0.059	0.214ProCys: 0.214 ± 0.014	2.162ProAsp: 2.162 ± 0.041	2.703ProGlu: 2.703 ± 0.052	1.818ProPhe: 1.818 ± 0.043	1.935ProGly: 1.935 ± 0.058	0.601ProHis: 0.601 ± 0.025	2.742ProIle: 2.742 ± 0.055	2.468ProLys: 2.468 ± 0.05	3.036ProLeu: 3.036 ± 0.057	0.71ProMet: 0.71 ± 0.026	2.014ProAsn: 2.014 ± 0.046	0.81ProPro: 0.81 ± 0.032	1.189ProGln: 1.189 ± 0.037	0.963ProArg: 0.963 ± 0.028	2.194ProSer: 2.194 ± 0.052	2.048ProThr: 2.048 ± 0.059	2.415ProVal: 2.415 ± 0.057	0.323ProTrp: 0.323 ± 0.02	1.417ProTyr: 1.417 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	2.127GlnAla: 2.127 ± 0.048	0.209GlnCys: 0.209 ± 0.013	1.844GlnAsp: 1.844 ± 0.045	2.606GlnGlu: 2.606 ± 0.061	1.684GlnPhe: 1.684 ± 0.04	1.933GlnGly: 1.933 ± 0.051	0.73GlnHis: 0.73 ± 0.031	2.819GlnIle: 2.819 ± 0.06	2.879GlnLys: 2.879 ± 0.054	3.762GlnLeu: 3.762 ± 0.061	0.78GlnMet: 0.78 ± 0.029	2.148GlnAsn: 2.148 ± 0.043	1.192GlnPro: 1.192 ± 0.03	1.619GlnGln: 1.619 ± 0.051	1.517GlnArg: 1.517 ± 0.04	2.086GlnSer: 2.086 ± 0.044	1.976GlnThr: 1.976 ± 0.049	2.127GlnVal: 2.127 ± 0.045	0.426GlnTrp: 0.426 ± 0.018	1.474GlnTyr: 1.474 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	2.318ArgAla: 2.318 ± 0.047	0.227ArgCys: 0.227 ± 0.017	1.958ArgAsp: 1.958 ± 0.046	2.36ArgGlu: 2.36 ± 0.052	2.048ArgPhe: 2.048 ± 0.046	2.06ArgGly: 2.06 ± 0.047	0.672ArgHis: 0.672 ± 0.028	3.264ArgIle: 3.264 ± 0.067	2.918ArgLys: 2.918 ± 0.063	3.483ArgLeu: 3.483 ± 0.066	0.961ArgMet: 0.961 ± 0.027	2.153ArgAsn: 2.153 ± 0.051	1.127ArgPro: 1.127 ± 0.033	1.17ArgGln: 1.17 ± 0.028	1.432ArgArg: 1.432 ± 0.045	2.26ArgSer: 2.26 ± 0.054	2.124ArgThr: 2.124 ± 0.049	2.299ArgVal: 2.299 ± 0.053	0.416ArgTrp: 0.416 ± 0.023	1.672ArgTyr: 1.672 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	3.715SerAla: 3.715 ± 0.059	0.625SerCys: 0.625 ± 0.026	3.555SerAsp: 3.555 ± 0.072	3.993SerGlu: 3.993 ± 0.062	3.706SerPhe: 3.706 ± 0.062	4.697SerGly: 4.697 ± 0.079	1.13SerHis: 1.13 ± 0.032	5.407SerIle: 5.407 ± 0.082	4.799SerLys: 4.799 ± 0.086	6.099SerLeu: 6.099 ± 0.077	1.272SerMet: 1.272 ± 0.033	3.799SerAsn: 3.799 ± 0.078	2.003SerPro: 2.003 ± 0.045	2.231SerGln: 2.231 ± 0.051	2.271SerArg: 2.271 ± 0.047	4.234SerSer: 4.234 ± 0.077	3.761SerThr: 3.761 ± 0.071	3.896SerVal: 3.896 ± 0.062	0.666SerTrp: 0.666 ± 0.026	2.955SerTyr: 2.955 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	4.17ThrAla: 4.17 ± 0.097	0.413ThrCys: 0.413 ± 0.031	3.422ThrAsp: 3.422 ± 0.086	3.513ThrGlu: 3.513 ± 0.06	3.058ThrPhe: 3.058 ± 0.081	4.029ThrGly: 4.029 ± 0.11	1.146ThrHis: 1.146 ± 0.033	5.325ThrIle: 5.325 ± 0.081	3.858ThrLys: 3.858 ± 0.061	5.839ThrLeu: 5.839 ± 0.077	1.114ThrMet: 1.114 ± 0.035	3.293ThrAsn: 3.293 ± 0.076	2.598ThrPro: 2.598 ± 0.07	2.093ThrGln: 2.093 ± 0.043	1.842ThrArg: 1.842 ± 0.042	4.101ThrSer: 4.101 ± 0.068	4.134ThrThr: 4.134 ± 0.107	4.169ThrVal: 4.169 ± 0.109	0.527ThrTrp: 0.527 ± 0.022	2.595ThrTyr: 2.595 ± 0.086	0.0ThrXaa: 0.0 ± 0.0
Val	4.394ValAla: 4.394 ± 0.087	0.525ValCys: 0.525 ± 0.024	3.715ValAsp: 3.715 ± 0.068	3.717ValGlu: 3.717 ± 0.059	3.199ValPhe: 3.199 ± 0.057	3.837ValGly: 3.837 ± 0.061	1.09ValHis: 1.09 ± 0.037	4.981ValIle: 4.981 ± 0.074	4.035ValLys: 4.035 ± 0.082	6.26ValLeu: 6.26 ± 0.099	1.391ValMet: 1.391 ± 0.044	3.269ValAsn: 3.269 ± 0.07	2.17ValPro: 2.17 ± 0.048	2.02ValGln: 2.02 ± 0.042	2.167ValArg: 2.167 ± 0.046	4.447ValSer: 4.447 ± 0.069	3.961ValThr: 3.961 ± 0.125	4.301ValVal: 4.301 ± 0.084	0.569ValTrp: 0.569 ± 0.025	2.364ValTyr: 2.364 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.532TrpAla: 0.532 ± 0.026	0.088TrpCys: 0.088 ± 0.01	0.545TrpAsp: 0.545 ± 0.025	0.662TrpGlu: 0.662 ± 0.028	0.552TrpPhe: 0.552 ± 0.024	0.572TrpGly: 0.572 ± 0.025	0.199TrpHis: 0.199 ± 0.014	0.748TrpIle: 0.748 ± 0.029	0.737TrpLys: 0.737 ± 0.028	0.915TrpLeu: 0.915 ± 0.025	0.316TrpMet: 0.316 ± 0.02	0.654TrpAsn: 0.654 ± 0.022	0.209TrpPro: 0.209 ± 0.015	0.374TrpGln: 0.374 ± 0.018	0.405TrpArg: 0.405 ± 0.024	0.628TrpSer: 0.628 ± 0.027	0.531TrpThr: 0.531 ± 0.024	0.57TrpVal: 0.57 ± 0.024	0.142TrpTrp: 0.142 ± 0.012	0.419TrpTyr: 0.419 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.594TyrAla: 2.594 ± 0.052	0.306TyrCys: 0.306 ± 0.018	2.409TyrAsp: 2.409 ± 0.057	2.334TyrGlu: 2.334 ± 0.05	2.272TyrPhe: 2.272 ± 0.053	2.558TyrGly: 2.558 ± 0.057	0.88TyrHis: 0.88 ± 0.03	2.814TyrIle: 2.814 ± 0.055	2.853TyrLys: 2.853 ± 0.058	3.698TyrLeu: 3.698 ± 0.06	0.705TyrMet: 0.705 ± 0.028	2.386TyrAsn: 2.386 ± 0.056	1.512TyrPro: 1.512 ± 0.041	1.677TyrGln: 1.677 ± 0.046	1.757TyrArg: 1.757 ± 0.047	2.527TyrSer: 2.527 ± 0.053	2.668TyrThr: 2.668 ± 0.075	2.323TyrVal: 2.323 ± 0.047	0.446TyrTrp: 0.446 ± 0.022	1.812TyrTyr: 1.812 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3132 proteins (1033828 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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