Amino acid dipepetide frequency for Saccharibacillus sacchari DSM 19268

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.095AlaAla: 11.095 ± 0.608
0.731AlaCys: 0.731 ± 0.104
5.304AlaAsp: 5.304 ± 0.236
8.014AlaGlu: 8.014 ± 0.364
3.314AlaPhe: 3.314 ± 0.184
7.835AlaGly: 7.835 ± 0.35
1.652AlaHis: 1.652 ± 0.133
5.05AlaIle: 5.05 ± 0.252
4.828AlaLys: 4.828 ± 0.254
9.274AlaLeu: 9.274 ± 0.391
2.456AlaMet: 2.456 ± 0.151
2.435AlaAsn: 2.435 ± 0.16
3.091AlaPro: 3.091 ± 0.263
3.695AlaGln: 3.695 ± 0.305
4.849AlaArg: 4.849 ± 0.278
6.045AlaSer: 6.045 ± 0.335
3.801AlaThr: 3.801 ± 0.259
7.136AlaVal: 7.136 ± 0.266
0.805AlaTrp: 0.805 ± 0.085
2.435AlaTyr: 2.435 ± 0.17
0.0AlaXaa: 0.0 ± 0.0
Cys
0.561CysAla: 0.561 ± 0.085
0.053CysCys: 0.053 ± 0.02
0.381CysAsp: 0.381 ± 0.073
0.455CysGlu: 0.455 ± 0.07
0.265CysPhe: 0.265 ± 0.05
0.699CysGly: 0.699 ± 0.095
0.095CysHis: 0.095 ± 0.03
0.476CysIle: 0.476 ± 0.064
0.265CysLys: 0.265 ± 0.057
0.529CysLeu: 0.529 ± 0.08
0.18CysMet: 0.18 ± 0.048
0.127CysAsn: 0.127 ± 0.035
0.339CysPro: 0.339 ± 0.06
0.127CysGln: 0.127 ± 0.036
0.445CysArg: 0.445 ± 0.067
0.487CysSer: 0.487 ± 0.074
0.36CysThr: 0.36 ± 0.065
0.445CysVal: 0.445 ± 0.062
0.064CysTrp: 0.064 ± 0.026
0.244CysTyr: 0.244 ± 0.061
0.0CysXaa: 0.0 ± 0.0
Asp
5.135AspAla: 5.135 ± 0.243
0.339AspCys: 0.339 ± 0.066
2.784AspAsp: 2.784 ± 0.194
4.542AspGlu: 4.542 ± 0.26
2.064AspPhe: 2.064 ± 0.138
4.531AspGly: 4.531 ± 0.265
0.985AspHis: 0.985 ± 0.112
3.557AspIle: 3.557 ± 0.213
2.34AspLys: 2.34 ± 0.16
5.071AspLeu: 5.071 ± 0.213
1.408AspMet: 1.408 ± 0.118
1.736AspAsn: 1.736 ± 0.15
2.986AspPro: 2.986 ± 0.179
1.81AspGln: 1.81 ± 0.177
3.504AspArg: 3.504 ± 0.176
3.06AspSer: 3.06 ± 0.19
2.848AspThr: 2.848 ± 0.156
3.61AspVal: 3.61 ± 0.21
0.741AspTrp: 0.741 ± 0.087
1.916AspTyr: 1.916 ± 0.159
0.0AspXaa: 0.0 ± 0.0
Glu
8.237GluAla: 8.237 ± 0.357
0.402GluCys: 0.402 ± 0.085
3.716GluAsp: 3.716 ± 0.254
7.083GluGlu: 7.083 ± 0.331
2.488GluPhe: 2.488 ± 0.186
5.061GluGly: 5.061 ± 0.222
1.779GluHis: 1.779 ± 0.154
4.881GluIle: 4.881 ± 0.26
4.796GluLys: 4.796 ± 0.253
8.237GluLeu: 8.237 ± 0.345
2.393GluMet: 2.393 ± 0.186
2.763GluAsn: 2.763 ± 0.181
2.244GluPro: 2.244 ± 0.2
4.044GluGln: 4.044 ± 0.269
5.664GluArg: 5.664 ± 0.317
4.32GluSer: 4.32 ± 0.251
3.811GluThr: 3.811 ± 0.222
4.775GluVal: 4.775 ± 0.239
0.858GluTrp: 0.858 ± 0.089
1.853GluTyr: 1.853 ± 0.132
0.0GluXaa: 0.0 ± 0.0
Phe
3.674PheAla: 3.674 ± 0.234
0.222PheCys: 0.222 ± 0.058
2.679PheAsp: 2.679 ± 0.169
2.721PheGlu: 2.721 ± 0.191
1.313PhePhe: 1.313 ± 0.131
3.208PheGly: 3.208 ± 0.236
0.762PheHis: 0.762 ± 0.074
2.022PheIle: 2.022 ± 0.159
1.662PheLys: 1.662 ± 0.139
2.89PheLeu: 2.89 ± 0.231
1.09PheMet: 1.09 ± 0.112
1.122PheAsn: 1.122 ± 0.127
1.281PhePro: 1.281 ± 0.139
1.196PheGln: 1.196 ± 0.119
2.16PheArg: 2.16 ± 0.141
2.456PheSer: 2.456 ± 0.148
1.863PheThr: 1.863 ± 0.144
2.89PheVal: 2.89 ± 0.196
0.413PheTrp: 0.413 ± 0.06
0.953PheTyr: 0.953 ± 0.117
0.0PheXaa: 0.0 ± 0.0
Gly
6.119GlyAla: 6.119 ± 0.281
0.656GlyCys: 0.656 ± 0.092
4.372GlyAsp: 4.372 ± 0.217
6.204GlyGlu: 6.204 ± 0.254
3.25GlyPhe: 3.25 ± 0.193
6.405GlyGly: 6.405 ± 0.451
1.588GlyHis: 1.588 ± 0.141
5.262GlyIle: 5.262 ± 0.264
4.394GlyLys: 4.394 ± 0.257
7.072GlyLeu: 7.072 ± 0.362
2.562GlyMet: 2.562 ± 0.169
2.499GlyAsn: 2.499 ± 0.176
2.001GlyPro: 2.001 ± 0.166
3.271GlyGln: 3.271 ± 0.265
4.584GlyArg: 4.584 ± 0.27
5.145GlySer: 5.145 ± 0.234
4.732GlyThr: 4.732 ± 0.269
5.505GlyVal: 5.505 ± 0.247
0.783GlyTrp: 0.783 ± 0.105
2.499GlyTyr: 2.499 ± 0.156
0.0GlyXaa: 0.0 ± 0.0
His
1.662HisAla: 1.662 ± 0.15
0.159HisCys: 0.159 ± 0.044
0.995HisAsp: 0.995 ± 0.115
1.408HisGlu: 1.408 ± 0.119
0.858HisPhe: 0.858 ± 0.086
1.556HisGly: 1.556 ± 0.147
0.54HisHis: 0.54 ± 0.075
1.27HisIle: 1.27 ± 0.123
0.731HisLys: 0.731 ± 0.083
1.863HisLeu: 1.863 ± 0.149
0.519HisMet: 0.519 ± 0.086
0.508HisAsn: 0.508 ± 0.08
1.069HisPro: 1.069 ± 0.12
0.646HisGln: 0.646 ± 0.084
1.281HisArg: 1.281 ± 0.108
1.069HisSer: 1.069 ± 0.106
0.963HisThr: 0.963 ± 0.108
1.355HisVal: 1.355 ± 0.146
0.244HisTrp: 0.244 ± 0.049
0.826HisTyr: 0.826 ± 0.115
0.0HisXaa: 0.0 ± 0.0
Ile
6.014IleAla: 6.014 ± 0.282
0.498IleCys: 0.498 ± 0.077
3.631IleAsp: 3.631 ± 0.224
4.722IleGlu: 4.722 ± 0.244
1.874IlePhe: 1.874 ± 0.135
5.262IleGly: 5.262 ± 0.265
1.08IleHis: 1.08 ± 0.115
2.837IleIle: 2.837 ± 0.222
2.594IleLys: 2.594 ± 0.198
5.484IleLeu: 5.484 ± 0.274
1.323IleMet: 1.323 ± 0.116
1.906IleAsn: 1.906 ± 0.145
2.456IlePro: 2.456 ± 0.17
2.361IleGln: 2.361 ± 0.16
4.341IleArg: 4.341 ± 0.261
3.335IleSer: 3.335 ± 0.195
3.144IleThr: 3.144 ± 0.221
5.368IleVal: 5.368 ± 0.257
0.402IleTrp: 0.402 ± 0.079
1.323IleTyr: 1.323 ± 0.108
0.0IleXaa: 0.0 ± 0.0
Lys
4.807LysAla: 4.807 ± 0.227
0.222LysCys: 0.222 ± 0.051
2.53LysAsp: 2.53 ± 0.152
4.129LysGlu: 4.129 ± 0.211
1.239LysPhe: 1.239 ± 0.138
3.314LysGly: 3.314 ± 0.181
0.762LysHis: 0.762 ± 0.084
2.964LysIle: 2.964 ± 0.196
3.081LysLys: 3.081 ± 0.235
5.336LysLeu: 5.336 ± 0.23
1.535LysMet: 1.535 ± 0.153
1.885LysAsn: 1.885 ± 0.137
2.192LysPro: 2.192 ± 0.153
2.223LysGln: 2.223 ± 0.204
2.784LysArg: 2.784 ± 0.183
3.081LysSer: 3.081 ± 0.175
2.626LysThr: 2.626 ± 0.205
3.388LysVal: 3.388 ± 0.246
0.455LysTrp: 0.455 ± 0.077
1.006LysTyr: 1.006 ± 0.102
0.0LysXaa: 0.0 ± 0.0
Leu
8.66LeuAla: 8.66 ± 0.447
0.646LeuCys: 0.646 ± 0.093
5.516LeuAsp: 5.516 ± 0.242
7.411LeuGlu: 7.411 ± 0.324
3.748LeuPhe: 3.748 ± 0.247
7.125LeuGly: 7.125 ± 0.324
2.382LeuHis: 2.382 ± 0.162
5.685LeuIle: 5.685 ± 0.276
5.103LeuLys: 5.103 ± 0.258
10.577LeuLeu: 10.577 ± 0.459
2.414LeuMet: 2.414 ± 0.175
3.727LeuAsn: 3.727 ± 0.232
4.33LeuPro: 4.33 ± 0.261
3.79LeuGln: 3.79 ± 0.236
5.442LeuArg: 5.442 ± 0.277
6.596LeuSer: 6.596 ± 0.276
5.474LeuThr: 5.474 ± 0.239
5.908LeuVal: 5.908 ± 0.258
0.858LeuTrp: 0.858 ± 0.109
2.859LeuTyr: 2.859 ± 0.199
0.0LeuXaa: 0.0 ± 0.0
Met
2.096MetAla: 2.096 ± 0.138
0.074MetCys: 0.074 ± 0.026
1.546MetAsp: 1.546 ± 0.129
1.874MetGlu: 1.874 ± 0.141
0.995MetPhe: 0.995 ± 0.101
1.789MetGly: 1.789 ± 0.141
0.466MetHis: 0.466 ± 0.075
1.81MetIle: 1.81 ± 0.144
1.556MetLys: 1.556 ± 0.12
2.954MetLeu: 2.954 ± 0.214
0.985MetMet: 0.985 ± 0.094
1.376MetAsn: 1.376 ± 0.142
1.281MetPro: 1.281 ± 0.115
1.355MetGln: 1.355 ± 0.13
1.747MetArg: 1.747 ± 0.149
1.959MetSer: 1.959 ± 0.134
1.747MetThr: 1.747 ± 0.15
1.683MetVal: 1.683 ± 0.159
0.201MetTrp: 0.201 ± 0.046
0.688MetTyr: 0.688 ± 0.102
0.0MetXaa: 0.0 ± 0.0
Asn
3.07AsnAla: 3.07 ± 0.238
0.307AsnCys: 0.307 ± 0.056
1.736AsnAsp: 1.736 ± 0.141
2.657AsnGlu: 2.657 ± 0.165
1.196AsnPhe: 1.196 ± 0.108
2.753AsnGly: 2.753 ± 0.183
0.646AsnHis: 0.646 ± 0.078
1.916AsnIle: 1.916 ± 0.147
1.577AsnLys: 1.577 ± 0.153
3.197AsnLeu: 3.197 ± 0.197
0.91AsnMet: 0.91 ± 0.102
1.165AsnAsn: 1.165 ± 0.118
1.652AsnPro: 1.652 ± 0.132
1.249AsnGln: 1.249 ± 0.14
2.128AsnArg: 2.128 ± 0.146
1.662AsnSer: 1.662 ± 0.175
1.577AsnThr: 1.577 ± 0.163
2.689AsnVal: 2.689 ± 0.195
0.286AsnTrp: 0.286 ± 0.056
0.805AsnTyr: 0.805 ± 0.103
0.0AsnXaa: 0.0 ± 0.0
Pro
3.716ProAla: 3.716 ± 0.256
0.254ProCys: 0.254 ± 0.058
2.393ProAsp: 2.393 ± 0.141
4.013ProGlu: 4.013 ± 0.19
1.927ProPhe: 1.927 ± 0.158
3.377ProGly: 3.377 ± 0.225
0.72ProHis: 0.72 ± 0.089
2.297ProIle: 2.297 ± 0.155
1.853ProLys: 1.853 ± 0.149
3.208ProLeu: 3.208 ± 0.184
1.08ProMet: 1.08 ± 0.115
1.429ProAsn: 1.429 ± 0.123
1.218ProPro: 1.218 ± 0.146
1.683ProGln: 1.683 ± 0.14
1.588ProArg: 1.588 ± 0.145
2.329ProSer: 2.329 ± 0.166
2.223ProThr: 2.223 ± 0.199
3.049ProVal: 3.049 ± 0.171
0.339ProTrp: 0.339 ± 0.067
1.249ProTyr: 1.249 ± 0.135
0.0ProXaa: 0.0 ± 0.0
Gln
4.108GlnAla: 4.108 ± 0.284
0.201GlnCys: 0.201 ± 0.052
1.8GlnAsp: 1.8 ± 0.14
2.784GlnGlu: 2.784 ± 0.175
1.313GlnPhe: 1.313 ± 0.098
2.911GlnGly: 2.911 ± 0.226
0.709GlnHis: 0.709 ± 0.085
2.583GlnIle: 2.583 ± 0.181
1.81GlnLys: 1.81 ± 0.155
4.087GlnLeu: 4.087 ± 0.259
1.334GlnMet: 1.334 ± 0.118
1.376GlnAsn: 1.376 ± 0.12
1.641GlnPro: 1.641 ± 0.147
2.043GlnGln: 2.043 ± 0.271
2.456GlnArg: 2.456 ± 0.227
2.393GlnSer: 2.393 ± 0.204
2.53GlnThr: 2.53 ± 0.197
2.382GlnVal: 2.382 ± 0.176
0.275GlnTrp: 0.275 ± 0.052
1.122GlnTyr: 1.122 ± 0.109
0.0GlnXaa: 0.0 ± 0.0
Arg
4.849ArgAla: 4.849 ± 0.257
0.402ArgCys: 0.402 ± 0.072
2.774ArgAsp: 2.774 ± 0.183
5.219ArgGlu: 5.219 ± 0.328
2.319ArgPhe: 2.319 ± 0.147
4.214ArgGly: 4.214 ± 0.221
1.27ArgHis: 1.27 ± 0.108
3.949ArgIle: 3.949 ± 0.223
3.134ArgLys: 3.134 ± 0.197
6.151ArgLeu: 6.151 ± 0.278
2.117ArgMet: 2.117 ± 0.168
2.022ArgAsn: 2.022 ± 0.158
2.34ArgPro: 2.34 ± 0.163
2.117ArgGln: 2.117 ± 0.185
3.706ArgArg: 3.706 ± 0.302
3.801ArgSer: 3.801 ± 0.238
3.039ArgThr: 3.039 ± 0.18
3.526ArgVal: 3.526 ± 0.21
0.572ArgTrp: 0.572 ± 0.075
1.779ArgTyr: 1.779 ± 0.161
0.0ArgXaa: 0.0 ± 0.0
Ser
5.939SerAla: 5.939 ± 0.417
0.392SerCys: 0.392 ± 0.064
3.324SerAsp: 3.324 ± 0.201
5.039SerGlu: 5.039 ± 0.263
2.541SerPhe: 2.541 ± 0.176
6.045SerGly: 6.045 ± 0.277
0.953SerHis: 0.953 ± 0.106
3.568SerIle: 3.568 ± 0.208
2.647SerLys: 2.647 ± 0.178
6.003SerLeu: 6.003 ± 0.263
1.683SerMet: 1.683 ± 0.118
1.969SerAsn: 1.969 ± 0.125
2.276SerPro: 2.276 ± 0.153
2.202SerGln: 2.202 ± 0.179
3.504SerArg: 3.504 ± 0.199
4.15SerSer: 4.15 ± 0.28
3.144SerThr: 3.144 ± 0.186
4.372SerVal: 4.372 ± 0.225
0.561SerTrp: 0.561 ± 0.089
1.567SerTyr: 1.567 ± 0.12
0.0SerXaa: 0.0 ± 0.0
Thr
4.987ThrAla: 4.987 ± 0.311
0.286ThrCys: 0.286 ± 0.055
3.007ThrAsp: 3.007 ± 0.195
3.822ThrGlu: 3.822 ± 0.213
1.832ThrPhe: 1.832 ± 0.154
4.881ThrGly: 4.881 ± 0.246
1.048ThrHis: 1.048 ± 0.111
3.187ThrIle: 3.187 ± 0.223
2.086ThrLys: 2.086 ± 0.168
5.463ThrLeu: 5.463 ± 0.255
1.112ThrMet: 1.112 ± 0.101
1.355ThrAsn: 1.355 ± 0.115
3.007ThrPro: 3.007 ± 0.186
2.064ThrGln: 2.064 ± 0.166
2.403ThrArg: 2.403 ± 0.156
3.123ThrSer: 3.123 ± 0.211
2.816ThrThr: 2.816 ± 0.204
4.298ThrVal: 4.298 ± 0.231
0.381ThrTrp: 0.381 ± 0.055
1.525ThrTyr: 1.525 ± 0.154
0.0ThrXaa: 0.0 ± 0.0
Val
5.41ValAla: 5.41 ± 0.294
0.582ValCys: 0.582 ± 0.071
4.182ValAsp: 4.182 ± 0.234
4.627ValGlu: 4.627 ± 0.256
2.615ValPhe: 2.615 ± 0.166
4.87ValGly: 4.87 ± 0.23
1.366ValHis: 1.366 ± 0.128
4.372ValIle: 4.372 ± 0.24
3.547ValLys: 3.547 ± 0.229
7.03ValLeu: 7.03 ± 0.299
1.895ValMet: 1.895 ± 0.129
2.477ValAsn: 2.477 ± 0.188
3.028ValPro: 3.028 ± 0.172
2.636ValGln: 2.636 ± 0.166
4.267ValArg: 4.267 ± 0.199
4.743ValSer: 4.743 ± 0.257
4.14ValThr: 4.14 ± 0.197
5.092ValVal: 5.092 ± 0.255
0.678ValTrp: 0.678 ± 0.084
2.308ValTyr: 2.308 ± 0.172
0.0ValXaa: 0.0 ± 0.0
Trp
0.847TrpAla: 0.847 ± 0.098
0.042TrpCys: 0.042 ± 0.019
0.614TrpAsp: 0.614 ± 0.087
0.656TrpGlu: 0.656 ± 0.084
0.265TrpPhe: 0.265 ± 0.051
0.614TrpGly: 0.614 ± 0.102
0.254TrpHis: 0.254 ± 0.063
0.678TrpIle: 0.678 ± 0.085
0.402TrpLys: 0.402 ± 0.066
1.207TrpLeu: 1.207 ± 0.117
0.286TrpMet: 0.286 ± 0.054
0.339TrpAsn: 0.339 ± 0.064
0.36TrpPro: 0.36 ± 0.06
0.349TrpGln: 0.349 ± 0.06
0.392TrpArg: 0.392 ± 0.069
0.498TrpSer: 0.498 ± 0.061
0.508TrpThr: 0.508 ± 0.073
0.561TrpVal: 0.561 ± 0.069
0.095TrpTrp: 0.095 ± 0.031
0.286TrpTyr: 0.286 ± 0.058
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.869TyrAla: 2.869 ± 0.176
0.127TyrCys: 0.127 ± 0.038
1.683TyrAsp: 1.683 ± 0.158
2.022TyrGlu: 2.022 ± 0.134
1.165TyrPhe: 1.165 ± 0.121
2.456TyrGly: 2.456 ± 0.18
0.466TyrHis: 0.466 ± 0.069
1.588TyrIle: 1.588 ± 0.129
1.154TyrLys: 1.154 ± 0.128
2.615TyrLeu: 2.615 ± 0.186
0.889TyrMet: 0.889 ± 0.097
0.963TyrAsn: 0.963 ± 0.089
1.154TyrPro: 1.154 ± 0.109
0.995TyrGln: 0.995 ± 0.095
2.054TyrArg: 2.054 ± 0.154
1.63TyrSer: 1.63 ± 0.127
1.334TyrThr: 1.334 ± 0.11
1.832TyrVal: 1.832 ± 0.142
0.244TyrTrp: 0.244 ± 0.047
1.027TyrTyr: 1.027 ± 0.116
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 299 proteins (94455 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski