Amino acid dipepetide frequency for Rarobacter faecitabidus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.113AlaAla: 19.113 ± 0.253
0.744AlaCys: 0.744 ± 0.033
7.886AlaAsp: 7.886 ± 0.116
6.909AlaGlu: 6.909 ± 0.121
3.238AlaPhe: 3.238 ± 0.072
12.48AlaGly: 12.48 ± 0.155
2.3AlaHis: 2.3 ± 0.058
6.256AlaIle: 6.256 ± 0.098
3.978AlaLys: 3.978 ± 0.107
12.473AlaLeu: 12.473 ± 0.168
2.438AlaMet: 2.438 ± 0.067
3.106AlaAsn: 3.106 ± 0.072
6.229AlaPro: 6.229 ± 0.122
4.298AlaGln: 4.298 ± 0.071
8.892AlaArg: 8.892 ± 0.131
8.151AlaSer: 8.151 ± 0.132
8.998AlaThr: 8.998 ± 0.15
10.191AlaVal: 10.191 ± 0.137
1.787AlaTrp: 1.787 ± 0.049
2.483AlaTyr: 2.483 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.68CysAla: 0.68 ± 0.031
0.048CysCys: 0.048 ± 0.008
0.331CysAsp: 0.331 ± 0.019
0.292CysGlu: 0.292 ± 0.02
0.134CysPhe: 0.134 ± 0.013
0.614CysGly: 0.614 ± 0.031
0.15CysHis: 0.15 ± 0.015
0.188CysIle: 0.188 ± 0.016
0.105CysLys: 0.105 ± 0.012
0.481CysLeu: 0.481 ± 0.025
0.068CysMet: 0.068 ± 0.008
0.146CysAsn: 0.146 ± 0.014
0.334CysPro: 0.334 ± 0.023
0.15CysGln: 0.15 ± 0.012
0.339CysArg: 0.339 ± 0.022
0.4CysSer: 0.4 ± 0.023
0.363CysThr: 0.363 ± 0.025
0.477CysVal: 0.477 ± 0.021
0.069CysTrp: 0.069 ± 0.009
0.133CysTyr: 0.133 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.467AspAla: 7.467 ± 0.095
0.294AspCys: 0.294 ± 0.023
3.807AspAsp: 3.807 ± 0.078
4.696AspGlu: 4.696 ± 0.094
1.766AspPhe: 1.766 ± 0.047
5.846AspGly: 5.846 ± 0.104
1.078AspHis: 1.078 ± 0.038
2.463AspIle: 2.463 ± 0.058
1.267AspLys: 1.267 ± 0.042
6.244AspLeu: 6.244 ± 0.1
0.794AspMet: 0.794 ± 0.03
1.19AspAsn: 1.19 ± 0.042
3.856AspPro: 3.856 ± 0.079
1.825AspGln: 1.825 ± 0.05
3.929AspArg: 3.929 ± 0.069
3.405AspSer: 3.405 ± 0.065
2.932AspThr: 2.932 ± 0.058
5.043AspVal: 5.043 ± 0.073
0.864AspTrp: 0.864 ± 0.036
1.379AspTyr: 1.379 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
6.348GluAla: 6.348 ± 0.122
0.305GluCys: 0.305 ± 0.02
2.833GluAsp: 2.833 ± 0.075
2.386GluGlu: 2.386 ± 0.063
1.761GluPhe: 1.761 ± 0.05
3.431GluGly: 3.431 ± 0.076
1.238GluHis: 1.238 ± 0.04
2.932GluIle: 2.932 ± 0.069
1.262GluLys: 1.262 ± 0.044
6.032GluLeu: 6.032 ± 0.115
0.849GluMet: 0.849 ± 0.035
1.259GluAsn: 1.259 ± 0.036
2.915GluPro: 2.915 ± 0.076
2.119GluGln: 2.119 ± 0.058
4.31GluArg: 4.31 ± 0.094
3.222GluSer: 3.222 ± 0.072
2.759GluThr: 2.759 ± 0.065
4.667GluVal: 4.667 ± 0.085
0.741GluTrp: 0.741 ± 0.033
1.193GluTyr: 1.193 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.854PheAla: 3.854 ± 0.071
0.171PheCys: 0.171 ± 0.013
2.222PheAsp: 2.222 ± 0.048
1.586PheGlu: 1.586 ± 0.046
0.845PhePhe: 0.845 ± 0.036
2.991PheGly: 2.991 ± 0.063
0.531PheHis: 0.531 ± 0.025
1.094PheIle: 1.094 ± 0.038
0.711PheLys: 0.711 ± 0.03
2.291PheLeu: 2.291 ± 0.063
0.365PheMet: 0.365 ± 0.023
0.75PheAsn: 0.75 ± 0.03
1.263PhePro: 1.263 ± 0.035
0.705PheGln: 0.705 ± 0.033
1.486PheArg: 1.486 ± 0.042
1.819PheSer: 1.819 ± 0.05
2.083PheThr: 2.083 ± 0.054
2.414PheVal: 2.414 ± 0.058
0.369PheTrp: 0.369 ± 0.025
0.607PheTyr: 0.607 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
10.537GlyAla: 10.537 ± 0.136
0.548GlyCys: 0.548 ± 0.029
5.313GlyAsp: 5.313 ± 0.086
4.663GlyGlu: 4.663 ± 0.085
2.833GlyPhe: 2.833 ± 0.064
7.858GlyGly: 7.858 ± 0.135
1.756GlyHis: 1.756 ± 0.048
4.512GlyIle: 4.512 ± 0.075
3.395GlyLys: 3.395 ± 0.087
7.923GlyLeu: 7.923 ± 0.113
1.736GlyMet: 1.736 ± 0.049
2.326GlyAsn: 2.326 ± 0.071
3.693GlyPro: 3.693 ± 0.065
2.966GlyGln: 2.966 ± 0.062
5.985GlyArg: 5.985 ± 0.093
6.312GlySer: 6.312 ± 0.108
6.53GlyThr: 6.53 ± 0.145
7.079GlyVal: 7.079 ± 0.097
1.431GlyTrp: 1.431 ± 0.039
2.277GlyTyr: 2.277 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
2.223HisAla: 2.223 ± 0.06
0.123HisCys: 0.123 ± 0.012
1.161HisAsp: 1.161 ± 0.036
1.023HisGlu: 1.023 ± 0.037
0.505HisPhe: 0.505 ± 0.026
1.78HisGly: 1.78 ± 0.048
0.5HisHis: 0.5 ± 0.029
0.707HisIle: 0.707 ± 0.031
0.346HisLys: 0.346 ± 0.021
1.869HisLeu: 1.869 ± 0.05
0.238HisMet: 0.238 ± 0.019
0.455HisAsn: 0.455 ± 0.019
1.199HisPro: 1.199 ± 0.04
0.562HisGln: 0.562 ± 0.03
1.439HisArg: 1.439 ± 0.049
1.135HisSer: 1.135 ± 0.04
1.028HisThr: 1.028 ± 0.035
1.577HisVal: 1.577 ± 0.045
0.309HisTrp: 0.309 ± 0.018
0.431HisTyr: 0.431 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
7.174IleAla: 7.174 ± 0.106
0.257IleCys: 0.257 ± 0.019
3.66IleAsp: 3.66 ± 0.063
3.111IleGlu: 3.111 ± 0.068
1.116IlePhe: 1.116 ± 0.038
4.434IleGly: 4.434 ± 0.088
0.727IleHis: 0.727 ± 0.03
1.752IleIle: 1.752 ± 0.053
1.32IleLys: 1.32 ± 0.043
3.468IleLeu: 3.468 ± 0.086
0.602IleMet: 0.602 ± 0.031
1.167IleAsn: 1.167 ± 0.041
2.465IlePro: 2.465 ± 0.052
1.072IleGln: 1.072 ± 0.034
2.704IleArg: 2.704 ± 0.061
2.961IleSer: 2.961 ± 0.053
3.16IleThr: 3.16 ± 0.073
4.545IleVal: 4.545 ± 0.091
0.523IleTrp: 0.523 ± 0.026
0.762IleTyr: 0.762 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
3.421LysAla: 3.421 ± 0.09
0.123LysCys: 0.123 ± 0.013
1.377LysAsp: 1.377 ± 0.045
1.062LysGlu: 1.062 ± 0.04
0.775LysPhe: 0.775 ± 0.033
1.96LysGly: 1.96 ± 0.062
0.475LysHis: 0.475 ± 0.022
1.425LysIle: 1.425 ± 0.05
1.588LysLys: 1.588 ± 0.069
2.424LysLeu: 2.424 ± 0.06
0.45LysMet: 0.45 ± 0.022
0.769LysAsn: 0.769 ± 0.032
1.505LysPro: 1.505 ± 0.047
0.821LysGln: 0.821 ± 0.03
1.932LysArg: 1.932 ± 0.055
1.892LysSer: 1.892 ± 0.058
1.975LysThr: 1.975 ± 0.069
2.859LysVal: 2.859 ± 0.086
0.407LysTrp: 0.407 ± 0.025
0.675LysTyr: 0.675 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
13.694LeuAla: 13.694 ± 0.17
0.468LeuCys: 0.468 ± 0.027
5.939LeuAsp: 5.939 ± 0.103
4.438LeuGlu: 4.438 ± 0.079
2.167LeuPhe: 2.167 ± 0.07
8.307LeuGly: 8.307 ± 0.117
1.642LeuHis: 1.642 ± 0.046
4.255LeuIle: 4.255 ± 0.096
2.109LeuLys: 2.109 ± 0.059
8.296LeuLeu: 8.296 ± 0.161
1.336LeuMet: 1.336 ± 0.044
1.991LeuAsn: 1.991 ± 0.044
5.2LeuPro: 5.2 ± 0.09
2.446LeuGln: 2.446 ± 0.053
7.057LeuArg: 7.057 ± 0.125
5.733LeuSer: 5.733 ± 0.088
6.975LeuThr: 6.975 ± 0.113
8.022LeuVal: 8.022 ± 0.128
1.149LeuTrp: 1.149 ± 0.038
1.552LeuTyr: 1.552 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
2.01MetAla: 2.01 ± 0.055
0.093MetCys: 0.093 ± 0.01
0.806MetAsp: 0.806 ± 0.032
0.555MetGlu: 0.555 ± 0.029
0.444MetPhe: 0.444 ± 0.023
1.157MetGly: 1.157 ± 0.043
0.307MetHis: 0.307 ± 0.021
0.766MetIle: 0.766 ± 0.034
0.436MetLys: 0.436 ± 0.023
1.558MetLeu: 1.558 ± 0.046
0.245MetMet: 0.245 ± 0.02
0.489MetAsn: 0.489 ± 0.023
0.918MetPro: 0.918 ± 0.034
0.409MetGln: 0.409 ± 0.023
1.307MetArg: 1.307 ± 0.041
1.394MetSer: 1.394 ± 0.039
1.548MetThr: 1.548 ± 0.047
1.192MetVal: 1.192 ± 0.044
0.207MetTrp: 0.207 ± 0.015
0.264MetTyr: 0.264 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.001AsnAla: 3.001 ± 0.069
0.165AsnCys: 0.165 ± 0.015
1.385AsnAsp: 1.385 ± 0.042
1.127AsnGlu: 1.127 ± 0.037
0.717AsnPhe: 0.717 ± 0.03
2.371AsnGly: 2.371 ± 0.079
0.425AsnHis: 0.425 ± 0.024
0.97AsnIle: 0.97 ± 0.039
0.603AsnLys: 0.603 ± 0.026
2.195AsnLeu: 2.195 ± 0.052
0.361AsnMet: 0.361 ± 0.02
0.713AsnAsn: 0.713 ± 0.039
1.902AsnPro: 1.902 ± 0.043
0.76AsnGln: 0.76 ± 0.031
1.341AsnArg: 1.341 ± 0.042
1.43AsnSer: 1.43 ± 0.048
1.352AsnThr: 1.352 ± 0.048
2.128AsnVal: 2.128 ± 0.051
0.407AsnTrp: 0.407 ± 0.022
0.638AsnTyr: 0.638 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
7.544ProAla: 7.544 ± 0.139
0.24ProCys: 0.24 ± 0.016
3.449ProAsp: 3.449 ± 0.071
3.191ProGlu: 3.191 ± 0.07
1.35ProPhe: 1.35 ± 0.041
5.514ProGly: 5.514 ± 0.101
1.021ProHis: 1.021 ± 0.034
2.249ProIle: 2.249 ± 0.057
1.279ProLys: 1.279 ± 0.042
4.264ProLeu: 4.264 ± 0.076
0.771ProMet: 0.771 ± 0.029
1.273ProAsn: 1.273 ± 0.042
2.264ProPro: 2.264 ± 0.088
1.59ProGln: 1.59 ± 0.046
3.212ProArg: 3.212 ± 0.068
3.558ProSer: 3.558 ± 0.066
3.416ProThr: 3.416 ± 0.074
4.586ProVal: 4.586 ± 0.078
0.808ProTrp: 0.808 ± 0.03
1.017ProTyr: 1.017 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
3.866GlnAla: 3.866 ± 0.068
0.179GlnCys: 0.179 ± 0.015
1.485GlnAsp: 1.485 ± 0.045
1.354GlnGlu: 1.354 ± 0.043
0.964GlnPhe: 0.964 ± 0.032
2.4GlnGly: 2.4 ± 0.048
0.619GlnHis: 0.619 ± 0.027
1.64GlnIle: 1.64 ± 0.042
0.675GlnLys: 0.675 ± 0.029
2.997GlnLeu: 2.997 ± 0.062
0.524GlnMet: 0.524 ± 0.026
0.678GlnAsn: 0.678 ± 0.03
1.746GlnPro: 1.746 ± 0.054
1.213GlnGln: 1.213 ± 0.048
2.434GlnArg: 2.434 ± 0.056
1.837GlnSer: 1.837 ± 0.054
1.726GlnThr: 1.726 ± 0.053
2.982GlnVal: 2.982 ± 0.061
0.629GlnTrp: 0.629 ± 0.03
0.769GlnTyr: 0.769 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
8.344ArgAla: 8.344 ± 0.143
0.325ArgCys: 0.325 ± 0.021
4.015ArgAsp: 4.015 ± 0.08
4.001ArgGlu: 4.001 ± 0.094
2.105ArgPhe: 2.105 ± 0.056
5.431ArgGly: 5.431 ± 0.099
1.384ArgHis: 1.384 ± 0.047
3.652ArgIle: 3.652 ± 0.072
1.838ArgLys: 1.838 ± 0.05
6.529ArgLeu: 6.529 ± 0.118
1.42ArgMet: 1.42 ± 0.04
1.522ArgAsn: 1.522 ± 0.042
3.417ArgPro: 3.417 ± 0.068
2.099ArgGln: 2.099 ± 0.058
5.811ArgArg: 5.811 ± 0.118
4.27ArgSer: 4.27 ± 0.067
4.164ArgThr: 4.164 ± 0.076
5.75ArgVal: 5.75 ± 0.094
1.113ArgTrp: 1.113 ± 0.038
1.612ArgTyr: 1.612 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
8.756SerAla: 8.756 ± 0.116
0.343SerCys: 0.343 ± 0.023
3.725SerAsp: 3.725 ± 0.065
2.964SerGlu: 2.964 ± 0.06
1.951SerPhe: 1.951 ± 0.053
6.795SerGly: 6.795 ± 0.121
1.147SerHis: 1.147 ± 0.038
2.898SerIle: 2.898 ± 0.058
1.638SerLys: 1.638 ± 0.049
5.747SerLeu: 5.747 ± 0.078
1.151SerMet: 1.151 ± 0.038
1.576SerAsn: 1.576 ± 0.05
3.37SerPro: 3.37 ± 0.066
2.009SerGln: 2.009 ± 0.052
3.984SerArg: 3.984 ± 0.077
4.652SerSer: 4.652 ± 0.095
4.122SerThr: 4.122 ± 0.086
5.195SerVal: 5.195 ± 0.089
1.031SerTrp: 1.031 ± 0.041
1.419SerTyr: 1.419 ± 0.05
0.0SerXaa: 0.0 ± 0.0
Thr
8.6ThrAla: 8.6 ± 0.138
0.353ThrCys: 0.353 ± 0.024
3.588ThrAsp: 3.588 ± 0.079
2.948ThrGlu: 2.948 ± 0.056
1.973ThrPhe: 1.973 ± 0.05
6.527ThrGly: 6.527 ± 0.128
1.044ThrHis: 1.044 ± 0.04
3.551ThrIle: 3.551 ± 0.077
1.864ThrLys: 1.864 ± 0.07
6.01ThrLeu: 6.01 ± 0.086
0.962ThrMet: 0.962 ± 0.038
1.62ThrAsn: 1.62 ± 0.05
3.936ThrPro: 3.936 ± 0.086
2.0ThrGln: 2.0 ± 0.054
3.801ThrArg: 3.801 ± 0.068
4.468ThrSer: 4.468 ± 0.107
4.665ThrThr: 4.665 ± 0.131
6.472ThrVal: 6.472 ± 0.166
1.089ThrTrp: 1.089 ± 0.039
1.736ThrTyr: 1.736 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
11.377ValAla: 11.377 ± 0.144
0.447ValCys: 0.447 ± 0.022
4.99ValAsp: 4.99 ± 0.08
4.44ValGlu: 4.44 ± 0.088
2.306ValPhe: 2.306 ± 0.053
6.763ValGly: 6.763 ± 0.12
1.527ValHis: 1.527 ± 0.049
4.252ValIle: 4.252 ± 0.08
2.649ValLys: 2.649 ± 0.086
8.108ValLeu: 8.108 ± 0.129
1.283ValMet: 1.283 ± 0.042
1.972ValAsn: 1.972 ± 0.05
4.572ValPro: 4.572 ± 0.076
2.242ValGln: 2.242 ± 0.051
5.988ValArg: 5.988 ± 0.091
5.378ValSer: 5.378 ± 0.092
7.104ValThr: 7.104 ± 0.151
7.954ValVal: 7.954 ± 0.132
1.013ValTrp: 1.013 ± 0.039
1.497ValTyr: 1.497 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
1.439TrpAla: 1.439 ± 0.043
0.114TrpCys: 0.114 ± 0.012
0.834TrpAsp: 0.834 ± 0.034
0.623TrpGlu: 0.623 ± 0.028
0.508TrpPhe: 0.508 ± 0.028
1.06TrpGly: 1.06 ± 0.038
0.384TrpHis: 0.384 ± 0.024
0.678TrpIle: 0.678 ± 0.029
0.336TrpLys: 0.336 ± 0.022
1.703TrpLeu: 1.703 ± 0.065
0.261TrpMet: 0.261 ± 0.018
0.473TrpAsn: 0.473 ± 0.025
0.662TrpPro: 0.662 ± 0.029
0.672TrpGln: 0.672 ± 0.03
1.193TrpArg: 1.193 ± 0.038
1.039TrpSer: 1.039 ± 0.035
0.987TrpThr: 0.987 ± 0.042
0.961TrpVal: 0.961 ± 0.041
0.345TrpTrp: 0.345 ± 0.021
0.343TrpTyr: 0.343 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.505TyrAla: 2.505 ± 0.061
0.157TyrCys: 0.157 ± 0.015
1.34TyrAsp: 1.34 ± 0.046
1.194TyrGlu: 1.194 ± 0.039
0.699TyrPhe: 0.699 ± 0.032
1.955TyrGly: 1.955 ± 0.053
0.354TyrHis: 0.354 ± 0.021
0.739TyrIle: 0.739 ± 0.032
0.517TyrLys: 0.517 ± 0.027
2.162TyrLeu: 2.162 ± 0.057
0.249TyrMet: 0.249 ± 0.018
0.518TyrAsn: 0.518 ± 0.032
1.151TyrPro: 1.151 ± 0.042
0.761TyrGln: 0.761 ± 0.03
1.657TyrArg: 1.657 ± 0.044
1.417TyrSer: 1.417 ± 0.048
1.318TyrThr: 1.318 ± 0.048
1.767TyrVal: 1.767 ± 0.052
0.325TyrTrp: 0.325 ± 0.021
0.579TyrTyr: 0.579 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2325 proteins (835814 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski