Amino acid dipepetide frequency for Streptococcus urinalis 2285-97

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.406AlaAla: 4.406 ± 0.13
0.415AlaCys: 0.415 ± 0.028
3.545AlaAsp: 3.545 ± 0.081
3.931AlaGlu: 3.931 ± 0.102
3.214AlaPhe: 3.214 ± 0.08
4.392AlaGly: 4.392 ± 0.101
1.073AlaHis: 1.073 ± 0.038
6.303AlaIle: 6.303 ± 0.107
5.355AlaLys: 5.355 ± 0.104
6.783AlaLeu: 6.783 ± 0.109
1.737AlaMet: 1.737 ± 0.057
3.397AlaAsn: 3.397 ± 0.08
1.685AlaPro: 1.685 ± 0.049
2.774AlaGln: 2.774 ± 0.085
2.353AlaArg: 2.353 ± 0.071
4.596AlaSer: 4.596 ± 0.103
3.933AlaThr: 3.933 ± 0.089
4.603AlaVal: 4.603 ± 0.106
0.566AlaTrp: 0.566 ± 0.032
2.655AlaTyr: 2.655 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
0.283CysAla: 0.283 ± 0.024
0.056CysCys: 0.056 ± 0.009
0.313CysAsp: 0.313 ± 0.023
0.234CysGlu: 0.234 ± 0.021
0.31CysPhe: 0.31 ± 0.026
0.466CysGly: 0.466 ± 0.034
0.205CysHis: 0.205 ± 0.018
0.343CysIle: 0.343 ± 0.024
0.215CysLys: 0.215 ± 0.018
0.591CysLeu: 0.591 ± 0.027
0.119CysMet: 0.119 ± 0.015
0.176CysAsn: 0.176 ± 0.017
0.235CysPro: 0.235 ± 0.02
0.386CysGln: 0.386 ± 0.027
0.211CysArg: 0.211 ± 0.019
0.324CysSer: 0.324 ± 0.024
0.207CysThr: 0.207 ± 0.018
0.342CysVal: 0.342 ± 0.023
0.027CysTrp: 0.027 ± 0.006
0.24CysTyr: 0.24 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.473AspAla: 3.473 ± 0.093
0.318AspCys: 0.318 ± 0.022
3.254AspAsp: 3.254 ± 0.094
3.732AspGlu: 3.732 ± 0.088
3.26AspPhe: 3.26 ± 0.083
3.575AspGly: 3.575 ± 0.087
1.127AspHis: 1.127 ± 0.045
4.826AspIle: 4.826 ± 0.084
4.333AspLys: 4.333 ± 0.092
5.78AspLeu: 5.78 ± 0.102
1.558AspMet: 1.558 ± 0.051
2.861AspAsn: 2.861 ± 0.073
1.61AspPro: 1.61 ± 0.048
2.224AspGln: 2.224 ± 0.067
1.869AspArg: 1.869 ± 0.056
3.392AspSer: 3.392 ± 0.089
2.785AspThr: 2.785 ± 0.067
3.607AspVal: 3.607 ± 0.08
0.585AspTrp: 0.585 ± 0.03
2.933AspTyr: 2.933 ± 0.076
0.0AspXaa: 0.0 ± 0.0
Glu
4.678GluAla: 4.678 ± 0.114
0.251GluCys: 0.251 ± 0.02
3.561GluAsp: 3.561 ± 0.075
5.269GluGlu: 5.269 ± 0.12
2.494GluPhe: 2.494 ± 0.07
3.375GluGly: 3.375 ± 0.078
1.183GluHis: 1.183 ± 0.044
4.996GluIle: 4.996 ± 0.106
6.187GluLys: 6.187 ± 0.105
6.555GluLeu: 6.555 ± 0.126
1.955GluMet: 1.955 ± 0.059
4.007GluAsn: 4.007 ± 0.075
1.551GluPro: 1.551 ± 0.049
2.438GluGln: 2.438 ± 0.075
2.636GluArg: 2.636 ± 0.077
3.906GluSer: 3.906 ± 0.088
4.026GluThr: 4.026 ± 0.087
4.348GluVal: 4.348 ± 0.099
0.534GluTrp: 0.534 ± 0.03
1.935GluTyr: 1.935 ± 0.061
0.0GluXaa: 0.0 ± 0.0
Phe
2.941PheAla: 2.941 ± 0.076
0.283PheCys: 0.283 ± 0.022
3.089PheAsp: 3.089 ± 0.08
3.184PheGlu: 3.184 ± 0.077
2.087PhePhe: 2.087 ± 0.068
3.232PheGly: 3.232 ± 0.081
0.78PheHis: 0.78 ± 0.037
3.592PheIle: 3.592 ± 0.08
3.023PheLys: 3.023 ± 0.064
4.508PheLeu: 4.508 ± 0.103
1.119PheMet: 1.119 ± 0.045
2.27PheAsn: 2.27 ± 0.063
1.486PhePro: 1.486 ± 0.049
1.605PheGln: 1.605 ± 0.056
1.391PheArg: 1.391 ± 0.045
3.575PheSer: 3.575 ± 0.081
2.526PheThr: 2.526 ± 0.067
2.918PheVal: 2.918 ± 0.068
0.447PheTrp: 0.447 ± 0.032
1.888PheTyr: 1.888 ± 0.074
0.0PheXaa: 0.0 ± 0.0
Gly
3.995GlyAla: 3.995 ± 0.096
0.345GlyCys: 0.345 ± 0.025
3.2GlyAsp: 3.2 ± 0.066
3.262GlyGlu: 3.262 ± 0.075
3.216GlyPhe: 3.216 ± 0.079
3.998GlyGly: 3.998 ± 0.116
1.362GlyHis: 1.362 ± 0.045
5.5GlyIle: 5.5 ± 0.12
4.799GlyLys: 4.799 ± 0.098
6.408GlyLeu: 6.408 ± 0.108
1.814GlyMet: 1.814 ± 0.062
2.985GlyAsn: 2.985 ± 0.079
1.257GlyPro: 1.257 ± 0.052
2.836GlyGln: 2.836 ± 0.062
2.31GlyArg: 2.31 ± 0.071
3.794GlySer: 3.794 ± 0.088
3.681GlyThr: 3.681 ± 0.114
4.311GlyVal: 4.311 ± 0.092
0.567GlyTrp: 0.567 ± 0.032
2.572GlyTyr: 2.572 ± 0.072
0.0GlyXaa: 0.0 ± 0.0
His
1.019HisAla: 1.019 ± 0.042
0.119HisCys: 0.119 ± 0.012
1.028HisAsp: 1.028 ± 0.042
1.092HisGlu: 1.092 ± 0.043
1.291HisPhe: 1.291 ± 0.048
1.117HisGly: 1.117 ± 0.044
0.647HisHis: 0.647 ± 0.036
1.501HisIle: 1.501 ± 0.054
1.116HisLys: 1.116 ± 0.042
2.237HisLeu: 2.237 ± 0.058
0.483HisMet: 0.483 ± 0.028
0.835HisAsn: 0.835 ± 0.038
0.857HisPro: 0.857 ± 0.036
1.055HisGln: 1.055 ± 0.044
0.761HisArg: 0.761 ± 0.039
1.154HisSer: 1.154 ± 0.044
0.842HisThr: 0.842 ± 0.04
1.156HisVal: 1.156 ± 0.05
0.186HisTrp: 0.186 ± 0.017
1.065HisTyr: 1.065 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
6.123IleAla: 6.123 ± 0.116
0.552IleCys: 0.552 ± 0.031
4.944IleAsp: 4.944 ± 0.094
5.179IleGlu: 5.179 ± 0.109
3.362IlePhe: 3.362 ± 0.076
5.335IleGly: 5.335 ± 0.097
1.303IleHis: 1.303 ± 0.047
6.373IleIle: 6.373 ± 0.131
5.619IleLys: 5.619 ± 0.111
7.563IleLeu: 7.563 ± 0.142
1.828IleMet: 1.828 ± 0.062
4.036IleAsn: 4.036 ± 0.097
2.996IlePro: 2.996 ± 0.074
2.583IleGln: 2.583 ± 0.064
2.574IleArg: 2.574 ± 0.072
5.926IleSer: 5.926 ± 0.107
4.565IleThr: 4.565 ± 0.093
5.176IleVal: 5.176 ± 0.095
0.644IleTrp: 0.644 ± 0.032
2.639IleTyr: 2.639 ± 0.064
0.0IleXaa: 0.0 ± 0.0
Lys
5.608LysAla: 5.608 ± 0.116
0.27LysCys: 0.27 ± 0.023
4.462LysAsp: 4.462 ± 0.106
6.571LysGlu: 6.571 ± 0.109
2.121LysPhe: 2.121 ± 0.054
4.152LysGly: 4.152 ± 0.091
1.44LysHis: 1.44 ± 0.05
5.242LysIle: 5.242 ± 0.097
6.338LysLys: 6.338 ± 0.121
6.257LysLeu: 6.257 ± 0.115
2.216LysMet: 2.216 ± 0.059
4.139LysAsn: 4.139 ± 0.085
2.316LysPro: 2.316 ± 0.064
3.122LysGln: 3.122 ± 0.077
3.208LysArg: 3.208 ± 0.079
4.979LysSer: 4.979 ± 0.102
4.877LysThr: 4.877 ± 0.1
4.999LysVal: 4.999 ± 0.1
0.726LysTrp: 0.726 ± 0.034
2.361LysTyr: 2.361 ± 0.066
0.0LysXaa: 0.0 ± 0.0
Leu
7.462LeuAla: 7.462 ± 0.121
0.502LeuCys: 0.502 ± 0.031
5.562LeuAsp: 5.562 ± 0.104
6.519LeuGlu: 6.519 ± 0.125
4.445LeuPhe: 4.445 ± 0.103
6.071LeuGly: 6.071 ± 0.117
1.502LeuHis: 1.502 ± 0.051
7.446LeuIle: 7.446 ± 0.154
7.358LeuLys: 7.358 ± 0.141
9.426LeuLeu: 9.426 ± 0.175
2.384LeuMet: 2.384 ± 0.066
4.823LeuAsn: 4.823 ± 0.088
3.61LeuPro: 3.61 ± 0.085
3.176LeuGln: 3.176 ± 0.081
3.159LeuArg: 3.159 ± 0.074
7.744LeuSer: 7.744 ± 0.113
6.052LeuThr: 6.052 ± 0.098
6.401LeuVal: 6.401 ± 0.11
0.653LeuTrp: 0.653 ± 0.037
2.966LeuTyr: 2.966 ± 0.075
0.0LeuXaa: 0.0 ± 0.0
Met
1.981MetAla: 1.981 ± 0.056
0.127MetCys: 0.127 ± 0.016
1.305MetAsp: 1.305 ± 0.043
1.272MetGlu: 1.272 ± 0.046
0.898MetPhe: 0.898 ± 0.037
1.598MetGly: 1.598 ± 0.067
0.361MetHis: 0.361 ± 0.022
2.222MetIle: 2.222 ± 0.057
1.987MetLys: 1.987 ± 0.06
2.181MetLeu: 2.181 ± 0.054
0.747MetMet: 0.747 ± 0.043
1.208MetAsn: 1.208 ± 0.043
0.814MetPro: 0.814 ± 0.036
0.849MetGln: 0.849 ± 0.039
0.92MetArg: 0.92 ± 0.035
2.039MetSer: 2.039 ± 0.064
2.27MetThr: 2.27 ± 0.057
1.644MetVal: 1.644 ± 0.053
0.149MetTrp: 0.149 ± 0.016
0.602MetTyr: 0.602 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.305AsnAla: 3.305 ± 0.08
0.291AsnCys: 0.291 ± 0.021
2.938AsnAsp: 2.938 ± 0.072
2.938AsnGlu: 2.938 ± 0.072
1.941AsnPhe: 1.941 ± 0.054
3.653AsnGly: 3.653 ± 0.08
1.482AsnHis: 1.482 ± 0.048
3.675AsnIle: 3.675 ± 0.087
3.532AsnLys: 3.532 ± 0.082
4.6AsnLeu: 4.6 ± 0.098
1.294AsnMet: 1.294 ± 0.044
2.57AsnAsn: 2.57 ± 0.071
2.26AsnPro: 2.26 ± 0.06
3.189AsnGln: 3.189 ± 0.078
2.017AsnArg: 2.017 ± 0.054
2.949AsnSer: 2.949 ± 0.082
2.667AsnThr: 2.667 ± 0.076
3.027AsnVal: 3.027 ± 0.074
0.569AsnTrp: 0.569 ± 0.031
2.154AsnTyr: 2.154 ± 0.065
0.0AsnXaa: 0.0 ± 0.0
Pro
1.861ProAla: 1.861 ± 0.06
0.119ProCys: 0.119 ± 0.015
1.844ProAsp: 1.844 ± 0.058
2.604ProGlu: 2.604 ± 0.065
1.626ProPhe: 1.626 ± 0.054
1.656ProGly: 1.656 ± 0.059
0.637ProHis: 0.637 ± 0.034
2.613ProIle: 2.613 ± 0.069
2.547ProLys: 2.547 ± 0.074
2.761ProLeu: 2.761 ± 0.064
0.652ProMet: 0.652 ± 0.035
1.831ProAsn: 1.831 ± 0.053
0.525ProPro: 0.525 ± 0.035
1.208ProGln: 1.208 ± 0.048
0.93ProArg: 0.93 ± 0.041
2.124ProSer: 2.124 ± 0.058
1.957ProThr: 1.957 ± 0.054
2.254ProVal: 2.254 ± 0.067
0.24ProTrp: 0.24 ± 0.021
1.313ProTyr: 1.313 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
3.058GlnAla: 3.058 ± 0.091
0.141GlnCys: 0.141 ± 0.015
2.117GlnAsp: 2.117 ± 0.067
2.966GlnGlu: 2.966 ± 0.075
2.186GlnPhe: 2.186 ± 0.053
2.001GlnGly: 2.001 ± 0.05
0.687GlnHis: 0.687 ± 0.033
3.038GlnIle: 3.038 ± 0.076
3.575GlnLys: 3.575 ± 0.074
4.553GlnLeu: 4.553 ± 0.092
1.11GlnMet: 1.11 ± 0.044
2.334GlnAsn: 2.334 ± 0.072
1.054GlnPro: 1.054 ± 0.043
1.536GlnGln: 1.536 ± 0.059
1.291GlnArg: 1.291 ± 0.045
2.705GlnSer: 2.705 ± 0.071
2.427GlnThr: 2.427 ± 0.06
2.944GlnVal: 2.944 ± 0.085
0.299GlnTrp: 0.299 ± 0.024
1.499GlnTyr: 1.499 ± 0.052
0.0GlnXaa: 0.0 ± 0.0
Arg
2.089ArgAla: 2.089 ± 0.064
0.175ArgCys: 0.175 ± 0.018
2.006ArgAsp: 2.006 ± 0.064
2.569ArgGlu: 2.569 ± 0.082
1.764ArgPhe: 1.764 ± 0.054
2.03ArgGly: 2.03 ± 0.055
0.822ArgHis: 0.822 ± 0.037
2.645ArgIle: 2.645 ± 0.062
2.597ArgLys: 2.597 ± 0.066
3.629ArgLeu: 3.629 ± 0.083
0.903ArgMet: 0.903 ± 0.037
1.682ArgAsn: 1.682 ± 0.052
1.13ArgPro: 1.13 ± 0.046
2.031ArgGln: 2.031 ± 0.054
1.647ArgArg: 1.647 ± 0.058
1.858ArgSer: 1.858 ± 0.054
1.795ArgThr: 1.795 ± 0.057
2.386ArgVal: 2.386 ± 0.074
0.283ArgTrp: 0.283 ± 0.025
1.478ArgTyr: 1.478 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
4.088SerAla: 4.088 ± 0.103
0.272SerCys: 0.272 ± 0.02
4.085SerAsp: 4.085 ± 0.1
4.271SerGlu: 4.271 ± 0.101
3.335SerPhe: 3.335 ± 0.081
4.592SerGly: 4.592 ± 0.089
1.653SerHis: 1.653 ± 0.045
5.2SerIle: 5.2 ± 0.118
5.002SerLys: 5.002 ± 0.097
6.684SerLeu: 6.684 ± 0.134
1.456SerMet: 1.456 ± 0.048
3.341SerAsn: 3.341 ± 0.074
1.892SerPro: 1.892 ± 0.052
3.594SerGln: 3.594 ± 0.092
2.367SerArg: 2.367 ± 0.068
4.888SerSer: 4.888 ± 0.141
3.823SerThr: 3.823 ± 0.12
4.343SerVal: 4.343 ± 0.094
0.587SerTrp: 0.587 ± 0.028
2.634SerTyr: 2.634 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
3.818ThrAla: 3.818 ± 0.088
0.288ThrCys: 0.288 ± 0.022
3.206ThrAsp: 3.206 ± 0.089
3.451ThrGlu: 3.451 ± 0.074
2.898ThrPhe: 2.898 ± 0.073
3.928ThrGly: 3.928 ± 0.083
1.081ThrHis: 1.081 ± 0.041
5.184ThrIle: 5.184 ± 0.104
4.305ThrLys: 4.305 ± 0.085
5.557ThrLeu: 5.557 ± 0.097
1.272ThrMet: 1.272 ± 0.044
2.891ThrAsn: 2.891 ± 0.078
2.295ThrPro: 2.295 ± 0.065
2.081ThrGln: 2.081 ± 0.065
1.71ThrArg: 1.71 ± 0.054
4.198ThrSer: 4.198 ± 0.121
3.561ThrThr: 3.561 ± 0.15
4.363ThrVal: 4.363 ± 0.11
0.539ThrTrp: 0.539 ± 0.034
2.52ThrTyr: 2.52 ± 0.072
0.0ThrXaa: 0.0 ± 0.0
Val
4.809ValAla: 4.809 ± 0.104
0.401ValCys: 0.401 ± 0.027
3.926ValAsp: 3.926 ± 0.095
4.217ValGlu: 4.217 ± 0.104
2.957ValPhe: 2.957 ± 0.077
4.171ValGly: 4.171 ± 0.078
0.987ValHis: 0.987 ± 0.037
5.411ValIle: 5.411 ± 0.097
4.648ValLys: 4.648 ± 0.092
6.058ValLeu: 6.058 ± 0.114
1.542ValMet: 1.542 ± 0.052
3.343ValAsn: 3.343 ± 0.077
2.256ValPro: 2.256 ± 0.058
1.904ValGln: 1.904 ± 0.051
2.275ValArg: 2.275 ± 0.063
4.987ValSer: 4.987 ± 0.089
4.697ValThr: 4.697 ± 0.114
4.535ValVal: 4.535 ± 0.104
0.563ValTrp: 0.563 ± 0.033
2.306ValTyr: 2.306 ± 0.068
0.0ValXaa: 0.0 ± 0.0
Trp
0.471TrpAla: 0.471 ± 0.028
0.052TrpCys: 0.052 ± 0.011
0.455TrpAsp: 0.455 ± 0.025
0.558TrpGlu: 0.558 ± 0.027
0.445TrpPhe: 0.445 ± 0.028
0.548TrpGly: 0.548 ± 0.027
0.2TrpHis: 0.2 ± 0.015
0.626TrpIle: 0.626 ± 0.031
0.545TrpLys: 0.545 ± 0.033
0.984TrpLeu: 0.984 ± 0.038
0.243TrpMet: 0.243 ± 0.02
0.498TrpAsn: 0.498 ± 0.029
0.148TrpPro: 0.148 ± 0.016
0.445TrpGln: 0.445 ± 0.03
0.356TrpArg: 0.356 ± 0.026
0.56TrpSer: 0.56 ± 0.035
0.509TrpThr: 0.509 ± 0.027
0.505TrpVal: 0.505 ± 0.032
0.102TrpTrp: 0.102 ± 0.013
0.359TrpTyr: 0.359 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.248TyrAla: 2.248 ± 0.055
0.307TyrCys: 0.307 ± 0.024
2.265TyrAsp: 2.265 ± 0.057
2.066TyrGlu: 2.066 ± 0.057
2.097TyrPhe: 2.097 ± 0.061
2.322TyrGly: 2.322 ± 0.062
1.028TyrHis: 1.028 ± 0.044
2.583TyrIle: 2.583 ± 0.066
2.322TyrLys: 2.322 ± 0.061
4.146TyrLeu: 4.146 ± 0.092
0.741TyrMet: 0.741 ± 0.038
1.822TyrAsn: 1.822 ± 0.056
1.324TyrPro: 1.324 ± 0.052
2.483TyrGln: 2.483 ± 0.08
1.536TyrArg: 1.536 ± 0.059
2.41TyrSer: 2.41 ± 0.079
1.946TyrThr: 1.946 ± 0.066
2.13TyrVal: 2.13 ± 0.061
0.343TyrTrp: 0.343 ± 0.021
1.771TyrTyr: 1.771 ± 0.061
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2206 proteins (629093 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski