Amino acid dipepetide frequency for Wenling picorna-like virus 5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.3AlaAla: 4.3 ± 0.317
0.782AlaCys: 0.782 ± 0.419
4.3AlaAsp: 4.3 ± 0.972
3.518AlaGlu: 3.518 ± 0.574
0.782AlaPhe: 0.782 ± 0.419
5.082AlaGly: 5.082 ± 2.519
1.955AlaHis: 1.955 ± 0.263
3.127AlaIle: 3.127 ± 0.29
5.082AlaLys: 5.082 ± 0.756
7.428AlaLeu: 7.428 ± 1.357
0.782AlaMet: 0.782 ± 0.236
1.173AlaAsn: 1.173 ± 0.027
1.955AlaPro: 1.955 ± 0.263
1.564AlaGln: 1.564 ± 1.128
1.564AlaArg: 1.564 ± 0.473
5.473AlaSer: 5.473 ± 0.999
1.564AlaThr: 1.564 ± 1.128
6.255AlaVal: 6.255 ± 0.581
1.173AlaTrp: 1.173 ± 0.682
1.955AlaTyr: 1.955 ± 0.918
0.0AlaXaa: 0.0 ± 0.0
Cys
1.955CysAla: 1.955 ± 1.047
0.782CysCys: 0.782 ± 0.419
1.955CysAsp: 1.955 ± 1.047
2.737CysGlu: 2.737 ± 0.81
1.564CysPhe: 1.564 ± 0.182
3.127CysGly: 3.127 ± 1.02
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.391CysLeu: 0.391 ± 0.209
0.391CysMet: 0.391 ± 0.209
1.955CysAsn: 1.955 ± 0.392
0.391CysPro: 0.391 ± 0.209
1.564CysGln: 1.564 ± 0.182
0.391CysArg: 0.391 ± 0.209
0.391CysSer: 0.391 ± 0.209
1.955CysThr: 1.955 ± 0.392
1.955CysVal: 1.955 ± 0.263
0.391CysTrp: 0.391 ± 0.209
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.691AspAla: 4.691 ± 0.108
0.391AspCys: 0.391 ± 0.446
7.037AspAsp: 7.037 ± 0.493
5.082AspGlu: 5.082 ± 0.554
3.909AspPhe: 3.909 ± 0.128
4.691AspGly: 4.691 ± 0.763
2.737AspHis: 2.737 ± 0.81
6.255AspIle: 6.255 ± 0.729
2.346AspLys: 2.346 ± 1.364
6.646AspLeu: 6.646 ± 2.337
1.955AspMet: 1.955 ± 1.047
1.955AspAsn: 1.955 ± 0.263
2.737AspPro: 2.737 ± 0.155
1.173AspGln: 1.173 ± 0.628
2.737AspArg: 2.737 ± 0.81
7.037AspSer: 7.037 ± 1.803
3.518AspThr: 3.518 ± 1.229
4.3AspVal: 4.3 ± 0.317
2.346AspTrp: 2.346 ± 1.256
1.564AspTyr: 1.564 ± 0.837
0.0AspXaa: 0.0 ± 0.0
Glu
5.864GluAla: 5.864 ± 0.79
0.782GluCys: 0.782 ± 0.419
4.691GluAsp: 4.691 ± 0.547
4.691GluGlu: 4.691 ± 1.202
2.346GluPhe: 2.346 ± 0.601
2.346GluGly: 2.346 ± 0.601
2.346GluHis: 2.346 ± 0.709
2.346GluIle: 2.346 ± 0.054
5.082GluLys: 5.082 ± 0.101
3.909GluLeu: 3.909 ± 1.438
1.955GluMet: 1.955 ± 0.392
3.909GluAsn: 3.909 ± 1.438
3.909GluPro: 3.909 ± 0.527
1.955GluGln: 1.955 ± 0.918
1.173GluArg: 1.173 ± 0.027
5.473GluSer: 5.473 ± 0.311
2.737GluThr: 2.737 ± 1.155
5.473GluVal: 5.473 ± 0.999
1.564GluTrp: 1.564 ± 0.182
0.391GluTyr: 0.391 ± 0.209
0.0GluXaa: 0.0 ± 0.0
Phe
1.564PheAla: 1.564 ± 0.473
0.782PheCys: 0.782 ± 0.419
3.127PheAsp: 3.127 ± 0.945
2.737PheGlu: 2.737 ± 0.81
1.564PhePhe: 1.564 ± 0.473
3.518PheGly: 3.518 ± 0.081
1.955PheHis: 1.955 ± 0.263
2.737PheIle: 2.737 ± 0.5
4.691PheLys: 4.691 ± 0.108
2.346PheLeu: 2.346 ± 1.256
1.173PheMet: 1.173 ± 0.628
0.782PheAsn: 0.782 ± 0.236
1.564PhePro: 1.564 ± 1.128
1.564PheGln: 1.564 ± 0.473
3.518PheArg: 3.518 ± 0.081
1.955PheSer: 1.955 ± 0.263
3.127PheThr: 3.127 ± 0.365
2.737PheVal: 2.737 ± 0.5
0.0PheTrp: 0.0 ± 0.0
1.173PheTyr: 1.173 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
1.564GlyAla: 1.564 ± 0.473
1.564GlyCys: 1.564 ± 0.837
5.864GlyAsp: 5.864 ± 1.445
4.691GlyGlu: 4.691 ± 0.763
3.127GlyPhe: 3.127 ± 0.945
3.518GlyGly: 3.518 ± 1.884
1.173GlyHis: 1.173 ± 0.628
2.346GlyIle: 2.346 ± 1.364
3.909GlyLys: 3.909 ± 0.527
5.864GlyLeu: 5.864 ± 0.135
2.346GlyMet: 2.346 ± 1.256
3.518GlyAsn: 3.518 ± 0.081
2.346GlyPro: 2.346 ± 0.601
1.564GlyGln: 1.564 ± 0.182
3.127GlyArg: 3.127 ± 0.29
5.473GlySer: 5.473 ± 0.344
3.127GlyThr: 3.127 ± 0.29
6.646GlyVal: 6.646 ± 0.371
1.173GlyTrp: 1.173 ± 0.682
1.564GlyTyr: 1.564 ± 0.473
0.0GlyXaa: 0.0 ± 0.0
His
2.346HisAla: 2.346 ± 1.364
0.391HisCys: 0.391 ± 0.209
0.782HisAsp: 0.782 ± 0.236
0.782HisGlu: 0.782 ± 0.419
0.782HisPhe: 0.782 ± 0.236
1.564HisGly: 1.564 ± 0.837
0.782HisHis: 0.782 ± 0.419
0.391HisIle: 0.391 ± 0.209
2.737HisLys: 2.737 ± 1.465
2.346HisLeu: 2.346 ± 0.054
0.391HisMet: 0.391 ± 0.446
1.564HisAsn: 1.564 ± 0.473
0.782HisPro: 0.782 ± 0.236
0.391HisGln: 0.391 ± 0.209
0.782HisArg: 0.782 ± 0.236
2.346HisSer: 2.346 ± 0.054
1.564HisThr: 1.564 ± 0.473
1.955HisVal: 1.955 ± 0.392
0.782HisTrp: 0.782 ± 0.419
1.564HisTyr: 1.564 ± 0.182
0.0HisXaa: 0.0 ± 0.0
Ile
2.346IleAla: 2.346 ± 0.601
1.564IleCys: 1.564 ± 0.182
3.127IleAsp: 3.127 ± 0.29
5.082IleGlu: 5.082 ± 1.209
1.564IlePhe: 1.564 ± 0.182
3.518IleGly: 3.518 ± 0.081
1.564IleHis: 1.564 ± 0.182
3.909IleIle: 3.909 ± 0.783
3.127IleLys: 3.127 ± 0.365
3.518IleLeu: 3.518 ± 0.574
1.955IleMet: 1.955 ± 1.047
1.955IleAsn: 1.955 ± 1.047
1.173IlePro: 1.173 ± 1.337
1.173IleGln: 1.173 ± 0.682
1.955IleArg: 1.955 ± 0.392
3.518IleSer: 3.518 ± 1.391
3.127IleThr: 3.127 ± 1.02
3.909IleVal: 3.909 ± 1.182
0.0IleTrp: 0.0 ± 0.0
1.564IleTyr: 1.564 ± 1.128
0.0IleXaa: 0.0 ± 0.0
Lys
3.518LysAla: 3.518 ± 0.081
3.127LysCys: 3.127 ± 1.02
5.864LysAsp: 5.864 ± 1.83
5.864LysGlu: 5.864 ± 0.52
2.737LysPhe: 2.737 ± 0.155
4.3LysGly: 4.3 ± 0.338
0.391LysHis: 0.391 ± 0.209
1.955LysIle: 1.955 ± 0.392
8.991LysLys: 8.991 ± 4.16
6.646LysLeu: 6.646 ± 1.682
0.391LysMet: 0.391 ± 0.446
3.518LysAsn: 3.518 ± 0.081
3.518LysPro: 3.518 ± 0.081
2.346LysGln: 2.346 ± 0.054
2.346LysArg: 2.346 ± 0.054
5.082LysSer: 5.082 ± 0.756
3.909LysThr: 3.909 ± 0.783
8.21LysVal: 8.21 ± 1.121
0.0LysTrp: 0.0 ± 0.0
1.955LysTyr: 1.955 ± 0.263
0.0LysXaa: 0.0 ± 0.0
Leu
3.909LeuAla: 3.909 ± 0.527
0.782LeuCys: 0.782 ± 0.419
6.255LeuAsp: 6.255 ± 0.074
4.691LeuGlu: 4.691 ± 1.418
2.346LeuPhe: 2.346 ± 1.256
7.037LeuGly: 7.037 ± 1.148
1.564LeuHis: 1.564 ± 0.473
3.127LeuIle: 3.127 ± 0.365
3.518LeuLys: 3.518 ± 0.081
7.037LeuLeu: 7.037 ± 1.148
1.955LeuMet: 1.955 ± 0.212
4.691LeuAsn: 4.691 ± 0.763
1.173LeuPro: 1.173 ± 0.628
3.518LeuGln: 3.518 ± 1.391
3.518LeuArg: 3.518 ± 1.229
8.21LeuSer: 8.21 ± 1.776
3.518LeuThr: 3.518 ± 1.391
5.473LeuVal: 5.473 ± 1.654
1.955LeuTrp: 1.955 ± 1.047
2.346LeuTyr: 2.346 ± 0.601
0.0LeuXaa: 0.0 ± 0.0
Met
1.955MetAla: 1.955 ± 0.918
0.391MetCys: 0.391 ± 0.446
1.955MetAsp: 1.955 ± 0.392
1.173MetGlu: 1.173 ± 0.628
0.782MetPhe: 0.782 ± 0.419
1.564MetGly: 1.564 ± 0.473
0.391MetHis: 0.391 ± 0.209
1.173MetIle: 1.173 ± 0.628
1.955MetLys: 1.955 ± 0.392
2.346MetLeu: 2.346 ± 0.601
1.173MetMet: 1.173 ± 0.628
2.737MetAsn: 2.737 ± 0.5
1.173MetPro: 1.173 ± 0.628
1.173MetGln: 1.173 ± 0.628
0.782MetArg: 0.782 ± 0.236
5.082MetSer: 5.082 ± 1.411
0.391MetThr: 0.391 ± 0.209
1.564MetVal: 1.564 ± 0.473
0.391MetTrp: 0.391 ± 0.209
1.564MetTyr: 1.564 ± 0.182
0.0MetXaa: 0.0 ± 0.0
Asn
2.737AsnAla: 2.737 ± 1.465
0.391AsnCys: 0.391 ± 0.209
4.691AsnAsp: 4.691 ± 0.547
1.564AsnGlu: 1.564 ± 0.837
3.127AsnPhe: 3.127 ± 0.945
0.782AsnGly: 0.782 ± 0.891
1.564AsnHis: 1.564 ± 0.473
1.564AsnIle: 1.564 ± 0.473
3.518AsnLys: 3.518 ± 0.574
3.909AsnLeu: 3.909 ± 0.783
1.173AsnMet: 1.173 ± 0.027
0.782AsnAsn: 0.782 ± 0.236
3.127AsnPro: 3.127 ± 0.945
1.564AsnGln: 1.564 ± 0.182
1.564AsnArg: 1.564 ± 0.837
2.737AsnSer: 2.737 ± 0.155
1.564AsnThr: 1.564 ± 0.182
2.737AsnVal: 2.737 ± 0.5
0.782AsnTrp: 0.782 ± 0.419
2.346AsnTyr: 2.346 ± 1.364
0.0AsnXaa: 0.0 ± 0.0
Pro
2.346ProAla: 2.346 ± 0.054
0.0ProCys: 0.0 ± 0.0
2.737ProAsp: 2.737 ± 0.155
1.955ProGlu: 1.955 ± 0.263
3.518ProPhe: 3.518 ± 0.081
1.955ProGly: 1.955 ± 0.263
1.173ProHis: 1.173 ± 0.628
5.082ProIle: 5.082 ± 0.101
2.737ProLys: 2.737 ± 2.465
2.737ProLeu: 2.737 ± 1.155
1.564ProMet: 1.564 ± 1.783
1.173ProAsn: 1.173 ± 0.628
0.0ProPro: 0.0 ± 0.0
0.782ProGln: 0.782 ± 0.891
1.173ProArg: 1.173 ± 0.628
2.737ProSer: 2.737 ± 1.465
1.564ProThr: 1.564 ± 1.783
2.737ProVal: 2.737 ± 0.5
1.955ProTrp: 1.955 ± 0.263
1.564ProTyr: 1.564 ± 1.128
0.0ProXaa: 0.0 ± 0.0
Gln
2.346GlnAla: 2.346 ± 1.364
0.391GlnCys: 0.391 ± 0.209
1.564GlnAsp: 1.564 ± 0.182
1.564GlnGlu: 1.564 ± 0.182
2.737GlnPhe: 2.737 ± 0.155
2.346GlnGly: 2.346 ± 0.709
0.782GlnHis: 0.782 ± 0.236
2.346GlnIle: 2.346 ± 1.364
2.346GlnLys: 2.346 ± 0.054
1.564GlnLeu: 1.564 ± 0.182
1.564GlnMet: 1.564 ± 0.182
1.955GlnAsn: 1.955 ± 0.918
1.173GlnPro: 1.173 ± 0.682
0.391GlnGln: 0.391 ± 0.209
2.737GlnArg: 2.737 ± 1.465
2.737GlnSer: 2.737 ± 0.5
1.173GlnThr: 1.173 ± 0.027
1.564GlnVal: 1.564 ± 0.182
0.782GlnTrp: 0.782 ± 0.236
1.173GlnTyr: 1.173 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
2.346ArgAla: 2.346 ± 0.601
2.346ArgCys: 2.346 ± 0.601
1.955ArgAsp: 1.955 ± 1.047
1.955ArgGlu: 1.955 ± 1.047
1.173ArgPhe: 1.173 ± 0.682
1.955ArgGly: 1.955 ± 0.918
1.173ArgHis: 1.173 ± 0.628
2.346ArgIle: 2.346 ± 0.054
3.127ArgLys: 3.127 ± 1.02
5.864ArgLeu: 5.864 ± 0.52
1.173ArgMet: 1.173 ± 0.628
2.737ArgAsn: 2.737 ± 0.81
1.564ArgPro: 1.564 ± 0.473
2.737ArgGln: 2.737 ± 0.81
2.737ArgArg: 2.737 ± 1.465
1.173ArgSer: 1.173 ± 0.628
1.955ArgThr: 1.955 ± 0.392
3.518ArgVal: 3.518 ± 1.229
0.782ArgTrp: 0.782 ± 0.419
1.173ArgTyr: 1.173 ± 0.682
0.0ArgXaa: 0.0 ± 0.0
Ser
4.691SerAla: 4.691 ± 1.418
3.518SerCys: 3.518 ± 1.229
6.255SerAsp: 6.255 ± 0.729
4.691SerGlu: 4.691 ± 0.763
5.082SerPhe: 5.082 ± 1.209
3.909SerGly: 3.909 ± 0.527
0.391SerHis: 0.391 ± 0.209
5.082SerIle: 5.082 ± 1.209
4.691SerLys: 4.691 ± 1.857
6.646SerLeu: 6.646 ± 0.939
3.909SerMet: 3.909 ± 1.438
1.955SerAsn: 1.955 ± 0.918
3.127SerPro: 3.127 ± 0.29
1.955SerGln: 1.955 ± 0.918
3.518SerArg: 3.518 ± 1.229
6.255SerSer: 6.255 ± 2.694
4.691SerThr: 4.691 ± 0.763
5.082SerVal: 5.082 ± 0.101
1.173SerTrp: 1.173 ± 1.337
3.127SerTyr: 3.127 ± 0.365
0.0SerXaa: 0.0 ± 0.0
Thr
4.691ThrAla: 4.691 ± 2.073
0.782ThrCys: 0.782 ± 0.236
3.518ThrAsp: 3.518 ± 2.046
2.346ThrGlu: 2.346 ± 0.709
1.564ThrPhe: 1.564 ± 0.182
3.518ThrGly: 3.518 ± 0.736
1.955ThrHis: 1.955 ± 0.392
2.346ThrIle: 2.346 ± 0.601
4.3ThrLys: 4.3 ± 0.338
2.737ThrLeu: 2.737 ± 0.155
1.173ThrMet: 1.173 ± 0.628
1.564ThrAsn: 1.564 ± 0.837
2.346ThrPro: 2.346 ± 0.054
3.518ThrGln: 3.518 ± 0.081
2.346ThrArg: 2.346 ± 0.601
2.346ThrSer: 2.346 ± 0.709
2.346ThrThr: 2.346 ± 0.054
4.691ThrVal: 4.691 ± 1.418
0.0ThrTrp: 0.0 ± 0.0
3.909ThrTyr: 3.909 ± 0.527
0.0ThrXaa: 0.0 ± 0.0
Val
3.518ValAla: 3.518 ± 1.391
1.955ValCys: 1.955 ± 0.392
2.737ValAsp: 2.737 ± 0.81
3.127ValGlu: 3.127 ± 0.365
2.346ValPhe: 2.346 ± 0.054
5.082ValGly: 5.082 ± 0.756
2.737ValHis: 2.737 ± 0.5
2.346ValIle: 2.346 ± 0.601
6.255ValLys: 6.255 ± 2.039
3.127ValLeu: 3.127 ± 1.6
1.564ValMet: 1.564 ± 0.279
3.127ValAsn: 3.127 ± 0.365
7.037ValPro: 7.037 ± 2.782
3.127ValGln: 3.127 ± 0.29
5.082ValArg: 5.082 ± 2.066
7.819ValSer: 7.819 ± 3.674
5.473ValThr: 5.473 ± 2.965
5.864ValVal: 5.864 ± 0.79
1.173ValTrp: 1.173 ± 0.027
3.127ValTyr: 3.127 ± 0.29
0.0ValXaa: 0.0 ± 0.0
Trp
1.564TrpAla: 1.564 ± 0.837
0.782TrpCys: 0.782 ± 0.419
1.564TrpAsp: 1.564 ± 0.837
1.564TrpGlu: 1.564 ± 0.473
0.391TrpPhe: 0.391 ± 0.446
0.782TrpGly: 0.782 ± 0.236
0.0TrpHis: 0.0 ± 0.0
0.782TrpIle: 0.782 ± 0.419
1.955TrpLys: 1.955 ± 0.392
1.173TrpLeu: 1.173 ± 0.682
0.782TrpMet: 0.782 ± 0.419
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.391TrpGln: 0.391 ± 0.209
1.173TrpArg: 1.173 ± 1.337
1.564TrpSer: 1.564 ± 0.473
1.173TrpThr: 1.173 ± 0.628
0.782TrpVal: 0.782 ± 0.236
0.391TrpTrp: 0.391 ± 0.209
0.391TrpTyr: 0.391 ± 0.209
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.564TyrAla: 1.564 ± 0.473
0.391TyrCys: 0.391 ± 0.209
3.127TyrAsp: 3.127 ± 1.02
3.127TyrGlu: 3.127 ± 1.02
1.173TyrPhe: 1.173 ± 0.682
3.909TyrGly: 3.909 ± 1.182
0.391TyrHis: 0.391 ± 0.446
0.391TyrIle: 0.391 ± 0.446
4.3TyrLys: 4.3 ± 0.317
0.782TyrLeu: 0.782 ± 0.419
1.955TyrMet: 1.955 ± 0.918
1.173TyrAsn: 1.173 ± 0.682
0.391TyrPro: 0.391 ± 0.446
0.782TyrGln: 0.782 ± 0.419
1.564TyrArg: 1.564 ± 0.837
2.346TyrSer: 2.346 ± 1.364
3.518TyrThr: 3.518 ± 0.081
1.173TyrVal: 1.173 ± 0.682
0.391TyrTrp: 0.391 ± 0.446
2.737TyrTyr: 2.737 ± 0.155
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2559 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski