Amino acid dipepetide frequency for Streptomyces jeddahensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.159AlaAla: 21.159 ± 0.149	1.076AlaCys: 1.076 ± 0.025	8.097AlaAsp: 8.097 ± 0.062	8.745AlaGlu: 8.745 ± 0.095	3.463AlaPhe: 3.463 ± 0.046	12.693AlaGly: 12.693 ± 0.094	2.729AlaHis: 2.729 ± 0.034	3.815AlaIle: 3.815 ± 0.041	3.08AlaLys: 3.08 ± 0.048	13.865AlaLeu: 13.865 ± 0.116	2.58AlaMet: 2.58 ± 0.033	2.007AlaAsn: 2.007 ± 0.032	6.735AlaPro: 6.735 ± 0.073	3.92AlaGln: 3.92 ± 0.041	9.719AlaArg: 9.719 ± 0.081	6.272AlaSer: 6.272 ± 0.055	7.0AlaThr: 7.0 ± 0.054	12.091AlaVal: 12.091 ± 0.085	1.863AlaTrp: 1.863 ± 0.029	2.941AlaTyr: 2.941 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.061CysAla: 1.061 ± 0.022	0.096CysCys: 0.096 ± 0.007	0.462CysAsp: 0.462 ± 0.015	0.409CysGlu: 0.409 ± 0.013	0.22CysPhe: 0.22 ± 0.01	0.97CysGly: 0.97 ± 0.021	0.19CysHis: 0.19 ± 0.009	0.212CysIle: 0.212 ± 0.01	0.118CysLys: 0.118 ± 0.008	0.752CysLeu: 0.752 ± 0.019	0.133CysMet: 0.133 ± 0.007	0.154CysAsn: 0.154 ± 0.009	0.479CysPro: 0.479 ± 0.015	0.18CysGln: 0.18 ± 0.008	0.605CysArg: 0.605 ± 0.016	0.452CysSer: 0.452 ± 0.014	0.552CysThr: 0.552 ± 0.014	0.632CysVal: 0.632 ± 0.017	0.139CysTrp: 0.139 ± 0.007	0.161CysTyr: 0.161 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.54AspAla: 7.54 ± 0.061	0.433AspCys: 0.433 ± 0.013	3.649AspAsp: 3.649 ± 0.043	3.921AspGlu: 3.921 ± 0.048	1.664AspPhe: 1.664 ± 0.03	6.449AspGly: 6.449 ± 0.069	1.396AspHis: 1.396 ± 0.025	2.073AspIle: 2.073 ± 0.032	1.32AspLys: 1.32 ± 0.028	5.92AspLeu: 5.92 ± 0.057	0.89AspMet: 0.89 ± 0.018	1.015AspAsn: 1.015 ± 0.023	4.345AspPro: 4.345 ± 0.042	1.637AspGln: 1.637 ± 0.025	4.625AspArg: 4.625 ± 0.047	2.626AspSer: 2.626 ± 0.035	3.224AspThr: 3.224 ± 0.04	4.745AspVal: 4.745 ± 0.047	1.04AspTrp: 1.04 ± 0.022	1.149AspTyr: 1.149 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	7.376GluAla: 7.376 ± 0.089	0.355GluCys: 0.355 ± 0.012	2.862GluAsp: 2.862 ± 0.036	3.487GluGlu: 3.487 ± 0.049	1.471GluPhe: 1.471 ± 0.03	4.411GluGly: 4.411 ± 0.044	1.506GluHis: 1.506 ± 0.027	2.299GluIle: 2.299 ± 0.031	1.61GluLys: 1.61 ± 0.032	6.629GluLeu: 6.629 ± 0.06	0.896GluMet: 0.896 ± 0.02	1.092GluAsn: 1.092 ± 0.022	3.447GluPro: 3.447 ± 0.041	2.34GluGln: 2.34 ± 0.036	5.253GluArg: 5.253 ± 0.063	2.647GluSer: 2.647 ± 0.036	2.928GluThr: 2.928 ± 0.039	4.335GluVal: 4.335 ± 0.046	0.822GluTrp: 0.822 ± 0.021	1.201GluTyr: 1.201 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.657PheAla: 3.657 ± 0.041	0.259PheCys: 0.259 ± 0.01	1.917PheAsp: 1.917 ± 0.029	1.43PheGlu: 1.43 ± 0.023	0.895PhePhe: 0.895 ± 0.023	3.056PheGly: 3.056 ± 0.041	0.614PheHis: 0.614 ± 0.018	0.773PheIle: 0.773 ± 0.02	0.575PheLys: 0.575 ± 0.017	2.544PheLeu: 2.544 ± 0.04	0.421PheMet: 0.421 ± 0.013	0.631PheAsn: 0.631 ± 0.021	1.357PhePro: 1.357 ± 0.023	0.725PheGln: 0.725 ± 0.017	1.867PheArg: 1.867 ± 0.027	1.496PheSer: 1.496 ± 0.027	2.057PheThr: 2.057 ± 0.033	2.252PheVal: 2.252 ± 0.036	0.465PheTrp: 0.465 ± 0.015	0.608PheTyr: 0.608 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	10.996GlyAla: 10.996 ± 0.085	0.857GlyCys: 0.857 ± 0.02	5.195GlyAsp: 5.195 ± 0.053	5.078GlyGlu: 5.078 ± 0.05	2.904GlyPhe: 2.904 ± 0.037	8.747GlyGly: 8.747 ± 0.093	2.334GlyHis: 2.334 ± 0.035	3.726GlyIle: 3.726 ± 0.04	2.551GlyLys: 2.551 ± 0.042	9.4GlyLeu: 9.4 ± 0.072	2.036GlyMet: 2.036 ± 0.03	1.898GlyAsn: 1.898 ± 0.036	5.091GlyPro: 5.091 ± 0.062	2.774GlyGln: 2.774 ± 0.039	7.605GlyArg: 7.605 ± 0.067	5.645GlySer: 5.645 ± 0.053	6.384GlyThr: 6.384 ± 0.062	7.394GlyVal: 7.394 ± 0.055	1.701GlyTrp: 1.701 ± 0.031	2.369GlyTyr: 2.369 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.71HisAla: 2.71 ± 0.031	0.212HisCys: 0.212 ± 0.01	1.351HisAsp: 1.351 ± 0.024	1.233HisGlu: 1.233 ± 0.026	0.659HisPhe: 0.659 ± 0.015	2.448HisGly: 2.448 ± 0.035	0.655HisHis: 0.655 ± 0.02	0.747HisIle: 0.747 ± 0.017	0.377HisLys: 0.377 ± 0.014	2.309HisLeu: 2.309 ± 0.038	0.349HisMet: 0.349 ± 0.012	0.411HisAsn: 0.411 ± 0.013	1.751HisPro: 1.751 ± 0.022	0.64HisGln: 0.64 ± 0.017	2.05HisArg: 2.05 ± 0.035	0.991HisSer: 0.991 ± 0.02	1.323HisThr: 1.323 ± 0.024	1.716HisVal: 1.716 ± 0.027	0.394HisTrp: 0.394 ± 0.014	0.506HisTyr: 0.506 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	5.133IleAla: 5.133 ± 0.048	0.303IleCys: 0.303 ± 0.011	2.42IleAsp: 2.42 ± 0.033	2.118IleGlu: 2.118 ± 0.033	0.775IlePhe: 0.775 ± 0.02	3.759IleGly: 3.759 ± 0.046	0.672IleHis: 0.672 ± 0.017	1.02IleIle: 1.02 ± 0.023	0.858IleLys: 0.858 ± 0.022	2.564IleLeu: 2.564 ± 0.037	0.485IleMet: 0.485 ± 0.015	0.761IleAsn: 0.761 ± 0.018	1.964IlePro: 1.964 ± 0.034	0.799IleGln: 0.799 ± 0.02	2.378IleArg: 2.378 ± 0.032	1.814IleSer: 1.814 ± 0.028	2.377IleThr: 2.377 ± 0.036	2.94IleVal: 2.94 ± 0.041	0.41IleTrp: 0.41 ± 0.014	0.594IleTyr: 0.594 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	3.17LysAla: 3.17 ± 0.048	0.123LysCys: 0.123 ± 0.007	1.449LysAsp: 1.449 ± 0.032	1.295LysGlu: 1.295 ± 0.027	0.503LysPhe: 0.503 ± 0.016	1.985LysGly: 1.985 ± 0.033	0.471LysHis: 0.471 ± 0.015	0.966LysIle: 0.966 ± 0.022	0.968LysLys: 0.968 ± 0.032	2.203LysLeu: 2.203 ± 0.039	0.414LysMet: 0.414 ± 0.013	0.581LysAsn: 0.581 ± 0.018	1.472LysPro: 1.472 ± 0.026	0.784LysGln: 0.784 ± 0.021	1.553LysArg: 1.553 ± 0.026	1.235LysSer: 1.235 ± 0.026	1.387LysThr: 1.387 ± 0.028	1.98LysVal: 1.98 ± 0.039	0.297LysTrp: 0.297 ± 0.011	0.532LysTyr: 0.532 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	14.444LeuAla: 14.444 ± 0.101	0.846LeuCys: 0.846 ± 0.02	6.419LeuAsp: 6.419 ± 0.056	4.717LeuGlu: 4.717 ± 0.051	2.579LeuPhe: 2.579 ± 0.042	9.12LeuGly: 9.12 ± 0.066	2.234LeuHis: 2.234 ± 0.027	3.494LeuIle: 3.494 ± 0.042	2.174LeuLys: 2.174 ± 0.037	10.851LeuLeu: 10.851 ± 0.103	1.697LeuMet: 1.697 ± 0.028	1.74LeuAsn: 1.74 ± 0.028	6.333LeuPro: 6.333 ± 0.055	2.392LeuGln: 2.392 ± 0.036	8.163LeuArg: 8.163 ± 0.074	5.345LeuSer: 5.345 ± 0.043	6.621LeuThr: 6.621 ± 0.054	8.611LeuVal: 8.611 ± 0.07	1.285LeuTrp: 1.285 ± 0.023	1.919LeuTyr: 1.919 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.337MetAla: 2.337 ± 0.033	0.148MetCys: 0.148 ± 0.008	0.898MetAsp: 0.898 ± 0.021	0.751MetGlu: 0.751 ± 0.016	0.476MetPhe: 0.476 ± 0.013	1.376MetGly: 1.376 ± 0.025	0.389MetHis: 0.389 ± 0.012	0.683MetIle: 0.683 ± 0.02	0.458MetLys: 0.458 ± 0.016	1.737MetLeu: 1.737 ± 0.029	0.315MetMet: 0.315 ± 0.012	0.462MetAsn: 0.462 ± 0.013	1.12MetPro: 1.12 ± 0.02	0.483MetGln: 0.483 ± 0.014	1.45MetArg: 1.45 ± 0.024	1.381MetSer: 1.381 ± 0.024	1.537MetThr: 1.537 ± 0.025	1.304MetVal: 1.304 ± 0.024	0.232MetTrp: 0.232 ± 0.011	0.348MetTyr: 0.348 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.295AsnAla: 2.295 ± 0.035	0.163AsnCys: 0.163 ± 0.009	1.012AsnAsp: 1.012 ± 0.022	0.889AsnGlu: 0.889 ± 0.018	0.52AsnPhe: 0.52 ± 0.017	2.039AsnGly: 2.039 ± 0.036	0.425AsnHis: 0.425 ± 0.014	0.709AsnIle: 0.709 ± 0.018	0.476AsnLys: 0.476 ± 0.014	1.719AsnLeu: 1.719 ± 0.032	0.31AsnMet: 0.31 ± 0.01	0.464AsnAsn: 0.464 ± 0.016	1.444AsnPro: 1.444 ± 0.025	0.567AsnGln: 0.567 ± 0.019	1.288AsnArg: 1.288 ± 0.022	0.995AsnSer: 0.995 ± 0.026	1.198AsnThr: 1.198 ± 0.031	1.457AsnVal: 1.457 ± 0.028	0.308AsnTrp: 0.308 ± 0.012	0.446AsnTyr: 0.446 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	8.066ProAla: 8.066 ± 0.078	0.331ProCys: 0.331 ± 0.013	4.38ProAsp: 4.38 ± 0.047	4.32ProGlu: 4.32 ± 0.047	1.546ProPhe: 1.546 ± 0.024	6.508ProGly: 6.508 ± 0.069	1.401ProHis: 1.401 ± 0.027	1.377ProIle: 1.377 ± 0.026	1.284ProLys: 1.284 ± 0.026	5.26ProLeu: 5.26 ± 0.052	1.038ProMet: 1.038 ± 0.021	0.928ProAsn: 0.928 ± 0.02	3.392ProPro: 3.392 ± 0.053	1.806ProGln: 1.806 ± 0.034	3.836ProArg: 3.836 ± 0.051	3.431ProSer: 3.431 ± 0.06	3.141ProThr: 3.141 ± 0.039	5.38ProVal: 5.38 ± 0.051	0.908ProTrp: 0.908 ± 0.021	1.48ProTyr: 1.48 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.871GlnAla: 3.871 ± 0.045	0.174GlnCys: 0.174 ± 0.008	1.512GlnAsp: 1.512 ± 0.026	1.506GlnGlu: 1.506 ± 0.025	0.699GlnPhe: 0.699 ± 0.018	2.374GlnGly: 2.374 ± 0.035	0.677GlnHis: 0.677 ± 0.018	1.196GlnIle: 1.196 ± 0.023	0.707GlnLys: 0.707 ± 0.019	3.213GlnLeu: 3.213 ± 0.04	0.534GlnMet: 0.534 ± 0.015	0.562GlnAsn: 0.562 ± 0.018	1.845GlnPro: 1.845 ± 0.036	1.372GlnGln: 1.372 ± 0.03	2.487GlnArg: 2.487 ± 0.035	1.39GlnSer: 1.39 ± 0.026	1.421GlnThr: 1.421 ± 0.024	2.347GlnVal: 2.347 ± 0.031	0.511GlnTrp: 0.511 ± 0.015	0.659GlnTyr: 0.659 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.236ArgAla: 9.236 ± 0.078	0.598ArgCys: 0.598 ± 0.018	4.22ArgAsp: 4.22 ± 0.04	4.488ArgGlu: 4.488 ± 0.045	2.247ArgPhe: 2.247 ± 0.032	5.764ArgGly: 5.764 ± 0.054	2.143ArgHis: 2.143 ± 0.037	3.381ArgIle: 3.381 ± 0.038	1.737ArgLys: 1.737 ± 0.031	8.435ArgLeu: 8.435 ± 0.072	1.685ArgMet: 1.685 ± 0.031	1.444ArgAsn: 1.444 ± 0.029	4.729ArgPro: 4.729 ± 0.058	2.315ArgGln: 2.315 ± 0.034	7.527ArgArg: 7.527 ± 0.08	4.039ArgSer: 4.039 ± 0.044	5.194ArgThr: 5.194 ± 0.049	5.54ArgVal: 5.54 ± 0.058	1.345ArgTrp: 1.345 ± 0.024	1.771ArgTyr: 1.771 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	7.005SerAla: 7.005 ± 0.06	0.423SerCys: 0.423 ± 0.013	2.842SerAsp: 2.842 ± 0.037	2.539SerGlu: 2.539 ± 0.035	1.613SerPhe: 1.613 ± 0.031	6.305SerGly: 6.305 ± 0.072	1.072SerHis: 1.072 ± 0.021	1.539SerIle: 1.539 ± 0.027	1.148SerLys: 1.148 ± 0.025	4.859SerLeu: 4.859 ± 0.047	1.073SerMet: 1.073 ± 0.024	0.949SerAsn: 0.949 ± 0.02	3.257SerPro: 3.257 ± 0.04	1.322SerGln: 1.322 ± 0.025	3.711SerArg: 3.711 ± 0.041	3.142SerSer: 3.142 ± 0.046	3.238SerThr: 3.238 ± 0.043	4.335SerVal: 4.335 ± 0.039	0.929SerTrp: 0.929 ± 0.02	1.226SerTyr: 1.226 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	8.82ThrAla: 8.82 ± 0.066	0.436ThrCys: 0.436 ± 0.012	3.655ThrAsp: 3.655 ± 0.051	3.23ThrGlu: 3.23 ± 0.036	1.654ThrPhe: 1.654 ± 0.032	6.683ThrGly: 6.683 ± 0.064	1.203ThrHis: 1.203 ± 0.023	1.883ThrIle: 1.883 ± 0.029	1.251ThrLys: 1.251 ± 0.029	5.564ThrLeu: 5.564 ± 0.047	0.981ThrMet: 0.981 ± 0.022	1.06ThrAsn: 1.06 ± 0.024	4.02ThrPro: 4.02 ± 0.047	1.464ThrGln: 1.464 ± 0.027	3.768ThrArg: 3.768 ± 0.047	3.328ThrSer: 3.328 ± 0.045	3.867ThrThr: 3.867 ± 0.064	5.945ThrVal: 5.945 ± 0.051	0.96ThrTrp: 0.96 ± 0.022	1.428ThrTyr: 1.428 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	10.402ValAla: 10.402 ± 0.079	0.777ValCys: 0.777 ± 0.018	4.829ValAsp: 4.829 ± 0.048	4.691ValGlu: 4.691 ± 0.045	2.478ValPhe: 2.478 ± 0.039	6.473ValGly: 6.473 ± 0.056	1.955ValHis: 1.955 ± 0.031	3.085ValIle: 3.085 ± 0.04	1.821ValLys: 1.821 ± 0.03	9.313ValLeu: 9.313 ± 0.069	1.476ValMet: 1.476 ± 0.027	1.664ValAsn: 1.664 ± 0.031	5.156ValPro: 5.156 ± 0.05	2.241ValGln: 2.241 ± 0.029	6.851ValArg: 6.851 ± 0.056	4.364ValSer: 4.364 ± 0.043	5.45ValThr: 5.45 ± 0.053	7.811ValVal: 7.811 ± 0.07	1.141ValTrp: 1.141 ± 0.022	1.61ValTyr: 1.61 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.69TrpAla: 1.69 ± 0.027	0.166TrpCys: 0.166 ± 0.009	0.867TrpAsp: 0.867 ± 0.022	0.735TrpGlu: 0.735 ± 0.017	0.529TrpPhe: 0.529 ± 0.014	1.141TrpGly: 1.141 ± 0.023	0.382TrpHis: 0.382 ± 0.012	0.595TrpIle: 0.595 ± 0.016	0.395TrpLys: 0.395 ± 0.014	1.782TrpLeu: 1.782 ± 0.031	0.292TrpMet: 0.292 ± 0.012	0.438TrpAsn: 0.438 ± 0.014	0.771TrpPro: 0.771 ± 0.016	0.639TrpGln: 0.639 ± 0.018	1.288TrpArg: 1.288 ± 0.024	0.954TrpSer: 0.954 ± 0.022	1.06TrpThr: 1.06 ± 0.024	0.988TrpVal: 0.988 ± 0.021	0.32TrpTrp: 0.32 ± 0.012	0.414TrpTyr: 0.414 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.883TyrAla: 2.883 ± 0.035	0.201TyrCys: 0.201 ± 0.01	1.625TyrAsp: 1.625 ± 0.03	1.387TyrGlu: 1.387 ± 0.024	0.706TyrPhe: 0.706 ± 0.018	2.384TyrGly: 2.384 ± 0.034	0.384TyrHis: 0.384 ± 0.013	0.569TyrIle: 0.569 ± 0.017	0.459TyrLys: 0.459 ± 0.016	2.061TyrLeu: 2.061 ± 0.033	0.28TyrMet: 0.28 ± 0.011	0.463TyrAsn: 0.463 ± 0.015	1.105TyrPro: 1.105 ± 0.024	0.656TyrGln: 0.656 ± 0.02	1.813TyrArg: 1.813 ± 0.029	0.983TyrSer: 0.983 ± 0.021	1.24TyrThr: 1.24 ± 0.03	1.785TyrVal: 1.785 ± 0.025	0.377TyrTrp: 0.377 ± 0.013	0.492TyrTyr: 0.492 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7356 proteins (2403687 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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