Amino acid dipepetide frequency for Listeria phage LMTA-148

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.82AlaAla: 0.82 ± 0.327
0.238AlaCys: 0.238 ± 0.085
3.358AlaAsp: 3.358 ± 0.305
4.177AlaGlu: 4.177 ± 0.403
2.142AlaPhe: 2.142 ± 0.236
4.098AlaGly: 4.098 ± 0.514
1.005AlaHis: 1.005 ± 0.146
3.913AlaIle: 3.913 ± 0.328
4.812AlaLys: 4.812 ± 0.398
5.447AlaLeu: 5.447 ± 0.377
1.533AlaMet: 1.533 ± 0.266
3.49AlaAsn: 3.49 ± 0.338
1.771AlaPro: 1.771 ± 0.285
2.221AlaGln: 2.221 ± 0.322
2.697AlaArg: 2.697 ± 0.277
4.733AlaSer: 4.733 ± 0.393
3.834AlaThr: 3.834 ± 0.326
4.098AlaVal: 4.098 ± 0.3
0.317AlaTrp: 0.317 ± 0.091
2.882AlaTyr: 2.882 ± 0.326
0.0AlaXaa: 0.0 ± 0.0
Cys
0.159CysAla: 0.159 ± 0.062
0.079CysCys: 0.079 ± 0.046
0.291CysAsp: 0.291 ± 0.098
0.37CysGlu: 0.37 ± 0.101
0.238CysPhe: 0.238 ± 0.082
0.397CysGly: 0.397 ± 0.095
0.238CysHis: 0.238 ± 0.081
0.344CysIle: 0.344 ± 0.084
0.714CysLys: 0.714 ± 0.129
0.423CysLeu: 0.423 ± 0.103
0.132CysMet: 0.132 ± 0.059
0.529CysAsn: 0.529 ± 0.121
0.344CysPro: 0.344 ± 0.116
0.185CysGln: 0.185 ± 0.066
0.291CysArg: 0.291 ± 0.092
0.555CysSer: 0.555 ± 0.143
0.238CysThr: 0.238 ± 0.066
0.317CysVal: 0.317 ± 0.082
0.0CysTrp: 0.0 ± 0.0
0.449CysTyr: 0.449 ± 0.105
0.0CysXaa: 0.0 ± 0.0
Asp
2.353AspAla: 2.353 ± 0.282
0.397AspCys: 0.397 ± 0.099
2.591AspAsp: 2.591 ± 0.273
3.966AspGlu: 3.966 ± 0.356
2.908AspPhe: 2.908 ± 0.274
3.305AspGly: 3.305 ± 0.366
0.476AspHis: 0.476 ± 0.109
4.548AspIle: 4.548 ± 0.392
6.002AspLys: 6.002 ± 0.454
5.552AspLeu: 5.552 ± 0.335
1.639AspMet: 1.639 ± 0.214
4.495AspAsn: 4.495 ± 0.342
1.56AspPro: 1.56 ± 0.176
1.454AspGln: 1.454 ± 0.233
2.618AspArg: 2.618 ± 0.28
4.31AspSer: 4.31 ± 0.381
3.622AspThr: 3.622 ± 0.334
3.781AspVal: 3.781 ± 0.381
0.714AspTrp: 0.714 ± 0.145
3.516AspTyr: 3.516 ± 0.324
0.0AspXaa: 0.0 ± 0.0
Glu
5.658GluAla: 5.658 ± 0.431
0.529GluCys: 0.529 ± 0.126
5.129GluAsp: 5.129 ± 0.411
8.884GluGlu: 8.884 ± 0.923
2.935GluPhe: 2.935 ± 0.257
4.177GluGly: 4.177 ± 0.332
1.084GluHis: 1.084 ± 0.204
4.283GluIle: 4.283 ± 0.35
7.985GluLys: 7.985 ± 0.593
7.72GluLeu: 7.72 ± 0.534
1.824GluMet: 1.824 ± 0.235
4.31GluAsn: 4.31 ± 0.271
1.666GluPro: 1.666 ± 0.248
2.961GluGln: 2.961 ± 0.256
3.516GluArg: 3.516 ± 0.316
4.786GluSer: 4.786 ± 0.301
4.098GluThr: 4.098 ± 0.333
6.425GluVal: 6.425 ± 0.476
0.74GluTrp: 0.74 ± 0.155
2.988GluTyr: 2.988 ± 0.308
0.0GluXaa: 0.0 ± 0.0
Phe
1.745PheAla: 1.745 ± 0.218
0.238PheCys: 0.238 ± 0.089
2.194PheAsp: 2.194 ± 0.238
2.565PheGlu: 2.565 ± 0.277
1.613PhePhe: 1.613 ± 0.19
2.3PheGly: 2.3 ± 0.315
0.608PheHis: 0.608 ± 0.118
2.803PheIle: 2.803 ± 0.287
2.75PheLys: 2.75 ± 0.249
3.834PheLeu: 3.834 ± 0.353
0.978PheMet: 0.978 ± 0.165
2.194PheAsn: 2.194 ± 0.273
1.084PhePro: 1.084 ± 0.18
1.137PheGln: 1.137 ± 0.175
1.269PheArg: 1.269 ± 0.171
3.226PheSer: 3.226 ± 0.36
2.459PheThr: 2.459 ± 0.226
3.173PheVal: 3.173 ± 0.318
0.212PheTrp: 0.212 ± 0.072
2.247PheTyr: 2.247 ± 0.26
0.0PheXaa: 0.0 ± 0.0
Gly
4.019GlyAla: 4.019 ± 0.682
0.529GlyCys: 0.529 ± 0.129
3.834GlyAsp: 3.834 ± 0.406
3.966GlyGlu: 3.966 ± 0.312
2.194GlyPhe: 2.194 ± 0.227
4.891GlyGly: 4.891 ± 0.765
0.925GlyHis: 0.925 ± 0.163
4.045GlyIle: 4.045 ± 0.355
5.499GlyLys: 5.499 ± 0.474
3.94GlyLeu: 3.94 ± 0.391
1.771GlyMet: 1.771 ± 0.226
3.622GlyAsn: 3.622 ± 0.293
0.026GlyPro: 0.026 ± 0.025
1.56GlyGln: 1.56 ± 0.263
2.38GlyArg: 2.38 ± 0.225
4.495GlySer: 4.495 ± 0.535
4.072GlyThr: 4.072 ± 0.414
4.495GlyVal: 4.495 ± 0.354
0.635GlyTrp: 0.635 ± 0.125
3.014GlyTyr: 3.014 ± 0.278
0.0GlyXaa: 0.0 ± 0.0
His
0.714HisAla: 0.714 ± 0.136
0.159HisCys: 0.159 ± 0.058
0.82HisAsp: 0.82 ± 0.15
0.873HisGlu: 0.873 ± 0.137
0.529HisPhe: 0.529 ± 0.119
0.767HisGly: 0.767 ± 0.146
0.291HisHis: 0.291 ± 0.105
1.19HisIle: 1.19 ± 0.227
1.216HisLys: 1.216 ± 0.193
1.348HisLeu: 1.348 ± 0.185
0.317HisMet: 0.317 ± 0.089
0.687HisAsn: 0.687 ± 0.126
0.449HisPro: 0.449 ± 0.119
0.423HisGln: 0.423 ± 0.096
0.582HisArg: 0.582 ± 0.136
1.058HisSer: 1.058 ± 0.17
1.11HisThr: 1.11 ± 0.176
1.058HisVal: 1.058 ± 0.188
0.317HisTrp: 0.317 ± 0.124
0.925HisTyr: 0.925 ± 0.187
0.0HisXaa: 0.0 ± 0.0
Ile
4.23IleAla: 4.23 ± 0.385
0.291IleCys: 0.291 ± 0.093
4.177IleAsp: 4.177 ± 0.357
5.711IleGlu: 5.711 ± 0.446
1.745IlePhe: 1.745 ± 0.217
3.94IleGly: 3.94 ± 0.371
0.952IleHis: 0.952 ± 0.177
4.574IleIle: 4.574 ± 0.357
5.447IleLys: 5.447 ± 0.395
4.838IleLeu: 4.838 ± 0.381
1.904IleMet: 1.904 ± 0.214
3.569IleAsn: 3.569 ± 0.311
2.38IlePro: 2.38 ± 0.276
2.247IleGln: 2.247 ± 0.227
3.014IleArg: 3.014 ± 0.288
4.257IleSer: 4.257 ± 0.333
3.649IleThr: 3.649 ± 0.29
4.336IleVal: 4.336 ± 0.316
0.449IleTrp: 0.449 ± 0.127
2.3IleTyr: 2.3 ± 0.213
0.0IleXaa: 0.0 ± 0.0
Lys
5.05LysAla: 5.05 ± 0.359
0.423LysCys: 0.423 ± 0.144
5.685LysAsp: 5.685 ± 0.442
9.783LysGlu: 9.783 ± 0.709
3.041LysPhe: 3.041 ± 0.265
5.367LysGly: 5.367 ± 0.452
1.401LysHis: 1.401 ± 0.216
4.944LysIle: 4.944 ± 0.423
8.778LysLys: 8.778 ± 0.648
7.007LysLeu: 7.007 ± 0.467
1.93LysMet: 1.93 ± 0.204
5.156LysAsn: 5.156 ± 0.389
2.803LysPro: 2.803 ± 0.299
3.252LysGln: 3.252 ± 0.295
3.305LysArg: 3.305 ± 0.296
4.891LysSer: 4.891 ± 0.347
4.6LysThr: 4.6 ± 0.412
6.187LysVal: 6.187 ± 0.435
0.873LysTrp: 0.873 ± 0.129
3.305LysTyr: 3.305 ± 0.259
0.0LysXaa: 0.0 ± 0.0
Leu
6.108LeuAla: 6.108 ± 0.397
0.608LeuCys: 0.608 ± 0.112
6.108LeuAsp: 6.108 ± 0.427
7.112LeuGlu: 7.112 ± 0.448
3.173LeuPhe: 3.173 ± 0.283
5.552LeuGly: 5.552 ± 0.38
0.925LeuHis: 0.925 ± 0.153
4.151LeuIle: 4.151 ± 0.315
6.24LeuLys: 6.24 ± 0.417
6.372LeuLeu: 6.372 ± 0.525
1.983LeuMet: 1.983 ± 0.211
4.865LeuAsn: 4.865 ± 0.402
3.226LeuPro: 3.226 ± 0.381
2.935LeuGln: 2.935 ± 0.339
3.807LeuArg: 3.807 ± 0.385
5.526LeuSer: 5.526 ± 0.419
5.209LeuThr: 5.209 ± 0.426
5.87LeuVal: 5.87 ± 0.497
0.767LeuTrp: 0.767 ± 0.11
3.199LeuTyr: 3.199 ± 0.265
0.0LeuXaa: 0.0 ± 0.0
Met
1.666MetAla: 1.666 ± 0.21
0.132MetCys: 0.132 ± 0.067
1.084MetAsp: 1.084 ± 0.166
1.877MetGlu: 1.877 ± 0.238
1.137MetPhe: 1.137 ± 0.158
1.137MetGly: 1.137 ± 0.218
0.132MetHis: 0.132 ± 0.058
1.296MetIle: 1.296 ± 0.196
2.247MetLys: 2.247 ± 0.269
2.036MetLeu: 2.036 ± 0.285
0.317MetMet: 0.317 ± 0.083
1.401MetAsn: 1.401 ± 0.183
1.058MetPro: 1.058 ± 0.168
0.978MetGln: 0.978 ± 0.153
1.401MetArg: 1.401 ± 0.193
2.036MetSer: 2.036 ± 0.212
1.904MetThr: 1.904 ± 0.222
1.401MetVal: 1.401 ± 0.241
0.264MetTrp: 0.264 ± 0.068
1.137MetTyr: 1.137 ± 0.205
0.0MetXaa: 0.0 ± 0.0
Asn
2.829AsnAla: 2.829 ± 0.306
0.238AsnCys: 0.238 ± 0.077
2.485AsnAsp: 2.485 ± 0.243
3.649AsnGlu: 3.649 ± 0.325
2.327AsnPhe: 2.327 ± 0.283
3.437AsnGly: 3.437 ± 0.298
1.005AsnHis: 1.005 ± 0.194
4.125AsnIle: 4.125 ± 0.388
5.711AsnLys: 5.711 ± 0.356
4.838AsnLeu: 4.838 ± 0.403
1.93AsnMet: 1.93 ± 0.215
3.384AsnAsn: 3.384 ± 0.307
2.115AsnPro: 2.115 ± 0.247
1.771AsnGln: 1.771 ± 0.178
2.327AsnArg: 2.327 ± 0.266
3.728AsnSer: 3.728 ± 0.406
4.045AsnThr: 4.045 ± 0.322
3.305AsnVal: 3.305 ± 0.323
0.793AsnTrp: 0.793 ± 0.135
2.697AsnTyr: 2.697 ± 0.283
0.0AsnXaa: 0.0 ± 0.0
Pro
1.666ProAla: 1.666 ± 0.263
0.106ProCys: 0.106 ± 0.05
1.904ProAsp: 1.904 ± 0.239
2.459ProGlu: 2.459 ± 0.218
1.269ProPhe: 1.269 ± 0.165
0.449ProGly: 0.449 ± 0.115
0.397ProHis: 0.397 ± 0.1
1.666ProIle: 1.666 ± 0.186
3.041ProLys: 3.041 ± 0.336
2.406ProLeu: 2.406 ± 0.269
1.005ProMet: 1.005 ± 0.186
1.719ProAsn: 1.719 ± 0.174
0.767ProPro: 0.767 ± 0.155
1.269ProGln: 1.269 ± 0.218
0.899ProArg: 0.899 ± 0.172
2.406ProSer: 2.406 ± 0.275
2.274ProThr: 2.274 ± 0.282
1.904ProVal: 1.904 ± 0.31
0.185ProTrp: 0.185 ± 0.076
1.428ProTyr: 1.428 ± 0.22
0.0ProXaa: 0.0 ± 0.0
Gln
2.961GlnAla: 2.961 ± 0.451
0.159GlnCys: 0.159 ± 0.058
1.851GlnAsp: 1.851 ± 0.218
2.776GlnGlu: 2.776 ± 0.294
1.243GlnPhe: 1.243 ± 0.203
2.353GlnGly: 2.353 ± 0.246
0.423GlnHis: 0.423 ± 0.11
1.666GlnIle: 1.666 ± 0.207
2.565GlnLys: 2.565 ± 0.293
3.226GlnLeu: 3.226 ± 0.259
0.82GlnMet: 0.82 ± 0.15
1.296GlnAsn: 1.296 ± 0.159
0.873GlnPro: 0.873 ± 0.228
2.406GlnGln: 2.406 ± 0.778
1.454GlnArg: 1.454 ± 0.218
2.221GlnSer: 2.221 ± 0.284
1.983GlnThr: 1.983 ± 0.233
2.882GlnVal: 2.882 ± 0.262
0.159GlnTrp: 0.159 ± 0.063
1.296GlnTyr: 1.296 ± 0.2
0.0GlnXaa: 0.0 ± 0.0
Arg
2.512ArgAla: 2.512 ± 0.31
0.159ArgCys: 0.159 ± 0.066
2.776ArgAsp: 2.776 ± 0.229
3.807ArgGlu: 3.807 ± 0.348
1.719ArgPhe: 1.719 ± 0.22
2.432ArgGly: 2.432 ± 0.283
0.608ArgHis: 0.608 ± 0.123
2.855ArgIle: 2.855 ± 0.235
3.675ArgLys: 3.675 ± 0.302
3.754ArgLeu: 3.754 ± 0.3
1.031ArgMet: 1.031 ± 0.202
2.618ArgAsn: 2.618 ± 0.255
0.687ArgPro: 0.687 ± 0.104
1.586ArgGln: 1.586 ± 0.217
1.401ArgArg: 1.401 ± 0.191
2.009ArgSer: 2.009 ± 0.289
2.512ArgThr: 2.512 ± 0.276
3.437ArgVal: 3.437 ± 0.287
0.344ArgTrp: 0.344 ± 0.093
1.851ArgTyr: 1.851 ± 0.225
0.0ArgXaa: 0.0 ± 0.0
Ser
3.887SerAla: 3.887 ± 0.342
0.397SerCys: 0.397 ± 0.105
3.596SerAsp: 3.596 ± 0.339
4.574SerGlu: 4.574 ± 0.358
2.935SerPhe: 2.935 ± 0.288
3.834SerGly: 3.834 ± 0.422
1.19SerHis: 1.19 ± 0.176
5.367SerIle: 5.367 ± 0.428
6.16SerLys: 6.16 ± 0.412
6.425SerLeu: 6.425 ± 0.471
1.692SerMet: 1.692 ± 0.226
3.384SerAsn: 3.384 ± 0.345
2.062SerPro: 2.062 ± 0.244
2.221SerGln: 2.221 ± 0.239
3.358SerArg: 3.358 ± 0.338
5.182SerSer: 5.182 ± 0.412
4.23SerThr: 4.23 ± 0.372
4.786SerVal: 4.786 ± 0.372
0.767SerTrp: 0.767 ± 0.134
3.146SerTyr: 3.146 ± 0.293
0.0SerXaa: 0.0 ± 0.0
Thr
4.072ThrAla: 4.072 ± 0.383
0.37ThrCys: 0.37 ± 0.099
3.702ThrAsp: 3.702 ± 0.288
4.997ThrGlu: 4.997 ± 0.33
2.935ThrPhe: 2.935 ± 0.269
4.415ThrGly: 4.415 ± 0.369
1.137ThrHis: 1.137 ± 0.192
4.177ThrIle: 4.177 ± 0.353
4.548ThrLys: 4.548 ± 0.336
5.182ThrLeu: 5.182 ± 0.404
1.19ThrMet: 1.19 ± 0.17
2.829ThrAsn: 2.829 ± 0.299
2.459ThrPro: 2.459 ± 0.242
1.507ThrGln: 1.507 ± 0.211
2.194ThrArg: 2.194 ± 0.246
4.521ThrSer: 4.521 ± 0.341
4.045ThrThr: 4.045 ± 0.331
5.261ThrVal: 5.261 ± 0.396
0.714ThrTrp: 0.714 ± 0.123
2.935ThrTyr: 2.935 ± 0.347
0.026ThrXaa: 0.026 ± 0.027
Val
4.627ValAla: 4.627 ± 0.299
0.502ValCys: 0.502 ± 0.116
4.838ValAsp: 4.838 ± 0.327
5.949ValGlu: 5.949 ± 0.379
2.67ValPhe: 2.67 ± 0.311
3.913ValGly: 3.913 ± 0.3
0.899ValHis: 0.899 ± 0.149
4.6ValIle: 4.6 ± 0.427
5.711ValLys: 5.711 ± 0.437
5.129ValLeu: 5.129 ± 0.425
1.375ValMet: 1.375 ± 0.197
3.992ValAsn: 3.992 ± 0.291
2.459ValPro: 2.459 ± 0.276
2.432ValGln: 2.432 ± 0.255
2.75ValArg: 2.75 ± 0.275
5.526ValSer: 5.526 ± 0.415
5.288ValThr: 5.288 ± 0.462
5.209ValVal: 5.209 ± 0.373
0.608ValTrp: 0.608 ± 0.116
3.173ValTyr: 3.173 ± 0.343
0.0ValXaa: 0.0 ± 0.0
Trp
0.397TrpAla: 0.397 ± 0.105
0.159TrpCys: 0.159 ± 0.064
0.714TrpAsp: 0.714 ± 0.136
0.767TrpGlu: 0.767 ± 0.142
0.344TrpPhe: 0.344 ± 0.094
0.74TrpGly: 0.74 ± 0.156
0.317TrpHis: 0.317 ± 0.096
0.397TrpIle: 0.397 ± 0.093
0.793TrpLys: 0.793 ± 0.148
0.793TrpLeu: 0.793 ± 0.131
0.079TrpMet: 0.079 ± 0.044
0.476TrpAsn: 0.476 ± 0.113
0.0TrpPro: 0.0 ± 0.0
0.291TrpGln: 0.291 ± 0.102
0.238TrpArg: 0.238 ± 0.06
0.476TrpSer: 0.476 ± 0.111
0.635TrpThr: 0.635 ± 0.139
0.82TrpVal: 0.82 ± 0.142
0.264TrpTrp: 0.264 ± 0.091
0.74TrpTyr: 0.74 ± 0.135
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.115TyrAla: 2.115 ± 0.2
0.582TyrCys: 0.582 ± 0.126
2.67TyrAsp: 2.67 ± 0.232
3.437TyrGlu: 3.437 ± 0.281
1.533TyrPhe: 1.533 ± 0.178
2.406TyrGly: 2.406 ± 0.289
0.82TyrHis: 0.82 ± 0.165
3.067TyrIle: 3.067 ± 0.301
3.887TyrLys: 3.887 ± 0.321
3.49TyrLeu: 3.49 ± 0.363
1.163TyrMet: 1.163 ± 0.18
2.723TyrAsn: 2.723 ± 0.231
1.428TyrPro: 1.428 ± 0.191
1.771TyrGln: 1.771 ± 0.284
2.247TyrArg: 2.247 ± 0.244
3.252TyrSer: 3.252 ± 0.318
3.411TyrThr: 3.411 ± 0.363
2.908TyrVal: 2.908 ± 0.328
0.317TyrTrp: 0.317 ± 0.084
1.983TyrTyr: 1.983 ± 0.262
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.026XaaArg: 0.026 ± 0.027
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 177 proteins (37823 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski