Amino acid dipepetide frequency for Paraburkholderia eburnea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.573AlaAla: 18.573 ± 0.171	1.352AlaCys: 1.352 ± 0.027	6.812AlaAsp: 6.812 ± 0.071	5.679AlaGlu: 5.679 ± 0.067	4.499AlaPhe: 4.499 ± 0.051	10.461AlaGly: 10.461 ± 0.09	3.18AlaHis: 3.18 ± 0.046	5.817AlaIle: 5.817 ± 0.053	3.539AlaLys: 3.539 ± 0.056	15.296AlaLeu: 15.296 ± 0.121	3.226AlaMet: 3.226 ± 0.04	3.481AlaAsn: 3.481 ± 0.052	6.381AlaPro: 6.381 ± 0.085	6.391AlaGln: 6.391 ± 0.07	9.772AlaArg: 9.772 ± 0.098	7.904AlaSer: 7.904 ± 0.074	6.592AlaThr: 6.592 ± 0.064	8.769AlaVal: 8.769 ± 0.076	1.908AlaTrp: 1.908 ± 0.038	2.653AlaTyr: 2.653 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	1.365CysAla: 1.365 ± 0.029	0.117CysCys: 0.117 ± 0.008	0.524CysAsp: 0.524 ± 0.015	0.511CysGlu: 0.511 ± 0.016	0.315CysPhe: 0.315 ± 0.012	0.992CysGly: 0.992 ± 0.024	0.249CysHis: 0.249 ± 0.012	0.37CysIle: 0.37 ± 0.015	0.213CysLys: 0.213 ± 0.01	0.769CysLeu: 0.769 ± 0.022	0.195CysMet: 0.195 ± 0.011	0.224CysAsn: 0.224 ± 0.011	0.427CysPro: 0.427 ± 0.018	0.225CysGln: 0.225 ± 0.012	0.577CysArg: 0.577 ± 0.019	0.495CysSer: 0.495 ± 0.017	0.482CysThr: 0.482 ± 0.015	0.782CysVal: 0.782 ± 0.021	0.132CysTrp: 0.132 ± 0.008	0.22CysTyr: 0.22 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.292AspAla: 8.292 ± 0.087	0.473AspCys: 0.473 ± 0.018	3.243AspAsp: 3.243 ± 0.047	3.35AspGlu: 3.35 ± 0.047	1.931AspPhe: 1.931 ± 0.028	4.593AspGly: 4.593 ± 0.054	1.168AspHis: 1.168 ± 0.031	2.458AspIle: 2.458 ± 0.036	1.442AspLys: 1.442 ± 0.032	5.202AspLeu: 5.202 ± 0.052	1.135AspMet: 1.135 ± 0.022	1.294AspAsn: 1.294 ± 0.028	2.89AspPro: 2.89 ± 0.039	1.575AspGln: 1.575 ± 0.031	3.158AspArg: 3.158 ± 0.044	2.512AspSer: 2.512 ± 0.036	2.885AspThr: 2.885 ± 0.04	4.258AspVal: 4.258 ± 0.045	0.928AspTrp: 0.928 ± 0.022	1.549AspTyr: 1.549 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	6.793GluAla: 6.793 ± 0.076	0.391GluCys: 0.391 ± 0.014	2.144GluAsp: 2.144 ± 0.038	2.405GluGlu: 2.405 ± 0.039	1.73GluPhe: 1.73 ± 0.029	3.494GluGly: 3.494 ± 0.052	1.443GluHis: 1.443 ± 0.03	2.714GluIle: 2.714 ± 0.044	1.681GluLys: 1.681 ± 0.04	5.195GluLeu: 5.195 ± 0.063	1.164GluMet: 1.164 ± 0.027	1.366GluAsn: 1.366 ± 0.026	2.462GluPro: 2.462 ± 0.038	2.296GluGln: 2.296 ± 0.037	4.919GluArg: 4.919 ± 0.063	2.664GluSer: 2.664 ± 0.039	2.848GluThr: 2.848 ± 0.04	3.464GluVal: 3.464 ± 0.045	0.712GluTrp: 0.712 ± 0.017	1.144GluTyr: 1.144 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	4.885PheAla: 4.885 ± 0.06	0.419PheCys: 0.419 ± 0.013	2.639PheAsp: 2.639 ± 0.038	2.095PheGlu: 2.095 ± 0.034	1.44PhePhe: 1.44 ± 0.03	3.738PheGly: 3.738 ± 0.049	0.769PheHis: 0.769 ± 0.018	1.55PheIle: 1.55 ± 0.03	0.957PheLys: 0.957 ± 0.026	2.858PheLeu: 2.858 ± 0.047	0.809PheMet: 0.809 ± 0.022	1.153PheAsn: 1.153 ± 0.023	1.536PhePro: 1.536 ± 0.029	0.974PheGln: 0.974 ± 0.02	1.963PheArg: 1.963 ± 0.033	2.293PheSer: 2.293 ± 0.035	1.971PheThr: 1.971 ± 0.034	3.212PheVal: 3.212 ± 0.046	0.544PheTrp: 0.544 ± 0.016	0.973PheTyr: 0.973 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	10.165GlyAla: 10.165 ± 0.088	0.839GlyCys: 0.839 ± 0.022	3.961GlyAsp: 3.961 ± 0.048	4.408GlyGlu: 4.408 ± 0.054	3.51GlyPhe: 3.51 ± 0.051	6.85GlyGly: 6.85 ± 0.097	1.987GlyHis: 1.987 ± 0.034	4.072GlyIle: 4.072 ± 0.047	3.089GlyLys: 3.089 ± 0.044	7.944GlyLeu: 7.944 ± 0.074	2.15GlyMet: 2.15 ± 0.032	2.381GlyAsn: 2.381 ± 0.039	2.93GlyPro: 2.93 ± 0.042	2.764GlyGln: 2.764 ± 0.043	5.101GlyArg: 5.101 ± 0.059	4.537GlySer: 4.537 ± 0.078	4.625GlyThr: 4.625 ± 0.059	6.871GlyVal: 6.871 ± 0.066	1.401GlyTrp: 1.401 ± 0.028	2.464GlyTyr: 2.464 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	3.355HisAla: 3.355 ± 0.048	0.265HisCys: 0.265 ± 0.013	1.442HisAsp: 1.442 ± 0.03	1.287HisGlu: 1.287 ± 0.026	0.959HisPhe: 0.959 ± 0.024	2.268HisGly: 2.268 ± 0.04	0.657HisHis: 0.657 ± 0.021	0.919HisIle: 0.919 ± 0.023	0.516HisLys: 0.516 ± 0.016	2.145HisLeu: 2.145 ± 0.035	0.528HisMet: 0.528 ± 0.016	0.579HisAsn: 0.579 ± 0.019	1.425HisPro: 1.425 ± 0.029	0.622HisGln: 0.622 ± 0.018	1.519HisArg: 1.519 ± 0.028	1.088HisSer: 1.088 ± 0.024	1.179HisThr: 1.179 ± 0.027	1.739HisVal: 1.739 ± 0.031	0.436HisTrp: 0.436 ± 0.015	0.706HisTyr: 0.706 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.059IleAla: 7.059 ± 0.06	0.434IleCys: 0.434 ± 0.015	3.492IleAsp: 3.492 ± 0.048	3.238IleGlu: 3.238 ± 0.046	1.392IlePhe: 1.392 ± 0.03	4.748IleGly: 4.748 ± 0.061	0.893IleHis: 0.893 ± 0.018	1.491IleIle: 1.491 ± 0.031	1.241IleLys: 1.241 ± 0.026	3.246IleLeu: 3.246 ± 0.046	0.705IleMet: 0.705 ± 0.019	1.302IleAsn: 1.302 ± 0.026	1.929IlePro: 1.929 ± 0.032	1.254IleGln: 1.254 ± 0.026	2.649IleArg: 2.649 ± 0.039	2.388IleSer: 2.388 ± 0.039	2.295IleThr: 2.295 ± 0.039	4.405IleVal: 4.405 ± 0.052	0.513IleTrp: 0.513 ± 0.018	1.024IleTyr: 1.024 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	3.402LysAla: 3.402 ± 0.055	0.142LysCys: 0.142 ± 0.008	1.397LysAsp: 1.397 ± 0.031	1.325LysGlu: 1.325 ± 0.032	0.827LysPhe: 0.827 ± 0.02	2.067LysGly: 2.067 ± 0.031	0.674LysHis: 0.674 ± 0.019	1.526LysIle: 1.526 ± 0.035	1.158LysLys: 1.158 ± 0.032	3.245LysLeu: 3.245 ± 0.046	0.723LysMet: 0.723 ± 0.021	0.816LysAsn: 0.816 ± 0.02	1.911LysPro: 1.911 ± 0.034	1.147LysGln: 1.147 ± 0.03	2.249LysArg: 2.249 ± 0.042	1.665LysSer: 1.665 ± 0.029	1.777LysThr: 1.777 ± 0.036	2.107LysVal: 2.107 ± 0.036	0.362LysTrp: 0.362 ± 0.014	0.66LysTyr: 0.66 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.692LeuAla: 14.692 ± 0.107	1.047LeuCys: 1.047 ± 0.021	6.19LeuAsp: 6.19 ± 0.062	4.972LeuGlu: 4.972 ± 0.059	3.663LeuPhe: 3.663 ± 0.047	8.225LeuGly: 8.225 ± 0.085	2.283LeuHis: 2.283 ± 0.04	4.684LeuIle: 4.684 ± 0.056	3.143LeuLys: 3.143 ± 0.043	9.856LeuLeu: 9.856 ± 0.083	2.235LeuMet: 2.235 ± 0.039	2.724LeuAsn: 2.724 ± 0.034	5.754LeuPro: 5.754 ± 0.055	3.26LeuGln: 3.26 ± 0.041	7.15LeuArg: 7.15 ± 0.073	5.931LeuSer: 5.931 ± 0.062	5.532LeuThr: 5.532 ± 0.054	7.44LeuVal: 7.44 ± 0.065	1.128LeuTrp: 1.128 ± 0.025	2.318LeuTyr: 2.318 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.481MetAla: 2.481 ± 0.038	0.175MetCys: 0.175 ± 0.009	0.923MetAsp: 0.923 ± 0.022	0.884MetGlu: 0.884 ± 0.024	0.733MetPhe: 0.733 ± 0.019	1.58MetGly: 1.58 ± 0.03	0.543MetHis: 0.543 ± 0.017	1.091MetIle: 1.091 ± 0.025	0.97MetLys: 0.97 ± 0.025	2.603MetLeu: 2.603 ± 0.038	0.576MetMet: 0.576 ± 0.016	0.956MetAsn: 0.956 ± 0.019	1.457MetPro: 1.457 ± 0.028	1.036MetGln: 1.036 ± 0.023	1.758MetArg: 1.758 ± 0.033	1.667MetSer: 1.667 ± 0.027	1.554MetThr: 1.554 ± 0.027	1.367MetVal: 1.367 ± 0.026	0.201MetTrp: 0.201 ± 0.011	0.386MetTyr: 0.386 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.847AsnAla: 3.847 ± 0.045	0.237AsnCys: 0.237 ± 0.012	1.496AsnAsp: 1.496 ± 0.029	1.338AsnGlu: 1.338 ± 0.03	1.003AsnPhe: 1.003 ± 0.024	2.705AsnGly: 2.705 ± 0.055	0.547AsnHis: 0.547 ± 0.015	1.212AsnIle: 1.212 ± 0.028	0.638AsnLys: 0.638 ± 0.02	2.69AsnLeu: 2.69 ± 0.038	0.573AsnMet: 0.573 ± 0.016	0.881AsnAsn: 0.881 ± 0.025	1.798AsnPro: 1.798 ± 0.031	0.942AsnGln: 0.942 ± 0.023	1.72AsnArg: 1.72 ± 0.027	1.39AsnSer: 1.39 ± 0.031	1.539AsnThr: 1.539 ± 0.032	2.282AsnVal: 2.282 ± 0.041	0.433AsnTrp: 0.433 ± 0.015	0.764AsnTyr: 0.764 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.69ProAla: 6.69 ± 0.064	0.354ProCys: 0.354 ± 0.013	3.273ProAsp: 3.273 ± 0.046	3.008ProGlu: 3.008 ± 0.037	1.922ProPhe: 1.922 ± 0.032	4.291ProGly: 4.291 ± 0.047	1.281ProHis: 1.281 ± 0.028	2.025ProIle: 2.025 ± 0.033	1.332ProLys: 1.332 ± 0.026	5.221ProLeu: 5.221 ± 0.053	1.087ProMet: 1.087 ± 0.024	1.389ProAsn: 1.389 ± 0.026	2.383ProPro: 2.383 ± 0.039	2.105ProGln: 2.105 ± 0.036	2.979ProArg: 2.979 ± 0.046	2.666ProSer: 2.666 ± 0.035	2.502ProThr: 2.502 ± 0.041	4.283ProVal: 4.283 ± 0.05	0.716ProTrp: 0.716 ± 0.018	1.199ProTyr: 1.199 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	4.776GlnAla: 4.776 ± 0.055	0.31GlnCys: 0.31 ± 0.013	1.475GlnAsp: 1.475 ± 0.024	1.347GlnGlu: 1.347 ± 0.029	1.323GlnPhe: 1.323 ± 0.025	2.629GlnGly: 2.629 ± 0.041	0.989GlnHis: 0.989 ± 0.023	1.998GlnIle: 1.998 ± 0.036	1.111GlnLys: 1.111 ± 0.027	3.75GlnLeu: 3.75 ± 0.048	1.04GlnMet: 1.04 ± 0.023	1.016GlnAsn: 1.016 ± 0.027	2.086GlnPro: 2.086 ± 0.033	1.992GlnGln: 1.992 ± 0.042	3.063GlnArg: 3.063 ± 0.045	2.13GlnSer: 2.13 ± 0.035	2.131GlnThr: 2.131 ± 0.038	2.414GlnVal: 2.414 ± 0.037	0.582GlnTrp: 0.582 ± 0.015	1.023GlnTyr: 1.023 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	8.886ArgAla: 8.886 ± 0.084	0.576ArgCys: 0.576 ± 0.021	3.831ArgAsp: 3.831 ± 0.047	4.531ArgGlu: 4.531 ± 0.056	2.962ArgPhe: 2.962 ± 0.038	4.591ArgGly: 4.591 ± 0.058	1.908ArgHis: 1.908 ± 0.036	3.478ArgIle: 3.478 ± 0.045	2.009ArgLys: 2.009 ± 0.031	7.244ArgLeu: 7.244 ± 0.08	1.745ArgMet: 1.745 ± 0.03	1.922ArgAsn: 1.922 ± 0.033	2.922ArgPro: 2.922 ± 0.04	2.43ArgGln: 2.43 ± 0.035	5.334ArgArg: 5.334 ± 0.065	3.355ArgSer: 3.355 ± 0.047	3.459ArgThr: 3.459 ± 0.043	5.429ArgVal: 5.429 ± 0.06	1.058ArgTrp: 1.058 ± 0.022	2.036ArgTyr: 2.036 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	7.209SerAla: 7.209 ± 0.078	0.432SerCys: 0.432 ± 0.017	2.763SerAsp: 2.763 ± 0.039	2.461SerGlu: 2.461 ± 0.04	2.149SerPhe: 2.149 ± 0.036	5.43SerGly: 5.43 ± 0.074	1.287SerHis: 1.287 ± 0.023	2.633SerIle: 2.633 ± 0.037	1.533SerLys: 1.533 ± 0.033	5.713SerLeu: 5.713 ± 0.054	1.32SerMet: 1.32 ± 0.027	1.741SerAsn: 1.741 ± 0.037	2.797SerPro: 2.797 ± 0.036	1.902SerGln: 1.902 ± 0.033	3.602SerArg: 3.602 ± 0.045	3.388SerSer: 3.388 ± 0.068	3.224SerThr: 3.224 ± 0.057	4.338SerVal: 4.338 ± 0.053	0.756SerTrp: 0.756 ± 0.019	1.326SerTyr: 1.326 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.01ThrAla: 6.01 ± 0.074	0.413ThrCys: 0.413 ± 0.014	2.6ThrAsp: 2.6 ± 0.04	2.213ThrGlu: 2.213 ± 0.039	1.973ThrPhe: 1.973 ± 0.035	4.704ThrGly: 4.704 ± 0.055	1.314ThrHis: 1.314 ± 0.027	2.522ThrIle: 2.522 ± 0.037	1.207ThrLys: 1.207 ± 0.029	6.8ThrLeu: 6.8 ± 0.057	1.155ThrMet: 1.155 ± 0.025	1.362ThrAsn: 1.362 ± 0.048	3.746ThrPro: 3.746 ± 0.042	2.116ThrGln: 2.116 ± 0.037	3.767ThrArg: 3.767 ± 0.049	3.044ThrSer: 3.044 ± 0.053	2.978ThrThr: 2.978 ± 0.045	4.305ThrVal: 4.305 ± 0.052	0.732ThrTrp: 0.732 ± 0.019	1.195ThrTyr: 1.195 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	9.649ValAla: 9.649 ± 0.077	0.793ValCys: 0.793 ± 0.022	4.11ValAsp: 4.11 ± 0.055	4.209ValGlu: 4.209 ± 0.05	2.832ValPhe: 2.832 ± 0.042	5.534ValGly: 5.534 ± 0.058	1.538ValHis: 1.538 ± 0.029	3.582ValIle: 3.582 ± 0.046	2.408ValLys: 2.408 ± 0.043	7.939ValLeu: 7.939 ± 0.074	1.768ValMet: 1.768 ± 0.033	2.314ValAsn: 2.314 ± 0.042	3.987ValPro: 3.987 ± 0.045	2.542ValGln: 2.542 ± 0.038	5.215ValArg: 5.215 ± 0.057	4.718ValSer: 4.718 ± 0.047	4.488ValThr: 4.488 ± 0.049	6.095ValVal: 6.095 ± 0.071	0.994ValTrp: 0.994 ± 0.028	1.681ValTyr: 1.681 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.196TrpAla: 1.196 ± 0.027	0.161TrpCys: 0.161 ± 0.01	0.621TrpAsp: 0.621 ± 0.017	0.512TrpGlu: 0.512 ± 0.018	0.578TrpPhe: 0.578 ± 0.017	0.917TrpGly: 0.917 ± 0.022	0.406TrpHis: 0.406 ± 0.015	0.711TrpIle: 0.711 ± 0.017	0.408TrpLys: 0.408 ± 0.014	2.054TrpLeu: 2.054 ± 0.035	0.375TrpMet: 0.375 ± 0.013	0.467TrpAsn: 0.467 ± 0.014	0.687TrpPro: 0.687 ± 0.018	0.704TrpGln: 0.704 ± 0.019	1.303TrpArg: 1.303 ± 0.03	0.848TrpSer: 0.848 ± 0.023	0.735TrpThr: 0.735 ± 0.021	0.93TrpVal: 0.93 ± 0.022	0.219TrpTrp: 0.219 ± 0.01	0.332TrpTyr: 0.332 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.959TyrAla: 2.959 ± 0.04	0.254TyrCys: 0.254 ± 0.012	1.399TyrAsp: 1.399 ± 0.026	1.257TyrGlu: 1.257 ± 0.024	1.034TyrPhe: 1.034 ± 0.024	2.235TyrGly: 2.235 ± 0.038	0.517TyrHis: 0.517 ± 0.017	0.848TyrIle: 0.848 ± 0.023	0.583TyrLys: 0.583 ± 0.02	2.46TyrLeu: 2.46 ± 0.032	0.432TyrMet: 0.432 ± 0.017	0.668TyrAsn: 0.668 ± 0.02	1.2TyrPro: 1.2 ± 0.026	0.906TyrGln: 0.906 ± 0.022	1.905TyrArg: 1.905 ± 0.029	1.321TyrSer: 1.321 ± 0.027	1.362TyrThr: 1.362 ± 0.028	1.905TyrVal: 1.905 ± 0.029	0.407TyrTrp: 0.407 ± 0.014	0.662TyrTyr: 0.662 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6148 proteins (2001719 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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