Amino acid dipepetide frequency for Pseudanabaena sp. PCC 7367

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.451AlaAla: 9.451 ± 0.107
0.847AlaCys: 0.847 ± 0.028
5.488AlaAsp: 5.488 ± 0.073
6.133AlaGlu: 6.133 ± 0.092
2.854AlaPhe: 2.854 ± 0.049
6.039AlaGly: 6.039 ± 0.084
1.466AlaHis: 1.466 ± 0.037
8.877AlaIle: 8.877 ± 0.099
4.805AlaLys: 4.805 ± 0.073
8.566AlaLeu: 8.566 ± 0.108
2.027AlaMet: 2.027 ± 0.05
4.768AlaAsn: 4.768 ± 0.097
3.591AlaPro: 3.591 ± 0.061
5.006AlaGln: 5.006 ± 0.079
3.766AlaArg: 3.766 ± 0.058
5.264AlaSer: 5.264 ± 0.073
5.214AlaThr: 5.214 ± 0.071
5.547AlaVal: 5.547 ± 0.078
1.037AlaTrp: 1.037 ± 0.034
2.54AlaTyr: 2.54 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.654CysAla: 0.654 ± 0.026
0.133CysCys: 0.133 ± 0.01
0.706CysAsp: 0.706 ± 0.025
0.462CysGlu: 0.462 ± 0.02
0.368CysPhe: 0.368 ± 0.016
0.738CysGly: 0.738 ± 0.024
0.249CysHis: 0.249 ± 0.016
0.567CysIle: 0.567 ± 0.02
0.302CysLys: 0.302 ± 0.016
1.065CysLeu: 1.065 ± 0.038
0.178CysMet: 0.178 ± 0.013
0.361CysAsn: 0.361 ± 0.02
0.479CysPro: 0.479 ± 0.02
0.529CysGln: 0.529 ± 0.019
0.501CysArg: 0.501 ± 0.019
0.521CysSer: 0.521 ± 0.021
0.411CysThr: 0.411 ± 0.019
0.514CysVal: 0.514 ± 0.018
0.125CysTrp: 0.125 ± 0.01
0.321CysTyr: 0.321 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
4.378AspAla: 4.378 ± 0.074
0.599AspCys: 0.599 ± 0.024
2.842AspAsp: 2.842 ± 0.077
2.81AspGlu: 2.81 ± 0.059
2.519AspPhe: 2.519 ± 0.054
3.608AspGly: 3.608 ± 0.074
1.156AspHis: 1.156 ± 0.036
3.338AspIle: 3.338 ± 0.057
1.795AspLys: 1.795 ± 0.042
7.266AspLeu: 7.266 ± 0.103
0.988AspMet: 0.988 ± 0.027
1.983AspAsn: 1.983 ± 0.05
3.327AspPro: 3.327 ± 0.078
3.292AspGln: 3.292 ± 0.065
6.249AspArg: 6.249 ± 0.077
3.089AspSer: 3.089 ± 0.055
2.407AspThr: 2.407 ± 0.048
3.091AspVal: 3.091 ± 0.057
0.905AspTrp: 0.905 ± 0.027
2.028AspTyr: 2.028 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
5.964GluAla: 5.964 ± 0.087
0.368GluCys: 0.368 ± 0.017
2.69GluAsp: 2.69 ± 0.054
3.224GluGlu: 3.224 ± 0.066
2.442GluPhe: 2.442 ± 0.046
2.901GluGly: 2.901 ± 0.056
1.185GluHis: 1.185 ± 0.031
4.665GluIle: 4.665 ± 0.062
2.601GluLys: 2.601 ± 0.051
7.273GluLeu: 7.273 ± 0.094
1.436GluMet: 1.436 ± 0.037
2.246GluAsn: 2.246 ± 0.048
3.044GluPro: 3.044 ± 0.054
3.922GluGln: 3.922 ± 0.08
2.849GluArg: 2.849 ± 0.052
3.521GluSer: 3.521 ± 0.069
3.171GluThr: 3.171 ± 0.055
4.153GluVal: 4.153 ± 0.062
0.669GluTrp: 0.669 ± 0.023
1.742GluTyr: 1.742 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.425PheAla: 3.425 ± 0.058
0.475PheCys: 0.475 ± 0.02
2.497PheAsp: 2.497 ± 0.043
2.206PheGlu: 2.206 ± 0.043
1.577PhePhe: 1.577 ± 0.041
3.004PheGly: 3.004 ± 0.052
0.581PheHis: 0.581 ± 0.022
2.084PheIle: 2.084 ± 0.041
1.552PheLys: 1.552 ± 0.034
3.734PheLeu: 3.734 ± 0.063
0.805PheMet: 0.805 ± 0.027
1.744PheAsn: 1.744 ± 0.045
1.579PhePro: 1.579 ± 0.038
1.394PheGln: 1.394 ± 0.036
1.719PheArg: 1.719 ± 0.038
2.645PheSer: 2.645 ± 0.052
2.201PheThr: 2.201 ± 0.047
2.436PheVal: 2.436 ± 0.051
0.69PheTrp: 0.69 ± 0.024
1.257PheTyr: 1.257 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
5.727GlyAla: 5.727 ± 0.094
0.682GlyCys: 0.682 ± 0.023
4.351GlyAsp: 4.351 ± 0.072
3.729GlyGlu: 3.729 ± 0.055
2.96GlyPhe: 2.96 ± 0.057
4.686GlyGly: 4.686 ± 0.106
1.213GlyHis: 1.213 ± 0.032
4.999GlyIle: 4.999 ± 0.073
3.63GlyLys: 3.63 ± 0.061
6.941GlyLeu: 6.941 ± 0.081
1.708GlyMet: 1.708 ± 0.04
3.277GlyAsn: 3.277 ± 0.086
1.214GlyPro: 1.214 ± 0.031
3.225GlyGln: 3.225 ± 0.055
3.066GlyArg: 3.066 ± 0.056
4.269GlySer: 4.269 ± 0.067
3.613GlyThr: 3.613 ± 0.066
4.37GlyVal: 4.37 ± 0.072
1.06GlyTrp: 1.06 ± 0.03
2.248GlyTyr: 2.248 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.327HisAla: 1.327 ± 0.036
0.244HisCys: 0.244 ± 0.015
1.0HisAsp: 1.0 ± 0.03
0.984HisGlu: 0.984 ± 0.029
0.699HisPhe: 0.699 ± 0.027
1.151HisGly: 1.151 ± 0.035
0.583HisHis: 0.583 ± 0.026
0.972HisIle: 0.972 ± 0.029
0.833HisLys: 0.833 ± 0.026
2.143HisLeu: 2.143 ± 0.046
0.341HisMet: 0.341 ± 0.016
0.878HisAsn: 0.878 ± 0.027
1.185HisPro: 1.185 ± 0.034
1.105HisGln: 1.105 ± 0.033
1.022HisArg: 1.022 ± 0.029
1.155HisSer: 1.155 ± 0.03
0.864HisThr: 0.864 ± 0.028
0.946HisVal: 0.946 ± 0.029
0.289HisTrp: 0.289 ± 0.014
0.638HisTyr: 0.638 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
8.797IleAla: 8.797 ± 0.099
0.719IleCys: 0.719 ± 0.026
4.855IleAsp: 4.855 ± 0.069
4.786IleGlu: 4.786 ± 0.061
2.407IlePhe: 2.407 ± 0.045
4.792IleGly: 4.792 ± 0.075
1.073IleHis: 1.073 ± 0.033
3.299IleIle: 3.299 ± 0.056
2.97IleLys: 2.97 ± 0.055
5.852IleLeu: 5.852 ± 0.076
1.157IleMet: 1.157 ± 0.033
3.205IleAsn: 3.205 ± 0.058
3.046IlePro: 3.046 ± 0.053
2.374IleGln: 2.374 ± 0.046
2.829IleArg: 2.829 ± 0.049
4.469IleSer: 4.469 ± 0.066
3.919IleThr: 3.919 ± 0.072
4.391IleVal: 4.391 ± 0.062
0.852IleTrp: 0.852 ± 0.029
1.792IleTyr: 1.792 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
3.867LysAla: 3.867 ± 0.064
0.276LysCys: 0.276 ± 0.016
2.021LysAsp: 2.021 ± 0.049
2.403LysGlu: 2.403 ± 0.057
1.654LysPhe: 1.654 ± 0.042
2.297LysGly: 2.297 ± 0.049
0.883LysHis: 0.883 ± 0.026
2.899LysIle: 2.899 ± 0.055
1.947LysLys: 1.947 ± 0.054
5.22LysLeu: 5.22 ± 0.067
0.901LysMet: 0.901 ± 0.029
1.655LysAsn: 1.655 ± 0.039
2.507LysPro: 2.507 ± 0.053
2.787LysGln: 2.787 ± 0.06
2.245LysArg: 2.245 ± 0.054
2.897LysSer: 2.897 ± 0.057
2.32LysThr: 2.32 ± 0.049
2.786LysVal: 2.786 ± 0.051
0.443LysTrp: 0.443 ± 0.021
1.358LysTyr: 1.358 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
10.736LeuAla: 10.736 ± 0.112
0.929LeuCys: 0.929 ± 0.031
6.182LeuAsp: 6.182 ± 0.083
6.986LeuGlu: 6.986 ± 0.084
3.585LeuPhe: 3.585 ± 0.064
7.421LeuGly: 7.421 ± 0.092
1.732LeuHis: 1.732 ± 0.044
6.607LeuIle: 6.607 ± 0.083
4.703LeuLys: 4.703 ± 0.066
10.059LeuLeu: 10.059 ± 0.147
1.972LeuMet: 1.972 ± 0.043
4.52LeuAsn: 4.52 ± 0.065
5.501LeuPro: 5.501 ± 0.074
4.765LeuGln: 4.765 ± 0.07
5.331LeuArg: 5.331 ± 0.077
7.194LeuSer: 7.194 ± 0.09
5.781LeuThr: 5.781 ± 0.059
7.512LeuVal: 7.512 ± 0.089
1.223LeuTrp: 1.223 ± 0.033
2.403LeuTyr: 2.403 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
2.308MetAla: 2.308 ± 0.041
0.15MetCys: 0.15 ± 0.011
0.857MetAsp: 0.857 ± 0.03
0.996MetGlu: 0.996 ± 0.03
0.678MetPhe: 0.678 ± 0.023
1.488MetGly: 1.488 ± 0.041
0.395MetHis: 0.395 ± 0.02
1.252MetIle: 1.252 ± 0.033
0.742MetLys: 0.742 ± 0.024
2.111MetLeu: 2.111 ± 0.049
0.447MetMet: 0.447 ± 0.02
0.757MetAsn: 0.757 ± 0.025
1.335MetPro: 1.335 ± 0.033
1.124MetGln: 1.124 ± 0.031
1.047MetArg: 1.047 ± 0.03
1.387MetSer: 1.387 ± 0.037
1.212MetThr: 1.212 ± 0.031
1.455MetVal: 1.455 ± 0.036
0.181MetTrp: 0.181 ± 0.012
0.396MetTyr: 0.396 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.389AsnAla: 3.389 ± 0.05
0.427AsnCys: 0.427 ± 0.018
2.069AsnAsp: 2.069 ± 0.05
1.853AsnGlu: 1.853 ± 0.043
1.805AsnPhe: 1.805 ± 0.043
2.983AsnGly: 2.983 ± 0.075
1.015AsnHis: 1.015 ± 0.029
2.534AsnIle: 2.534 ± 0.049
1.461AsnLys: 1.461 ± 0.031
5.775AsnLeu: 5.775 ± 0.112
0.848AsnMet: 0.848 ± 0.03
2.173AsnAsn: 2.173 ± 0.053
3.037AsnPro: 3.037 ± 0.058
3.059AsnGln: 3.059 ± 0.06
2.383AsnArg: 2.383 ± 0.052
3.041AsnSer: 3.041 ± 0.06
2.126AsnThr: 2.126 ± 0.047
2.157AsnVal: 2.157 ± 0.047
0.665AsnTrp: 0.665 ± 0.024
1.442AsnTyr: 1.442 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
4.1ProAla: 4.1 ± 0.064
0.305ProCys: 0.305 ± 0.02
3.605ProAsp: 3.605 ± 0.066
4.009ProGlu: 4.009 ± 0.068
1.59ProPhe: 1.59 ± 0.042
3.231ProGly: 3.231 ± 0.056
0.857ProHis: 0.857 ± 0.026
3.424ProIle: 3.424 ± 0.049
2.07ProLys: 2.07 ± 0.051
4.094ProLeu: 4.094 ± 0.062
0.83ProMet: 0.83 ± 0.027
2.388ProAsn: 2.388 ± 0.051
2.229ProPro: 2.229 ± 0.05
2.388ProGln: 2.388 ± 0.05
1.87ProArg: 1.87 ± 0.041
2.767ProSer: 2.767 ± 0.053
3.105ProThr: 3.105 ± 0.067
3.045ProVal: 3.045 ± 0.054
0.577ProTrp: 0.577 ± 0.022
1.227ProTyr: 1.227 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
5.311GlnAla: 5.311 ± 0.075
0.293GlnCys: 0.293 ± 0.016
2.442GlnAsp: 2.442 ± 0.048
3.247GlnGlu: 3.247 ± 0.067
1.789GlnPhe: 1.789 ± 0.043
2.859GlnGly: 2.859 ± 0.045
0.885GlnHis: 0.885 ± 0.026
3.91GlnIle: 3.91 ± 0.045
2.488GlnLys: 2.488 ± 0.043
5.714GlnLeu: 5.714 ± 0.082
1.1GlnMet: 1.1 ± 0.036
2.153GlnAsn: 2.153 ± 0.052
2.909GlnPro: 2.909 ± 0.054
3.349GlnGln: 3.349 ± 0.08
2.721GlnArg: 2.721 ± 0.049
3.307GlnSer: 3.307 ± 0.07
2.984GlnThr: 2.984 ± 0.053
3.894GlnVal: 3.894 ± 0.052
0.616GlnTrp: 0.616 ± 0.025
1.152GlnTyr: 1.152 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
3.797ArgAla: 3.797 ± 0.057
0.455ArgCys: 0.455 ± 0.02
2.913ArgAsp: 2.913 ± 0.051
2.793ArgGlu: 2.793 ± 0.056
2.112ArgPhe: 2.112 ± 0.044
3.019ArgGly: 3.019 ± 0.048
1.088ArgHis: 1.088 ± 0.028
3.345ArgIle: 3.345 ± 0.054
2.16ArgLys: 2.16 ± 0.052
5.987ArgLeu: 5.987 ± 0.077
1.04ArgMet: 1.04 ± 0.032
2.11ArgAsn: 2.11 ± 0.04
2.157ArgPro: 2.157 ± 0.045
3.383ArgGln: 3.383 ± 0.054
3.017ArgArg: 3.017 ± 0.05
4.191ArgSer: 4.191 ± 0.063
2.354ArgThr: 2.354 ± 0.047
3.266ArgVal: 3.266 ± 0.057
0.703ArgTrp: 0.703 ± 0.024
1.827ArgTyr: 1.827 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
5.219SerAla: 5.219 ± 0.063
0.606SerCys: 0.606 ± 0.024
4.06SerAsp: 4.06 ± 0.063
3.655SerGlu: 3.655 ± 0.059
2.499SerPhe: 2.499 ± 0.048
4.893SerGly: 4.893 ± 0.087
1.228SerHis: 1.228 ± 0.034
4.122SerIle: 4.122 ± 0.065
2.711SerLys: 2.711 ± 0.05
6.874SerLeu: 6.874 ± 0.085
1.346SerMet: 1.346 ± 0.033
3.066SerAsn: 3.066 ± 0.06
3.281SerPro: 3.281 ± 0.058
3.406SerGln: 3.406 ± 0.059
3.078SerArg: 3.078 ± 0.049
4.54SerSer: 4.54 ± 0.072
3.414SerThr: 3.414 ± 0.053
3.389SerVal: 3.389 ± 0.057
0.852SerTrp: 0.852 ± 0.024
1.744SerTyr: 1.744 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
5.102ThrAla: 5.102 ± 0.075
0.497ThrCys: 0.497 ± 0.021
2.941ThrAsp: 2.941 ± 0.066
3.311ThrGlu: 3.311 ± 0.056
1.887ThrPhe: 1.887 ± 0.043
3.988ThrGly: 3.988 ± 0.066
0.831ThrHis: 0.831 ± 0.028
4.078ThrIle: 4.078 ± 0.069
2.401ThrLys: 2.401 ± 0.05
5.072ThrLeu: 5.072 ± 0.073
0.973ThrMet: 0.973 ± 0.031
2.625ThrAsn: 2.625 ± 0.05
2.845ThrPro: 2.845 ± 0.061
2.35ThrGln: 2.35 ± 0.049
2.207ThrArg: 2.207 ± 0.045
3.38ThrSer: 3.38 ± 0.056
3.337ThrThr: 3.337 ± 0.071
3.573ThrVal: 3.573 ± 0.06
0.667ThrTrp: 0.667 ± 0.022
1.648ThrTyr: 1.648 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
6.286ValAla: 6.286 ± 0.075
0.692ValCys: 0.692 ± 0.025
3.783ValAsp: 3.783 ± 0.058
4.121ValGlu: 4.121 ± 0.062
2.38ValPhe: 2.38 ± 0.05
4.738ValGly: 4.738 ± 0.068
0.961ValHis: 0.961 ± 0.03
4.317ValIle: 4.317 ± 0.067
2.841ValLys: 2.841 ± 0.059
6.233ValLeu: 6.233 ± 0.079
1.473ValMet: 1.473 ± 0.037
2.917ValAsn: 2.917 ± 0.052
2.791ValPro: 2.791 ± 0.05
2.475ValGln: 2.475 ± 0.046
3.059ValArg: 3.059 ± 0.05
3.979ValSer: 3.979 ± 0.064
3.517ValThr: 3.517 ± 0.061
4.909ValVal: 4.909 ± 0.086
0.802ValTrp: 0.802 ± 0.028
1.755ValTyr: 1.755 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
0.935TrpAla: 0.935 ± 0.026
0.141TrpCys: 0.141 ± 0.012
0.583TrpAsp: 0.583 ± 0.021
0.641TrpGlu: 0.641 ± 0.022
0.537TrpPhe: 0.537 ± 0.023
0.873TrpGly: 0.873 ± 0.026
0.364TrpHis: 0.364 ± 0.018
0.735TrpIle: 0.735 ± 0.023
0.334TrpLys: 0.334 ± 0.017
1.923TrpLeu: 1.923 ± 0.052
0.242TrpMet: 0.242 ± 0.016
0.408TrpAsn: 0.408 ± 0.019
0.33TrpPro: 0.33 ± 0.017
1.525TrpGln: 1.525 ± 0.042
0.94TrpArg: 0.94 ± 0.032
0.726TrpSer: 0.726 ± 0.024
0.448TrpThr: 0.448 ± 0.018
0.784TrpVal: 0.784 ± 0.028
0.237TrpTrp: 0.237 ± 0.017
0.345TrpTyr: 0.345 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.512TyrAla: 2.512 ± 0.041
0.347TyrCys: 0.347 ± 0.016
1.788TyrAsp: 1.788 ± 0.061
1.717TyrGlu: 1.717 ± 0.041
1.262TyrPhe: 1.262 ± 0.038
2.256TyrGly: 2.256 ± 0.044
0.617TyrHis: 0.617 ± 0.025
1.563TyrIle: 1.563 ± 0.038
1.023TyrLys: 1.023 ± 0.031
3.241TyrLeu: 3.241 ± 0.053
0.504TyrMet: 0.504 ± 0.021
1.005TyrAsn: 1.005 ± 0.031
1.322TyrPro: 1.322 ± 0.036
1.664TyrGln: 1.664 ± 0.039
1.815TyrArg: 1.815 ± 0.037
1.64TyrSer: 1.64 ± 0.04
1.318TyrThr: 1.318 ± 0.037
1.811TyrVal: 1.811 ± 0.041
0.458TyrTrp: 0.458 ± 0.02
1.011TyrTyr: 1.011 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3824 proteins (1251467 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski