Amino acid dipepetide frequency for Methylotenera versatilis (strain 301)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.982AlaAla: 9.982 ± 0.141	0.959AlaCys: 0.959 ± 0.033	5.244AlaAsp: 5.244 ± 0.08	5.973AlaGlu: 5.973 ± 0.114	3.509AlaPhe: 3.509 ± 0.07	6.982AlaGly: 6.982 ± 0.116	1.943AlaHis: 1.943 ± 0.05	6.474AlaIle: 6.474 ± 0.11	6.018AlaLys: 6.018 ± 0.118	10.482AlaLeu: 10.482 ± 0.129	2.819AlaMet: 2.819 ± 0.061	4.469AlaAsn: 4.469 ± 0.077	3.37AlaPro: 3.37 ± 0.082	3.862AlaGln: 3.862 ± 0.061	4.061AlaArg: 4.061 ± 0.076	6.088AlaSer: 6.088 ± 0.096	5.129AlaThr: 5.129 ± 0.08	6.477AlaVal: 6.477 ± 0.094	1.152AlaTrp: 1.152 ± 0.043	2.637AlaTyr: 2.637 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.786CysAla: 0.786 ± 0.042	0.12CysCys: 0.12 ± 0.013	0.473CysAsp: 0.473 ± 0.024	0.502CysGlu: 0.502 ± 0.034	0.347CysPhe: 0.347 ± 0.021	0.765CysGly: 0.765 ± 0.027	0.334CysHis: 0.334 ± 0.066	0.495CysIle: 0.495 ± 0.025	0.443CysLys: 0.443 ± 0.03	0.817CysLeu: 0.817 ± 0.028	0.238CysMet: 0.238 ± 0.017	0.365CysAsn: 0.365 ± 0.019	0.445CysPro: 0.445 ± 0.027	0.297CysGln: 0.297 ± 0.018	0.363CysArg: 0.363 ± 0.023	0.538CysSer: 0.538 ± 0.024	0.497CysThr: 0.497 ± 0.025	0.644CysVal: 0.644 ± 0.028	0.08CysTrp: 0.08 ± 0.009	0.254CysTyr: 0.254 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	5.436AspAla: 5.436 ± 0.091	0.462AspCys: 0.462 ± 0.025	2.823AspAsp: 2.823 ± 0.072	3.336AspGlu: 3.336 ± 0.06	2.399AspPhe: 2.399 ± 0.062	3.925AspGly: 3.925 ± 0.096	0.951AspHis: 0.951 ± 0.033	3.737AspIle: 3.737 ± 0.071	3.017AspLys: 3.017 ± 0.058	5.347AspLeu: 5.347 ± 0.086	1.322AspMet: 1.322 ± 0.042	2.111AspAsn: 2.111 ± 0.067	1.903AspPro: 1.903 ± 0.057	1.637AspGln: 1.637 ± 0.047	2.164AspArg: 2.164 ± 0.057	2.928AspSer: 2.928 ± 0.067	2.921AspThr: 2.921 ± 0.11	3.833AspVal: 3.833 ± 0.065	0.839AspTrp: 0.839 ± 0.034	1.732AspTyr: 1.732 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	5.818GluAla: 5.818 ± 0.116	0.434GluCys: 0.434 ± 0.023	2.534GluAsp: 2.534 ± 0.058	2.751GluGlu: 2.751 ± 0.058	2.246GluPhe: 2.246 ± 0.052	3.155GluGly: 3.155 ± 0.065	1.384GluHis: 1.384 ± 0.04	4.053GluIle: 4.053 ± 0.07	3.395GluLys: 3.395 ± 0.078	5.804GluLeu: 5.804 ± 0.119	1.582GluMet: 1.582 ± 0.044	2.65GluAsn: 2.65 ± 0.054	1.845GluPro: 1.845 ± 0.04	2.625GluGln: 2.625 ± 0.064	2.892GluArg: 2.892 ± 0.073	3.359GluSer: 3.359 ± 0.06	3.086GluThr: 3.086 ± 0.056	4.175GluVal: 4.175 ± 0.073	0.66GluTrp: 0.66 ± 0.026	1.631GluTyr: 1.631 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.709PheAla: 3.709 ± 0.066	0.405PheCys: 0.405 ± 0.025	2.554PheAsp: 2.554 ± 0.057	2.272PheGlu: 2.272 ± 0.055	1.619PhePhe: 1.619 ± 0.054	3.134PheGly: 3.134 ± 0.065	0.702PheHis: 0.702 ± 0.032	2.539PheIle: 2.539 ± 0.06	2.12PheLys: 2.12 ± 0.053	3.468PheLeu: 3.468 ± 0.068	0.975PheMet: 0.975 ± 0.031	2.064PheAsn: 2.064 ± 0.051	1.37PhePro: 1.37 ± 0.037	1.173PheGln: 1.173 ± 0.037	1.418PheArg: 1.418 ± 0.044	2.984PheSer: 2.984 ± 0.049	2.35PheThr: 2.35 ± 0.06	2.787PheVal: 2.787 ± 0.055	0.548PheTrp: 0.548 ± 0.028	1.264PheTyr: 1.264 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	6.088GlyAla: 6.088 ± 0.106	0.751GlyCys: 0.751 ± 0.046	3.616GlyAsp: 3.616 ± 0.081	3.853GlyGlu: 3.853 ± 0.075	3.129GlyPhe: 3.129 ± 0.063	5.261GlyGly: 5.261 ± 0.159	1.612GlyHis: 1.612 ± 0.039	4.72GlyIle: 4.72 ± 0.093	4.325GlyLys: 4.325 ± 0.066	7.322GlyLeu: 7.322 ± 0.103	1.968GlyMet: 1.968 ± 0.045	3.014GlyAsn: 3.014 ± 0.15	1.505GlyPro: 1.505 ± 0.047	2.381GlyGln: 2.381 ± 0.047	2.976GlyArg: 2.976 ± 0.069	4.173GlySer: 4.173 ± 0.104	3.659GlyThr: 3.659 ± 0.108	5.304GlyVal: 5.304 ± 0.09	0.958GlyTrp: 0.958 ± 0.037	2.355GlyTyr: 2.355 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.091HisAla: 2.091 ± 0.046	0.243HisCys: 0.243 ± 0.015	1.199HisAsp: 1.199 ± 0.037	1.226HisGlu: 1.226 ± 0.037	1.035HisPhe: 1.035 ± 0.035	1.56HisGly: 1.56 ± 0.039	0.708HisHis: 0.708 ± 0.029	1.445HisIle: 1.445 ± 0.038	1.023HisLys: 1.023 ± 0.048	2.265HisLeu: 2.265 ± 0.06	0.588HisMet: 0.588 ± 0.024	0.817HisAsn: 0.817 ± 0.034	1.148HisPro: 1.148 ± 0.037	1.032HisGln: 1.032 ± 0.039	0.903HisArg: 0.903 ± 0.03	1.278HisSer: 1.278 ± 0.037	1.107HisThr: 1.107 ± 0.043	1.471HisVal: 1.471 ± 0.04	0.325HisTrp: 0.325 ± 0.018	0.793HisTyr: 0.793 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.094IleAla: 7.094 ± 0.101	0.581IleCys: 0.581 ± 0.028	3.973IleAsp: 3.973 ± 0.069	4.176IleGlu: 4.176 ± 0.07	2.382IlePhe: 2.382 ± 0.067	4.89IleGly: 4.89 ± 0.092	1.318IleHis: 1.318 ± 0.041	3.616IleIle: 3.616 ± 0.091	3.915IleLys: 3.915 ± 0.072	5.633IleLeu: 5.633 ± 0.092	1.308IleMet: 1.308 ± 0.044	3.215IleAsn: 3.215 ± 0.059	2.675IlePro: 2.675 ± 0.06	2.296IleGln: 2.296 ± 0.045	2.603IleArg: 2.603 ± 0.059	4.709IleSer: 4.709 ± 0.076	4.046IleThr: 4.046 ± 0.085	4.333IleVal: 4.333 ± 0.089	0.647IleTrp: 0.647 ± 0.031	1.697IleTyr: 1.697 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	5.278LysAla: 5.278 ± 0.093	0.314LysCys: 0.314 ± 0.023	2.736LysAsp: 2.736 ± 0.077	2.869LysGlu: 2.869 ± 0.063	1.921LysPhe: 1.921 ± 0.052	3.09LysGly: 3.09 ± 0.072	1.367LysHis: 1.367 ± 0.046	3.634LysIle: 3.634 ± 0.065	3.192LysLys: 3.192 ± 0.074	6.305LysLeu: 6.305 ± 0.095	1.551LysMet: 1.551 ± 0.045	2.698LysAsn: 2.698 ± 0.062	2.846LysPro: 2.846 ± 0.06	2.777LysGln: 2.777 ± 0.074	2.637LysArg: 2.637 ± 0.055	3.722LysSer: 3.722 ± 0.069	3.325LysThr: 3.325 ± 0.066	4.02LysVal: 4.02 ± 0.076	0.543LysTrp: 0.543 ± 0.026	1.388LysTyr: 1.388 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	10.615LeuAla: 10.615 ± 0.125	0.91LeuCys: 0.91 ± 0.038	5.634LeuAsp: 5.634 ± 0.079	5.679LeuGlu: 5.679 ± 0.092	3.902LeuPhe: 3.902 ± 0.085	7.17LeuGly: 7.17 ± 0.106	2.164LeuHis: 2.164 ± 0.054	6.643LeuIle: 6.643 ± 0.11	5.997LeuLys: 5.997 ± 0.095	10.837LeuLeu: 10.837 ± 0.154	2.702LeuMet: 2.702 ± 0.06	5.03LeuAsn: 5.03 ± 0.083	4.642LeuPro: 4.642 ± 0.074	4.068LeuGln: 4.068 ± 0.079	4.708LeuArg: 4.708 ± 0.079	7.518LeuSer: 7.518 ± 0.098	6.031LeuThr: 6.031 ± 0.092	6.87LeuVal: 6.87 ± 0.076	1.013LeuTrp: 1.013 ± 0.038	2.406LeuTyr: 2.406 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.542MetAla: 2.542 ± 0.046	0.155MetCys: 0.155 ± 0.014	1.156MetAsp: 1.156 ± 0.036	1.115MetGlu: 1.115 ± 0.038	0.874MetPhe: 0.874 ± 0.032	1.642MetGly: 1.642 ± 0.039	0.647MetHis: 0.647 ± 0.023	1.47MetIle: 1.47 ± 0.047	1.423MetLys: 1.423 ± 0.043	3.005MetLeu: 3.005 ± 0.064	0.833MetMet: 0.833 ± 0.03	1.2MetAsn: 1.2 ± 0.039	1.376MetPro: 1.376 ± 0.041	1.551MetGln: 1.551 ± 0.037	1.45MetArg: 1.45 ± 0.046	1.819MetSer: 1.819 ± 0.043	1.525MetThr: 1.525 ± 0.039	1.711MetVal: 1.711 ± 0.053	0.233MetTrp: 0.233 ± 0.015	0.496MetTyr: 0.496 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	4.294AsnAla: 4.294 ± 0.083	0.372AsnCys: 0.372 ± 0.022	2.374AsnAsp: 2.374 ± 0.119	2.379AsnGlu: 2.379 ± 0.049	1.691AsnPhe: 1.691 ± 0.05	3.215AsnGly: 3.215 ± 0.098	1.025AsnHis: 1.025 ± 0.043	3.207AsnIle: 3.207 ± 0.071	2.536AsnLys: 2.536 ± 0.056	4.636AsnLeu: 4.636 ± 0.087	1.147AsnMet: 1.147 ± 0.035	2.233AsnAsn: 2.233 ± 0.062	2.275AsnPro: 2.275 ± 0.051	2.254AsnGln: 2.254 ± 0.047	2.009AsnArg: 2.009 ± 0.05	2.741AsnSer: 2.741 ± 0.059	2.766AsnThr: 2.766 ± 0.08	2.998AsnVal: 2.998 ± 0.07	0.571AsnTrp: 0.571 ± 0.027	1.208AsnTyr: 1.208 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	3.83ProAla: 3.83 ± 0.077	0.281ProCys: 0.281 ± 0.018	2.297ProAsp: 2.297 ± 0.051	2.748ProGlu: 2.748 ± 0.06	1.635ProPhe: 1.635 ± 0.042	2.161ProGly: 2.161 ± 0.069	0.868ProHis: 0.868 ± 0.031	2.64ProIle: 2.64 ± 0.047	2.216ProLys: 2.216 ± 0.049	4.04ProLeu: 4.04 ± 0.075	1.024ProMet: 1.024 ± 0.032	2.065ProAsn: 2.065 ± 0.047	1.35ProPro: 1.35 ± 0.039	1.498ProGln: 1.498 ± 0.053	1.418ProArg: 1.418 ± 0.042	2.525ProSer: 2.525 ± 0.062	2.354ProThr: 2.354 ± 0.055	3.157ProVal: 3.157 ± 0.083	0.481ProTrp: 0.481 ± 0.022	1.251ProTyr: 1.251 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	4.445GlnAla: 4.445 ± 0.069	0.288GlnCys: 0.288 ± 0.017	1.865GlnAsp: 1.865 ± 0.044	1.881GlnGlu: 1.881 ± 0.054	1.573GlnPhe: 1.573 ± 0.038	2.457GlnGly: 2.457 ± 0.047	1.202GlnHis: 1.202 ± 0.043	2.529GlnIle: 2.529 ± 0.058	2.172GlnLys: 2.172 ± 0.055	4.613GlnLeu: 4.613 ± 0.076	1.042GlnMet: 1.042 ± 0.032	1.714GlnAsn: 1.714 ± 0.054	1.612GlnPro: 1.612 ± 0.041	2.16GlnGln: 2.16 ± 0.062	1.996GlnArg: 1.996 ± 0.056	2.638GlnSer: 2.638 ± 0.052	2.273GlnThr: 2.273 ± 0.055	2.916GlnVal: 2.916 ± 0.059	0.488GlnTrp: 0.488 ± 0.023	1.203GlnTyr: 1.203 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	3.704ArgAla: 3.704 ± 0.077	0.361ArgCys: 0.361 ± 0.018	2.433ArgAsp: 2.433 ± 0.061	2.854ArgGlu: 2.854 ± 0.07	1.934ArgPhe: 1.934 ± 0.048	2.741ArgGly: 2.741 ± 0.067	1.043ArgHis: 1.043 ± 0.037	3.027ArgIle: 3.027 ± 0.065	2.315ArgLys: 2.315 ± 0.051	4.872ArgLeu: 4.872 ± 0.092	1.282ArgMet: 1.282 ± 0.042	1.952ArgAsn: 1.952 ± 0.046	1.58ArgPro: 1.58 ± 0.043	1.8ArgGln: 1.8 ± 0.04	2.166ArgArg: 2.166 ± 0.061	2.392ArgSer: 2.392 ± 0.049	2.186ArgThr: 2.186 ± 0.051	3.16ArgVal: 3.16 ± 0.063	0.597ArgTrp: 0.597 ± 0.028	1.587ArgTyr: 1.587 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.139SerAla: 6.139 ± 0.085	0.59SerCys: 0.59 ± 0.037	3.24SerAsp: 3.24 ± 0.062	3.394SerGlu: 3.394 ± 0.064	2.65SerPhe: 2.65 ± 0.057	4.835SerGly: 4.835 ± 0.087	1.481SerHis: 1.481 ± 0.037	4.3SerIle: 4.3 ± 0.086	3.403SerLys: 3.403 ± 0.061	6.869SerLeu: 6.869 ± 0.093	1.642SerMet: 1.642 ± 0.04	3.058SerAsn: 3.058 ± 0.061	2.542SerPro: 2.542 ± 0.06	2.677SerGln: 2.677 ± 0.07	2.798SerArg: 2.798 ± 0.073	4.173SerSer: 4.173 ± 0.084	3.686SerThr: 3.686 ± 0.079	4.275SerVal: 4.275 ± 0.078	0.764SerTrp: 0.764 ± 0.026	1.884SerTyr: 1.884 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	5.192ThrAla: 5.192 ± 0.092	0.507ThrCys: 0.507 ± 0.054	2.858ThrAsp: 2.858 ± 0.089	3.105ThrGlu: 3.105 ± 0.061	2.163ThrPhe: 2.163 ± 0.051	4.455ThrGly: 4.455 ± 0.109	1.249ThrHis: 1.249 ± 0.039	3.491ThrIle: 3.491 ± 0.077	2.817ThrLys: 2.817 ± 0.064	6.414ThrLeu: 6.414 ± 0.119	1.202ThrMet: 1.202 ± 0.037	2.488ThrAsn: 2.488 ± 0.073	3.029ThrPro: 3.029 ± 0.064	2.444ThrGln: 2.444 ± 0.062	2.223ThrArg: 2.223 ± 0.051	3.552ThrSer: 3.552 ± 0.068	3.406ThrThr: 3.406 ± 0.094	3.867ThrVal: 3.867 ± 0.082	0.636ThrTrp: 0.636 ± 0.031	1.536ThrTyr: 1.536 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	6.982ValAla: 6.982 ± 0.116	0.662ValCys: 0.662 ± 0.029	3.752ValAsp: 3.752 ± 0.066	4.038ValGlu: 4.038 ± 0.067	2.598ValPhe: 2.598 ± 0.056	4.721ValGly: 4.721 ± 0.085	1.281ValHis: 1.281 ± 0.04	4.842ValIle: 4.842 ± 0.085	3.881ValLys: 3.881 ± 0.075	7.03ValLeu: 7.03 ± 0.081	2.046ValMet: 2.046 ± 0.063	3.279ValAsn: 3.279 ± 0.071	2.699ValPro: 2.699 ± 0.05	2.326ValGln: 2.326 ± 0.059	3.078ValArg: 3.078 ± 0.062	4.787ValSer: 4.787 ± 0.081	4.255ValThr: 4.255 ± 0.084	5.165ValVal: 5.165 ± 0.105	0.762ValTrp: 0.762 ± 0.029	1.728ValTyr: 1.728 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.914TrpAla: 0.914 ± 0.036	0.118TrpCys: 0.118 ± 0.011	0.543TrpAsp: 0.543 ± 0.022	0.519TrpGlu: 0.519 ± 0.022	0.527TrpPhe: 0.527 ± 0.023	0.704TrpGly: 0.704 ± 0.033	0.335TrpHis: 0.335 ± 0.019	0.709TrpIle: 0.709 ± 0.035	0.55TrpLys: 0.55 ± 0.031	1.745TrpLeu: 1.745 ± 0.055	0.336TrpMet: 0.336 ± 0.019	0.445TrpAsn: 0.445 ± 0.028	0.384TrpPro: 0.384 ± 0.016	0.8TrpGln: 0.8 ± 0.03	0.707TrpArg: 0.707 ± 0.029	0.662TrpSer: 0.662 ± 0.03	0.495TrpThr: 0.495 ± 0.022	0.895TrpVal: 0.895 ± 0.03	0.2TrpTrp: 0.2 ± 0.017	0.311TrpTyr: 0.311 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.689TyrAla: 2.689 ± 0.053	0.291TyrCys: 0.291 ± 0.021	1.522TyrAsp: 1.522 ± 0.041	1.41TyrGlu: 1.41 ± 0.04	1.319TyrPhe: 1.319 ± 0.04	2.108TyrGly: 2.108 ± 0.05	0.643TyrHis: 0.643 ± 0.025	1.534TyrIle: 1.534 ± 0.049	1.456TyrLys: 1.456 ± 0.049	3.037TyrLeu: 3.037 ± 0.061	0.612TyrMet: 0.612 ± 0.026	1.064TyrAsn: 1.064 ± 0.034	1.239TyrPro: 1.239 ± 0.038	1.409TyrGln: 1.409 ± 0.044	1.417TyrArg: 1.417 ± 0.037	1.816TyrSer: 1.816 ± 0.05	1.535TyrThr: 1.535 ± 0.05	1.854TyrVal: 1.854 ± 0.04	0.404TyrTrp: 0.404 ± 0.023	0.872TyrTyr: 0.872 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2752 proteins (909469 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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