Amino acid dipepetide frequency for Mangrovibacterium diazotrophicum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.551AlaAla: 5.551 ± 0.078	0.784AlaCys: 0.784 ± 0.027	4.455AlaAsp: 4.455 ± 0.061	4.958AlaGlu: 4.958 ± 0.062	3.414AlaPhe: 3.414 ± 0.043	5.242AlaGly: 5.242 ± 0.074	1.108AlaHis: 1.108 ± 0.027	4.926AlaIle: 4.926 ± 0.052	4.143AlaLys: 4.143 ± 0.061	6.396AlaLeu: 6.396 ± 0.078	1.747AlaMet: 1.747 ± 0.033	3.356AlaAsn: 3.356 ± 0.047	2.166AlaPro: 2.166 ± 0.036	2.624AlaGln: 2.624 ± 0.038	2.605AlaArg: 2.605 ± 0.043	4.533AlaSer: 4.533 ± 0.068	3.757AlaThr: 3.757 ± 0.074	4.851AlaVal: 4.851 ± 0.062	0.918AlaTrp: 0.918 ± 0.022	2.788AlaTyr: 2.788 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.536CysAla: 0.536 ± 0.02	0.12CysCys: 0.12 ± 0.009	0.508CysAsp: 0.508 ± 0.019	0.495CysGlu: 0.495 ± 0.017	0.451CysPhe: 0.451 ± 0.015	0.733CysGly: 0.733 ± 0.028	0.256CysHis: 0.256 ± 0.027	0.532CysIle: 0.532 ± 0.02	0.478CysLys: 0.478 ± 0.017	0.838CysLeu: 0.838 ± 0.022	0.205CysMet: 0.205 ± 0.012	0.408CysAsn: 0.408 ± 0.018	0.432CysPro: 0.432 ± 0.026	0.339CysGln: 0.339 ± 0.013	0.368CysArg: 0.368 ± 0.015	0.694CysSer: 0.694 ± 0.032	0.486CysThr: 0.486 ± 0.024	0.499CysVal: 0.499 ± 0.019	0.132CysTrp: 0.132 ± 0.009	0.322CysTyr: 0.322 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.963AspAla: 3.963 ± 0.054	0.534AspCys: 0.534 ± 0.026	3.342AspAsp: 3.342 ± 0.052	4.321AspGlu: 4.321 ± 0.059	3.39AspPhe: 3.39 ± 0.041	4.479AspGly: 4.479 ± 0.066	1.037AspHis: 1.037 ± 0.028	3.66AspIle: 3.66 ± 0.047	3.341AspLys: 3.341 ± 0.044	5.705AspLeu: 5.705 ± 0.064	1.306AspMet: 1.306 ± 0.031	2.688AspAsn: 2.688 ± 0.051	2.349AspPro: 2.349 ± 0.043	2.171AspGln: 2.171 ± 0.041	2.394AspArg: 2.394 ± 0.041	3.504AspSer: 3.504 ± 0.052	2.376AspThr: 2.376 ± 0.034	3.669AspVal: 3.669 ± 0.051	0.975AspTrp: 0.975 ± 0.027	2.974AspTyr: 2.974 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.621GluAla: 4.621 ± 0.058	0.439GluCys: 0.439 ± 0.018	3.383GluAsp: 3.383 ± 0.048	4.623GluGlu: 4.623 ± 0.057	2.93GluPhe: 2.93 ± 0.046	4.022GluGly: 4.022 ± 0.055	1.162GluHis: 1.162 ± 0.027	5.024GluIle: 5.024 ± 0.062	5.203GluLys: 5.203 ± 0.068	6.76GluLeu: 6.76 ± 0.084	1.89GluMet: 1.89 ± 0.038	3.929GluAsn: 3.929 ± 0.057	1.841GluPro: 1.841 ± 0.038	2.753GluGln: 2.753 ± 0.047	2.674GluArg: 2.674 ± 0.043	3.775GluSer: 3.775 ± 0.046	3.543GluThr: 3.543 ± 0.051	4.328GluVal: 4.328 ± 0.054	0.78GluTrp: 0.78 ± 0.022	2.574GluTyr: 2.574 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.352PheAla: 3.352 ± 0.042	0.468PheCys: 0.468 ± 0.017	3.224PheAsp: 3.224 ± 0.048	3.223PheGlu: 3.223 ± 0.047	2.444PhePhe: 2.444 ± 0.045	3.51PheGly: 3.51 ± 0.056	0.891PheHis: 0.891 ± 0.027	3.138PheIle: 3.138 ± 0.045	2.776PheLys: 2.776 ± 0.047	4.438PheLeu: 4.438 ± 0.065	1.226PheMet: 1.226 ± 0.025	2.761PheAsn: 2.761 ± 0.038	1.838PhePro: 1.838 ± 0.032	1.699PheGln: 1.699 ± 0.033	2.082PheArg: 2.082 ± 0.038	3.94PheSer: 3.94 ± 0.05	2.78PheThr: 2.78 ± 0.042	3.279PheVal: 3.279 ± 0.047	0.691PheTrp: 0.691 ± 0.021	2.149PheTyr: 2.149 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.549GlyAla: 4.549 ± 0.064	0.667GlyCys: 0.667 ± 0.023	3.832GlyAsp: 3.832 ± 0.054	4.348GlyGlu: 4.348 ± 0.059	3.548GlyPhe: 3.548 ± 0.05	4.843GlyGly: 4.843 ± 0.074	1.175GlyHis: 1.175 ± 0.029	5.208GlyIle: 5.208 ± 0.062	4.877GlyLys: 4.877 ± 0.056	6.176GlyLeu: 6.176 ± 0.071	1.864GlyMet: 1.864 ± 0.035	3.52GlyAsn: 3.52 ± 0.059	1.606GlyPro: 1.606 ± 0.034	2.377GlyGln: 2.377 ± 0.038	2.54GlyArg: 2.54 ± 0.043	4.356GlySer: 4.356 ± 0.059	4.318GlyThr: 4.318 ± 0.079	4.664GlyVal: 4.664 ± 0.069	1.086GlyTrp: 1.086 ± 0.03	3.068GlyTyr: 3.068 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.085HisAla: 1.085 ± 0.025	0.189HisCys: 0.189 ± 0.01	0.908HisAsp: 0.908 ± 0.024	1.054HisGlu: 1.054 ± 0.027	1.142HisPhe: 1.142 ± 0.028	1.171HisGly: 1.171 ± 0.031	0.472HisHis: 0.472 ± 0.02	1.132HisIle: 1.132 ± 0.025	0.903HisLys: 0.903 ± 0.024	1.744HisLeu: 1.744 ± 0.033	0.368HisMet: 0.368 ± 0.015	0.824HisAsn: 0.824 ± 0.021	0.949HisPro: 0.949 ± 0.026	0.726HisGln: 0.726 ± 0.023	0.786HisArg: 0.786 ± 0.02	1.09HisSer: 1.09 ± 0.024	0.801HisThr: 0.801 ± 0.023	0.997HisVal: 0.997 ± 0.025	0.283HisTrp: 0.283 ± 0.013	0.816HisTyr: 0.816 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.092IleAla: 5.092 ± 0.06	0.638IleCys: 0.638 ± 0.019	4.458IleAsp: 4.458 ± 0.053	4.615IleGlu: 4.615 ± 0.058	3.102IlePhe: 3.102 ± 0.059	4.808IleGly: 4.808 ± 0.062	1.253IleHis: 1.253 ± 0.029	4.377IleIle: 4.377 ± 0.061	3.888IleLys: 3.888 ± 0.059	6.177IleLeu: 6.177 ± 0.067	1.243IleMet: 1.243 ± 0.031	3.375IleAsn: 3.375 ± 0.048	3.09IlePro: 3.09 ± 0.044	2.478IleGln: 2.478 ± 0.044	3.19IleArg: 3.19 ± 0.049	5.137IleSer: 5.137 ± 0.058	3.851IleThr: 3.851 ± 0.071	4.28IleVal: 4.28 ± 0.053	0.801IleTrp: 0.801 ± 0.021	2.575IleTyr: 2.575 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	4.716LysAla: 4.716 ± 0.065	0.397LysCys: 0.397 ± 0.016	3.583LysAsp: 3.583 ± 0.049	4.588LysGlu: 4.588 ± 0.068	2.414LysPhe: 2.414 ± 0.041	3.889LysGly: 3.889 ± 0.05	1.131LysHis: 1.131 ± 0.031	4.583LysIle: 4.583 ± 0.06	4.614LysLys: 4.614 ± 0.062	6.218LysLeu: 6.218 ± 0.066	1.813LysMet: 1.813 ± 0.04	3.57LysAsn: 3.57 ± 0.044	2.321LysPro: 2.321 ± 0.039	2.548LysGln: 2.548 ± 0.046	2.72LysArg: 2.72 ± 0.045	3.97LysSer: 3.97 ± 0.044	3.692LysThr: 3.692 ± 0.058	4.233LysVal: 4.233 ± 0.053	0.761LysTrp: 0.761 ± 0.02	2.677LysTyr: 2.677 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	6.755LeuAla: 6.755 ± 0.07	0.781LeuCys: 0.781 ± 0.023	5.058LeuAsp: 5.058 ± 0.058	5.726LeuGlu: 5.726 ± 0.064	4.928LeuPhe: 4.928 ± 0.064	5.799LeuGly: 5.799 ± 0.068	1.579LeuHis: 1.579 ± 0.035	6.449LeuIle: 6.449 ± 0.069	7.048LeuLys: 7.048 ± 0.076	8.961LeuLeu: 8.961 ± 0.098	2.261LeuMet: 2.261 ± 0.039	5.129LeuAsn: 5.129 ± 0.058	3.862LeuPro: 3.862 ± 0.05	3.334LeuGln: 3.334 ± 0.05	3.6LeuArg: 3.6 ± 0.049	6.694LeuSer: 6.694 ± 0.068	5.378LeuThr: 5.378 ± 0.072	6.187LeuVal: 6.187 ± 0.068	0.963LeuTrp: 0.963 ± 0.027	3.285LeuTyr: 3.285 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	1.912MetAla: 1.912 ± 0.039	0.159MetCys: 0.159 ± 0.01	1.285MetAsp: 1.285 ± 0.029	1.588MetGlu: 1.588 ± 0.032	0.891MetPhe: 0.891 ± 0.026	1.662MetGly: 1.662 ± 0.036	0.402MetHis: 0.402 ± 0.016	1.505MetIle: 1.505 ± 0.033	2.282MetLys: 2.282 ± 0.038	2.167MetLeu: 2.167 ± 0.035	0.63MetMet: 0.63 ± 0.02	1.424MetAsn: 1.424 ± 0.031	1.042MetPro: 1.042 ± 0.023	0.913MetGln: 0.913 ± 0.026	0.997MetArg: 0.997 ± 0.024	1.389MetSer: 1.389 ± 0.03	1.379MetThr: 1.379 ± 0.032	1.539MetVal: 1.539 ± 0.031	0.231MetTrp: 0.231 ± 0.012	0.731MetTyr: 0.731 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.244AsnAla: 3.244 ± 0.052	0.52AsnCys: 0.52 ± 0.027	2.784AsnAsp: 2.784 ± 0.039	3.242AsnGlu: 3.242 ± 0.041	2.636AsnPhe: 2.636 ± 0.037	3.782AsnGly: 3.782 ± 0.059	0.934AsnHis: 0.934 ± 0.026	3.526AsnIle: 3.526 ± 0.049	3.004AsnLys: 3.004 ± 0.045	4.916AsnLeu: 4.916 ± 0.066	1.278AsnMet: 1.278 ± 0.025	2.496AsnAsn: 2.496 ± 0.047	2.698AsnPro: 2.698 ± 0.042	2.079AsnGln: 2.079 ± 0.038	2.316AsnArg: 2.316 ± 0.041	3.408AsnSer: 3.408 ± 0.049	2.723AsnThr: 2.723 ± 0.046	2.998AsnVal: 2.998 ± 0.046	0.836AsnTrp: 0.836 ± 0.022	2.638AsnTyr: 2.638 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	2.82ProAla: 2.82 ± 0.046	0.246ProCys: 0.246 ± 0.016	2.761ProAsp: 2.761 ± 0.039	3.445ProGlu: 3.445 ± 0.052	1.869ProPhe: 1.869 ± 0.037	2.764ProGly: 2.764 ± 0.042	0.629ProHis: 0.629 ± 0.019	2.337ProIle: 2.337 ± 0.036	2.025ProLys: 2.025 ± 0.034	3.05ProLeu: 3.05 ± 0.043	0.843ProMet: 0.843 ± 0.024	1.835ProAsn: 1.835 ± 0.03	0.974ProPro: 0.974 ± 0.028	1.262ProGln: 1.262 ± 0.028	1.201ProArg: 1.201 ± 0.027	2.258ProSer: 2.258 ± 0.041	2.027ProThr: 2.027 ± 0.055	3.13ProVal: 3.13 ± 0.053	0.498ProTrp: 0.498 ± 0.017	1.499ProTyr: 1.499 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	2.662GlnAla: 2.662 ± 0.041	0.239GlnCys: 0.239 ± 0.014	1.703GlnAsp: 1.703 ± 0.03	2.231GlnGlu: 2.231 ± 0.033	1.762GlnPhe: 1.762 ± 0.03	1.947GlnGly: 1.947 ± 0.037	0.622GlnHis: 0.622 ± 0.018	2.691GlnIle: 2.691 ± 0.043	2.684GlnLys: 2.684 ± 0.043	4.022GlnLeu: 4.022 ± 0.052	0.936GlnMet: 0.936 ± 0.022	2.07GlnAsn: 2.07 ± 0.039	1.336GlnPro: 1.336 ± 0.029	1.793GlnGln: 1.793 ± 0.039	1.489GlnArg: 1.489 ± 0.033	2.323GlnSer: 2.323 ± 0.044	2.16GlnThr: 2.16 ± 0.037	2.384GlnVal: 2.384 ± 0.037	0.448GlnTrp: 0.448 ± 0.018	1.494GlnTyr: 1.494 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.398ArgAla: 2.398 ± 0.035	0.306ArgCys: 0.306 ± 0.017	2.088ArgAsp: 2.088 ± 0.038	2.817ArgGlu: 2.817 ± 0.043	2.309ArgPhe: 2.309 ± 0.041	2.23ArgGly: 2.23 ± 0.039	0.707ArgHis: 0.707 ± 0.02	3.138ArgIle: 3.138 ± 0.044	2.989ArgLys: 2.989 ± 0.044	3.981ArgLeu: 3.981 ± 0.051	1.176ArgMet: 1.176 ± 0.021	2.213ArgAsn: 2.213 ± 0.039	1.323ArgPro: 1.323 ± 0.027	1.565ArgGln: 1.565 ± 0.031	1.699ArgArg: 1.699 ± 0.035	2.345ArgSer: 2.345 ± 0.039	2.048ArgThr: 2.048 ± 0.032	2.546ArgVal: 2.546 ± 0.044	0.596ArgTrp: 0.596 ± 0.02	1.896ArgTyr: 1.896 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	4.508SerAla: 4.508 ± 0.063	0.709SerCys: 0.709 ± 0.024	3.877SerAsp: 3.877 ± 0.053	4.042SerGlu: 4.042 ± 0.052	3.663SerPhe: 3.663 ± 0.055	5.303SerGly: 5.303 ± 0.081	1.052SerHis: 1.052 ± 0.026	4.499SerIle: 4.499 ± 0.061	3.677SerLys: 3.677 ± 0.045	6.178SerLeu: 6.178 ± 0.063	1.482SerMet: 1.482 ± 0.039	3.157SerAsn: 3.157 ± 0.046	2.533SerPro: 2.533 ± 0.038	2.239SerGln: 2.239 ± 0.04	2.585SerArg: 2.585 ± 0.045	4.693SerSer: 4.693 ± 0.069	3.551SerThr: 3.551 ± 0.051	4.547SerVal: 4.547 ± 0.057	1.029SerTrp: 1.029 ± 0.026	3.017SerTyr: 3.017 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	4.144ThrAla: 4.144 ± 0.072	0.421ThrCys: 0.421 ± 0.026	3.574ThrAsp: 3.574 ± 0.062	3.423ThrGlu: 3.423 ± 0.042	2.598ThrPhe: 2.598 ± 0.041	4.453ThrGly: 4.453 ± 0.064	0.858ThrHis: 0.858 ± 0.022	4.159ThrIle: 4.159 ± 0.072	2.981ThrLys: 2.981 ± 0.042	4.658ThrLeu: 4.658 ± 0.06	1.072ThrMet: 1.072 ± 0.027	2.832ThrAsn: 2.832 ± 0.049	2.426ThrPro: 2.426 ± 0.052	1.72ThrGln: 1.72 ± 0.04	1.978ThrArg: 1.978 ± 0.038	3.56ThrSer: 3.56 ± 0.064	3.401ThrThr: 3.401 ± 0.071	3.977ThrVal: 3.977 ± 0.098	0.607ThrTrp: 0.607 ± 0.026	2.334ThrTyr: 2.334 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	4.808ValAla: 4.808 ± 0.056	0.67ValCys: 0.67 ± 0.023	4.112ValAsp: 4.112 ± 0.059	4.249ValGlu: 4.249 ± 0.053	3.323ValPhe: 3.323 ± 0.046	4.168ValGly: 4.168 ± 0.06	1.076ValHis: 1.076 ± 0.025	4.386ValIle: 4.386 ± 0.061	4.215ValLys: 4.215 ± 0.05	6.106ValLeu: 6.106 ± 0.059	1.518ValMet: 1.518 ± 0.03	3.43ValAsn: 3.43 ± 0.048	2.574ValPro: 2.574 ± 0.037	2.046ValGln: 2.046 ± 0.034	2.546ValArg: 2.546 ± 0.034	4.769ValSer: 4.769 ± 0.058	3.73ValThr: 3.73 ± 0.092	4.826ValVal: 4.826 ± 0.06	0.812ValTrp: 0.812 ± 0.024	2.568ValTyr: 2.568 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.854TrpAla: 0.854 ± 0.021	0.129TrpCys: 0.129 ± 0.01	0.815TrpAsp: 0.815 ± 0.023	0.882TrpGlu: 0.882 ± 0.023	0.623TrpPhe: 0.623 ± 0.022	1.018TrpGly: 1.018 ± 0.027	0.249TrpHis: 0.249 ± 0.012	0.849TrpIle: 0.849 ± 0.023	0.878TrpLys: 0.878 ± 0.026	1.192TrpLeu: 1.192 ± 0.032	0.384TrpMet: 0.384 ± 0.016	0.765TrpAsn: 0.765 ± 0.023	0.358TrpPro: 0.358 ± 0.017	0.555TrpGln: 0.555 ± 0.02	0.572TrpArg: 0.572 ± 0.017	0.82TrpSer: 0.82 ± 0.021	0.801TrpThr: 0.801 ± 0.031	0.773TrpVal: 0.773 ± 0.023	0.218TrpTrp: 0.218 ± 0.012	0.546TrpTyr: 0.546 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.751TyrAla: 2.751 ± 0.046	0.414TyrCys: 0.414 ± 0.017	2.429TyrAsp: 2.429 ± 0.044	2.386TyrGlu: 2.386 ± 0.037	2.475TyrPhe: 2.475 ± 0.045	2.799TyrGly: 2.799 ± 0.047	0.848TyrHis: 0.848 ± 0.022	2.31TyrIle: 2.31 ± 0.043	2.433TyrLys: 2.433 ± 0.039	4.096TyrLeu: 4.096 ± 0.052	0.881TyrMet: 0.881 ± 0.025	2.273TyrAsn: 2.273 ± 0.041	1.753TyrPro: 1.753 ± 0.034	1.773TyrGln: 1.773 ± 0.037	2.031TyrArg: 2.031 ± 0.034	3.082TyrSer: 3.082 ± 0.053	2.374TyrThr: 2.374 ± 0.045	2.223TyrVal: 2.223 ± 0.04	0.619TyrTrp: 0.619 ± 0.023	2.085TyrTyr: 2.085 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4641 proteins (1732579 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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