Amino acid dipepetide frequency for Penicillium sp. occitanis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.624AlaAla: 8.624 ± 0.065	0.988AlaCys: 0.988 ± 0.013	4.209AlaAsp: 4.209 ± 0.032	4.978AlaGlu: 4.978 ± 0.041	3.181AlaPhe: 3.181 ± 0.028	5.618AlaGly: 5.618 ± 0.04	1.687AlaHis: 1.687 ± 0.018	4.697AlaIle: 4.697 ± 0.028	3.889AlaLys: 3.889 ± 0.031	7.576AlaLeu: 7.576 ± 0.043	1.946AlaMet: 1.946 ± 0.017	3.121AlaAsn: 3.121 ± 0.025	4.118AlaPro: 4.118 ± 0.038	3.255AlaGln: 3.255 ± 0.027	4.436AlaArg: 4.436 ± 0.031	6.884AlaSer: 6.884 ± 0.042	5.377AlaThr: 5.377 ± 0.03	5.404AlaVal: 5.404 ± 0.034	1.166AlaTrp: 1.166 ± 0.015	2.279AlaTyr: 2.279 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.89CysAla: 0.89 ± 0.016	0.188CysCys: 0.188 ± 0.007	0.618CysAsp: 0.618 ± 0.011	0.548CysGlu: 0.548 ± 0.01	0.536CysPhe: 0.536 ± 0.01	0.838CysGly: 0.838 ± 0.016	0.299CysHis: 0.299 ± 0.008	0.711CysIle: 0.711 ± 0.013	0.428CysLys: 0.428 ± 0.01	1.204CysLeu: 1.204 ± 0.013	0.247CysMet: 0.247 ± 0.006	0.402CysAsn: 0.402 ± 0.009	0.565CysPro: 0.565 ± 0.011	0.42CysGln: 0.42 ± 0.008	0.633CysArg: 0.633 ± 0.012	0.79CysSer: 0.79 ± 0.013	0.634CysThr: 0.634 ± 0.011	0.771CysVal: 0.771 ± 0.011	0.194CysTrp: 0.194 ± 0.006	0.339CysTyr: 0.339 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	4.563AspAla: 4.563 ± 0.031	0.591AspCys: 0.591 ± 0.01	4.188AspAsp: 4.188 ± 0.045	4.478AspGlu: 4.478 ± 0.035	2.289AspPhe: 2.289 ± 0.022	3.878AspGly: 3.878 ± 0.027	1.235AspHis: 1.235 ± 0.016	3.455AspIle: 3.455 ± 0.028	2.355AspLys: 2.355 ± 0.023	5.192AspLeu: 5.192 ± 0.035	1.302AspMet: 1.302 ± 0.016	2.087AspAsn: 2.087 ± 0.02	3.133AspPro: 3.133 ± 0.025	1.889AspGln: 1.889 ± 0.018	2.904AspArg: 2.904 ± 0.026	4.146AspSer: 4.146 ± 0.03	3.119AspThr: 3.119 ± 0.025	3.835AspVal: 3.835 ± 0.027	0.894AspTrp: 0.894 ± 0.012	1.789AspTyr: 1.789 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	5.109GluAla: 5.109 ± 0.039	0.565GluCys: 0.565 ± 0.01	4.21GluAsp: 4.21 ± 0.041	5.425GluGlu: 5.425 ± 0.051	2.049GluPhe: 2.049 ± 0.019	3.508GluGly: 3.508 ± 0.025	1.391GluHis: 1.391 ± 0.015	3.486GluIle: 3.486 ± 0.028	3.819GluLys: 3.819 ± 0.033	5.22GluLeu: 5.22 ± 0.032	1.444GluMet: 1.444 ± 0.02	2.565GluAsn: 2.565 ± 0.026	2.525GluPro: 2.525 ± 0.024	2.522GluGln: 2.522 ± 0.022	3.688GluArg: 3.688 ± 0.032	4.376GluSer: 4.376 ± 0.03	3.7GluThr: 3.7 ± 0.028	3.563GluVal: 3.563 ± 0.026	0.893GluTrp: 0.893 ± 0.012	1.832GluTyr: 1.832 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.127PheAla: 3.127 ± 0.025	0.536PheCys: 0.536 ± 0.012	2.368PheAsp: 2.368 ± 0.018	2.263PheGlu: 2.263 ± 0.022	1.709PhePhe: 1.709 ± 0.021	2.928PheGly: 2.928 ± 0.03	0.918PheHis: 0.918 ± 0.013	2.017PheIle: 2.017 ± 0.022	1.518PheLys: 1.518 ± 0.018	3.683PheLeu: 3.683 ± 0.032	0.849PheMet: 0.849 ± 0.012	1.54PheAsn: 1.54 ± 0.017	1.948PhePro: 1.948 ± 0.019	1.474PheGln: 1.474 ± 0.015	1.934PheArg: 1.934 ± 0.018	3.117PheSer: 3.117 ± 0.024	2.235PheThr: 2.235 ± 0.02	2.519PheVal: 2.519 ± 0.024	0.664PheTrp: 0.664 ± 0.012	1.215PheTyr: 1.215 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.087GlyAla: 5.087 ± 0.036	0.795GlyCys: 0.795 ± 0.012	3.468GlyAsp: 3.468 ± 0.023	3.372GlyGlu: 3.372 ± 0.024	2.896GlyPhe: 2.896 ± 0.025	5.45GlyGly: 5.45 ± 0.044	1.654GlyHis: 1.654 ± 0.019	3.852GlyIle: 3.852 ± 0.032	3.328GlyLys: 3.328 ± 0.027	6.141GlyLeu: 6.141 ± 0.035	1.522GlyMet: 1.522 ± 0.018	2.604GlyAsn: 2.604 ± 0.024	3.026GlyPro: 3.026 ± 0.025	2.498GlyGln: 2.498 ± 0.022	3.741GlyArg: 3.741 ± 0.031	5.478GlySer: 5.478 ± 0.038	3.981GlyThr: 3.981 ± 0.029	4.368GlyVal: 4.368 ± 0.028	1.157GlyTrp: 1.157 ± 0.017	2.321GlyTyr: 2.321 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	1.755HisAla: 1.755 ± 0.02	0.285HisCys: 0.285 ± 0.008	1.34HisAsp: 1.34 ± 0.014	1.38HisGlu: 1.38 ± 0.018	0.94HisPhe: 0.94 ± 0.014	1.681HisGly: 1.681 ± 0.019	0.83HisHis: 0.83 ± 0.015	1.304HisIle: 1.304 ± 0.015	0.903HisLys: 0.903 ± 0.012	2.209HisLeu: 2.209 ± 0.019	0.475HisMet: 0.475 ± 0.009	0.903HisAsn: 0.903 ± 0.014	1.519HisPro: 1.519 ± 0.018	0.958HisGln: 0.958 ± 0.015	1.427HisArg: 1.427 ± 0.018	1.756HisSer: 1.756 ± 0.018	1.273HisThr: 1.273 ± 0.016	1.447HisVal: 1.447 ± 0.017	0.348HisTrp: 0.348 ± 0.008	0.717HisTyr: 0.717 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.6IleAla: 4.6 ± 0.029	0.783IleCys: 0.783 ± 0.012	3.257IleAsp: 3.257 ± 0.024	3.229IleGlu: 3.229 ± 0.026	2.25IlePhe: 2.25 ± 0.022	3.559IleGly: 3.559 ± 0.027	1.295IleHis: 1.295 ± 0.014	2.996IleIle: 2.996 ± 0.027	2.382IleLys: 2.382 ± 0.022	5.035IleLeu: 5.035 ± 0.034	1.099IleMet: 1.099 ± 0.015	2.129IleAsn: 2.129 ± 0.02	3.293IlePro: 3.293 ± 0.024	2.131IleGln: 2.131 ± 0.02	2.936IleArg: 2.936 ± 0.023	4.313IleSer: 4.313 ± 0.025	3.194IleThr: 3.194 ± 0.027	3.542IleVal: 3.542 ± 0.03	0.779IleTrp: 0.779 ± 0.014	1.654IleTyr: 1.654 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.034LysAla: 4.034 ± 0.03	0.441LysCys: 0.441 ± 0.009	2.802LysAsp: 2.802 ± 0.024	3.419LysGlu: 3.419 ± 0.032	1.526LysPhe: 1.526 ± 0.018	2.823LysGly: 2.823 ± 0.029	1.085LysHis: 1.085 ± 0.013	2.49LysIle: 2.49 ± 0.021	3.149LysLys: 3.149 ± 0.04	4.05LysLeu: 4.05 ± 0.028	0.981LysMet: 0.981 ± 0.012	1.847LysAsn: 1.847 ± 0.019	2.526LysPro: 2.526 ± 0.024	1.837LysGln: 1.837 ± 0.018	3.212LysArg: 3.212 ± 0.033	3.573LysSer: 3.573 ± 0.028	2.861LysThr: 2.861 ± 0.022	2.821LysVal: 2.821 ± 0.021	0.703LysTrp: 0.703 ± 0.01	1.495LysTyr: 1.495 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.625LeuAla: 7.625 ± 0.043	1.151LeuCys: 1.151 ± 0.015	5.3LeuAsp: 5.3 ± 0.032	5.561LeuGlu: 5.561 ± 0.039	3.47LeuPhe: 3.47 ± 0.029	5.915LeuGly: 5.915 ± 0.035	2.237LeuHis: 2.237 ± 0.023	4.469LeuIle: 4.469 ± 0.034	4.254LeuLys: 4.254 ± 0.027	8.617LeuLeu: 8.617 ± 0.057	1.822LeuMet: 1.822 ± 0.018	3.454LeuAsn: 3.454 ± 0.028	5.286LeuPro: 5.286 ± 0.031	3.975LeuGln: 3.975 ± 0.028	5.527LeuArg: 5.527 ± 0.033	7.516LeuSer: 7.516 ± 0.042	4.973LeuThr: 4.973 ± 0.03	5.481LeuVal: 5.481 ± 0.035	1.223LeuTrp: 1.223 ± 0.017	2.532LeuTyr: 2.532 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.144MetAla: 2.144 ± 0.02	0.231MetCys: 0.231 ± 0.007	1.207MetAsp: 1.207 ± 0.013	1.261MetGlu: 1.261 ± 0.016	0.785MetPhe: 0.785 ± 0.012	1.428MetGly: 1.428 ± 0.016	0.476MetHis: 0.476 ± 0.01	1.147MetIle: 1.147 ± 0.015	0.979MetLys: 0.979 ± 0.013	1.857MetLeu: 1.857 ± 0.022	0.567MetMet: 0.567 ± 0.01	0.859MetAsn: 0.859 ± 0.013	1.171MetPro: 1.171 ± 0.016	0.845MetGln: 0.845 ± 0.013	1.187MetArg: 1.187 ± 0.016	1.84MetSer: 1.84 ± 0.018	1.376MetThr: 1.376 ± 0.015	1.28MetVal: 1.28 ± 0.015	0.26MetTrp: 0.26 ± 0.007	0.536MetTyr: 0.536 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.311AsnAla: 3.311 ± 0.024	0.433AsnCys: 0.433 ± 0.01	2.217AsnAsp: 2.217 ± 0.023	2.246AsnGlu: 2.246 ± 0.022	1.489AsnPhe: 1.489 ± 0.015	3.161AsnGly: 3.161 ± 0.026	0.925AsnHis: 0.925 ± 0.012	2.388AsnIle: 2.388 ± 0.02	1.674AsnLys: 1.674 ± 0.016	3.492AsnLeu: 3.492 ± 0.022	0.892AsnMet: 0.892 ± 0.014	1.861AsnAsn: 1.861 ± 0.021	2.442AsnPro: 2.442 ± 0.022	1.438AsnGln: 1.438 ± 0.015	1.953AsnArg: 1.953 ± 0.019	2.898AsnSer: 2.898 ± 0.025	2.49AsnThr: 2.49 ± 0.024	2.561AsnVal: 2.561 ± 0.02	0.608AsnTrp: 0.608 ± 0.011	1.182AsnTyr: 1.182 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	4.649ProAla: 4.649 ± 0.039	0.452ProCys: 0.452 ± 0.01	3.059ProAsp: 3.059 ± 0.023	3.714ProGlu: 3.714 ± 0.026	2.055ProPhe: 2.055 ± 0.021	3.504ProGly: 3.504 ± 0.026	1.188ProHis: 1.188 ± 0.017	2.649ProIle: 2.649 ± 0.023	2.409ProLys: 2.409 ± 0.021	4.583ProLeu: 4.583 ± 0.029	0.975ProMet: 0.975 ± 0.015	2.195ProAsn: 2.195 ± 0.021	4.185ProPro: 4.185 ± 0.051	2.255ProGln: 2.255 ± 0.023	2.958ProArg: 2.958 ± 0.027	5.508ProSer: 5.508 ± 0.043	3.737ProThr: 3.737 ± 0.03	3.477ProVal: 3.477 ± 0.025	0.757ProTrp: 0.757 ± 0.012	1.562ProTyr: 1.562 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.3GlnAla: 3.3 ± 0.028	0.403GlnCys: 0.403 ± 0.009	2.03GlnAsp: 2.03 ± 0.021	2.431GlnGlu: 2.431 ± 0.024	1.368GlnPhe: 1.368 ± 0.015	2.32GlnGly: 2.32 ± 0.02	1.04GlnHis: 1.04 ± 0.013	2.1GlnIle: 2.1 ± 0.021	2.048GlnLys: 2.048 ± 0.02	3.501GlnLeu: 3.501 ± 0.027	0.857GlnMet: 0.857 ± 0.014	1.745GlnAsn: 1.745 ± 0.017	2.378GlnPro: 2.378 ± 0.027	2.417GlnGln: 2.417 ± 0.034	2.54GlnArg: 2.54 ± 0.025	3.187GlnSer: 3.187 ± 0.025	2.426GlnThr: 2.426 ± 0.021	2.171GlnVal: 2.171 ± 0.021	0.594GlnTrp: 0.594 ± 0.011	1.26GlnTyr: 1.26 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	4.211ArgAla: 4.211 ± 0.031	0.602ArgCys: 0.602 ± 0.011	3.239ArgAsp: 3.239 ± 0.03	3.617ArgGlu: 3.617 ± 0.03	2.118ArgPhe: 2.118 ± 0.02	3.339ArgGly: 3.339 ± 0.027	1.437ArgHis: 1.437 ± 0.017	3.031ArgIle: 3.031 ± 0.024	3.311ArgLys: 3.311 ± 0.026	5.368ArgLeu: 5.368 ± 0.034	1.201ArgMet: 1.201 ± 0.014	2.31ArgAsn: 2.31 ± 0.021	3.016ArgPro: 3.016 ± 0.028	2.475ArgGln: 2.475 ± 0.026	4.577ArgArg: 4.577 ± 0.043	4.36ArgSer: 4.36 ± 0.037	3.075ArgThr: 3.075 ± 0.021	3.227ArgVal: 3.227 ± 0.023	0.899ArgTrp: 0.899 ± 0.013	1.699ArgTyr: 1.699 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	6.446SerAla: 6.446 ± 0.038	0.766SerCys: 0.766 ± 0.015	4.28SerAsp: 4.28 ± 0.031	4.183SerGlu: 4.183 ± 0.03	3.126SerPhe: 3.126 ± 0.027	5.327SerGly: 5.327 ± 0.033	1.91SerHis: 1.91 ± 0.018	4.389SerIle: 4.389 ± 0.033	3.688SerLys: 3.688 ± 0.028	7.435SerLeu: 7.435 ± 0.038	1.69SerMet: 1.69 ± 0.018	3.248SerAsn: 3.248 ± 0.025	4.985SerPro: 4.985 ± 0.039	3.287SerGln: 3.287 ± 0.028	4.66SerArg: 4.66 ± 0.034	8.756SerSer: 8.756 ± 0.065	5.895SerThr: 5.895 ± 0.042	4.709SerVal: 4.709 ± 0.03	1.151SerTrp: 1.151 ± 0.015	2.213SerTyr: 2.213 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	5.328ThrAla: 5.328 ± 0.033	0.687ThrCys: 0.687 ± 0.012	3.031ThrAsp: 3.031 ± 0.024	3.391ThrGlu: 3.391 ± 0.027	2.36ThrPhe: 2.36 ± 0.025	4.312ThrGly: 4.312 ± 0.034	1.271ThrHis: 1.271 ± 0.016	3.433ThrIle: 3.433 ± 0.027	2.655ThrLys: 2.655 ± 0.024	5.32ThrLeu: 5.32 ± 0.033	1.205ThrMet: 1.205 ± 0.015	2.377ThrAsn: 2.377 ± 0.021	4.089ThrPro: 4.089 ± 0.039	2.18ThrGln: 2.18 ± 0.022	2.937ThrArg: 2.937 ± 0.022	5.586ThrSer: 5.586 ± 0.038	4.809ThrThr: 4.809 ± 0.047	3.947ThrVal: 3.947 ± 0.026	0.925ThrTrp: 0.925 ± 0.014	1.779ThrTyr: 1.779 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.214ValAla: 5.214 ± 0.034	0.768ValCys: 0.768 ± 0.012	3.805ValAsp: 3.805 ± 0.026	3.877ValGlu: 3.877 ± 0.035	2.544ValPhe: 2.544 ± 0.024	3.991ValGly: 3.991 ± 0.031	1.408ValHis: 1.408 ± 0.014	3.371ValIle: 3.371 ± 0.025	2.872ValLys: 2.872 ± 0.025	5.673ValLeu: 5.673 ± 0.039	1.312ValMet: 1.312 ± 0.017	2.441ValAsn: 2.441 ± 0.023	3.484ValPro: 3.484 ± 0.025	2.443ValGln: 2.443 ± 0.019	3.284ValArg: 3.284 ± 0.028	4.81ValSer: 4.81 ± 0.034	3.747ValThr: 3.747 ± 0.027	4.462ValVal: 4.462 ± 0.042	0.876ValTrp: 0.876 ± 0.013	1.845ValTyr: 1.845 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.148TrpAla: 1.148 ± 0.016	0.191TrpCys: 0.191 ± 0.006	0.912TrpAsp: 0.912 ± 0.015	0.839TrpGlu: 0.839 ± 0.012	0.565TrpPhe: 0.565 ± 0.01	0.915TrpGly: 0.915 ± 0.014	0.368TrpHis: 0.368 ± 0.008	0.854TrpIle: 0.854 ± 0.011	0.842TrpLys: 0.842 ± 0.013	1.385TrpLeu: 1.385 ± 0.018	0.381TrpMet: 0.381 ± 0.008	0.681TrpAsn: 0.681 ± 0.011	0.601TrpPro: 0.601 ± 0.01	0.595TrpGln: 0.595 ± 0.01	0.929TrpArg: 0.929 ± 0.012	1.079TrpSer: 1.079 ± 0.016	0.919TrpThr: 0.919 ± 0.015	0.894TrpVal: 0.894 ± 0.013	0.278TrpTrp: 0.278 ± 0.007	0.473TrpTyr: 0.473 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.266TyrAla: 2.266 ± 0.023	0.401TyrCys: 0.401 ± 0.009	1.781TyrAsp: 1.781 ± 0.017	1.678TyrGlu: 1.678 ± 0.018	1.307TyrPhe: 1.307 ± 0.017	2.241TyrGly: 2.241 ± 0.027	0.798TyrHis: 0.798 ± 0.012	1.618TyrIle: 1.618 ± 0.017	1.173TyrLys: 1.173 ± 0.016	2.848TyrLeu: 2.848 ± 0.024	0.671TyrMet: 0.671 ± 0.012	1.292TyrAsn: 1.292 ± 0.016	1.579TyrPro: 1.579 ± 0.019	1.223TyrGln: 1.223 ± 0.015	1.648TyrArg: 1.648 ± 0.018	2.171TyrSer: 2.171 ± 0.023	1.798TyrThr: 1.798 ± 0.018	1.748TyrVal: 1.748 ± 0.02	0.481TyrTrp: 0.481 ± 0.009	1.065TyrTyr: 1.065 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11231 proteins (5743013 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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