Amino acid dipepetide frequency for Massilia namucuonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.483AlaAla: 20.483 ± 0.187
1.25AlaCys: 1.25 ± 0.024
6.87AlaAsp: 6.87 ± 0.071
6.791AlaGlu: 6.791 ± 0.064
3.876AlaPhe: 3.876 ± 0.037
12.084AlaGly: 12.084 ± 0.094
2.521AlaHis: 2.521 ± 0.036
5.644AlaIle: 5.644 ± 0.053
4.055AlaLys: 4.055 ± 0.052
14.568AlaLeu: 14.568 ± 0.14
3.636AlaMet: 3.636 ± 0.039
3.459AlaAsn: 3.459 ± 0.045
6.936AlaPro: 6.936 ± 0.082
5.203AlaGln: 5.203 ± 0.068
9.05AlaArg: 9.05 ± 0.076
7.065AlaSer: 7.065 ± 0.064
6.406AlaThr: 6.406 ± 0.071
8.626AlaVal: 8.626 ± 0.063
1.789AlaTrp: 1.789 ± 0.034
2.959AlaTyr: 2.959 ± 0.036
0.0AlaXaa: 0.0 ± 0.0
Cys
1.226CysAla: 1.226 ± 0.026
0.127CysCys: 0.127 ± 0.007
0.498CysAsp: 0.498 ± 0.013
0.438CysGlu: 0.438 ± 0.014
0.27CysPhe: 0.27 ± 0.01
0.958CysGly: 0.958 ± 0.022
0.255CysHis: 0.255 ± 0.012
0.309CysIle: 0.309 ± 0.011
0.238CysLys: 0.238 ± 0.009
0.796CysLeu: 0.796 ± 0.02
0.199CysMet: 0.199 ± 0.01
0.227CysAsn: 0.227 ± 0.009
0.388CysPro: 0.388 ± 0.013
0.241CysGln: 0.241 ± 0.01
0.544CysArg: 0.544 ± 0.016
0.446CysSer: 0.446 ± 0.014
0.419CysThr: 0.419 ± 0.016
0.654CysVal: 0.654 ± 0.018
0.118CysTrp: 0.118 ± 0.007
0.223CysTyr: 0.223 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.036AspAla: 7.036 ± 0.057
0.44AspCys: 0.44 ± 0.015
2.835AspAsp: 2.835 ± 0.039
3.026AspGlu: 3.026 ± 0.035
2.088AspPhe: 2.088 ± 0.03
5.526AspGly: 5.526 ± 0.055
1.069AspHis: 1.069 ± 0.022
2.653AspIle: 2.653 ± 0.035
1.976AspLys: 1.976 ± 0.031
5.103AspLeu: 5.103 ± 0.058
1.349AspMet: 1.349 ± 0.026
1.517AspAsn: 1.517 ± 0.027
2.887AspPro: 2.887 ± 0.036
1.867AspGln: 1.867 ± 0.038
3.055AspArg: 3.055 ± 0.039
2.48AspSer: 2.48 ± 0.034
2.808AspThr: 2.808 ± 0.04
3.713AspVal: 3.713 ± 0.039
0.889AspTrp: 0.889 ± 0.021
1.607AspTyr: 1.607 ± 0.026
0.0AspXaa: 0.0 ± 0.0
Glu
6.425GluAla: 6.425 ± 0.059
0.362GluCys: 0.362 ± 0.014
2.189GluAsp: 2.189 ± 0.029
2.775GluGlu: 2.775 ± 0.045
1.851GluPhe: 1.851 ± 0.028
3.66GluGly: 3.66 ± 0.042
1.303GluHis: 1.303 ± 0.024
2.599GluIle: 2.599 ± 0.04
1.876GluLys: 1.876 ± 0.033
6.139GluLeu: 6.139 ± 0.063
1.282GluMet: 1.282 ± 0.026
1.403GluAsn: 1.403 ± 0.027
2.294GluPro: 2.294 ± 0.034
2.718GluGln: 2.718 ± 0.046
4.673GluArg: 4.673 ± 0.057
2.399GluSer: 2.399 ± 0.031
2.583GluThr: 2.583 ± 0.031
3.543GluVal: 3.543 ± 0.041
0.73GluTrp: 0.73 ± 0.017
1.204GluTyr: 1.204 ± 0.023
0.0GluXaa: 0.0 ± 0.0
Phe
3.889PheAla: 3.889 ± 0.042
0.362PheCys: 0.362 ± 0.014
2.446PheAsp: 2.446 ± 0.031
1.835PheGlu: 1.835 ± 0.03
1.235PhePhe: 1.235 ± 0.027
3.35PheGly: 3.35 ± 0.038
0.776PheHis: 0.776 ± 0.02
1.495PheIle: 1.495 ± 0.029
1.282PheLys: 1.282 ± 0.028
2.865PheLeu: 2.865 ± 0.035
0.839PheMet: 0.839 ± 0.018
1.295PheAsn: 1.295 ± 0.022
1.481PhePro: 1.481 ± 0.025
1.148PheGln: 1.148 ± 0.022
1.872PheArg: 1.872 ± 0.03
2.315PheSer: 2.315 ± 0.037
1.949PheThr: 1.949 ± 0.032
2.357PheVal: 2.357 ± 0.032
0.438PheTrp: 0.438 ± 0.015
0.935PheTyr: 0.935 ± 0.021
0.0PheXaa: 0.0 ± 0.0
Gly
11.23GlyAla: 11.23 ± 0.107
0.801GlyCys: 0.801 ± 0.019
4.474GlyAsp: 4.474 ± 0.054
4.476GlyGlu: 4.476 ± 0.049
3.123GlyPhe: 3.123 ± 0.034
8.244GlyGly: 8.244 ± 0.101
1.93GlyHis: 1.93 ± 0.033
3.816GlyIle: 3.816 ± 0.045
3.886GlyLys: 3.886 ± 0.052
8.259GlyLeu: 8.259 ± 0.072
2.496GlyMet: 2.496 ± 0.033
2.646GlyAsn: 2.646 ± 0.056
3.13GlyPro: 3.13 ± 0.038
3.253GlyGln: 3.253 ± 0.037
5.41GlyArg: 5.41 ± 0.052
4.439GlySer: 4.439 ± 0.059
4.425GlyThr: 4.425 ± 0.069
6.774GlyVal: 6.774 ± 0.064
1.384GlyTrp: 1.384 ± 0.026
2.717GlyTyr: 2.717 ± 0.03
0.0GlyXaa: 0.0 ± 0.0
His
2.806HisAla: 2.806 ± 0.038
0.235HisCys: 0.235 ± 0.011
1.146HisAsp: 1.146 ± 0.023
1.123HisGlu: 1.123 ± 0.021
0.887HisPhe: 0.887 ± 0.02
2.112HisGly: 2.112 ± 0.029
0.589HisHis: 0.589 ± 0.017
0.959HisIle: 0.959 ± 0.019
0.64HisLys: 0.64 ± 0.014
2.045HisLeu: 2.045 ± 0.031
0.493HisMet: 0.493 ± 0.016
0.575HisAsn: 0.575 ± 0.016
1.351HisPro: 1.351 ± 0.022
0.721HisGln: 0.721 ± 0.017
1.3HisArg: 1.3 ± 0.024
1.048HisSer: 1.048 ± 0.022
1.077HisThr: 1.077 ± 0.02
1.523HisVal: 1.523 ± 0.025
0.371HisTrp: 0.371 ± 0.013
0.674HisTyr: 0.674 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
6.239IleAla: 6.239 ± 0.062
0.388IleCys: 0.388 ± 0.013
3.023IleAsp: 3.023 ± 0.034
2.762IleGlu: 2.762 ± 0.037
1.243IlePhe: 1.243 ± 0.023
4.176IleGly: 4.176 ± 0.048
0.88IleHis: 0.88 ± 0.018
1.623IleIle: 1.623 ± 0.024
1.624IleLys: 1.624 ± 0.032
3.425IleLeu: 3.425 ± 0.045
0.843IleMet: 0.843 ± 0.019
1.579IleAsn: 1.579 ± 0.029
2.016IlePro: 2.016 ± 0.03
1.206IleGln: 1.206 ± 0.023
2.435IleArg: 2.435 ± 0.032
2.533IleSer: 2.533 ± 0.033
2.379IleThr: 2.379 ± 0.041
3.454IleVal: 3.454 ± 0.037
0.437IleTrp: 0.437 ± 0.014
1.007IleTyr: 1.007 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
4.149LysAla: 4.149 ± 0.059
0.173LysCys: 0.173 ± 0.01
1.772LysAsp: 1.772 ± 0.03
1.768LysGlu: 1.768 ± 0.028
1.054LysPhe: 1.054 ± 0.022
2.519LysGly: 2.519 ± 0.038
0.705LysHis: 0.705 ± 0.017
1.645LysIle: 1.645 ± 0.027
1.453LysLys: 1.453 ± 0.035
3.92LysLeu: 3.92 ± 0.044
0.962LysMet: 0.962 ± 0.023
1.137LysAsn: 1.137 ± 0.025
2.133LysPro: 2.133 ± 0.038
1.305LysGln: 1.305 ± 0.028
2.35LysArg: 2.35 ± 0.037
1.902LysSer: 1.902 ± 0.036
2.019LysThr: 2.019 ± 0.033
2.55LysVal: 2.55 ± 0.032
0.397LysTrp: 0.397 ± 0.012
0.792LysTyr: 0.792 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
15.087LeuAla: 15.087 ± 0.113
0.957LeuCys: 0.957 ± 0.022
5.894LeuAsp: 5.894 ± 0.054
5.275LeuGlu: 5.275 ± 0.061
3.275LeuPhe: 3.275 ± 0.041
8.145LeuGly: 8.145 ± 0.074
2.159LeuHis: 2.159 ± 0.033
3.935LeuIle: 3.935 ± 0.043
3.67LeuLys: 3.67 ± 0.043
10.715LeuLeu: 10.715 ± 0.087
2.343LeuMet: 2.343 ± 0.031
3.092LeuAsn: 3.092 ± 0.039
5.737LeuPro: 5.737 ± 0.056
3.451LeuGln: 3.451 ± 0.046
7.789LeuArg: 7.789 ± 0.069
6.172LeuSer: 6.172 ± 0.066
5.323LeuThr: 5.323 ± 0.065
6.792LeuVal: 6.792 ± 0.058
1.146LeuTrp: 1.146 ± 0.024
2.335LeuTyr: 2.335 ± 0.033
0.0LeuXaa: 0.0 ± 0.0
Met
3.186MetAla: 3.186 ± 0.041
0.166MetCys: 0.166 ± 0.008
1.225MetAsp: 1.225 ± 0.023
1.229MetGlu: 1.229 ± 0.024
0.751MetPhe: 0.751 ± 0.019
1.812MetGly: 1.812 ± 0.028
0.561MetHis: 0.561 ± 0.017
0.976MetIle: 0.976 ± 0.023
1.068MetLys: 1.068 ± 0.022
2.835MetLeu: 2.835 ± 0.031
0.666MetMet: 0.666 ± 0.017
0.919MetAsn: 0.919 ± 0.017
1.422MetPro: 1.422 ± 0.024
0.976MetGln: 0.976 ± 0.02
1.881MetArg: 1.881 ± 0.03
1.552MetSer: 1.552 ± 0.024
1.515MetThr: 1.515 ± 0.025
1.701MetVal: 1.701 ± 0.024
0.24MetTrp: 0.24 ± 0.01
0.487MetTyr: 0.487 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
3.726AsnAla: 3.726 ± 0.051
0.288AsnCys: 0.288 ± 0.011
1.537AsnAsp: 1.537 ± 0.028
1.349AsnGlu: 1.349 ± 0.024
1.09AsnPhe: 1.09 ± 0.025
2.925AsnGly: 2.925 ± 0.049
0.606AsnHis: 0.606 ± 0.016
1.444AsnIle: 1.444 ± 0.026
1.026AsnLys: 1.026 ± 0.023
2.942AsnLeu: 2.942 ± 0.038
0.718AsnMet: 0.718 ± 0.016
1.036AsnAsn: 1.036 ± 0.027
1.869AsnPro: 1.869 ± 0.031
1.086AsnGln: 1.086 ± 0.025
1.774AsnArg: 1.774 ± 0.027
1.543AsnSer: 1.543 ± 0.031
1.683AsnThr: 1.683 ± 0.032
2.183AsnVal: 2.183 ± 0.034
0.495AsnTrp: 0.495 ± 0.013
0.891AsnTyr: 0.891 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
7.683ProAla: 7.683 ± 0.076
0.331ProCys: 0.331 ± 0.011
3.147ProAsp: 3.147 ± 0.043
3.155ProGlu: 3.155 ± 0.039
1.687ProPhe: 1.687 ± 0.025
4.733ProGly: 4.733 ± 0.048
1.056ProHis: 1.056 ± 0.023
1.694ProIle: 1.694 ± 0.027
1.44ProLys: 1.44 ± 0.024
4.911ProLeu: 4.911 ± 0.05
1.205ProMet: 1.205 ± 0.025
1.394ProAsn: 1.394 ± 0.028
2.784ProPro: 2.784 ± 0.045
1.754ProGln: 1.754 ± 0.028
3.026ProArg: 3.026 ± 0.042
2.67ProSer: 2.67 ± 0.031
2.274ProThr: 2.274 ± 0.048
4.018ProVal: 4.018 ± 0.045
0.669ProTrp: 0.669 ± 0.018
1.251ProTyr: 1.251 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
5.225GlnAla: 5.225 ± 0.059
0.268GlnCys: 0.268 ± 0.012
1.578GlnAsp: 1.578 ± 0.031
1.604GlnGlu: 1.604 ± 0.027
1.299GlnPhe: 1.299 ± 0.022
2.816GlnGly: 2.816 ± 0.034
0.821GlnHis: 0.821 ± 0.019
1.693GlnIle: 1.693 ± 0.048
1.161GlnLys: 1.161 ± 0.022
4.07GlnLeu: 4.07 ± 0.062
0.96GlnMet: 0.96 ± 0.017
0.993GlnAsn: 0.993 ± 0.023
2.095GlnPro: 2.095 ± 0.029
1.803GlnGln: 1.803 ± 0.039
2.964GlnArg: 2.964 ± 0.036
1.927GlnSer: 1.927 ± 0.025
1.853GlnThr: 1.853 ± 0.028
2.705GlnVal: 2.705 ± 0.041
0.558GlnTrp: 0.558 ± 0.015
0.936GlnTyr: 0.936 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
8.11ArgAla: 8.11 ± 0.076
0.544ArgCys: 0.544 ± 0.016
3.803ArgAsp: 3.803 ± 0.042
3.912ArgGlu: 3.912 ± 0.051
2.566ArgPhe: 2.566 ± 0.035
4.848ArgGly: 4.848 ± 0.054
1.896ArgHis: 1.896 ± 0.029
3.263ArgIle: 3.263 ± 0.041
2.309ArgLys: 2.309 ± 0.039
7.44ArgLeu: 7.44 ± 0.068
1.891ArgMet: 1.891 ± 0.03
2.023ArgAsn: 2.023 ± 0.031
3.028ArgPro: 3.028 ± 0.037
2.982ArgGln: 2.982 ± 0.044
4.815ArgArg: 4.815 ± 0.061
3.034ArgSer: 3.034 ± 0.036
3.036ArgThr: 3.036 ± 0.033
4.896ArgVal: 4.896 ± 0.048
0.995ArgTrp: 0.995 ± 0.022
2.07ArgTyr: 2.07 ± 0.03
0.0ArgXaa: 0.0 ± 0.0
Ser
6.788SerAla: 6.788 ± 0.063
0.429SerCys: 0.429 ± 0.016
2.687SerAsp: 2.687 ± 0.037
2.449SerGlu: 2.449 ± 0.033
2.03SerPhe: 2.03 ± 0.029
5.62SerGly: 5.62 ± 0.073
1.186SerHis: 1.186 ± 0.022
2.436SerIle: 2.436 ± 0.033
1.736SerLys: 1.736 ± 0.032
5.46SerLeu: 5.46 ± 0.05
1.365SerMet: 1.365 ± 0.023
1.662SerAsn: 1.662 ± 0.028
2.687SerPro: 2.687 ± 0.036
1.818SerGln: 1.818 ± 0.034
3.243SerArg: 3.243 ± 0.037
3.163SerSer: 3.163 ± 0.044
2.923SerThr: 2.923 ± 0.046
3.917SerVal: 3.917 ± 0.047
0.799SerTrp: 0.799 ± 0.017
1.578SerTyr: 1.578 ± 0.026
0.0SerXaa: 0.0 ± 0.0
Thr
6.479ThrAla: 6.479 ± 0.077
0.365ThrCys: 0.365 ± 0.014
2.552ThrAsp: 2.552 ± 0.04
2.367ThrGlu: 2.367 ± 0.037
1.686ThrPhe: 1.686 ± 0.032
4.973ThrGly: 4.973 ± 0.058
1.053ThrHis: 1.053 ± 0.019
2.381ThrIle: 2.381 ± 0.041
1.309ThrLys: 1.309 ± 0.026
6.103ThrLeu: 6.103 ± 0.068
1.205ThrMet: 1.205 ± 0.021
1.425ThrAsn: 1.425 ± 0.027
3.256ThrPro: 3.256 ± 0.039
1.73ThrGln: 1.73 ± 0.035
3.211ThrArg: 3.211 ± 0.038
2.735ThrSer: 2.735 ± 0.04
2.795ThrThr: 2.795 ± 0.059
4.294ThrVal: 4.294 ± 0.059
0.666ThrTrp: 0.666 ± 0.018
1.303ThrTyr: 1.303 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
9.302ValAla: 9.302 ± 0.07
0.694ValCys: 0.694 ± 0.02
4.049ValAsp: 4.049 ± 0.044
3.864ValGlu: 3.864 ± 0.044
2.531ValPhe: 2.531 ± 0.034
5.236ValGly: 5.236 ± 0.053
1.403ValHis: 1.403 ± 0.025
3.134ValIle: 3.134 ± 0.039
2.586ValLys: 2.586 ± 0.031
7.378ValLeu: 7.378 ± 0.052
1.784ValMet: 1.784 ± 0.026
2.448ValAsn: 2.448 ± 0.037
3.582ValPro: 3.582 ± 0.041
2.364ValGln: 2.364 ± 0.034
4.881ValArg: 4.881 ± 0.051
4.201ValSer: 4.201 ± 0.048
4.153ValThr: 4.153 ± 0.059
5.463ValVal: 5.463 ± 0.063
0.861ValTrp: 0.861 ± 0.021
1.812ValTyr: 1.812 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
1.178TrpAla: 1.178 ± 0.023
0.132TrpCys: 0.132 ± 0.008
0.676TrpAsp: 0.676 ± 0.017
0.556TrpGlu: 0.556 ± 0.015
0.532TrpPhe: 0.532 ± 0.016
0.922TrpGly: 0.922 ± 0.023
0.325TrpHis: 0.325 ± 0.011
0.594TrpIle: 0.594 ± 0.016
0.476TrpLys: 0.476 ± 0.014
1.738TrpLeu: 1.738 ± 0.031
0.402TrpMet: 0.402 ± 0.015
0.524TrpAsn: 0.524 ± 0.015
0.598TrpPro: 0.598 ± 0.016
0.661TrpGln: 0.661 ± 0.015
1.257TrpArg: 1.257 ± 0.026
0.855TrpSer: 0.855 ± 0.018
0.772TrpThr: 0.772 ± 0.021
0.852TrpVal: 0.852 ± 0.019
0.239TrpTrp: 0.239 ± 0.011
0.347TrpTyr: 0.347 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.026TyrAla: 3.026 ± 0.037
0.261TyrCys: 0.261 ± 0.011
1.524TyrAsp: 1.524 ± 0.044
1.253TyrGlu: 1.253 ± 0.025
1.088TyrPhe: 1.088 ± 0.024
2.253TyrGly: 2.253 ± 0.031
0.581TyrHis: 0.581 ± 0.014
0.977TyrIle: 0.977 ± 0.019
0.89TyrLys: 0.89 ± 0.021
2.58TyrLeu: 2.58 ± 0.038
0.531TyrMet: 0.531 ± 0.014
0.857TyrAsn: 0.857 ± 0.022
1.208TyrPro: 1.208 ± 0.022
1.044TyrGln: 1.044 ± 0.022
1.932TyrArg: 1.932 ± 0.032
1.497TyrSer: 1.497 ± 0.025
1.497TyrThr: 1.497 ± 0.025
1.712TyrVal: 1.712 ± 0.03
0.414TyrTrp: 0.414 ± 0.013
0.797TyrTyr: 0.797 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.001XaaXaa: 0.001 ± 0.001
Statistics based on 7034 proteins (2567245 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski