Amino acid dipepetide frequency for Helicobacter didelphidarum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.067AlaAla: 2.067 ± 0.074	0.946AlaCys: 0.946 ± 0.055	2.524AlaAsp: 2.524 ± 0.069	2.509AlaGlu: 2.509 ± 0.07	3.062AlaPhe: 3.062 ± 0.068	3.205AlaGly: 3.205 ± 0.085	1.257AlaHis: 1.257 ± 0.046	5.589AlaIle: 5.589 ± 0.099	5.481AlaLys: 5.481 ± 0.09	6.6AlaLeu: 6.6 ± 0.114	1.868AlaMet: 1.868 ± 0.054	3.945AlaAsn: 3.945 ± 0.08	1.546AlaPro: 1.546 ± 0.055	2.65AlaGln: 2.65 ± 0.061	2.376AlaArg: 2.376 ± 0.057	3.546AlaSer: 3.546 ± 0.072	3.34AlaThr: 3.34 ± 0.071	2.544AlaVal: 2.544 ± 0.082	0.468AlaTrp: 0.468 ± 0.026	2.32AlaTyr: 2.32 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.783CysAla: 0.783 ± 0.034	0.154CysCys: 0.154 ± 0.015	0.698CysAsp: 0.698 ± 0.032	0.857CysGlu: 0.857 ± 0.04	0.712CysPhe: 0.712 ± 0.034	0.902CysGly: 0.902 ± 0.04	0.278CysHis: 0.278 ± 0.024	1.217CysIle: 1.217 ± 0.038	1.04CysLys: 1.04 ± 0.038	1.08CysLeu: 1.08 ± 0.037	0.348CysMet: 0.348 ± 0.022	0.767CysAsn: 0.767 ± 0.035	0.36CysPro: 0.36 ± 0.026	0.305CysGln: 0.305 ± 0.021	0.319CysArg: 0.319 ± 0.024	0.722CysSer: 0.722 ± 0.036	0.423CysThr: 0.423 ± 0.025	0.931CysVal: 0.931 ± 0.04	0.073CysTrp: 0.073 ± 0.011	0.569CysTyr: 0.569 ± 0.029	0.0CysXaa: 0.0 ± 0.0
Asp	2.01AspAla: 2.01 ± 0.063	0.789AspCys: 0.789 ± 0.035	2.476AspAsp: 2.476 ± 0.065	3.674AspGlu: 3.674 ± 0.091	3.839AspPhe: 3.839 ± 0.075	2.5AspGly: 2.5 ± 0.072	0.406AspHis: 0.406 ± 0.027	5.556AspIle: 5.556 ± 0.09	4.715AspLys: 4.715 ± 0.094	4.354AspLeu: 4.354 ± 0.085	1.565AspMet: 1.565 ± 0.047	3.269AspAsn: 3.269 ± 0.06	1.024AspPro: 1.024 ± 0.044	0.544AspGln: 0.544 ± 0.027	1.558AspArg: 1.558 ± 0.047	6.017AspSer: 6.017 ± 0.128	3.24AspThr: 3.24 ± 0.078	2.19AspVal: 2.19 ± 0.069	0.441AspTrp: 0.441 ± 0.023	2.335AspTyr: 2.335 ± 0.069	0.0AspXaa: 0.0 ± 0.0
Glu	3.817GluAla: 3.817 ± 0.078	0.905GluCys: 0.905 ± 0.034	2.486GluAsp: 2.486 ± 0.067	3.988GluGlu: 3.988 ± 0.093	3.085GluPhe: 3.085 ± 0.062	2.621GluGly: 2.621 ± 0.066	1.131GluHis: 1.131 ± 0.039	6.831GluIle: 6.831 ± 0.106	5.618GluLys: 5.618 ± 0.106	5.769GluLeu: 5.769 ± 0.107	1.561GluMet: 1.561 ± 0.047	4.577GluAsn: 4.577 ± 0.093	1.089GluPro: 1.089 ± 0.041	2.422GluGln: 2.422 ± 0.06	2.618GluArg: 2.618 ± 0.065	5.552GluSer: 5.552 ± 0.118	2.566GluThr: 2.566 ± 0.077	3.759GluVal: 3.759 ± 0.08	0.548GluTrp: 0.548 ± 0.027	2.995GluTyr: 2.995 ± 0.071	0.0GluXaa: 0.0 ± 0.0
Phe	3.223PheAla: 3.223 ± 0.082	0.853PheCys: 0.853 ± 0.034	3.004PheAsp: 3.004 ± 0.07	3.038PheGlu: 3.038 ± 0.075	3.192PhePhe: 3.192 ± 0.09	3.339PheGly: 3.339 ± 0.089	1.127PheHis: 1.127 ± 0.04	4.847PheIle: 4.847 ± 0.104	3.228PheLys: 3.228 ± 0.075	5.539PheLeu: 5.539 ± 0.117	1.301PheMet: 1.301 ± 0.046	2.892PheAsn: 2.892 ± 0.072	1.413PhePro: 1.413 ± 0.05	1.61PheGln: 1.61 ± 0.051	1.568PheArg: 1.568 ± 0.044	4.02PheSer: 4.02 ± 0.087	2.351PheThr: 2.351 ± 0.058	3.053PheVal: 3.053 ± 0.076	0.447PheTrp: 0.447 ± 0.026	2.751PheTyr: 2.751 ± 0.066	0.0PheXaa: 0.0 ± 0.0
Gly	3.437GlyAla: 3.437 ± 0.094	0.654GlyCys: 0.654 ± 0.039	2.706GlyAsp: 2.706 ± 0.069	3.181GlyGlu: 3.181 ± 0.07	3.511GlyPhe: 3.511 ± 0.078	4.061GlyGly: 4.061 ± 0.107	0.967GlyHis: 0.967 ± 0.038	5.703GlyIle: 5.703 ± 0.094	4.31GlyLys: 4.31 ± 0.106	4.906GlyLeu: 4.906 ± 0.082	1.501GlyMet: 1.501 ± 0.05	3.096GlyAsn: 3.096 ± 0.074	0.605GlyPro: 0.605 ± 0.033	1.431GlyGln: 1.431 ± 0.052	1.795GlyArg: 1.795 ± 0.06	3.283GlySer: 3.283 ± 0.077	2.191GlyThr: 2.191 ± 0.061	3.917GlyVal: 3.917 ± 0.094	0.429GlyTrp: 0.429 ± 0.028	2.669GlyTyr: 2.669 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	1.366HisAla: 1.366 ± 0.051	0.268HisCys: 0.268 ± 0.021	1.046HisAsp: 1.046 ± 0.042	1.244HisGlu: 1.244 ± 0.038	1.208HisPhe: 1.208 ± 0.043	1.051HisGly: 1.051 ± 0.045	0.464HisHis: 0.464 ± 0.027	2.408HisIle: 2.408 ± 0.054	1.864HisLys: 1.864 ± 0.056	1.843HisLeu: 1.843 ± 0.057	0.27HisMet: 0.27 ± 0.022	1.758HisAsn: 1.758 ± 0.054	0.612HisPro: 0.612 ± 0.029	0.648HisGln: 0.648 ± 0.029	0.751HisArg: 0.751 ± 0.033	1.494HisSer: 1.494 ± 0.044	1.547HisThr: 1.547 ± 0.05	0.674HisVal: 0.674 ± 0.033	0.149HisTrp: 0.149 ± 0.015	0.959HisTyr: 0.959 ± 0.038	0.0HisXaa: 0.0 ± 0.0
Ile	6.712IleAla: 6.712 ± 0.114	1.221IleCys: 1.221 ± 0.044	5.085IleAsp: 5.085 ± 0.092	6.056IleGlu: 6.056 ± 0.11	4.917IlePhe: 4.917 ± 0.099	5.143IleGly: 5.143 ± 0.112	2.038IleHis: 2.038 ± 0.06	7.8IleIle: 7.8 ± 0.116	6.622IleLys: 6.622 ± 0.113	10.172IleLeu: 10.172 ± 0.142	1.971IleMet: 1.971 ± 0.06	5.299IleAsn: 5.299 ± 0.093	3.476IlePro: 3.476 ± 0.077	3.822IleGln: 3.822 ± 0.078	2.622IleArg: 2.622 ± 0.059	5.933IleSer: 5.933 ± 0.092	4.879IleThr: 4.879 ± 0.083	4.922IleVal: 4.922 ± 0.092	0.667IleTrp: 0.667 ± 0.037	3.624IleTyr: 3.624 ± 0.07	0.0IleXaa: 0.0 ± 0.0
Lys	4.489LysAla: 4.489 ± 0.09	0.621LysCys: 0.621 ± 0.031	5.721LysAsp: 5.721 ± 0.11	7.13LysGlu: 7.13 ± 0.132	2.805LysPhe: 2.805 ± 0.072	3.65LysGly: 3.65 ± 0.081	1.642LysHis: 1.642 ± 0.046	7.977LysIle: 7.977 ± 0.114	6.906LysLys: 6.906 ± 0.125	6.409LysLeu: 6.409 ± 0.104	1.991LysMet: 1.991 ± 0.048	6.28LysAsn: 6.28 ± 0.117	2.223LysPro: 2.223 ± 0.063	3.823LysGln: 3.823 ± 0.083	3.025LysArg: 3.025 ± 0.07	4.917LysSer: 4.917 ± 0.089	4.001LysThr: 4.001 ± 0.075	3.797LysVal: 3.797 ± 0.085	0.529LysTrp: 0.529 ± 0.027	3.263LysTyr: 3.263 ± 0.073	0.0LysXaa: 0.0 ± 0.0
Leu	5.839LeuAla: 5.839 ± 0.103	1.563LeuCys: 1.563 ± 0.048	5.617LeuAsp: 5.617 ± 0.105	7.456LeuGlu: 7.456 ± 0.117	4.908LeuPhe: 4.908 ± 0.108	5.701LeuGly: 5.701 ± 0.098	2.625LeuHis: 2.625 ± 0.064	6.805LeuIle: 6.805 ± 0.106	7.71LeuLys: 7.71 ± 0.115	8.996LeuLeu: 8.996 ± 0.154	1.991LeuMet: 1.991 ± 0.056	5.601LeuAsn: 5.601 ± 0.105	3.24LeuPro: 3.24 ± 0.07	5.288LeuGln: 5.288 ± 0.117	3.888LeuArg: 3.888 ± 0.066	7.188LeuSer: 7.188 ± 0.112	4.099LeuThr: 4.099 ± 0.077	4.232LeuVal: 4.232 ± 0.083	0.763LeuTrp: 0.763 ± 0.038	3.99LeuTyr: 3.99 ± 0.088	0.0LeuXaa: 0.0 ± 0.0
Met	1.482MetAla: 1.482 ± 0.046	0.254MetCys: 0.254 ± 0.02	1.079MetAsp: 1.079 ± 0.046	1.239MetGlu: 1.239 ± 0.045	1.022MetPhe: 1.022 ± 0.049	1.472MetGly: 1.472 ± 0.053	0.368MetHis: 0.368 ± 0.026	1.974MetIle: 1.974 ± 0.052	1.862MetLys: 1.862 ± 0.063	2.624MetLeu: 2.624 ± 0.074	0.506MetMet: 0.506 ± 0.026	1.397MetAsn: 1.397 ± 0.044	1.049MetPro: 1.049 ± 0.043	1.84MetGln: 1.84 ± 0.06	1.21MetArg: 1.21 ± 0.042	1.646MetSer: 1.646 ± 0.047	0.882MetThr: 0.882 ± 0.036	1.127MetVal: 1.127 ± 0.042	0.165MetTrp: 0.165 ± 0.016	0.711MetTyr: 0.711 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	4.265AsnAla: 4.265 ± 0.098	0.455AsnCys: 0.455 ± 0.029	3.339AsnAsp: 3.339 ± 0.067	4.036AsnGlu: 4.036 ± 0.07	3.144AsnPhe: 3.144 ± 0.07	3.375AsnGly: 3.375 ± 0.089	1.397AsnHis: 1.397 ± 0.045	6.908AsnIle: 6.908 ± 0.116	5.121AsnLys: 5.121 ± 0.095	6.828AsnLeu: 6.828 ± 0.117	1.59AsnMet: 1.59 ± 0.058	4.467AsnAsn: 4.467 ± 0.11	2.772AsnPro: 2.772 ± 0.066	2.347AsnGln: 2.347 ± 0.071	1.929AsnArg: 1.929 ± 0.056	3.398AsnSer: 3.398 ± 0.077	4.167AsnThr: 4.167 ± 0.091	2.906AsnVal: 2.906 ± 0.067	0.255AsnTrp: 0.255 ± 0.02	2.345AsnTyr: 2.345 ± 0.064	0.0AsnXaa: 0.0 ± 0.0
Pro	1.307ProAla: 1.307 ± 0.044	0.331ProCys: 0.331 ± 0.02	1.198ProAsp: 1.198 ± 0.043	1.4ProGlu: 1.4 ± 0.048	1.684ProPhe: 1.684 ± 0.05	0.853ProGly: 0.853 ± 0.036	0.933ProHis: 0.933 ± 0.038	2.809ProIle: 2.809 ± 0.062	2.542ProLys: 2.542 ± 0.066	3.254ProLeu: 3.254 ± 0.065	0.663ProMet: 0.663 ± 0.035	2.37ProAsn: 2.37 ± 0.051	1.005ProPro: 1.005 ± 0.047	1.53ProGln: 1.53 ± 0.051	0.908ProArg: 0.908 ± 0.044	1.846ProSer: 1.846 ± 0.052	1.823ProThr: 1.823 ± 0.053	1.159ProVal: 1.159 ± 0.051	0.17ProTrp: 0.17 ± 0.016	1.588ProTyr: 1.588 ± 0.06	0.0ProXaa: 0.0 ± 0.0
Gln	2.466GlnAla: 2.466 ± 0.058	0.479GlnCys: 0.479 ± 0.025	2.921GlnAsp: 2.921 ± 0.08	3.565GlnGlu: 3.565 ± 0.083	1.31GlnPhe: 1.31 ± 0.045	1.952GlnGly: 1.952 ± 0.057	0.943GlnHis: 0.943 ± 0.038	3.534GlnIle: 3.534 ± 0.069	3.888GlnLys: 3.888 ± 0.09	2.426GlnLeu: 2.426 ± 0.052	0.873GlnMet: 0.873 ± 0.036	3.698GlnAsn: 3.698 ± 0.097	0.946GlnPro: 0.946 ± 0.042	2.061GlnGln: 2.061 ± 0.073	1.489GlnArg: 1.489 ± 0.052	3.159GlnSer: 3.159 ± 0.075	2.252GlnThr: 2.252 ± 0.066	1.772GlnVal: 1.772 ± 0.048	0.316GlnTrp: 0.316 ± 0.023	1.788GlnTyr: 1.788 ± 0.052	0.0GlnXaa: 0.0 ± 0.0
Arg	1.935ArgAla: 1.935 ± 0.06	0.261ArgCys: 0.261 ± 0.022	2.416ArgAsp: 2.416 ± 0.067	2.925ArgGlu: 2.925 ± 0.073	2.109ArgPhe: 2.109 ± 0.058	2.025ArgGly: 2.025 ± 0.058	0.663ArgHis: 0.663 ± 0.033	3.621ArgIle: 3.621 ± 0.074	2.524ArgLys: 2.524 ± 0.06	3.289ArgLeu: 3.289 ± 0.077	0.846ArgMet: 0.846 ± 0.036	2.151ArgAsn: 2.151 ± 0.058	0.825ArgPro: 0.825 ± 0.042	1.211ArgGln: 1.211 ± 0.047	1.182ArgArg: 1.182 ± 0.041	1.703ArgSer: 1.703 ± 0.054	1.434ArgThr: 1.434 ± 0.039	2.009ArgVal: 2.009 ± 0.063	0.242ArgTrp: 0.242 ± 0.018	1.714ArgTyr: 1.714 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	3.598SerAla: 3.598 ± 0.074	0.808SerCys: 0.808 ± 0.038	2.946SerAsp: 2.946 ± 0.068	3.31SerGlu: 3.31 ± 0.073	4.12SerPhe: 4.12 ± 0.1	3.759SerGly: 3.759 ± 0.098	1.9SerHis: 1.9 ± 0.062	6.271SerIle: 6.271 ± 0.106	5.791SerLys: 5.791 ± 0.099	7.884SerLeu: 7.884 ± 0.13	1.719SerMet: 1.719 ± 0.055	4.416SerAsn: 4.416 ± 0.102	2.038SerPro: 2.038 ± 0.055	3.154SerGln: 3.154 ± 0.078	2.08SerArg: 2.08 ± 0.056	4.403SerSer: 4.403 ± 0.102	3.008SerThr: 3.008 ± 0.062	3.714SerVal: 3.714 ± 0.074	0.487SerTrp: 0.487 ± 0.024	3.195SerTyr: 3.195 ± 0.07	0.0SerXaa: 0.0 ± 0.0
Thr	2.238ThrAla: 2.238 ± 0.069	0.508ThrCys: 0.508 ± 0.026	2.094ThrAsp: 2.094 ± 0.056	2.207ThrGlu: 2.207 ± 0.057	2.397ThrPhe: 2.397 ± 0.066	2.126ThrGly: 2.126 ± 0.07	1.516ThrHis: 1.516 ± 0.053	4.731ThrIle: 4.731 ± 0.101	4.306ThrLys: 4.306 ± 0.089	5.91ThrLeu: 5.91 ± 0.097	1.165ThrMet: 1.165 ± 0.042	3.375ThrAsn: 3.375 ± 0.073	2.334ThrPro: 2.334 ± 0.064	3.482ThrGln: 3.482 ± 0.086	1.793ThrArg: 1.793 ± 0.05	3.295ThrSer: 3.295 ± 0.082	3.083ThrThr: 3.083 ± 0.087	0.696ThrVal: 0.696 ± 0.041	0.376ThrTrp: 0.376 ± 0.024	2.026ThrTyr: 2.026 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	3.671ValAla: 3.671 ± 0.092	0.785ValCys: 0.785 ± 0.04	2.347ValAsp: 2.347 ± 0.06	2.911ValGlu: 2.911 ± 0.067	2.86ValPhe: 2.86 ± 0.069	3.53ValGly: 3.53 ± 0.08	0.747ValHis: 0.747 ± 0.034	4.207ValIle: 4.207 ± 0.085	3.566ValLys: 3.566 ± 0.085	4.909ValLeu: 4.909 ± 0.095	1.183ValMet: 1.183 ± 0.043	2.376ValAsn: 2.376 ± 0.058	1.328ValPro: 1.328 ± 0.046	1.595ValGln: 1.595 ± 0.051	1.91ValArg: 1.91 ± 0.063	3.442ValSer: 3.442 ± 0.076	1.888ValThr: 1.888 ± 0.052	3.17ValVal: 3.17 ± 0.079	0.452ValTrp: 0.452 ± 0.025	1.806ValTyr: 1.806 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.409TrpAla: 0.409 ± 0.026	0.102TrpCys: 0.102 ± 0.011	0.439TrpAsp: 0.439 ± 0.028	0.506TrpGlu: 0.506 ± 0.028	0.38TrpPhe: 0.38 ± 0.023	0.538TrpGly: 0.538 ± 0.031	0.196TrpHis: 0.196 ± 0.017	0.676TrpIle: 0.676 ± 0.034	0.454TrpLys: 0.454 ± 0.028	0.856TrpLeu: 0.856 ± 0.038	0.113TrpMet: 0.113 ± 0.013	0.476TrpAsn: 0.476 ± 0.026	0.062TrpPro: 0.062 ± 0.009	0.37TrpGln: 0.37 ± 0.021	0.367TrpArg: 0.367 ± 0.023	0.381TrpSer: 0.381 ± 0.025	0.223TrpThr: 0.223 ± 0.017	0.412TrpVal: 0.412 ± 0.029	0.128TrpTrp: 0.128 ± 0.015	0.35TrpTyr: 0.35 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.729TyrAla: 2.729 ± 0.071	0.583TyrCys: 0.583 ± 0.03	2.361TyrAsp: 2.361 ± 0.06	2.706TyrGlu: 2.706 ± 0.069	2.529TyrPhe: 2.529 ± 0.07	2.553TyrGly: 2.553 ± 0.068	1.028TyrHis: 1.028 ± 0.039	3.52TyrIle: 3.52 ± 0.087	3.65TyrLys: 3.65 ± 0.081	3.849TyrLeu: 3.849 ± 0.091	0.885TyrMet: 0.885 ± 0.038	2.834TyrAsn: 2.834 ± 0.059	1.424TyrPro: 1.424 ± 0.048	1.706TyrGln: 1.706 ± 0.048	1.697TyrArg: 1.697 ± 0.05	2.656TyrSer: 2.656 ± 0.063	2.258TyrThr: 2.258 ± 0.054	1.698TyrVal: 1.698 ± 0.052	0.331TyrTrp: 0.331 ± 0.025	2.103TyrTyr: 2.103 ± 0.072	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2279 proteins (689512 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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