Amino acid dipepetide frequency for Streptococcus satellite phage Javan621

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
1.304AlaCys: 1.304 ± 0.647
2.609AlaAsp: 2.609 ± 1.097
2.174AlaGlu: 2.174 ± 1.104
3.043AlaPhe: 3.043 ± 1.169
2.609AlaGly: 2.609 ± 1.22
0.0AlaHis: 0.0 ± 0.0
2.609AlaIle: 2.609 ± 0.897
3.478AlaLys: 3.478 ± 1.031
5.217AlaLeu: 5.217 ± 0.982
1.739AlaMet: 1.739 ± 0.775
3.043AlaAsn: 3.043 ± 0.959
1.304AlaPro: 1.304 ± 0.656
2.174AlaGln: 2.174 ± 1.141
1.739AlaArg: 1.739 ± 0.766
1.739AlaSer: 1.739 ± 0.675
3.913AlaThr: 3.913 ± 1.041
0.87AlaVal: 0.87 ± 0.491
0.0AlaTrp: 0.0 ± 0.0
3.043AlaTyr: 3.043 ± 0.948
0.0AlaXaa: 0.0 ± 0.0
Cys
0.435CysAla: 0.435 ± 0.336
0.0CysCys: 0.0 ± 0.0
0.435CysAsp: 0.435 ± 0.371
0.435CysGlu: 0.435 ± 0.491
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.435CysHis: 0.435 ± 0.344
2.174CysIle: 2.174 ± 0.701
0.435CysLys: 0.435 ± 0.479
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.87CysAsn: 0.87 ± 0.688
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.435CysVal: 0.435 ± 0.453
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.174AspAla: 2.174 ± 1.175
0.0AspCys: 0.0 ± 0.0
6.087AspAsp: 6.087 ± 1.72
3.478AspGlu: 3.478 ± 1.571
6.957AspPhe: 6.957 ± 1.788
2.174AspGly: 2.174 ± 0.867
0.435AspHis: 0.435 ± 0.404
9.565AspIle: 9.565 ± 1.631
6.957AspLys: 6.957 ± 1.209
5.652AspLeu: 5.652 ± 1.63
2.174AspMet: 2.174 ± 0.838
1.304AspAsn: 1.304 ± 0.799
1.304AspPro: 1.304 ± 0.895
2.609AspGln: 2.609 ± 0.824
2.609AspArg: 2.609 ± 0.774
4.348AspSer: 4.348 ± 1.39
4.783AspThr: 4.783 ± 2.154
0.87AspVal: 0.87 ± 0.671
0.87AspTrp: 0.87 ± 0.604
5.652AspTyr: 5.652 ± 2.104
0.0AspXaa: 0.0 ± 0.0
Glu
6.087GluAla: 6.087 ± 1.227
0.435GluCys: 0.435 ± 0.453
4.348GluAsp: 4.348 ± 1.684
4.348GluGlu: 4.348 ± 1.499
3.913GluPhe: 3.913 ± 0.891
1.304GluGly: 1.304 ± 0.795
0.87GluHis: 0.87 ± 0.619
4.348GluIle: 4.348 ± 1.899
7.391GluLys: 7.391 ± 1.763
6.087GluLeu: 6.087 ± 1.59
1.304GluMet: 1.304 ± 0.836
5.217GluAsn: 5.217 ± 1.404
4.783GluPro: 4.783 ± 1.257
2.609GluGln: 2.609 ± 1.434
3.478GluArg: 3.478 ± 1.104
0.87GluSer: 0.87 ± 0.537
5.217GluThr: 5.217 ± 1.53
5.217GluVal: 5.217 ± 1.079
1.304GluTrp: 1.304 ± 0.486
2.174GluTyr: 2.174 ± 0.591
0.0GluXaa: 0.0 ± 0.0
Phe
0.87PheAla: 0.87 ± 0.452
0.0PheCys: 0.0 ± 0.0
6.522PheAsp: 6.522 ± 1.832
6.087PheGlu: 6.087 ± 2.25
1.304PhePhe: 1.304 ± 0.954
2.174PheGly: 2.174 ± 0.578
1.304PheHis: 1.304 ± 1.007
5.217PheIle: 5.217 ± 1.367
3.478PheLys: 3.478 ± 0.861
2.174PheLeu: 2.174 ± 0.822
1.304PheMet: 1.304 ± 0.705
3.913PheAsn: 3.913 ± 1.197
1.304PhePro: 1.304 ± 0.721
1.739PheGln: 1.739 ± 0.729
2.609PheArg: 2.609 ± 0.828
2.174PheSer: 2.174 ± 1.037
2.174PheThr: 2.174 ± 0.814
3.478PheVal: 3.478 ± 1.014
0.0PheTrp: 0.0 ± 0.0
3.043PheTyr: 3.043 ± 1.637
0.0PheXaa: 0.0 ± 0.0
Gly
1.739GlyAla: 1.739 ± 0.9
0.0GlyCys: 0.0 ± 0.0
3.478GlyAsp: 3.478 ± 1.411
1.739GlyGlu: 1.739 ± 0.793
1.304GlyPhe: 1.304 ± 0.574
1.304GlyGly: 1.304 ± 0.598
0.435GlyHis: 0.435 ± 0.336
2.609GlyIle: 2.609 ± 1.053
6.087GlyLys: 6.087 ± 1.711
3.913GlyLeu: 3.913 ± 1.382
2.609GlyMet: 2.609 ± 1.352
3.478GlyAsn: 3.478 ± 1.273
0.0GlyPro: 0.0 ± 0.0
2.174GlyGln: 2.174 ± 0.722
1.304GlyArg: 1.304 ± 0.597
2.174GlySer: 2.174 ± 0.994
3.043GlyThr: 3.043 ± 0.902
2.609GlyVal: 2.609 ± 0.675
1.739GlyTrp: 1.739 ± 1.044
2.609GlyTyr: 2.609 ± 1.143
0.0GlyXaa: 0.0 ± 0.0
His
1.304HisAla: 1.304 ± 0.766
0.435HisCys: 0.435 ± 0.344
0.435HisAsp: 0.435 ± 0.404
1.739HisGlu: 1.739 ± 1.146
1.304HisPhe: 1.304 ± 0.717
0.435HisGly: 0.435 ± 0.336
0.0HisHis: 0.0 ± 0.0
0.87HisIle: 0.87 ± 0.593
0.435HisLys: 0.435 ± 0.344
0.87HisLeu: 0.87 ± 0.395
0.0HisMet: 0.0 ± 0.0
0.435HisAsn: 0.435 ± 0.336
0.0HisPro: 0.0 ± 0.0
0.435HisGln: 0.435 ± 0.479
0.0HisArg: 0.0 ± 0.0
1.739HisSer: 1.739 ± 0.69
1.739HisThr: 1.739 ± 0.812
0.435HisVal: 0.435 ± 0.344
0.435HisTrp: 0.435 ± 0.491
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
5.652IleAla: 5.652 ± 1.332
0.0IleCys: 0.0 ± 0.0
6.087IleAsp: 6.087 ± 1.234
6.087IleGlu: 6.087 ± 1.682
1.739IlePhe: 1.739 ± 0.709
6.087IleGly: 6.087 ± 1.607
0.435IleHis: 0.435 ± 0.404
4.783IleIle: 4.783 ± 1.153
5.652IleLys: 5.652 ± 1.386
10.435IleLeu: 10.435 ± 2.373
2.609IleMet: 2.609 ± 1.001
5.217IleAsn: 5.217 ± 1.851
2.609IlePro: 2.609 ± 1.267
2.609IleGln: 2.609 ± 0.621
3.043IleArg: 3.043 ± 0.845
6.957IleSer: 6.957 ± 0.895
6.522IleThr: 6.522 ± 1.387
2.609IleVal: 2.609 ± 1.32
0.0IleTrp: 0.0 ± 0.0
2.609IleTyr: 2.609 ± 1.352
0.0IleXaa: 0.0 ± 0.0
Lys
3.043LysAla: 3.043 ± 0.963
0.435LysCys: 0.435 ± 0.479
5.217LysAsp: 5.217 ± 1.409
8.261LysGlu: 8.261 ± 2.539
4.783LysPhe: 4.783 ± 1.395
5.217LysGly: 5.217 ± 1.446
1.739LysHis: 1.739 ± 0.547
6.087LysIle: 6.087 ± 1.409
8.261LysLys: 8.261 ± 2.507
6.957LysLeu: 6.957 ± 2.35
4.348LysMet: 4.348 ± 1.594
5.217LysAsn: 5.217 ± 1.192
3.913LysPro: 3.913 ± 1.675
3.913LysGln: 3.913 ± 1.141
3.913LysArg: 3.913 ± 1.647
5.217LysSer: 5.217 ± 1.717
3.913LysThr: 3.913 ± 1.342
4.783LysVal: 4.783 ± 1.276
0.435LysTrp: 0.435 ± 0.344
3.913LysTyr: 3.913 ± 0.884
0.0LysXaa: 0.0 ± 0.0
Leu
2.609LeuAla: 2.609 ± 0.836
0.87LeuCys: 0.87 ± 0.688
9.13LeuAsp: 9.13 ± 2.747
9.565LeuGlu: 9.565 ± 2.312
3.043LeuPhe: 3.043 ± 0.739
4.783LeuGly: 4.783 ± 1.375
0.435LeuHis: 0.435 ± 0.344
7.391LeuIle: 7.391 ± 1.493
6.957LeuLys: 6.957 ± 1.578
12.174LeuLeu: 12.174 ± 3.132
0.87LeuMet: 0.87 ± 0.594
5.652LeuAsn: 5.652 ± 1.26
5.652LeuPro: 5.652 ± 1.62
3.043LeuGln: 3.043 ± 1.14
4.348LeuArg: 4.348 ± 1.203
6.957LeuSer: 6.957 ± 1.409
6.522LeuThr: 6.522 ± 1.293
3.043LeuVal: 3.043 ± 1.192
0.435LeuTrp: 0.435 ± 0.344
3.913LeuTyr: 3.913 ± 0.792
0.0LeuXaa: 0.0 ± 0.0
Met
1.304MetAla: 1.304 ± 0.834
0.0MetCys: 0.0 ± 0.0
0.87MetAsp: 0.87 ± 0.59
0.87MetGlu: 0.87 ± 0.573
1.304MetPhe: 1.304 ± 0.905
0.435MetGly: 0.435 ± 0.453
0.435MetHis: 0.435 ± 0.491
0.87MetIle: 0.87 ± 0.593
4.348MetLys: 4.348 ± 1.078
3.478MetLeu: 3.478 ± 1.003
0.87MetMet: 0.87 ± 0.574
0.435MetAsn: 0.435 ± 0.344
0.0MetPro: 0.0 ± 0.0
0.87MetGln: 0.87 ± 0.577
3.478MetArg: 3.478 ± 0.89
1.304MetSer: 1.304 ± 0.766
3.478MetThr: 3.478 ± 0.954
0.87MetVal: 0.87 ± 0.669
0.435MetTrp: 0.435 ± 0.336
1.304MetTyr: 1.304 ± 0.702
0.0MetXaa: 0.0 ± 0.0
Asn
4.783AsnAla: 4.783 ± 1.383
0.87AsnCys: 0.87 ± 0.62
2.609AsnAsp: 2.609 ± 1.357
5.217AsnGlu: 5.217 ± 1.827
3.913AsnPhe: 3.913 ± 1.299
6.522AsnGly: 6.522 ± 1.548
0.435AsnHis: 0.435 ± 0.344
6.522AsnIle: 6.522 ± 1.897
5.217AsnLys: 5.217 ± 1.421
6.522AsnLeu: 6.522 ± 1.449
1.739AsnMet: 1.739 ± 0.923
4.348AsnAsn: 4.348 ± 1.864
2.174AsnPro: 2.174 ± 0.881
0.87AsnGln: 0.87 ± 0.379
1.739AsnArg: 1.739 ± 0.662
3.478AsnSer: 3.478 ± 1.571
3.043AsnThr: 3.043 ± 1.338
1.304AsnVal: 1.304 ± 0.506
0.0AsnTrp: 0.0 ± 0.0
5.652AsnTyr: 5.652 ± 1.482
0.0AsnXaa: 0.0 ± 0.0
Pro
0.435ProAla: 0.435 ± 0.336
0.0ProCys: 0.0 ± 0.0
4.348ProAsp: 4.348 ± 1.213
2.609ProGlu: 2.609 ± 1.188
2.609ProPhe: 2.609 ± 0.922
0.0ProGly: 0.0 ± 0.0
0.0ProHis: 0.0 ± 0.0
1.739ProIle: 1.739 ± 0.834
3.043ProLys: 3.043 ± 1.464
3.043ProLeu: 3.043 ± 1.026
2.174ProMet: 2.174 ± 0.769
3.478ProAsn: 3.478 ± 1.124
0.87ProPro: 0.87 ± 0.743
0.87ProGln: 0.87 ± 0.491
3.043ProArg: 3.043 ± 1.043
0.87ProSer: 0.87 ± 0.743
2.609ProThr: 2.609 ± 1.003
1.304ProVal: 1.304 ± 0.582
0.0ProTrp: 0.0 ± 0.0
1.739ProTyr: 1.739 ± 0.911
0.0ProXaa: 0.0 ± 0.0
Gln
4.348GlnAla: 4.348 ± 1.202
0.0GlnCys: 0.0 ± 0.0
0.87GlnAsp: 0.87 ± 0.573
1.739GlnGlu: 1.739 ± 1.39
1.739GlnPhe: 1.739 ± 0.764
1.739GlnGly: 1.739 ± 1.122
1.739GlnHis: 1.739 ± 0.799
2.609GlnIle: 2.609 ± 1.077
2.609GlnLys: 2.609 ± 0.85
3.043GlnLeu: 3.043 ± 1.081
0.435GlnMet: 0.435 ± 0.535
1.304GlnAsn: 1.304 ± 0.566
1.304GlnPro: 1.304 ± 0.915
0.87GlnGln: 0.87 ± 0.573
2.174GlnArg: 2.174 ± 1.009
3.913GlnSer: 3.913 ± 1.027
1.739GlnThr: 1.739 ± 0.831
2.174GlnVal: 2.174 ± 0.977
0.435GlnTrp: 0.435 ± 0.344
1.739GlnTyr: 1.739 ± 0.568
0.0GlnXaa: 0.0 ± 0.0
Arg
2.609ArgAla: 2.609 ± 0.759
0.0ArgCys: 0.0 ± 0.0
3.043ArgAsp: 3.043 ± 0.882
2.609ArgGlu: 2.609 ± 1.36
0.87ArgPhe: 0.87 ± 0.503
2.174ArgGly: 2.174 ± 1.171
0.87ArgHis: 0.87 ± 0.593
4.348ArgIle: 4.348 ± 1.191
4.783ArgLys: 4.783 ± 1.117
6.087ArgLeu: 6.087 ± 0.847
0.0ArgMet: 0.0 ± 0.0
3.913ArgAsn: 3.913 ± 0.927
2.174ArgPro: 2.174 ± 0.733
1.739ArgGln: 1.739 ± 0.96
1.739ArgArg: 1.739 ± 0.714
1.739ArgSer: 1.739 ± 1.0
2.609ArgThr: 2.609 ± 0.954
3.043ArgVal: 3.043 ± 0.955
0.87ArgTrp: 0.87 ± 0.667
1.304ArgTyr: 1.304 ± 0.782
0.0ArgXaa: 0.0 ± 0.0
Ser
1.304SerAla: 1.304 ± 0.643
0.0SerCys: 0.0 ± 0.0
6.957SerAsp: 6.957 ± 1.452
3.043SerGlu: 3.043 ± 0.846
0.435SerPhe: 0.435 ± 0.404
2.609SerGly: 2.609 ± 0.787
0.87SerHis: 0.87 ± 0.5
5.217SerIle: 5.217 ± 1.332
6.957SerLys: 6.957 ± 1.741
5.652SerLeu: 5.652 ± 1.314
0.435SerMet: 0.435 ± 0.336
5.217SerAsn: 5.217 ± 1.536
1.739SerPro: 1.739 ± 0.523
1.739SerGln: 1.739 ± 0.743
3.043SerArg: 3.043 ± 0.753
1.739SerSer: 1.739 ± 0.702
2.174SerThr: 2.174 ± 0.634
3.043SerVal: 3.043 ± 1.176
0.0SerTrp: 0.0 ± 0.0
2.609SerTyr: 2.609 ± 1.259
0.0SerXaa: 0.0 ± 0.0
Thr
1.304ThrAla: 1.304 ± 0.774
0.435ThrCys: 0.435 ± 0.344
2.174ThrAsp: 2.174 ± 1.006
3.913ThrGlu: 3.913 ± 0.913
6.087ThrPhe: 6.087 ± 1.467
1.739ThrGly: 1.739 ± 0.653
0.435ThrHis: 0.435 ± 0.336
6.087ThrIle: 6.087 ± 2.404
3.043ThrLys: 3.043 ± 1.216
8.696ThrLeu: 8.696 ± 2.352
2.609ThrMet: 2.609 ± 0.867
3.913ThrAsn: 3.913 ± 1.065
3.478ThrPro: 3.478 ± 0.751
1.739ThrGln: 1.739 ± 0.804
2.174ThrArg: 2.174 ± 0.712
3.043ThrSer: 3.043 ± 0.776
3.043ThrThr: 3.043 ± 0.996
4.783ThrVal: 4.783 ± 1.462
1.304ThrTrp: 1.304 ± 0.806
2.174ThrTyr: 2.174 ± 1.123
0.0ThrXaa: 0.0 ± 0.0
Val
1.739ValAla: 1.739 ± 0.736
0.0ValCys: 0.0 ± 0.0
1.304ValAsp: 1.304 ± 0.597
3.043ValGlu: 3.043 ± 0.991
2.609ValPhe: 2.609 ± 1.034
0.87ValGly: 0.87 ± 0.5
0.435ValHis: 0.435 ± 0.371
3.478ValIle: 3.478 ± 1.076
4.783ValLys: 4.783 ± 1.238
3.478ValLeu: 3.478 ± 1.371
0.435ValMet: 0.435 ± 0.575
5.652ValAsn: 5.652 ± 1.323
1.304ValPro: 1.304 ± 0.804
2.174ValGln: 2.174 ± 0.781
1.739ValArg: 1.739 ± 1.186
3.913ValSer: 3.913 ± 1.247
3.478ValThr: 3.478 ± 1.087
3.043ValVal: 3.043 ± 0.832
0.435ValTrp: 0.435 ± 0.344
3.043ValTyr: 3.043 ± 1.021
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.304TrpGlu: 1.304 ± 0.828
1.304TrpPhe: 1.304 ± 0.748
0.435TrpGly: 0.435 ± 0.344
0.435TrpHis: 0.435 ± 0.344
0.87TrpIle: 0.87 ± 0.514
0.0TrpLys: 0.0 ± 0.0
0.87TrpLeu: 0.87 ± 0.55
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.87TrpGln: 0.87 ± 0.571
0.87TrpArg: 0.87 ± 0.571
0.87TrpSer: 0.87 ± 0.5
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.87TrpTyr: 0.87 ± 0.6
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.87TyrAla: 0.87 ± 0.574
0.87TyrCys: 0.87 ± 0.606
3.478TyrAsp: 3.478 ± 1.594
3.043TyrGlu: 3.043 ± 1.57
2.609TyrPhe: 2.609 ± 0.96
1.739TyrGly: 1.739 ± 0.865
1.304TyrHis: 1.304 ± 1.198
4.348TyrIle: 4.348 ± 0.978
5.652TyrLys: 5.652 ± 2.031
3.043TyrLeu: 3.043 ± 0.919
0.87TyrMet: 0.87 ± 0.574
4.783TyrAsn: 4.783 ± 1.515
0.87TyrPro: 0.87 ± 0.612
3.478TyrGln: 3.478 ± 1.597
3.478TyrArg: 3.478 ± 1.005
1.739TyrSer: 1.739 ± 0.793
2.174TyrThr: 2.174 ± 1.544
3.043TyrVal: 3.043 ± 0.804
0.0TyrTrp: 0.0 ± 0.0
1.739TyrTyr: 1.739 ± 0.864
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 15 proteins (2301 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski