Amino acid dipepetide frequency for Hungatella hathewayi WAL-18680

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.444AlaAla: 8.444 ± 0.107	1.185AlaCys: 1.185 ± 0.029	4.486AlaAsp: 4.486 ± 0.06	5.403AlaGlu: 5.403 ± 0.071	3.083AlaPhe: 3.083 ± 0.049	7.833AlaGly: 7.833 ± 0.127	1.037AlaHis: 1.037 ± 0.027	4.866AlaIle: 4.866 ± 0.063	4.026AlaLys: 4.026 ± 0.056	7.089AlaLeu: 7.089 ± 0.071	2.656AlaMet: 2.656 ± 0.044	2.524AlaAsn: 2.524 ± 0.047	2.336AlaPro: 2.336 ± 0.038	2.206AlaGln: 2.206 ± 0.04	3.271AlaArg: 3.271 ± 0.048	4.487AlaSer: 4.487 ± 0.058	3.214AlaThr: 3.214 ± 0.049	6.91AlaVal: 6.91 ± 0.072	0.801AlaTrp: 0.801 ± 0.024	2.788AlaTyr: 2.788 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.973CysAla: 0.973 ± 0.024	0.271CysCys: 0.271 ± 0.016	0.767CysAsp: 0.767 ± 0.026	0.863CysGlu: 0.863 ± 0.025	0.653CysPhe: 0.653 ± 0.018	1.521CysGly: 1.521 ± 0.037	0.317CysHis: 0.317 ± 0.014	0.974CysIle: 0.974 ± 0.025	0.597CysLys: 0.597 ± 0.021	1.252CysLeu: 1.252 ± 0.032	0.469CysMet: 0.469 ± 0.017	0.504CysAsn: 0.504 ± 0.018	0.572CysPro: 0.572 ± 0.02	0.473CysGln: 0.473 ± 0.017	0.757CysArg: 0.757 ± 0.023	0.834CysSer: 0.834 ± 0.021	0.728CysThr: 0.728 ± 0.021	1.028CysVal: 1.028 ± 0.025	0.149CysTrp: 0.149 ± 0.011	0.807CysTyr: 0.807 ± 0.042	0.0CysXaa: 0.0 ± 0.0
Asp	4.023AspAla: 4.023 ± 0.059	0.849AspCys: 0.849 ± 0.023	2.713AspAsp: 2.713 ± 0.045	4.146AspGlu: 4.146 ± 0.057	2.328AspPhe: 2.328 ± 0.044	5.425AspGly: 5.425 ± 0.08	0.732AspHis: 0.732 ± 0.023	4.221AspIle: 4.221 ± 0.057	2.935AspLys: 2.935 ± 0.047	3.94AspLeu: 3.94 ± 0.048	1.972AspMet: 1.972 ± 0.038	2.18AspAsn: 2.18 ± 0.042	1.405AspPro: 1.405 ± 0.032	1.074AspGln: 1.074 ± 0.024	2.426AspArg: 2.426 ± 0.038	3.297AspSer: 3.297 ± 0.043	3.158AspThr: 3.158 ± 0.045	3.845AspVal: 3.845 ± 0.056	0.689AspTrp: 0.689 ± 0.022	2.69AspTyr: 2.69 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	5.746GluAla: 5.746 ± 0.075	0.751GluCys: 0.751 ± 0.023	4.089GluAsp: 4.089 ± 0.06	7.417GluGlu: 7.417 ± 0.075	2.529GluPhe: 2.529 ± 0.047	4.662GluGly: 4.662 ± 0.06	1.493GluHis: 1.493 ± 0.032	5.021GluIle: 5.021 ± 0.056	5.351GluLys: 5.351 ± 0.064	6.715GluLeu: 6.715 ± 0.077	2.589GluMet: 2.589 ± 0.047	3.592GluAsn: 3.592 ± 0.056	2.235GluPro: 2.235 ± 0.044	3.088GluGln: 3.088 ± 0.046	3.787GluArg: 3.787 ± 0.053	3.779GluSer: 3.779 ± 0.072	4.402GluThr: 4.402 ± 0.065	4.217GluVal: 4.217 ± 0.059	0.665GluTrp: 0.665 ± 0.022	3.024GluTyr: 3.024 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.001PheAla: 3.001 ± 0.051	0.713PheCys: 0.713 ± 0.02	2.401PheAsp: 2.401 ± 0.035	2.45PheGlu: 2.45 ± 0.042	1.677PhePhe: 1.677 ± 0.037	3.282PheGly: 3.282 ± 0.046	0.849PheHis: 0.849 ± 0.025	2.439PheIle: 2.439 ± 0.046	1.69PheLys: 1.69 ± 0.045	3.9PheLeu: 3.9 ± 0.061	1.18PheMet: 1.18 ± 0.028	1.367PheAsn: 1.367 ± 0.03	1.363PhePro: 1.363 ± 0.029	1.374PheGln: 1.374 ± 0.031	1.728PheArg: 1.728 ± 0.032	2.652PheSer: 2.652 ± 0.041	2.44PheThr: 2.44 ± 0.045	2.663PheVal: 2.663 ± 0.044	0.454PheTrp: 0.454 ± 0.015	1.764PheTyr: 1.764 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	6.092GlyAla: 6.092 ± 0.09	1.369GlyCys: 1.369 ± 0.031	4.068GlyAsp: 4.068 ± 0.051	5.507GlyGlu: 5.507 ± 0.061	3.175GlyPhe: 3.175 ± 0.048	6.467GlyGly: 6.467 ± 0.157	1.292GlyHis: 1.292 ± 0.03	6.433GlyIle: 6.433 ± 0.078	4.961GlyLys: 4.961 ± 0.054	6.329GlyLeu: 6.329 ± 0.059	2.868GlyMet: 2.868 ± 0.037	3.659GlyAsn: 3.659 ± 0.078	1.691GlyPro: 1.691 ± 0.032	2.536GlyGln: 2.536 ± 0.047	3.707GlyArg: 3.707 ± 0.054	4.837GlySer: 4.837 ± 0.099	5.184GlyThr: 5.184 ± 0.121	5.597GlyVal: 5.597 ± 0.063	0.891GlyTrp: 0.891 ± 0.027	3.448GlyTyr: 3.448 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.076HisAla: 1.076 ± 0.028	0.269HisCys: 0.269 ± 0.014	0.831HisAsp: 0.831 ± 0.027	1.014HisGlu: 1.014 ± 0.028	0.836HisPhe: 0.836 ± 0.026	1.44HisGly: 1.44 ± 0.031	0.407HisHis: 0.407 ± 0.017	1.226HisIle: 1.226 ± 0.032	0.75HisLys: 0.75 ± 0.023	1.562HisLeu: 1.562 ± 0.033	0.582HisMet: 0.582 ± 0.019	0.663HisAsn: 0.663 ± 0.02	0.816HisPro: 0.816 ± 0.024	0.548HisGln: 0.548 ± 0.021	0.798HisArg: 0.798 ± 0.022	0.949HisSer: 0.949 ± 0.023	0.937HisThr: 0.937 ± 0.023	1.192HisVal: 1.192 ± 0.028	0.167HisTrp: 0.167 ± 0.009	0.797HisTyr: 0.797 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.318IleAla: 5.318 ± 0.059	1.189IleCys: 1.189 ± 0.028	3.574IleAsp: 3.574 ± 0.049	4.246IleGlu: 4.246 ± 0.049	2.548IlePhe: 2.548 ± 0.059	5.309IleGly: 5.309 ± 0.064	1.277IleHis: 1.277 ± 0.029	4.491IleIle: 4.491 ± 0.068	3.327IleLys: 3.327 ± 0.047	6.593IleLeu: 6.593 ± 0.083	1.83IleMet: 1.83 ± 0.039	2.704IleAsn: 2.704 ± 0.039	3.257IlePro: 3.257 ± 0.046	2.326IleGln: 2.326 ± 0.036	3.605IleArg: 3.605 ± 0.045	4.747IleSer: 4.747 ± 0.066	4.141IleThr: 4.141 ± 0.053	4.592IleVal: 4.592 ± 0.064	0.684IleTrp: 0.684 ± 0.023	2.644IleTyr: 2.644 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.442LysAla: 4.442 ± 0.058	0.523LysCys: 0.523 ± 0.019	3.081LysAsp: 3.081 ± 0.05	5.188LysGlu: 5.188 ± 0.064	1.576LysPhe: 1.576 ± 0.033	3.657LysGly: 3.657 ± 0.045	0.884LysHis: 0.884 ± 0.026	3.716LysIle: 3.716 ± 0.049	4.493LysLys: 4.493 ± 0.066	4.743LysLeu: 4.743 ± 0.057	1.884LysMet: 1.884 ± 0.036	2.822LysAsn: 2.822 ± 0.046	1.967LysPro: 1.967 ± 0.041	2.072LysGln: 2.072 ± 0.038	2.887LysArg: 2.887 ± 0.048	3.039LysSer: 3.039 ± 0.048	3.347LysThr: 3.347 ± 0.043	3.67LysVal: 3.67 ± 0.051	0.536LysTrp: 0.536 ± 0.021	2.234LysTyr: 2.234 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	7.38LeuAla: 7.38 ± 0.067	1.449LeuCys: 1.449 ± 0.029	4.871LeuAsp: 4.871 ± 0.061	6.566LeuGlu: 6.566 ± 0.076	3.862LeuPhe: 3.862 ± 0.061	6.338LeuGly: 6.338 ± 0.078	1.493LeuHis: 1.493 ± 0.034	5.63LeuIle: 5.63 ± 0.071	5.53LeuLys: 5.53 ± 0.067	8.556LeuLeu: 8.556 ± 0.104	2.779LeuMet: 2.779 ± 0.043	3.729LeuAsn: 3.729 ± 0.045	3.78LeuPro: 3.78 ± 0.045	2.52LeuGln: 2.52 ± 0.048	3.642LeuArg: 3.642 ± 0.054	6.026LeuSer: 6.026 ± 0.073	5.166LeuThr: 5.166 ± 0.059	5.943LeuVal: 5.943 ± 0.065	0.857LeuTrp: 0.857 ± 0.023	3.361LeuTyr: 3.361 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.952MetAla: 2.952 ± 0.046	0.341MetCys: 0.341 ± 0.015	1.942MetAsp: 1.942 ± 0.035	2.89MetGlu: 2.89 ± 0.043	1.071MetPhe: 1.071 ± 0.027	2.407MetGly: 2.407 ± 0.044	0.368MetHis: 0.368 ± 0.013	2.226MetIle: 2.226 ± 0.041	2.513MetLys: 2.513 ± 0.045	2.819MetLeu: 2.819 ± 0.048	1.157MetMet: 1.157 ± 0.031	1.531MetAsn: 1.531 ± 0.032	1.176MetPro: 1.176 ± 0.024	0.863MetGln: 0.863 ± 0.024	1.474MetArg: 1.474 ± 0.029	1.879MetSer: 1.879 ± 0.034	1.949MetThr: 1.949 ± 0.037	2.228MetVal: 2.228 ± 0.036	0.246MetTrp: 0.246 ± 0.011	0.841MetTyr: 0.841 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.963AsnAla: 2.963 ± 0.05	0.72AsnCys: 0.72 ± 0.033	1.899AsnAsp: 1.899 ± 0.034	2.341AsnGlu: 2.341 ± 0.04	1.398AsnPhe: 1.398 ± 0.031	3.702AsnGly: 3.702 ± 0.071	0.891AsnHis: 0.891 ± 0.026	2.918AsnIle: 2.918 ± 0.044	1.878AsnLys: 1.878 ± 0.04	3.81AsnLeu: 3.81 ± 0.049	1.339AsnMet: 1.339 ± 0.029	1.635AsnAsn: 1.635 ± 0.036	2.197AsnPro: 2.197 ± 0.041	1.743AsnGln: 1.743 ± 0.034	2.26AsnArg: 2.26 ± 0.043	2.432AsnSer: 2.432 ± 0.05	2.302AsnThr: 2.302 ± 0.045	2.633AsnVal: 2.633 ± 0.043	0.474AsnTrp: 0.474 ± 0.018	1.766AsnTyr: 1.766 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	2.943ProAla: 2.943 ± 0.047	0.479ProCys: 0.479 ± 0.02	2.384ProAsp: 2.384 ± 0.037	3.611ProGlu: 3.611 ± 0.053	1.529ProPhe: 1.529 ± 0.032	2.98ProGly: 2.98 ± 0.049	0.6ProHis: 0.6 ± 0.018	2.122ProIle: 2.122 ± 0.036	1.586ProLys: 1.586 ± 0.038	2.881ProLeu: 2.881 ± 0.04	1.013ProMet: 1.013 ± 0.023	1.161ProAsn: 1.161 ± 0.028	0.97ProPro: 0.97 ± 0.037	1.048ProGln: 1.048 ± 0.029	1.03ProArg: 1.03 ± 0.024	2.04ProSer: 2.04 ± 0.038	1.634ProThr: 1.634 ± 0.035	3.378ProVal: 3.378 ± 0.051	0.415ProTrp: 0.415 ± 0.016	1.516ProTyr: 1.516 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.561GlnAla: 2.561 ± 0.046	0.387GlnCys: 0.387 ± 0.016	1.47GlnAsp: 1.47 ± 0.032	2.696GlnGlu: 2.696 ± 0.044	1.241GlnPhe: 1.241 ± 0.027	2.098GlnGly: 2.098 ± 0.039	0.404GlnHis: 0.404 ± 0.015	2.455GlnIle: 2.455 ± 0.039	2.09GlnLys: 2.09 ± 0.04	2.922GlnLeu: 2.922 ± 0.041	1.364GlnMet: 1.364 ± 0.026	1.522GlnAsn: 1.522 ± 0.03	1.069GlnPro: 1.069 ± 0.028	1.052GlnGln: 1.052 ± 0.027	1.278GlnArg: 1.278 ± 0.029	1.747GlnSer: 1.747 ± 0.035	1.79GlnThr: 1.79 ± 0.036	2.361GlnVal: 2.361 ± 0.039	0.354GlnTrp: 0.354 ± 0.015	1.462GlnTyr: 1.462 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	2.948ArgAla: 2.948 ± 0.044	0.609ArgCys: 0.609 ± 0.021	2.429ArgAsp: 2.429 ± 0.044	4.225ArgGlu: 4.225 ± 0.061	1.875ArgPhe: 1.875 ± 0.036	2.722ArgGly: 2.722 ± 0.043	0.818ArgHis: 0.818 ± 0.023	3.434ArgIle: 3.434 ± 0.044	3.07ArgLys: 3.07 ± 0.053	4.193ArgLeu: 4.193 ± 0.061	1.738ArgMet: 1.738 ± 0.033	2.083ArgAsn: 2.083 ± 0.038	1.465ArgPro: 1.465 ± 0.03	1.917ArgGln: 1.917 ± 0.033	2.585ArgArg: 2.585 ± 0.052	2.099ArgSer: 2.099 ± 0.034	2.369ArgThr: 2.369 ± 0.039	3.014ArgVal: 3.014 ± 0.05	0.463ArgTrp: 0.463 ± 0.016	2.111ArgTyr: 2.111 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	4.343SerAla: 4.343 ± 0.058	0.816SerCys: 0.816 ± 0.025	3.129SerAsp: 3.129 ± 0.049	3.708SerGlu: 3.708 ± 0.056	2.607SerPhe: 2.607 ± 0.04	5.839SerGly: 5.839 ± 0.104	1.124SerHis: 1.124 ± 0.029	4.102SerIle: 4.102 ± 0.057	2.765SerLys: 2.765 ± 0.039	5.244SerLeu: 5.244 ± 0.06	2.07SerMet: 2.07 ± 0.036	2.207SerAsn: 2.207 ± 0.04	2.037SerPro: 2.037 ± 0.035	2.08SerGln: 2.08 ± 0.042	3.048SerArg: 3.048 ± 0.046	3.973SerSer: 3.973 ± 0.079	3.019SerThr: 3.019 ± 0.053	4.415SerVal: 4.415 ± 0.058	0.718SerTrp: 0.718 ± 0.023	2.453SerTyr: 2.453 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.204ThrAla: 5.204 ± 0.077	0.663ThrCys: 0.663 ± 0.022	3.053ThrAsp: 3.053 ± 0.051	3.919ThrGlu: 3.919 ± 0.057	2.167ThrPhe: 2.167 ± 0.036	5.691ThrGly: 5.691 ± 0.11	0.781ThrHis: 0.781 ± 0.022	3.798ThrIle: 3.798 ± 0.054	2.571ThrLys: 2.571 ± 0.04	4.938ThrLeu: 4.938 ± 0.058	1.599ThrMet: 1.599 ± 0.032	1.976ThrAsn: 1.976 ± 0.039	2.427ThrPro: 2.427 ± 0.04	1.385ThrGln: 1.385 ± 0.031	2.093ThrArg: 2.093 ± 0.036	3.246ThrSer: 3.246 ± 0.059	3.095ThrThr: 3.095 ± 0.058	5.002ThrVal: 5.002 ± 0.058	0.599ThrTrp: 0.599 ± 0.026	2.133ThrTyr: 2.133 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	4.938ValAla: 4.938 ± 0.065	1.152ValCys: 1.152 ± 0.027	3.9ValAsp: 3.9 ± 0.049	5.206ValGlu: 5.206 ± 0.065	2.94ValPhe: 2.94 ± 0.041	4.754ValGly: 4.754 ± 0.066	1.035ValHis: 1.035 ± 0.025	5.159ValIle: 5.159 ± 0.063	4.061ValLys: 4.061 ± 0.057	6.865ValLeu: 6.865 ± 0.075	2.343ValMet: 2.343 ± 0.041	3.018ValAsn: 3.018 ± 0.041	2.707ValPro: 2.707 ± 0.042	1.824ValGln: 1.824 ± 0.032	3.101ValArg: 3.101 ± 0.05	4.782ValSer: 4.782 ± 0.054	4.669ValThr: 4.669 ± 0.069	5.184ValVal: 5.184 ± 0.068	0.727ValTrp: 0.727 ± 0.022	2.784ValTyr: 2.784 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.604TrpAla: 0.604 ± 0.018	0.149TrpCys: 0.149 ± 0.009	0.605TrpAsp: 0.605 ± 0.02	0.775TrpGlu: 0.775 ± 0.022	0.506TrpPhe: 0.506 ± 0.018	0.73TrpGly: 0.73 ± 0.02	0.161TrpHis: 0.161 ± 0.009	0.662TrpIle: 0.662 ± 0.02	0.74TrpLys: 0.74 ± 0.02	1.037TrpLeu: 1.037 ± 0.024	0.396TrpMet: 0.396 ± 0.015	0.623TrpAsn: 0.623 ± 0.019	0.258TrpPro: 0.258 ± 0.011	0.394TrpGln: 0.394 ± 0.016	0.441TrpArg: 0.441 ± 0.018	0.567TrpSer: 0.567 ± 0.019	0.517TrpThr: 0.517 ± 0.02	0.64TrpVal: 0.64 ± 0.017	0.135TrpTrp: 0.135 ± 0.009	0.504TrpTyr: 0.504 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.695TyrAla: 2.695 ± 0.041	0.626TyrCys: 0.626 ± 0.019	2.356TyrAsp: 2.356 ± 0.056	2.984TyrGlu: 2.984 ± 0.047	1.785TyrPhe: 1.785 ± 0.036	3.252TyrGly: 3.252 ± 0.052	0.895TyrHis: 0.895 ± 0.024	2.508TyrIle: 2.508 ± 0.038	1.826TyrLys: 1.826 ± 0.037	4.091TyrLeu: 4.091 ± 0.061	1.044TyrMet: 1.044 ± 0.023	1.803TyrAsn: 1.803 ± 0.044	1.591TyrPro: 1.591 ± 0.034	1.8TyrGln: 1.8 ± 0.036	2.252TyrArg: 2.252 ± 0.035	2.286TyrSer: 2.286 ± 0.039	2.277TyrThr: 2.277 ± 0.043	2.637TyrVal: 2.637 ± 0.037	0.42TyrTrp: 0.42 ± 0.016	1.912TyrTyr: 1.912 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5166 proteins (1708591 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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