Amino acid dipepetide frequency for Edwardsiella phage vB_EtaM_ET-ABTNL-9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.745AlaAla: 2.745 ± 0.457
1.003AlaCys: 1.003 ± 0.233
2.903AlaAsp: 2.903 ± 0.418
4.803AlaGlu: 4.803 ± 1.431
2.322AlaPhe: 2.322 ± 0.377
4.328AlaGly: 4.328 ± 0.476
1.056AlaHis: 1.056 ± 0.244
5.542AlaIle: 5.542 ± 0.705
5.384AlaLys: 5.384 ± 0.811
6.439AlaLeu: 6.439 ± 1.073
1.689AlaMet: 1.689 ± 0.299
3.325AlaAsn: 3.325 ± 0.406
1.583AlaPro: 1.583 ± 0.34
1.953AlaGln: 1.953 ± 0.459
3.484AlaArg: 3.484 ± 0.597
5.331AlaSer: 5.331 ± 0.545
4.17AlaThr: 4.17 ± 0.614
4.486AlaVal: 4.486 ± 0.5
0.686AlaTrp: 0.686 ± 0.185
2.322AlaTyr: 2.322 ± 0.41
0.0AlaXaa: 0.0 ± 0.0
Cys
0.528CysAla: 0.528 ± 0.158
0.158CysCys: 0.158 ± 0.11
0.739CysAsp: 0.739 ± 0.184
0.528CysGlu: 0.528 ± 0.195
0.792CysPhe: 0.792 ± 0.173
0.845CysGly: 0.845 ± 0.228
0.422CysHis: 0.422 ± 0.172
0.475CysIle: 0.475 ± 0.175
0.792CysLys: 0.792 ± 0.304
0.897CysLeu: 0.897 ± 0.251
0.0CysMet: 0.0 ± 0.0
0.739CysAsn: 0.739 ± 0.194
0.422CysPro: 0.422 ± 0.16
0.317CysGln: 0.317 ± 0.123
0.422CysArg: 0.422 ± 0.137
0.897CysSer: 0.897 ± 0.293
0.633CysThr: 0.633 ± 0.195
0.633CysVal: 0.633 ± 0.214
0.053CysTrp: 0.053 ± 0.051
0.422CysTyr: 0.422 ± 0.172
0.0CysXaa: 0.0 ± 0.0
Asp
3.959AspAla: 3.959 ± 0.475
0.528AspCys: 0.528 ± 0.16
4.064AspAsp: 4.064 ± 0.595
4.117AspGlu: 4.117 ± 0.446
3.061AspPhe: 3.061 ± 0.407
4.961AspGly: 4.961 ± 0.536
0.686AspHis: 0.686 ± 0.156
4.592AspIle: 4.592 ± 0.684
5.859AspLys: 5.859 ± 0.52
6.387AspLeu: 6.387 ± 0.583
2.111AspMet: 2.111 ± 0.306
3.695AspAsn: 3.695 ± 0.517
1.425AspPro: 1.425 ± 0.296
1.161AspGln: 1.161 ± 0.239
2.745AspArg: 2.745 ± 0.384
4.223AspSer: 4.223 ± 0.454
4.486AspThr: 4.486 ± 0.498
4.064AspVal: 4.064 ± 0.509
1.425AspTrp: 1.425 ± 0.276
2.322AspTyr: 2.322 ± 0.337
0.0AspXaa: 0.0 ± 0.0
Glu
7.02GluAla: 7.02 ± 1.336
0.792GluCys: 0.792 ± 0.209
5.648GluAsp: 5.648 ± 0.618
6.598GluGlu: 6.598 ± 0.711
2.956GluPhe: 2.956 ± 0.485
4.803GluGly: 4.803 ± 0.542
1.32GluHis: 1.32 ± 0.316
4.698GluIle: 4.698 ± 0.523
4.011GluLys: 4.011 ± 0.39
6.967GluLeu: 6.967 ± 0.687
1.953GluMet: 1.953 ± 0.301
2.956GluAsn: 2.956 ± 0.356
1.003GluPro: 1.003 ± 0.218
2.745GluGln: 2.745 ± 0.427
3.114GluArg: 3.114 ± 0.369
5.12GluSer: 5.12 ± 0.568
4.381GluThr: 4.381 ± 0.706
4.856GluVal: 4.856 ± 0.465
1.056GluTrp: 1.056 ± 0.226
3.642GluTyr: 3.642 ± 0.536
0.0GluXaa: 0.0 ± 0.0
Phe
2.586PheAla: 2.586 ± 0.334
0.369PheCys: 0.369 ± 0.147
2.692PheAsp: 2.692 ± 0.394
2.745PheGlu: 2.745 ± 0.341
1.003PhePhe: 1.003 ± 0.273
2.745PheGly: 2.745 ± 0.411
0.422PheHis: 0.422 ± 0.142
2.164PheIle: 2.164 ± 0.347
2.586PheLys: 2.586 ± 0.409
2.586PheLeu: 2.586 ± 0.387
1.32PheMet: 1.32 ± 0.331
2.534PheAsn: 2.534 ± 0.403
1.003PhePro: 1.003 ± 0.237
1.108PheGln: 1.108 ± 0.209
1.689PheArg: 1.689 ± 0.315
2.956PheSer: 2.956 ± 0.355
2.428PheThr: 2.428 ± 0.404
2.534PheVal: 2.534 ± 0.366
0.528PheTrp: 0.528 ± 0.181
1.583PheTyr: 1.583 ± 0.315
0.0PheXaa: 0.0 ± 0.0
Gly
3.853GlyAla: 3.853 ± 0.553
0.739GlyCys: 0.739 ± 0.224
4.645GlyAsp: 4.645 ± 0.628
4.803GlyGlu: 4.803 ± 0.554
2.639GlyPhe: 2.639 ± 0.439
4.856GlyGly: 4.856 ± 0.85
1.161GlyHis: 1.161 ± 0.238
3.589GlyIle: 3.589 ± 0.455
6.334GlyLys: 6.334 ± 0.605
4.381GlyLeu: 4.381 ± 0.64
1.636GlyMet: 1.636 ± 0.274
3.484GlyAsn: 3.484 ± 0.436
0.317GlyPro: 0.317 ± 0.142
1.689GlyGln: 1.689 ± 0.324
2.692GlyArg: 2.692 ± 0.426
4.645GlySer: 4.645 ± 0.487
3.431GlyThr: 3.431 ± 0.412
6.809GlyVal: 6.809 ± 0.623
1.108GlyTrp: 1.108 ± 0.225
3.642GlyTyr: 3.642 ± 0.458
0.0GlyXaa: 0.0 ± 0.0
His
0.792HisAla: 0.792 ± 0.196
0.369HisCys: 0.369 ± 0.143
1.108HisAsp: 1.108 ± 0.222
1.056HisGlu: 1.056 ± 0.257
0.581HisPhe: 0.581 ± 0.218
1.056HisGly: 1.056 ± 0.262
0.211HisHis: 0.211 ± 0.098
1.214HisIle: 1.214 ± 0.256
1.425HisLys: 1.425 ± 0.254
1.214HisLeu: 1.214 ± 0.313
0.158HisMet: 0.158 ± 0.091
1.108HisAsn: 1.108 ± 0.197
0.792HisPro: 0.792 ± 0.22
0.211HisGln: 0.211 ± 0.102
1.161HisArg: 1.161 ± 0.251
0.897HisSer: 0.897 ± 0.212
1.003HisThr: 1.003 ± 0.178
0.897HisVal: 0.897 ± 0.224
0.317HisTrp: 0.317 ± 0.121
0.897HisTyr: 0.897 ± 0.204
0.0HisXaa: 0.0 ± 0.0
Ile
4.434IleAla: 4.434 ± 0.43
0.739IleCys: 0.739 ± 0.213
4.486IleAsp: 4.486 ± 0.587
4.909IleGlu: 4.909 ± 0.604
1.795IlePhe: 1.795 ± 0.361
2.745IleGly: 2.745 ± 0.282
1.847IleHis: 1.847 ± 0.351
2.797IleIle: 2.797 ± 0.539
5.595IleLys: 5.595 ± 0.579
3.536IleLeu: 3.536 ± 0.407
1.161IleMet: 1.161 ± 0.226
4.117IleAsn: 4.117 ± 0.485
2.058IlePro: 2.058 ± 0.404
1.9IleGln: 1.9 ± 0.27
1.953IleArg: 1.953 ± 0.301
4.961IleSer: 4.961 ± 0.572
5.331IleThr: 5.331 ± 0.757
4.486IleVal: 4.486 ± 0.446
0.528IleTrp: 0.528 ± 0.165
1.847IleTyr: 1.847 ± 0.266
0.0IleXaa: 0.0 ± 0.0
Lys
6.387LysAla: 6.387 ± 0.646
0.475LysCys: 0.475 ± 0.233
6.07LysAsp: 6.07 ± 0.435
6.703LysGlu: 6.703 ± 0.548
2.217LysPhe: 2.217 ± 0.383
5.753LysGly: 5.753 ± 0.671
1.583LysHis: 1.583 ± 0.26
4.064LysIle: 4.064 ± 0.438
4.961LysLys: 4.961 ± 0.711
7.02LysLeu: 7.02 ± 0.845
1.847LysMet: 1.847 ± 0.381
3.431LysAsn: 3.431 ± 0.613
2.111LysPro: 2.111 ± 0.336
2.586LysGln: 2.586 ± 0.312
2.797LysArg: 2.797 ± 0.367
5.437LysSer: 5.437 ± 0.695
4.539LysThr: 4.539 ± 0.461
6.439LysVal: 6.439 ± 0.475
0.739LysTrp: 0.739 ± 0.226
3.431LysTyr: 3.431 ± 0.466
0.0LysXaa: 0.0 ± 0.0
Leu
6.175LeuAla: 6.175 ± 0.917
0.897LeuCys: 0.897 ± 0.199
5.859LeuAsp: 5.859 ± 0.574
6.387LeuGlu: 6.387 ± 0.598
3.114LeuPhe: 3.114 ± 0.567
6.492LeuGly: 6.492 ± 0.647
0.897LeuHis: 0.897 ± 0.248
4.486LeuIle: 4.486 ± 0.475
7.126LeuLys: 7.126 ± 0.571
5.12LeuLeu: 5.12 ± 0.784
1.847LeuMet: 1.847 ± 0.312
4.486LeuAsn: 4.486 ± 0.55
3.167LeuPro: 3.167 ± 0.589
2.428LeuGln: 2.428 ± 0.353
2.639LeuArg: 2.639 ± 0.441
6.756LeuSer: 6.756 ± 0.591
5.753LeuThr: 5.753 ± 0.585
4.434LeuVal: 4.434 ± 0.426
0.633LeuTrp: 0.633 ± 0.183
2.534LeuTyr: 2.534 ± 0.361
0.0LeuXaa: 0.0 ± 0.0
Met
1.583MetAla: 1.583 ± 0.322
0.264MetCys: 0.264 ± 0.15
1.161MetAsp: 1.161 ± 0.22
1.161MetGlu: 1.161 ± 0.312
0.845MetPhe: 0.845 ± 0.27
1.267MetGly: 1.267 ± 0.246
0.106MetHis: 0.106 ± 0.075
0.845MetIle: 0.845 ± 0.233
1.425MetLys: 1.425 ± 0.295
2.481MetLeu: 2.481 ± 0.389
0.581MetMet: 0.581 ± 0.16
1.32MetAsn: 1.32 ± 0.288
0.528MetPro: 0.528 ± 0.145
1.003MetGln: 1.003 ± 0.239
1.108MetArg: 1.108 ± 0.25
2.586MetSer: 2.586 ± 0.443
1.531MetThr: 1.531 ± 0.273
1.425MetVal: 1.425 ± 0.222
0.158MetTrp: 0.158 ± 0.1
1.214MetTyr: 1.214 ± 0.247
0.0MetXaa: 0.0 ± 0.0
Asn
2.85AsnAla: 2.85 ± 0.426
0.369AsnCys: 0.369 ± 0.132
2.903AsnAsp: 2.903 ± 0.454
3.747AsnGlu: 3.747 ± 0.458
1.847AsnPhe: 1.847 ± 0.297
3.959AsnGly: 3.959 ± 0.474
1.003AsnHis: 1.003 ± 0.2
3.747AsnIle: 3.747 ± 0.388
4.117AsnLys: 4.117 ± 0.373
4.17AsnLeu: 4.17 ± 0.453
1.214AsnMet: 1.214 ± 0.259
3.114AsnAsn: 3.114 ± 0.341
2.797AsnPro: 2.797 ± 0.403
1.953AsnGln: 1.953 ± 0.367
2.217AsnArg: 2.217 ± 0.353
3.695AsnSer: 3.695 ± 0.452
3.853AsnThr: 3.853 ± 0.55
2.534AsnVal: 2.534 ± 0.419
0.475AsnTrp: 0.475 ± 0.147
2.481AsnTyr: 2.481 ± 0.429
0.0AsnXaa: 0.0 ± 0.0
Pro
1.372ProAla: 1.372 ± 0.274
0.211ProCys: 0.211 ± 0.124
2.534ProAsp: 2.534 ± 0.352
2.639ProGlu: 2.639 ± 0.5
1.108ProPhe: 1.108 ± 0.233
0.0ProGly: 0.0 ± 0.0
0.317ProHis: 0.317 ± 0.105
2.481ProIle: 2.481 ± 0.416
2.692ProLys: 2.692 ± 0.403
1.742ProLeu: 1.742 ± 0.318
0.739ProMet: 0.739 ± 0.177
1.583ProAsn: 1.583 ± 0.285
1.108ProPro: 1.108 ± 0.227
0.845ProGln: 0.845 ± 0.24
1.583ProArg: 1.583 ± 0.294
2.85ProSer: 2.85 ± 0.481
1.795ProThr: 1.795 ± 0.322
1.636ProVal: 1.636 ± 0.291
0.0ProTrp: 0.0 ± 0.0
1.742ProTyr: 1.742 ± 0.252
0.0ProXaa: 0.0 ± 0.0
Gln
2.058GlnAla: 2.058 ± 0.347
0.264GlnCys: 0.264 ± 0.12
1.742GlnAsp: 1.742 ± 0.284
2.534GlnGlu: 2.534 ± 0.517
1.32GlnPhe: 1.32 ± 0.191
2.428GlnGly: 2.428 ± 0.408
0.264GlnHis: 0.264 ± 0.107
1.795GlnIle: 1.795 ± 0.389
2.956GlnLys: 2.956 ± 0.362
2.375GlnLeu: 2.375 ± 0.372
0.739GlnMet: 0.739 ± 0.23
1.531GlnAsn: 1.531 ± 0.272
1.267GlnPro: 1.267 ± 0.316
1.636GlnGln: 1.636 ± 0.342
1.689GlnArg: 1.689 ± 0.314
2.534GlnSer: 2.534 ± 0.343
1.689GlnThr: 1.689 ± 0.293
1.953GlnVal: 1.953 ± 0.281
0.369GlnTrp: 0.369 ± 0.137
1.32GlnTyr: 1.32 ± 0.403
0.0GlnXaa: 0.0 ± 0.0
Arg
3.009ArgAla: 3.009 ± 0.548
0.369ArgCys: 0.369 ± 0.152
3.061ArgAsp: 3.061 ± 0.444
3.009ArgGlu: 3.009 ± 0.394
2.006ArgPhe: 2.006 ± 0.313
3.167ArgGly: 3.167 ± 0.52
1.056ArgHis: 1.056 ± 0.248
3.484ArgIle: 3.484 ± 0.518
2.217ArgLys: 2.217 ± 0.339
3.906ArgLeu: 3.906 ± 0.66
1.003ArgMet: 1.003 ± 0.241
1.425ArgAsn: 1.425 ± 0.286
1.267ArgPro: 1.267 ± 0.284
1.32ArgGln: 1.32 ± 0.264
1.742ArgArg: 1.742 ± 0.247
2.322ArgSer: 2.322 ± 0.353
2.639ArgThr: 2.639 ± 0.328
3.589ArgVal: 3.589 ± 0.525
0.686ArgTrp: 0.686 ± 0.199
1.689ArgTyr: 1.689 ± 0.274
0.0ArgXaa: 0.0 ± 0.0
Ser
5.278SerAla: 5.278 ± 0.71
0.845SerCys: 0.845 ± 0.246
4.434SerAsp: 4.434 ± 0.437
5.489SerGlu: 5.489 ± 0.556
2.797SerPhe: 2.797 ± 0.367
5.014SerGly: 5.014 ± 0.388
1.161SerHis: 1.161 ± 0.24
4.645SerIle: 4.645 ± 0.561
6.07SerLys: 6.07 ± 0.53
6.492SerLeu: 6.492 ± 0.717
1.583SerMet: 1.583 ± 0.263
3.853SerAsn: 3.853 ± 0.425
1.847SerPro: 1.847 ± 0.356
2.797SerGln: 2.797 ± 0.446
3.114SerArg: 3.114 ± 0.416
6.228SerSer: 6.228 ± 0.571
4.434SerThr: 4.434 ± 0.42
4.539SerVal: 4.539 ± 0.493
0.422SerTrp: 0.422 ± 0.17
2.956SerTyr: 2.956 ± 0.417
0.0SerXaa: 0.0 ± 0.0
Thr
4.486ThrAla: 4.486 ± 0.746
0.792ThrCys: 0.792 ± 0.21
3.747ThrAsp: 3.747 ± 0.491
4.328ThrGlu: 4.328 ± 0.566
2.375ThrPhe: 2.375 ± 0.328
3.009ThrGly: 3.009 ± 0.41
1.32ThrHis: 1.32 ± 0.267
3.325ThrIle: 3.325 ± 0.503
6.228ThrLys: 6.228 ± 0.713
5.912ThrLeu: 5.912 ± 0.493
0.792ThrMet: 0.792 ± 0.185
3.009ThrAsn: 3.009 ± 0.444
2.217ThrPro: 2.217 ± 0.287
2.639ThrGln: 2.639 ± 0.344
2.428ThrArg: 2.428 ± 0.377
4.381ThrSer: 4.381 ± 0.52
4.011ThrThr: 4.011 ± 0.511
5.278ThrVal: 5.278 ± 0.529
0.633ThrTrp: 0.633 ± 0.188
2.639ThrTyr: 2.639 ± 0.382
0.0ThrXaa: 0.0 ± 0.0
Val
3.959ValAla: 3.959 ± 0.438
0.686ValCys: 0.686 ± 0.235
4.539ValAsp: 4.539 ± 0.505
5.964ValGlu: 5.964 ± 0.592
3.009ValPhe: 3.009 ± 0.389
5.173ValGly: 5.173 ± 0.596
0.739ValHis: 0.739 ± 0.226
4.011ValIle: 4.011 ± 0.381
5.014ValLys: 5.014 ± 0.59
4.909ValLeu: 4.909 ± 0.482
1.32ValMet: 1.32 ± 0.223
3.8ValAsn: 3.8 ± 0.361
2.27ValPro: 2.27 ± 0.357
1.689ValGln: 1.689 ± 0.266
3.853ValArg: 3.853 ± 0.449
5.384ValSer: 5.384 ± 0.548
4.011ValThr: 4.011 ± 0.49
5.595ValVal: 5.595 ± 0.526
1.161ValTrp: 1.161 ± 0.285
2.85ValTyr: 2.85 ± 0.447
0.0ValXaa: 0.0 ± 0.0
Trp
0.633TrpAla: 0.633 ± 0.172
0.264TrpCys: 0.264 ± 0.104
1.161TrpAsp: 1.161 ± 0.316
0.897TrpGlu: 0.897 ± 0.222
0.528TrpPhe: 0.528 ± 0.202
0.581TrpGly: 0.581 ± 0.186
0.317TrpHis: 0.317 ± 0.115
0.739TrpIle: 0.739 ± 0.197
0.581TrpLys: 0.581 ± 0.184
1.32TrpLeu: 1.32 ± 0.28
0.158TrpMet: 0.158 ± 0.091
0.633TrpAsn: 0.633 ± 0.166
0.0TrpPro: 0.0 ± 0.0
0.422TrpGln: 0.422 ± 0.154
0.264TrpArg: 0.264 ± 0.106
0.475TrpSer: 0.475 ± 0.141
0.739TrpThr: 0.739 ± 0.176
1.267TrpVal: 1.267 ± 0.276
0.158TrpTrp: 0.158 ± 0.09
0.369TrpTyr: 0.369 ± 0.115
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.847TyrAla: 1.847 ± 0.306
0.581TyrCys: 0.581 ± 0.192
2.375TyrAsp: 2.375 ± 0.357
3.22TyrGlu: 3.22 ± 0.537
1.267TyrPhe: 1.267 ± 0.274
3.325TyrGly: 3.325 ± 0.518
0.581TyrHis: 0.581 ± 0.197
2.534TyrIle: 2.534 ± 0.404
3.22TyrLys: 3.22 ± 0.488
3.378TyrLeu: 3.378 ± 0.471
0.686TyrMet: 0.686 ± 0.173
2.903TyrAsn: 2.903 ± 0.435
1.795TyrPro: 1.795 ± 0.347
2.058TyrGln: 2.058 ± 0.334
2.27TyrArg: 2.27 ± 0.347
2.322TyrSer: 2.322 ± 0.389
2.692TyrThr: 2.692 ± 0.406
2.481TyrVal: 2.481 ± 0.333
0.369TyrTrp: 0.369 ± 0.141
1.742TyrTyr: 1.742 ± 0.376
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 65 proteins (18947 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski