Amino acid dipepetide frequency for Ignavibacterium album (strain DSM 19864 / JCM 16511 / NBRC 101810 / Mat9-16)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.19AlaAla: 4.19 ± 0.078
0.48AlaCys: 0.48 ± 0.024
3.17AlaAsp: 3.17 ± 0.055
3.855AlaGlu: 3.855 ± 0.064
3.016AlaPhe: 3.016 ± 0.053
4.302AlaGly: 4.302 ± 0.073
0.84AlaHis: 0.84 ± 0.028
5.004AlaIle: 5.004 ± 0.079
4.205AlaLys: 4.205 ± 0.074
5.55AlaLeu: 5.55 ± 0.075
1.221AlaMet: 1.221 ± 0.036
2.834AlaAsn: 2.834 ± 0.061
1.608AlaPro: 1.608 ± 0.041
2.016AlaGln: 2.016 ± 0.045
2.117AlaArg: 2.117 ± 0.05
3.606AlaSer: 3.606 ± 0.06
2.833AlaThr: 2.833 ± 0.066
4.085AlaVal: 4.085 ± 0.066
0.469AlaTrp: 0.469 ± 0.021
2.117AlaTyr: 2.117 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.384CysAla: 0.384 ± 0.018
0.091CysCys: 0.091 ± 0.01
0.391CysAsp: 0.391 ± 0.017
0.49CysGlu: 0.49 ± 0.022
0.323CysPhe: 0.323 ± 0.018
0.615CysGly: 0.615 ± 0.024
0.275CysHis: 0.275 ± 0.037
0.498CysIle: 0.498 ± 0.02
0.478CysLys: 0.478 ± 0.021
0.528CysLeu: 0.528 ± 0.023
0.112CysMet: 0.112 ± 0.012
0.374CysAsn: 0.374 ± 0.018
0.353CysPro: 0.353 ± 0.022
0.166CysGln: 0.166 ± 0.012
0.306CysArg: 0.306 ± 0.016
0.517CysSer: 0.517 ± 0.025
0.391CysThr: 0.391 ± 0.021
0.428CysVal: 0.428 ± 0.024
0.089CysTrp: 0.089 ± 0.01
0.268CysTyr: 0.268 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
2.969AspAla: 2.969 ± 0.054
0.386AspCys: 0.386 ± 0.022
2.843AspAsp: 2.843 ± 0.058
4.434AspGlu: 4.434 ± 0.081
3.471AspPhe: 3.471 ± 0.056
3.517AspGly: 3.517 ± 0.065
0.615AspHis: 0.615 ± 0.023
4.415AspIle: 4.415 ± 0.069
4.38AspLys: 4.38 ± 0.071
4.95AspLeu: 4.95 ± 0.079
0.849AspMet: 0.849 ± 0.031
2.926AspAsn: 2.926 ± 0.056
2.0AspPro: 2.0 ± 0.047
1.212AspGln: 1.212 ± 0.034
1.791AspArg: 1.791 ± 0.036
3.656AspSer: 3.656 ± 0.075
2.297AspThr: 2.297 ± 0.046
3.493AspVal: 3.493 ± 0.065
0.682AspTrp: 0.682 ± 0.024
2.762AspTyr: 2.762 ± 0.051
0.0AspXaa: 0.0 ± 0.0
Glu
3.712GluAla: 3.712 ± 0.076
0.405GluCys: 0.405 ± 0.022
2.926GluAsp: 2.926 ± 0.055
4.901GluGlu: 4.901 ± 0.092
3.574GluPhe: 3.574 ± 0.068
3.221GluGly: 3.221 ± 0.06
0.928GluHis: 0.928 ± 0.029
6.872GluIle: 6.872 ± 0.095
6.709GluLys: 6.709 ± 0.107
6.877GluLeu: 6.877 ± 0.104
1.549GluMet: 1.549 ± 0.037
4.351GluAsn: 4.351 ± 0.072
1.718GluPro: 1.718 ± 0.046
2.158GluGln: 2.158 ± 0.058
2.696GluArg: 2.696 ± 0.052
3.517GluSer: 3.517 ± 0.06
3.033GluThr: 3.033 ± 0.058
4.213GluVal: 4.213 ± 0.065
0.58GluTrp: 0.58 ± 0.024
2.583GluTyr: 2.583 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
3.342PheAla: 3.342 ± 0.057
0.39PheCys: 0.39 ± 0.019
3.516PheAsp: 3.516 ± 0.057
3.5PheGlu: 3.5 ± 0.06
2.997PhePhe: 2.997 ± 0.061
3.888PheGly: 3.888 ± 0.07
0.807PheHis: 0.807 ± 0.027
4.951PheIle: 4.951 ± 0.08
3.204PheLys: 3.204 ± 0.056
5.079PheLeu: 5.079 ± 0.086
0.882PheMet: 0.882 ± 0.03
3.817PheAsn: 3.817 ± 0.072
1.984PhePro: 1.984 ± 0.049
1.481PheGln: 1.481 ± 0.037
2.219PheArg: 2.219 ± 0.047
4.53PheSer: 4.53 ± 0.08
3.138PheThr: 3.138 ± 0.055
3.483PheVal: 3.483 ± 0.057
0.607PheTrp: 0.607 ± 0.026
2.63PheTyr: 2.63 ± 0.051
0.0PheXaa: 0.0 ± 0.0
Gly
3.597GlyAla: 3.597 ± 0.071
0.584GlyCys: 0.584 ± 0.027
3.083GlyAsp: 3.083 ± 0.061
3.505GlyGlu: 3.505 ± 0.061
3.621GlyPhe: 3.621 ± 0.061
4.403GlyGly: 4.403 ± 0.097
0.857GlyHis: 0.857 ± 0.03
5.837GlyIle: 5.837 ± 0.091
4.937GlyLys: 4.937 ± 0.093
5.667GlyLeu: 5.667 ± 0.081
1.375GlyMet: 1.375 ± 0.037
3.779GlyAsn: 3.779 ± 0.077
1.459GlyPro: 1.459 ± 0.044
1.595GlyGln: 1.595 ± 0.047
2.308GlyArg: 2.308 ± 0.048
3.987GlySer: 3.987 ± 0.07
3.787GlyThr: 3.787 ± 0.082
4.065GlyVal: 4.065 ± 0.069
0.833GlyTrp: 0.833 ± 0.027
2.907GlyTyr: 2.907 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
0.664HisAla: 0.664 ± 0.029
0.156HisCys: 0.156 ± 0.011
0.556HisAsp: 0.556 ± 0.023
0.689HisGlu: 0.689 ± 0.027
0.964HisPhe: 0.964 ± 0.028
0.852HisGly: 0.852 ± 0.03
0.378HisHis: 0.378 ± 0.02
1.281HisIle: 1.281 ± 0.039
1.125HisLys: 1.125 ± 0.034
1.591HisLeu: 1.591 ± 0.043
0.193HisMet: 0.193 ± 0.013
0.881HisAsn: 0.881 ± 0.029
0.895HisPro: 0.895 ± 0.03
0.532HisGln: 0.532 ± 0.025
0.594HisArg: 0.594 ± 0.023
1.085HisSer: 1.085 ± 0.037
0.81HisThr: 0.81 ± 0.026
0.51HisVal: 0.51 ± 0.02
0.212HisTrp: 0.212 ± 0.015
0.649HisTyr: 0.649 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.398IleAla: 5.398 ± 0.077
0.619IleCys: 0.619 ± 0.024
5.057IleAsp: 5.057 ± 0.07
5.892IleGlu: 5.892 ± 0.087
4.796IlePhe: 4.796 ± 0.08
5.278IleGly: 5.278 ± 0.07
1.285IleHis: 1.285 ± 0.035
7.83IleIle: 7.83 ± 0.11
7.212IleLys: 7.212 ± 0.101
8.309IleLeu: 8.309 ± 0.102
1.318IleMet: 1.318 ± 0.04
5.085IleAsn: 5.085 ± 0.074
3.845IlePro: 3.845 ± 0.055
2.568IleGln: 2.568 ± 0.049
3.247IleArg: 3.247 ± 0.053
6.774IleSer: 6.774 ± 0.091
4.764IleThr: 4.764 ± 0.067
5.226IleVal: 5.226 ± 0.072
0.773IleTrp: 0.773 ± 0.03
3.56IleTyr: 3.56 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
4.031LysAla: 4.031 ± 0.077
0.396LysCys: 0.396 ± 0.02
4.221LysAsp: 4.221 ± 0.069
6.149LysGlu: 6.149 ± 0.101
4.028LysPhe: 4.028 ± 0.063
3.897LysGly: 3.897 ± 0.061
1.104LysHis: 1.104 ± 0.033
7.867LysIle: 7.867 ± 0.098
6.793LysLys: 6.793 ± 0.116
7.465LysLeu: 7.465 ± 0.09
1.943LysMet: 1.943 ± 0.041
5.215LysAsn: 5.215 ± 0.084
2.505LysPro: 2.505 ± 0.052
2.458LysGln: 2.458 ± 0.052
2.983LysArg: 2.983 ± 0.053
5.092LysSer: 5.092 ± 0.072
3.9LysThr: 3.9 ± 0.062
4.98LysVal: 4.98 ± 0.076
0.68LysTrp: 0.68 ± 0.027
3.308LysTyr: 3.308 ± 0.061
0.0LysXaa: 0.0 ± 0.0
Leu
5.536LeuAla: 5.536 ± 0.074
0.579LeuCys: 0.579 ± 0.027
4.348LeuAsp: 4.348 ± 0.056
5.428LeuGlu: 5.428 ± 0.086
5.309LeuPhe: 5.309 ± 0.095
5.584LeuGly: 5.584 ± 0.079
1.267LeuHis: 1.267 ± 0.034
8.831LeuIle: 8.831 ± 0.103
8.145LeuLys: 8.145 ± 0.104
8.888LeuLeu: 8.888 ± 0.122
1.869LeuMet: 1.869 ± 0.046
6.335LeuAsn: 6.335 ± 0.085
3.771LeuPro: 3.771 ± 0.062
2.824LeuGln: 2.824 ± 0.056
3.765LeuArg: 3.765 ± 0.062
7.415LeuSer: 7.415 ± 0.099
5.336LeuThr: 5.336 ± 0.072
5.316LeuVal: 5.316 ± 0.073
0.857LeuTrp: 0.857 ± 0.03
3.292LeuTyr: 3.292 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
1.092MetAla: 1.092 ± 0.037
0.103MetCys: 0.103 ± 0.011
0.863MetAsp: 0.863 ± 0.03
0.997MetGlu: 0.997 ± 0.031
0.929MetPhe: 0.929 ± 0.032
1.062MetGly: 1.062 ± 0.031
0.296MetHis: 0.296 ± 0.017
1.926MetIle: 1.926 ± 0.047
2.151MetLys: 2.151 ± 0.041
1.815MetLeu: 1.815 ± 0.038
0.539MetMet: 0.539 ± 0.021
1.364MetAsn: 1.364 ± 0.035
0.768MetPro: 0.768 ± 0.028
0.598MetGln: 0.598 ± 0.028
0.746MetArg: 0.746 ± 0.024
1.136MetSer: 1.136 ± 0.031
0.923MetThr: 0.923 ± 0.029
1.024MetVal: 1.024 ± 0.032
0.174MetTrp: 0.174 ± 0.012
0.515MetTyr: 0.515 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.13AsnAla: 3.13 ± 0.061
0.5AsnCys: 0.5 ± 0.024
3.206AsnAsp: 3.206 ± 0.052
3.987AsnGlu: 3.987 ± 0.06
3.719AsnPhe: 3.719 ± 0.065
3.784AsnGly: 3.784 ± 0.074
0.99AsnHis: 0.99 ± 0.034
5.001AsnIle: 5.001 ± 0.067
4.503AsnLys: 4.503 ± 0.078
6.186AsnLeu: 6.186 ± 0.093
0.946AsnMet: 0.946 ± 0.032
3.937AsnAsn: 3.937 ± 0.087
3.29AsnPro: 3.29 ± 0.058
2.27AsnGln: 2.27 ± 0.05
2.17AsnArg: 2.17 ± 0.045
4.503AsnSer: 4.503 ± 0.078
2.665AsnThr: 2.665 ± 0.06
3.228AsnVal: 3.228 ± 0.059
0.769AsnTrp: 0.769 ± 0.029
3.105AsnTyr: 3.105 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
2.154ProAla: 2.154 ± 0.042
0.223ProCys: 0.223 ± 0.016
2.589ProAsp: 2.589 ± 0.052
3.052ProGlu: 3.052 ± 0.06
2.175ProPhe: 2.175 ± 0.047
2.316ProGly: 2.316 ± 0.058
0.576ProHis: 0.576 ± 0.024
2.789ProIle: 2.789 ± 0.052
2.331ProLys: 2.331 ± 0.044
3.045ProLeu: 3.045 ± 0.05
0.619ProMet: 0.619 ± 0.024
2.33ProAsn: 2.33 ± 0.053
1.25ProPro: 1.25 ± 0.042
1.243ProGln: 1.243 ± 0.031
1.03ProArg: 1.03 ± 0.031
2.308ProSer: 2.308 ± 0.057
1.985ProThr: 1.985 ± 0.047
2.665ProVal: 2.665 ± 0.053
0.353ProTrp: 0.353 ± 0.022
1.388ProTyr: 1.388 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
1.557GlnAla: 1.557 ± 0.038
0.18GlnCys: 0.18 ± 0.013
1.219GlnAsp: 1.219 ± 0.038
1.712GlnGlu: 1.712 ± 0.041
1.637GlnPhe: 1.637 ± 0.04
1.486GlnGly: 1.486 ± 0.04
0.414GlnHis: 0.414 ± 0.019
2.96GlnIle: 2.96 ± 0.05
2.742GlnLys: 2.742 ± 0.06
3.037GlnLeu: 3.037 ± 0.051
0.718GlnMet: 0.718 ± 0.025
2.321GlnAsn: 2.321 ± 0.049
1.06GlnPro: 1.06 ± 0.033
1.235GlnGln: 1.235 ± 0.043
1.27GlnArg: 1.27 ± 0.036
2.108GlnSer: 2.108 ± 0.043
1.962GlnThr: 1.962 ± 0.047
1.717GlnVal: 1.717 ± 0.04
0.341GlnTrp: 0.341 ± 0.017
1.117GlnTyr: 1.117 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
2.007ArgAla: 2.007 ± 0.044
0.223ArgCys: 0.223 ± 0.014
1.928ArgAsp: 1.928 ± 0.04
2.63ArgGlu: 2.63 ± 0.057
2.108ArgPhe: 2.108 ± 0.045
2.034ArgGly: 2.034 ± 0.05
0.502ArgHis: 0.502 ± 0.023
3.653ArgIle: 3.653 ± 0.057
3.388ArgLys: 3.388 ± 0.059
3.513ArgLeu: 3.513 ± 0.059
0.907ArgMet: 0.907 ± 0.028
2.463ArgAsn: 2.463 ± 0.05
1.167ArgPro: 1.167 ± 0.033
1.081ArgGln: 1.081 ± 0.031
1.539ArgArg: 1.539 ± 0.044
1.932ArgSer: 1.932 ± 0.039
1.95ArgThr: 1.95 ± 0.048
2.19ArgVal: 2.19 ± 0.051
0.4ArgTrp: 0.4 ± 0.019
1.567ArgTyr: 1.567 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
4.014SerAla: 4.014 ± 0.058
0.486SerCys: 0.486 ± 0.021
4.225SerAsp: 4.225 ± 0.074
4.703SerGlu: 4.703 ± 0.077
4.292SerPhe: 4.292 ± 0.076
4.956SerGly: 4.956 ± 0.083
0.941SerHis: 0.941 ± 0.03
5.547SerIle: 5.547 ± 0.084
4.774SerLys: 4.774 ± 0.07
6.625SerLeu: 6.625 ± 0.088
1.162SerMet: 1.162 ± 0.036
3.911SerAsn: 3.911 ± 0.062
2.348SerPro: 2.348 ± 0.053
1.982SerGln: 1.982 ± 0.047
2.274SerArg: 2.274 ± 0.05
5.032SerSer: 5.032 ± 0.09
3.56SerThr: 3.56 ± 0.075
4.741SerVal: 4.741 ± 0.08
0.737SerTrp: 0.737 ± 0.029
2.626SerTyr: 2.626 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
3.231ThrAla: 3.231 ± 0.058
0.296ThrCys: 0.296 ± 0.017
2.999ThrAsp: 2.999 ± 0.059
3.272ThrGlu: 3.272 ± 0.06
2.892ThrPhe: 2.892 ± 0.058
3.926ThrGly: 3.926 ± 0.072
0.784ThrHis: 0.784 ± 0.032
4.607ThrIle: 4.607 ± 0.062
3.493ThrLys: 3.493 ± 0.06
4.952ThrLeu: 4.952 ± 0.068
0.804ThrMet: 0.804 ± 0.03
3.073ThrAsn: 3.073 ± 0.068
2.177ThrPro: 2.177 ± 0.046
1.555ThrGln: 1.555 ± 0.039
1.629ThrArg: 1.629 ± 0.039
3.583ThrSer: 3.583 ± 0.061
3.074ThrThr: 3.074 ± 0.073
3.332ThrVal: 3.332 ± 0.063
0.504ThrTrp: 0.504 ± 0.026
1.962ThrTyr: 1.962 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
3.79ValAla: 3.79 ± 0.063
0.532ValCys: 0.532 ± 0.023
3.521ValAsp: 3.521 ± 0.055
4.135ValGlu: 4.135 ± 0.074
3.264ValPhe: 3.264 ± 0.055
3.893ValGly: 3.893 ± 0.067
0.859ValHis: 0.859 ± 0.029
5.375ValIle: 5.375 ± 0.075
4.746ValLys: 4.746 ± 0.073
5.534ValLeu: 5.534 ± 0.064
1.158ValMet: 1.158 ± 0.033
3.618ValAsn: 3.618 ± 0.067
2.187ValPro: 2.187 ± 0.042
1.768ValGln: 1.768 ± 0.04
2.298ValArg: 2.298 ± 0.047
4.124ValSer: 4.124 ± 0.061
3.226ValThr: 3.226 ± 0.055
4.04ValVal: 4.04 ± 0.071
0.649ValTrp: 0.649 ± 0.028
2.59ValTyr: 2.59 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
0.586TrpAla: 0.586 ± 0.026
0.09TrpCys: 0.09 ± 0.009
0.579TrpAsp: 0.579 ± 0.024
0.628TrpGlu: 0.628 ± 0.025
0.534TrpPhe: 0.534 ± 0.027
0.683TrpGly: 0.683 ± 0.026
0.184TrpHis: 0.184 ± 0.013
0.875TrpIle: 0.875 ± 0.033
0.746TrpLys: 0.746 ± 0.022
0.971TrpLeu: 0.971 ± 0.03
0.253TrpMet: 0.253 ± 0.016
0.744TrpAsn: 0.744 ± 0.023
0.241TrpPro: 0.241 ± 0.016
0.476TrpGln: 0.476 ± 0.025
0.423TrpArg: 0.423 ± 0.02
0.639TrpSer: 0.639 ± 0.029
0.604TrpThr: 0.604 ± 0.029
0.544TrpVal: 0.544 ± 0.023
0.167TrpTrp: 0.167 ± 0.012
0.44TrpTyr: 0.44 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.136TyrAla: 2.136 ± 0.044
0.357TyrCys: 0.357 ± 0.02
2.409TyrAsp: 2.409 ± 0.042
2.565TyrGlu: 2.565 ± 0.057
2.795TyrPhe: 2.795 ± 0.049
2.488TyrGly: 2.488 ± 0.046
0.714TyrHis: 0.714 ± 0.026
2.72TyrIle: 2.72 ± 0.048
2.954TyrLys: 2.954 ± 0.053
4.118TyrLeu: 4.118 ± 0.062
0.602TyrMet: 0.602 ± 0.023
2.53TyrAsn: 2.53 ± 0.06
1.795TyrPro: 1.795 ± 0.046
1.574TyrGln: 1.574 ± 0.044
1.776TyrArg: 1.776 ± 0.038
3.393TyrSer: 3.393 ± 0.058
1.906TyrThr: 1.906 ± 0.04
2.027TyrVal: 2.027 ± 0.044
0.531TyrTrp: 0.531 ± 0.026
1.96TyrTyr: 1.96 ± 0.047
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3169 proteins (1115965 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski