Amino acid dipepetide frequency for Hydrogeniiclostidium mannosilyticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.447AlaAla: 11.447 ± 0.139	1.701AlaCys: 1.701 ± 0.052	4.861AlaAsp: 4.861 ± 0.079	6.611AlaGlu: 6.611 ± 0.095	3.813AlaPhe: 3.813 ± 0.062	8.282AlaGly: 8.282 ± 0.117	1.494AlaHis: 1.494 ± 0.042	4.641AlaIle: 4.641 ± 0.088	4.202AlaLys: 4.202 ± 0.074	9.522AlaLeu: 9.522 ± 0.137	2.486AlaMet: 2.486 ± 0.056	2.478AlaAsn: 2.478 ± 0.057	3.301AlaPro: 3.301 ± 0.069	3.509AlaGln: 3.509 ± 0.071	4.558AlaArg: 4.558 ± 0.072	4.492AlaSer: 4.492 ± 0.073	3.305AlaThr: 3.305 ± 0.076	8.033AlaVal: 8.033 ± 0.106	0.866AlaTrp: 0.866 ± 0.033	3.205AlaTyr: 3.205 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.584CysAla: 1.584 ± 0.046	0.396CysCys: 0.396 ± 0.023	0.898CysAsp: 0.898 ± 0.027	0.973CysGlu: 0.973 ± 0.038	0.729CysPhe: 0.729 ± 0.032	1.791CysGly: 1.791 ± 0.048	0.33CysHis: 0.33 ± 0.021	0.919CysIle: 0.919 ± 0.033	0.733CysLys: 0.733 ± 0.033	1.502CysLeu: 1.502 ± 0.045	0.453CysMet: 0.453 ± 0.026	0.558CysAsn: 0.558 ± 0.026	0.83CysPro: 0.83 ± 0.034	0.421CysGln: 0.421 ± 0.026	1.18CysArg: 1.18 ± 0.04	1.055CysSer: 1.055 ± 0.039	0.87CysThr: 0.87 ± 0.036	1.058CysVal: 1.058 ± 0.034	0.179CysTrp: 0.179 ± 0.015	0.623CysTyr: 0.623 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	4.374AspAla: 4.374 ± 0.076	0.927AspCys: 0.927 ± 0.041	2.298AspAsp: 2.298 ± 0.061	3.845AspGlu: 3.845 ± 0.081	2.709AspPhe: 2.709 ± 0.057	4.716AspGly: 4.716 ± 0.086	0.895AspHis: 0.895 ± 0.032	3.648AspIle: 3.648 ± 0.075	2.419AspLys: 2.419 ± 0.056	4.437AspLeu: 4.437 ± 0.073	1.496AspMet: 1.496 ± 0.045	1.756AspAsn: 1.756 ± 0.046	2.167AspPro: 2.167 ± 0.062	1.379AspGln: 1.379 ± 0.042	2.77AspArg: 2.77 ± 0.057	2.845AspSer: 2.845 ± 0.065	2.648AspThr: 2.648 ± 0.06	3.237AspVal: 3.237 ± 0.065	0.685AspTrp: 0.685 ± 0.035	2.405AspTyr: 2.405 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	6.596GluAla: 6.596 ± 0.089	0.756GluCys: 0.756 ± 0.03	3.467GluAsp: 3.467 ± 0.063	5.704GluGlu: 5.704 ± 0.09	2.081GluPhe: 2.081 ± 0.055	4.441GluGly: 4.441 ± 0.078	1.301GluHis: 1.301 ± 0.042	4.418GluIle: 4.418 ± 0.088	5.213GluLys: 5.213 ± 0.089	6.667GluLeu: 6.667 ± 0.106	1.935GluMet: 1.935 ± 0.049	3.556GluAsn: 3.556 ± 0.068	2.452GluPro: 2.452 ± 0.06	3.363GluGln: 3.363 ± 0.076	4.058GluArg: 4.058 ± 0.073	3.242GluSer: 3.242 ± 0.063	3.413GluThr: 3.413 ± 0.064	3.977GluVal: 3.977 ± 0.075	0.738GluTrp: 0.738 ± 0.032	2.457GluTyr: 2.457 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	3.195PheAla: 3.195 ± 0.059	0.903PheCys: 0.903 ± 0.034	2.458PheAsp: 2.458 ± 0.052	2.627PheGlu: 2.627 ± 0.058	2.013PhePhe: 2.013 ± 0.059	3.08PheGly: 3.08 ± 0.065	0.888PheHis: 0.888 ± 0.033	2.602PheIle: 2.602 ± 0.063	1.541PheLys: 1.541 ± 0.045	4.009PheLeu: 4.009 ± 0.083	1.057PheMet: 1.057 ± 0.035	1.377PheAsn: 1.377 ± 0.038	1.591PhePro: 1.591 ± 0.045	1.487PheGln: 1.487 ± 0.042	1.966PheArg: 1.966 ± 0.052	3.249PheSer: 3.249 ± 0.056	2.448PheThr: 2.448 ± 0.05	2.665PheVal: 2.665 ± 0.063	0.493PheTrp: 0.493 ± 0.027	1.789PheTyr: 1.789 ± 0.053	0.0PheXaa: 0.0 ± 0.0
Gly	6.582GlyAla: 6.582 ± 0.11	1.513GlyCys: 1.513 ± 0.046	3.748GlyAsp: 3.748 ± 0.082	5.195GlyGlu: 5.195 ± 0.089	3.317GlyPhe: 3.317 ± 0.076	6.113GlyGly: 6.113 ± 0.118	1.307GlyHis: 1.307 ± 0.045	5.053GlyIle: 5.053 ± 0.084	4.837GlyLys: 4.837 ± 0.072	7.177GlyLeu: 7.177 ± 0.1	2.332GlyMet: 2.332 ± 0.049	2.899GlyAsn: 2.899 ± 0.073	2.062GlyPro: 2.062 ± 0.084	2.387GlyGln: 2.387 ± 0.057	4.416GlyArg: 4.416 ± 0.085	4.453GlySer: 4.453 ± 0.084	4.146GlyThr: 4.146 ± 0.082	5.489GlyVal: 5.489 ± 0.09	0.907GlyTrp: 0.907 ± 0.035	3.093GlyTyr: 3.093 ± 0.077	0.0GlyXaa: 0.0 ± 0.0
His	1.493HisAla: 1.493 ± 0.043	0.371HisCys: 0.371 ± 0.02	0.824HisAsp: 0.824 ± 0.032	1.057HisGlu: 1.057 ± 0.037	0.938HisPhe: 0.938 ± 0.033	1.486HisGly: 1.486 ± 0.042	0.412HisHis: 0.412 ± 0.021	1.307HisIle: 1.307 ± 0.043	0.785HisLys: 0.785 ± 0.029	1.62HisLeu: 1.62 ± 0.043	0.467HisMet: 0.467 ± 0.024	0.708HisAsn: 0.708 ± 0.028	1.051HisPro: 1.051 ± 0.029	0.572HisGln: 0.572 ± 0.025	1.03HisArg: 1.03 ± 0.037	1.063HisSer: 1.063 ± 0.036	1.053HisThr: 1.053 ± 0.035	1.138HisVal: 1.138 ± 0.034	0.244HisTrp: 0.244 ± 0.019	0.753HisTyr: 0.753 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.32IleAla: 5.32 ± 0.085	1.157IleCys: 1.157 ± 0.037	3.451IleAsp: 3.451 ± 0.072	3.639IleGlu: 3.639 ± 0.073	2.47IlePhe: 2.47 ± 0.065	4.232IleGly: 4.232 ± 0.068	1.208IleHis: 1.208 ± 0.046	3.455IleIle: 3.455 ± 0.077	2.649IleLys: 2.649 ± 0.067	5.913IleLeu: 5.913 ± 0.099	1.351IleMet: 1.351 ± 0.04	2.128IleAsn: 2.128 ± 0.055	2.963IlePro: 2.963 ± 0.066	2.049IleGln: 2.049 ± 0.049	3.389IleArg: 3.389 ± 0.068	4.067IleSer: 4.067 ± 0.07	3.5IleThr: 3.5 ± 0.073	3.808IleVal: 3.808 ± 0.075	0.558IleTrp: 0.558 ± 0.027	2.001IleTyr: 2.001 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	4.81LysAla: 4.81 ± 0.09	0.528LysCys: 0.528 ± 0.027	2.688LysAsp: 2.688 ± 0.055	4.188LysGlu: 4.188 ± 0.075	1.335LysPhe: 1.335 ± 0.045	3.568LysGly: 3.568 ± 0.078	0.838LysHis: 0.838 ± 0.035	3.628LysIle: 3.628 ± 0.063	4.31LysLys: 4.31 ± 0.078	4.499LysLeu: 4.499 ± 0.077	1.55LysMet: 1.55 ± 0.044	2.676LysAsn: 2.676 ± 0.059	2.021LysPro: 2.021 ± 0.054	2.057LysGln: 2.057 ± 0.056	2.993LysArg: 2.993 ± 0.07	2.76LysSer: 2.76 ± 0.053	3.028LysThr: 3.028 ± 0.053	3.037LysVal: 3.037 ± 0.071	0.496LysTrp: 0.496 ± 0.026	1.963LysTyr: 1.963 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	8.958LeuAla: 8.958 ± 0.121	2.087LeuCys: 2.087 ± 0.055	4.916LeuAsp: 4.916 ± 0.07	6.538LeuGlu: 6.538 ± 0.085	4.295LeuPhe: 4.295 ± 0.09	6.27LeuGly: 6.27 ± 0.107	1.764LeuHis: 1.764 ± 0.042	4.927LeuIle: 4.927 ± 0.095	5.086LeuLys: 5.086 ± 0.069	10.608LeuLeu: 10.608 ± 0.175	2.488LeuMet: 2.488 ± 0.056	3.541LeuAsn: 3.541 ± 0.057	4.863LeuPro: 4.863 ± 0.076	3.535LeuGln: 3.535 ± 0.079	5.342LeuArg: 5.342 ± 0.086	6.858LeuSer: 6.858 ± 0.114	5.242LeuThr: 5.242 ± 0.082	5.728LeuVal: 5.728 ± 0.105	0.984LeuTrp: 0.984 ± 0.036	3.465LeuTyr: 3.465 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	2.531MetAla: 2.531 ± 0.053	0.347MetCys: 0.347 ± 0.018	1.589MetAsp: 1.589 ± 0.043	2.002MetGlu: 2.002 ± 0.047	0.798MetPhe: 0.798 ± 0.03	1.972MetGly: 1.972 ± 0.048	0.44MetHis: 0.44 ± 0.024	1.405MetIle: 1.405 ± 0.043	1.953MetLys: 1.953 ± 0.049	2.616MetLeu: 2.616 ± 0.06	0.753MetMet: 0.753 ± 0.032	1.292MetAsn: 1.292 ± 0.035	1.18MetPro: 1.18 ± 0.043	1.009MetGln: 1.009 ± 0.033	1.366MetArg: 1.366 ± 0.041	1.439MetSer: 1.439 ± 0.04	1.441MetThr: 1.441 ± 0.043	1.726MetVal: 1.726 ± 0.048	0.221MetTrp: 0.221 ± 0.015	0.65MetTyr: 0.65 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.164AsnAla: 3.164 ± 0.064	0.601AsnCys: 0.601 ± 0.028	1.78AsnAsp: 1.78 ± 0.043	2.227AsnGlu: 2.227 ± 0.058	1.43AsnPhe: 1.43 ± 0.04	3.514AsnGly: 3.514 ± 0.089	0.778AsnHis: 0.778 ± 0.028	2.701AsnIle: 2.701 ± 0.06	1.672AsnLys: 1.672 ± 0.05	3.286AsnLeu: 3.286 ± 0.064	1.045AsnMet: 1.045 ± 0.039	1.369AsnAsn: 1.369 ± 0.045	2.057AsnPro: 2.057 ± 0.046	1.283AsnGln: 1.283 ± 0.047	2.17AsnArg: 2.17 ± 0.051	1.965AsnSer: 1.965 ± 0.048	1.981AsnThr: 1.981 ± 0.049	2.27AsnVal: 2.27 ± 0.059	0.445AsnTrp: 0.445 ± 0.024	1.398AsnTyr: 1.398 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	4.355ProAla: 4.355 ± 0.088	0.631ProCys: 0.631 ± 0.027	2.582ProAsp: 2.582 ± 0.057	3.787ProGlu: 3.787 ± 0.061	1.833ProPhe: 1.833 ± 0.05	3.295ProGly: 3.295 ± 0.07	0.773ProHis: 0.773 ± 0.032	1.862ProIle: 1.862 ± 0.047	1.736ProLys: 1.736 ± 0.045	3.746ProLeu: 3.746 ± 0.064	0.988ProMet: 0.988 ± 0.035	1.285ProAsn: 1.285 ± 0.042	1.419ProPro: 1.419 ± 0.053	1.739ProGln: 1.739 ± 0.054	1.681ProArg: 1.681 ± 0.044	2.266ProSer: 2.266 ± 0.057	1.707ProThr: 1.707 ± 0.051	3.735ProVal: 3.735 ± 0.075	0.449ProTrp: 0.449 ± 0.025	1.593ProTyr: 1.593 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	3.784GlnAla: 3.784 ± 0.075	0.409GlnCys: 0.409 ± 0.022	1.652GlnAsp: 1.652 ± 0.052	2.796GlnGlu: 2.796 ± 0.068	1.106GlnPhe: 1.106 ± 0.035	2.494GlnGly: 2.494 ± 0.082	0.621GlnHis: 0.621 ± 0.029	2.231GlnIle: 2.231 ± 0.05	2.481GlnLys: 2.481 ± 0.055	3.37GlnLeu: 3.37 ± 0.068	1.055GlnMet: 1.055 ± 0.035	1.609GlnAsn: 1.609 ± 0.039	1.523GlnPro: 1.523 ± 0.052	1.694GlnGln: 1.694 ± 0.054	2.024GlnArg: 2.024 ± 0.058	1.872GlnSer: 1.872 ± 0.048	1.81GlnThr: 1.81 ± 0.046	2.265GlnVal: 2.265 ± 0.059	0.424GlnTrp: 0.424 ± 0.024	1.414GlnTyr: 1.414 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	4.609ArgAla: 4.609 ± 0.084	0.92ArgCys: 0.92 ± 0.033	2.514ArgAsp: 2.514 ± 0.053	4.355ArgGlu: 4.355 ± 0.081	2.473ArgPhe: 2.473 ± 0.055	3.327ArgGly: 3.327 ± 0.072	1.074ArgHis: 1.074 ± 0.043	3.227ArgIle: 3.227 ± 0.061	2.978ArgLys: 2.978 ± 0.064	5.881ArgLeu: 5.881 ± 0.089	1.627ArgMet: 1.627 ± 0.044	1.896ArgAsn: 1.896 ± 0.044	2.129ArgPro: 2.129 ± 0.054	2.184ArgGln: 2.184 ± 0.049	3.77ArgArg: 3.77 ± 0.076	2.75ArgSer: 2.75 ± 0.053	2.598ArgThr: 2.598 ± 0.057	3.658ArgVal: 3.658 ± 0.065	0.593ArgTrp: 0.593 ± 0.026	2.245ArgTyr: 2.245 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	5.313SerAla: 5.313 ± 0.085	0.937SerCys: 0.937 ± 0.034	2.75SerAsp: 2.75 ± 0.062	3.432SerGlu: 3.432 ± 0.073	2.841SerPhe: 2.841 ± 0.056	5.589SerGly: 5.589 ± 0.106	1.049SerHis: 1.049 ± 0.031	3.522SerIle: 3.522 ± 0.065	2.546SerLys: 2.546 ± 0.069	5.521SerLeu: 5.521 ± 0.086	1.602SerMet: 1.602 ± 0.043	1.857SerAsn: 1.857 ± 0.055	2.424SerPro: 2.424 ± 0.054	1.828SerGln: 1.828 ± 0.049	3.189SerArg: 3.189 ± 0.069	3.721SerSer: 3.721 ± 0.102	2.834SerThr: 2.834 ± 0.059	4.207SerVal: 4.207 ± 0.074	0.631SerTrp: 0.631 ± 0.028	2.146SerTyr: 2.146 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	5.292ThrAla: 5.292 ± 0.096	0.653ThrCys: 0.653 ± 0.03	2.86ThrAsp: 2.86 ± 0.063	3.292ThrGlu: 3.292 ± 0.072	1.939ThrPhe: 1.939 ± 0.049	4.965ThrGly: 4.965 ± 0.106	0.884ThrHis: 0.884 ± 0.036	3.039ThrIle: 3.039 ± 0.066	2.128ThrLys: 2.128 ± 0.059	5.129ThrLeu: 5.129 ± 0.092	1.187ThrMet: 1.187 ± 0.036	1.644ThrAsn: 1.644 ± 0.05	2.572ThrPro: 2.572 ± 0.061	1.573ThrGln: 1.573 ± 0.043	2.196ThrArg: 2.196 ± 0.052	2.541ThrSer: 2.541 ± 0.059	2.507ThrThr: 2.507 ± 0.067	4.491ThrVal: 4.491 ± 0.084	0.463ThrTrp: 0.463 ± 0.027	1.659ThrTyr: 1.659 ± 0.06	0.0ThrXaa: 0.0 ± 0.0
Val	5.431ValAla: 5.431 ± 0.076	1.331ValCys: 1.331 ± 0.042	3.565ValAsp: 3.565 ± 0.067	4.413ValGlu: 4.413 ± 0.07	3.106ValPhe: 3.106 ± 0.061	4.158ValGly: 4.158 ± 0.082	1.226ValHis: 1.226 ± 0.04	4.017ValIle: 4.017 ± 0.081	3.534ValLys: 3.534 ± 0.069	7.443ValLeu: 7.443 ± 0.109	1.713ValMet: 1.713 ± 0.047	2.569ValAsn: 2.569 ± 0.059	2.957ValPro: 2.957 ± 0.069	2.482ValGln: 2.482 ± 0.049	3.667ValArg: 3.667 ± 0.07	4.488ValSer: 4.488 ± 0.073	3.893ValThr: 3.893 ± 0.09	4.829ValVal: 4.829 ± 0.1	0.691ValTrp: 0.691 ± 0.031	2.552ValTyr: 2.552 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.844TrpAla: 0.844 ± 0.035	0.215TrpCys: 0.215 ± 0.014	0.549TrpAsp: 0.549 ± 0.029	0.733TrpGlu: 0.733 ± 0.029	0.506TrpPhe: 0.506 ± 0.025	0.783TrpGly: 0.783 ± 0.032	0.234TrpHis: 0.234 ± 0.018	0.555TrpIle: 0.555 ± 0.024	0.608TrpLys: 0.608 ± 0.027	1.1TrpLeu: 1.1 ± 0.039	0.28TrpMet: 0.28 ± 0.017	0.544TrpAsn: 0.544 ± 0.024	0.302TrpPro: 0.302 ± 0.018	0.498TrpGln: 0.498 ± 0.024	0.598TrpArg: 0.598 ± 0.025	0.623TrpSer: 0.623 ± 0.029	0.462TrpThr: 0.462 ± 0.025	0.655TrpVal: 0.655 ± 0.028	0.141TrpTrp: 0.141 ± 0.013	0.428TrpTyr: 0.428 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.125TyrAla: 3.125 ± 0.069	0.698TyrCys: 0.698 ± 0.031	2.203TyrAsp: 2.203 ± 0.066	2.42TyrGlu: 2.42 ± 0.063	1.707TyrPhe: 1.707 ± 0.051	2.951TyrGly: 2.951 ± 0.059	0.858TyrHis: 0.858 ± 0.033	2.152TyrIle: 2.152 ± 0.058	1.564TyrLys: 1.564 ± 0.046	3.449TyrLeu: 3.449 ± 0.073	0.862TyrMet: 0.862 ± 0.032	1.395TyrAsn: 1.395 ± 0.042	1.599TyrPro: 1.599 ± 0.042	1.587TyrGln: 1.587 ± 0.049	2.442TyrArg: 2.442 ± 0.054	2.191TyrSer: 2.191 ± 0.052	2.131TyrThr: 2.131 ± 0.063	2.059TyrVal: 2.059 ± 0.054	0.446TyrTrp: 0.446 ± 0.024	1.722TyrTyr: 1.722 ± 0.055	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2762 proteins (860027 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---